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List of works by Frits Peters

"One marker does not fit all": additional translational and validation studies are needed to identify faithful predictors of pemetrexed activity in mesothelioma

scientific article

"Open Sesame?": Biomarker Status of the Human Equilibrative Nucleoside Transporter-1 and Molecular Mechanisms Influencing its Expression and Activity in the Uptake and Cytotoxicity of Gemcitabine in Pancreatic Cancer

scientific article published on 31 October 2020

"The only thing I know is that I know nothing": 5-fluorouracil in human milk

scientific article published on 01 February 2012

11C-sorafenib and 15O-H2O PET for early evaluation of sorafenib therapy

scientific article published on 30 October 2020

2',2'-Difluoro-deoxycytidine (gemcitabine) incorporation into RNA and DNA of tumour cell lines

scientific article published on August 1993

3'-Azido-2',3'-dideoxythymidine induced deficiency of thymidine kinases 1, 2 and deoxycytidine kinase in H9 T-lymphoid cells

scientific article

3-(6-Phenylimidazo [2,1-b][1,3,4]thiadiazol-2-yl)-1H-Indole Derivatives as New Anticancer Agents in the Treatment of Pancreatic Ductal Adenocarcinoma

scientific article published on 14 January 2020

5'-nucleotidase cN-II emerges as a new predictive biomarker of response to gemcitabine/platinum combination chemotherapy in non-small cell lung cancer

scientific article published on 16 February 2018

5-Fluorouracil incorporation into RNA and DNA in relation to thymidylate synthase inhibition of human colorectal cancers

scientific article

5-Fluorouracil induced Fas upregulation associated with apoptosis in liver metastases of colorectal cancer patients

scientific article published in February 2001

5-ethyl-2'-deoxyuridine, a modulator of both antitumour action and pharmacokinetics of 5-fluorouracil

scientific article published on 01 December 1999

5-fluorouracil/leucovorin-induced inhibition of thymidylate synthase in normal tissues of mouse and man

scientific article published on 01 January 1997

A Structurally Altered Human Reduced Folate Carrier with Increased Folic Acid Transport Mediates a Novel Mechanism of Antifolate Resistance ⬇️

scientific article published on November 13, 1998

A bug in the resistance to EGFR inhibitors: is there a role for Mycoplasma and cytidine deaminase in reducing the activity of osimertinib in lung cancer patients?

scientific article published in 2021

A comparison of 5-fluorouracil metabolism in human colorectal cancer and colon mucosa ⬇️

scientific article published on 01 November 1991

A mechanopharmacology approach to overcome chemoresistance in pancreatic cancer.

scientific article published in March 2017

A multicenter phase II study of erlotinib and sorafenib in chemotherapy-naive patients with advanced non-small cell lung cancer

scientific article published on 15 April 2010

A novel cytidine analog, RX-3117, shows potent efficacy in xenograft models, even in tumors that are resistant to gemcitabine.

scientific article published on December 2014

A parallel dose-escalation study of weekly and twice-weekly bortezomib in combination with gemcitabine and cisplatin in the first-line treatment of patients with advanced solid tumors

scientific article

A phase I and pharmacokinetic study of gemcitabine given by 24-h hepatic arterial infusion

scientific article

A polymorphism in the promoter is associated with EZH2 expression but not with outcome in advanced pancreatic cancer patients

scientific article

A sensitive non-radioactive assay for pyrimidine nucleoside phosphorylase using reversed-phase high performance liquid chromatography

scientific article published on 01 November 1988

A sensitive, nonradiometric assay for dihydroorotic acid dehydrogenase using anion-exchange high-performance liquid chromatography

scientific article published on 01 February 1987

A single nucleotide polymorphism in EZH2 predicts overall survival rate in patients with cholangiocarcinoma

scientific article

A specific inhibitor of lactate dehydrogenase overcame the resistance toward gemcitabine in hypoxic mesothelioma cells, and modulated the expression of the human equilibrative transporter-1.

scientific article published on December 2016

ABCG2 harboring the Gly482 mutation confers high-level resistance to various hydrophilic antifolates

scientific article published on September 2005

AKT1 and SELP polymorphisms predict the risk of developing cachexia in pancreatic cancer patients

scientific article

Abstract 1267: Unusual mechanism of resistance to the novel cytidine analog fluorocyclopentenylcytosine (RX-3117)

scholarly article

Accumulation of thymidine-derived sugars in thymidine phosphorylase overexpressing cells

scientific article

Acquired tumor cell resistance to sunitinib causes resistance in a HT-29 human colon cancer xenograft mouse model without affecting sunitinib biodistribution or the tumor microvasculature

scientific article

Acridone-pyrimidine hybrids- design, synthesis, cytotoxicity studies in resistant and sensitive cancer cells and molecular docking studies.

scientific article published on 12 August 2017

Activity and substrate specificity of pyrimidine phosphorylases and their role in fluoropyrimidine sensitivity in colon cancer cell lines

scientific article published on 21 October 2006

Addition of leucovorin in modulation of 5-fluorouracil with methotrexate: potentiating or reversing effect?

scientific article published on 01 May 1995

Adenosine and deoxyadenosine metabolism in mammalian lymphocytes ⬇️

scientific article published on 01 January 1981

Adenosine deaminase and purine nucleoside phosphorylase in childhood lymphoblastic leukemia: relation with differentiation stage, in vitro drug resistance and clinical prognosis

scientific article published on May 1, 1992

Adherence and Patients' Experiences with the Use of Capecitabine in Daily Practice

scientific article published on 21 September 2016

Advances in purine and pyrimidine metabolism in health and diseases

scientific article

Allopurinol enhances the activity of hypoxanthine-guanine phosphoribosyltransferase in inflammatory bowel disease patients during low-dose thiopurine therapy: preliminary data of an ongoing series

scientific article

Alternative scheduling of pulsatile, high dose sunitinib efficiently suppresses tumor growth

scientific article published on 7 September 2016

Aminopeptidase antibodies in mesothelioma: new wine deserves new sacks

scientific article published on 24 May 2018

An Expedient Assay for Determination of Gemcitabine and Its Metabolite in Human Plasma Using Isocratic Ion-Pair Reversed-Phase High-Performance Liquid Chromatography ⬇️

scientific article published on October 1, 2003

Analysis of Drug Interactions

scientific article published on 01 January 2011

Analysis of deoxycytidine accumulation in gemcitabine treated patients

scientific article published on 01 January 2006

Anaplastic lymphoma kinase inhibition in metastatic non-small cell lung cancer: clinical impact of alectinib

scientific article

Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2.

scientific article

Antiproliferative activity and mechanism of action of fatty acid derivatives of arabinosylcytosine (ara-C) in leukemia and solid tumor cell lines

scientific article

Antiproliferative activity and mechanism of action of fatty acid derivatives of gemcitabine in leukemia and solid tumor cell lines and in human xenografts.

scientific article

Antiproliferative activity, mechanism of action and oral antitumor activity of CP-4126, a fatty acid derivative of gemcitabine, in in vitro and in vivo tumor models.

scientific article

Antiproliferative effects of novel aliphatic acetogenin analogs against aggressive solid tumor cell lines.

scientific article published on March 2011

Antipyrimidine effects of five different pyrimidine de novo synthesis inhibitors in three head and neck cancer cell lines

scientific article published on 03 May 2018

Antitumor activity and biodistribution of cisplatin nanocapsules in nude mice bearing human ovarian carcinoma xenografts

scientific article published on 01 August 2008

Antitumor activity of brequinar sodium (Dup-785) against human head and neck squamous cell carcinoma xenografts

scientific article published on February 1990

Antitumor activity of prolonged as compared with bolus administration of 2',2'-difluorodeoxycytidine in vivo against murine colon tumors

scientific article published on 01 January 1996

Antitumour activity, toxicity and inhibition of thymidylate synthase of prolonged administration of 5-fluorouracil in mice.

scientific article

Aphidicolin decreases ex vivo resistance to cytosine arabinoside in childhood acute leukaemia ⬇️

scientific article published on November 1, 2003

Assessment of mercaptopurine (6MP) metabolites and 6MP metabolic key-enzymes in childhood acute lymphoblastic leukemia

scientific article published in January 2014

Association between DNA-repair polymorphisms and survival in pancreatic cancer patients treated with combination chemotherapy.

scientific article published on 25 October 2011

Association of polymorphisms in AKT1 and EGFR with clinical outcome and toxicity in non-small cell lung cancer patients treated with gefitinib.

scientific article published on 16 February 2010

Augmentation of 1-β-d-Arabinofuranosylcytosine (Ara-C) cytotoxicity in leukaemia cells by co-administration with antisignalling drugs ⬇️

scientific article published on May 1, 1998

Basis for effective combination cancer chemotherapy with antimetabolites

scientific article

Better to be alone than in bad company: The antagonistic effect of cisplatin and crizotinib combination therapy in non-small cell lung cancer.

scientific article published on December 2016

Biochemical mechanisms of interferon modulation of 5-fluorouracil activity in colon cancer cells

Biochemical modification of the toxicity and the anti-tumour effect of 5-fluorouracil and cis-platinum by WR-2721 in mice

scientific article published on January 1, 1992

Biological Evaluation of the Antiproliferative and Anti-migratory Activity of a Series of 3-(6-Phenylimidazo[2,1-b][1,3,4]thiadiazol-2-yl)-1H-indole Derivatives Against Pancreatic Cancer Cells

scientific article published on 01 July 2019

Biological activity of 1-deazapurine nucleosides: role of deoxycytidine kinase?

scientific article published on 01 April 1999

Biotransformation of 6‐thioguanine in inflammatory bowel disease patients: a comparison of oral and intravenous administration of 6‐thioguanine ⬇️

scientific article published on June 1, 2011

Bortezomib and TRAIL: a perfect match for apoptotic elimination of tumour cells?

scientific article published on September 2012

Bortezomib induces schedule-dependent modulation of gemcitabine pharmacokinetics and pharmacodynamics in non-small cell lung cancer and blood mononuclear cells

scientific article published on 21 April 2009

Breastfeeding during R-CHOP chemotherapy: please abstain!

scientific article published on 19 August 2019

CX-5461 Inhibits Pancreatic Ductal Adenocarcinoma Cell Growth, Migration and Induces DNA Damage

scientific article published on 04 December 2019

Calcium/Magnesium Infusion for Oxaliplatin-Induced Neuropathy: Protective or Not?

scientific article published on 18 August 2014

Can cytidine deaminase be used as predictive biomarker for gemcitabine toxicity and response?

article

Cancer of the esophagus and gastric cardia: recent advances

scientific article published on January 2004

Cell cycle disturbances and apoptosis induced by topotecan and gemcitabine on human lung cancer cell lines.

scientific article published on May 1999

Cell cycle effects and increased adduct formation by temozolomide enhance the effect of cytotoxic and targeted agents in lung cancer cell lines

scientific article

Cell cycle effects of fatty acid derivatives of cytarabine, CP-4055, and of gemcitabine, CP-4126, as basis for the interaction with oxaliplatin and docetaxel.

scientific article

Cell specific cytotoxicity and structure-activity relationship of lipophilic 1-B-D-arabinofuranosylcytosine (ara-C) derivatives

scientific article

Cellular folate status modulates the expression of BCRP and MRP multidrug transporters in cancer cell lines from different origins

scientific article

Cellular pharmacology of multi- and duplex drugs consisting of ethynylcytidine and 5-fluoro-2'-deoxyuridine

scientific article

Cellular pharmacology studies of anticancer agents: recommendations from the EORTC-PAMM group

scientific article published on 28 December 2017

Cellular resistance against troxacitabine in human cell lines and pediatric patient acute myeloid leukemia blast cells

scientific article published on January 2006

Cellular response of X-ray sensitive hamster mutant cell lines to gemcitabine, cisplatin and 5-fluorouracil

scientific article published on July 2004

Changes in the status of p53 affect drug sensitivity to thymidylate synthase (TS) inhibitors by altering TS levels

scientific article published on March 2007

Characterization of and protection from neurotoxicity induced by oxaliplatin, bortezomib and epothilone-B.

scientific article

Chemosensitizing acridones: in vitro calmodulin dependent cAMP phosphodiesterase inhibition, docking, pharmacophore modeling and 3D QSAR studies

scientific article

Chemotherapy triggers apoptosis in a caspase-8-dependent and mitochondria-controlled manner in the non-small cell lung cancer cell line NCI-H460.

scientific article

Clinical and pharmacologic study of orally administered uridine

scientific article published on 01 March 1991

Clinical phase I and pharmacology study of gemcitabine (2', 2'-difluorodeoxycytidine) administered in a two-weekly schedule

scientific article published on 01 April 2007

Clinical relevance of biochemical modulation of 5-fluorouracil

scientific article published on July 1991

Coexisting Molecular Determinants of Acquired Oxaliplatin Resistance in Human Colorectal and Ovarian Cancer Cell Lines

scientific article published on 24 July 2019

Collateral sensitivity to gemcitabine (2',2'-difluorodeoxycytidine) and cytosine arabinoside of daunorubicin- and VM-26-resistant variants of human small cell lung cancer cell lines

scientific article published in June 2001

Combination Therapies of Artemisinin and its Derivatives as a Viable Approach for Future Cancer Treatment

scientific article published on 01 January 2019

Combination chemotherapy studies with gemcitabine

scientific article published on April 1997

Combination chemotherapy studies with gemcitabine and etoposide in non-small cell lung and ovarian cancer cell lines

scientific article published on February 1999

Combination therapy with gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, gemcitabine and cisplatin in patients with advanced solid tumors

scientific article

Combinations of 5-fluorouracil with UCN-01 or staurosporine

scientific article

Combined assessment of EGFR pathway-related molecular markers and prognosis of NSCLC patients

scientific article published on 02 December 2008

Comment on: Targeting the HGF/c-MET pathway in advanced pancreatic cancer: a key element of treatment that limits primary tumour growth and eliminates metastasis

scientific article published on 28 July 2020

Common resistance mechanisms to deoxynucleoside analogues in variants of the human erythroleukaemic line K562.

scientific article

Comparison of 5-Fluoro-2’-Deoxyuridine and 5-Fluorouracil in the Treatment of Murine Colon Cancer; Effects on Thymidylate Synthase ⬇️

scientific article published on January 1, 1994

Comparison of 5-fluoro-2′-deoxyuridine with 5-fluorouracil and their role in the treatment of colorectal cancer ⬇️

scientific article published on February 1, 1998

Comparison of continuous infusions and bolus injections of 5-fluorouracil with or without leucovorin: implications for inhibition of thymidylate synthase

scientific article published on 01 January 1993

Comparison of the sulforhodamine B protein and tetrazolium (MTT) assays for in vitro chemosensitivity testing ⬇️

scientific article published on January 1, 1991

Concentration and time dependent growth inhibition and metabolism in vitro by 2',2'-difluoro-deoxycytidine (gemcitabine).

scientific article published on January 1991

Concentration, synthesis and utilization of phosphoribosylpyrophosphate in lymphocytes of five mammalian species ⬇️

scientific article published on January 1, 1979

Contemporary reviews on cancer treatment

scientific article published on 01 January 2016

Correlation between cytidine deaminase genotype and gemcitabine deamination in blood samples

scientific article published in June 2008

Correlation of CDA, ERCC1, and XPD polymorphisms with response and survival in gemcitabine/cisplatin-treated advanced non-small cell lung cancer patients.

scientific article

Correlation of cytidine deaminase polymorphisms and activity with clinical outcome in gemcitabine-/platinum-treated advanced non-small-cell lung cancer patients

scientific article published on 7 June 2011

Crizotinib inhibits metabolic inactivation of gemcitabine in c-Met-driven pancreatic carcinoma

scientific article

Crizotinib sensitizes the erlotinib resistant HCC827GR5 cell line by influencing lysosomal function

scientific article published on 20 January 2020

Cross-Resistance to Thymidylate Synthase Inhibitors in P-Glycoprotein and Non-P-Glycoprotein Cell Lines ⬇️

scientific article published on January 1, 1994

Cross-resistance in the 2',2'-difluorodeoxycytidine (gemcitabine)-resistant human ovarian cancer cell line AG6000 to standard and investigational drugs

scientific article published on October 2000

Cross-resistance of the gemcitabine resistant human ovarian cancer cell line AG6000 to standard and investigational drugs.

scientific article published on January 1998

Cross-resistance to antifolates in multidrug resistant cell lines with P-glycoprotein or multidrug resistance protein expression ⬇️

scientific article published on June 15, 1997

Cross-resistance to clinically used tyrosine kinase inhibitors sunitinib, sorafenib and pazopanib.

scientific article

Cytidine deaminase enzymatic activity is a prognostic biomarker in gemcitabine/platinum-treated advanced non-small-cell lung cancer: a prospective validation study

scientific article published on 08 November 2018

Cytotoxic effects of anticancer agents on subconfluent and multilayered postconfluent cultures

scientific article published on 01 January 1993

Cytotoxicity of sphingoid marine compound analogs in mono- and multilayered solid tumor cell cultures

scientific article published on May 2006

Cytotoxicity studies of some novel fluoro acridone derivatives against sensitive and resistant cancer cell lines and their mechanistic studies

scientific article published on 30 April 2011

DNA copy number profiles correlate with outcome in colorectal cancer patients treated with fluoropyrimidine/antifolate-based regimens

scientific article published on December 2011

DNA copy number profiles of primary tumors as predictors of response to chemotherapy in advanced colorectal cancer

scientific article published on 15 January 2009

DNA methyltransferases expression in normal tissues and various human cancer cell lines, xenografts and tumors

scientific article published on 01 January 2018

DNA-bound platinum is the major determinant of cisplatin sensitivity in head and neck squamous carcinoma cells

scientific article

DUP 785 (NSC 368390): schedule-dependency of growth-inhibitory and antipyrimidine effects

scientific article published on 01 September 1988

Decrease in phospho-PRAS40 plays a role in the synergy between erlotinib and crizotinib in an EGFR and cMET wild-type squamous non-small cell lung cancer cell line

scientific article published on 10 May 2019

Decreased resistance to gemcitabine (2',2'-difluorodeoxycitidine) of cytosine arabinoside-resistant myeloblastic murine and rat leukemia cell lines: role of altered activity and substrate specificity of deoxycytidine kinase

scientific article published on February 1999

Deoxycytidine kinase and deoxycytidine deaminase activities in human tumour xenografts

scientific article published on 01 January 1993

Deoxyribose protects against rapamycin-induced cytotoxicity in colorectal cancer cells in vitro

scientific article

Design and synthesis of quinazolinone tagged acridones as cytotoxic agents and their effects on EGFR tyrosine kinase

scientific article

Design of new drug molecules to be used in reversing multidrug resistance in cancer cells

scientific article published on May 2009

Detection of an alternatively spliced form of deoxycytidine kinase mRNA in the 2'-2'-difluorodeoxycytidine (gemcitabine)-resistant human ovarian cancer cell line AG6000.

scientific article published on August 2004

Determinants of resistance to 2',2'-difluorodeoxycytidine (gemcitabine).

scientific article

Determinants of the therapeutic efficacy of thymidylate synthase inhibitors

scientific article published on 01 January 1998

Determinants of trifluorothymidine sensitivity and metabolism in colon and lung cancer cells

scientific article published in March 2005

Determination of the antimetabolite Gemcitabine (2',2'-difluoro-2'-deoxycytidine) and of 2',2'-difluoro-2'-deoxyuridine by 19F nuclear magnetic resonance spectroscopy

scientific article published on 01 October 1993

Determination of the phosphorylated metabolites of gemcitabine and of difluorodeoxyuridine by LCMSMS.

scientific article

Development and molecular characterization of a 2',2'-difluorodeoxycytidine-resistant variant of the human ovarian carcinoma cell line A2780.

scientific article published on August 1994

Development of a simple folylpolyglutamate synthetase assay in tissues and cell lines.

scientific article published on January 1993

Development of new molecular agents targeting key signalling pathways activated by growth factors in human cancer

scientific article published on 01 January 2013

Development, pharmacology, role of DT-diaphorase and prospects of the indoloquinone EO9.

scientific article published on April 1996

Differences in the induction of DNA damage, cell cycle arrest, and cell death by 5-fluorouracil and antifolates

scientific article published on 01 January 2000

Different drug sensitivity profiles of acute myeloid and lymphoblastic leukemia and normal peripheral blood mononuclear cells in children with and without Down syndrome

scientific article published in January 2002

Differential activation of cell death and autophagy results in an increased cytotoxic potential for trifluorothymidine compared to 5-fluorouracil in colon cancer cells.

scientific article published on May 2010

Differential effects of gemcitabine on nucleotide pools of 19 solid tumor cell lines

scientific article published on 01 January 1998

Differential effects of gemcitabine on ribonucleotide pools of twenty-one solid tumour and leukaemia cell lines.

scientific article

Differential expression of cell cycle and apoptosis related proteins in colorectal mucosa, primary colon tumours, and liver metastases

scientific article published on March 2002

Differential mRNA expression of Ara-C-metabolizing enzymes explains Ara-C sensitivity in MLL gene-rearranged infant acute lymphoblastic leukemia

scientific article

Differential methotrexate resistance in childhood T- versus common/preB-acute lymphoblastic leukemia can be measured by an in situ thymidylate synthase inhibition assay, but not by the MTT assay

scientific article published in February 1999

Dihydropyrimidine dehydrogenase in livers from mouse and rat, and in human liver, colon tumors, and mucosa in relation to anabolism of 5-fluorouracil

scientific article published on 01 January 1998

Discovery of N-hydroxyindole-based inhibitors of human lactate dehydrogenase isoform A (LDH-A) as starvation agents against cancer cells.

scientific article published on 18 February 2011

Disparate mechanisms of antifolate resistance provoked by methotrexate and its metabolite 7-hydroxymethotrexate in leukemia cells: implications for efficacy of methotrexate therapy.

scientific article published on 12 August 2004

Dose-finding and pharmacokinetic study of cisplatin, gemcitabine, and SU5416 in patients with solid tumors

scientific article

Double Trouble: A Case Series on Concomitant Genetic Aberrations in NSCLC.

scientific article

Downstream molecular determinants of response to 5-fluorouracil and antifolate thymidylate synthase inhibitors.

scientific article

Drug transport and metabolism of novel anticancer drugs

scientific article published on 01 May 2015

Drug transporters: recent advances concerning BCRP and tyrosine kinase inhibitors

scientific article published on 05 February 2008

Drug-induced apoptosis in lung cnacer cells is not mediated by the Fas/FasL (CD95/APO1) signaling pathway.

scientific article

Dynamics of antifolate transport via the reduced folate carrier and the membrane folate receptor in murine leukaemia cells in vitro and in vivo

scientific article published on 19 February 2008

EGF receptor-targeted therapy in non-small-cell lung cancer: role of germline polymorphisms in outcome and toxicity

scientific article published on August 2012

EO9 (Apaziquone): from the clinic to the laboratory and back again

scientific article published on January 2013

Effect of Leucovorin on 5-Fluorouracil Induced Inhibition of Thymidylate Synthase in Patients with Colon Cancer ⬇️

scientific article published on 01 January 1991

Effect of WR-2721 on the toxicity and antitumor activity of the combination of carboplatin and 5-fluorouracil

scientific article

Effect of dexamethasone on the antileukemic effect of cytarabine: role of deoxycytidine kinase

scientific article published on 30 July 2020

Effect of folate diastereoisomers on the binding of 5-fluoro-2'-deoxyuridine-5'-monophosphate to thymidylate synthase

scientific article published on 01 March 1993

Effect of folinic acid on fluorouracil activity and expression of thymidylate synthase

scientific article published on 01 April 1992

Effect of gemcitabine and cis-platinum combinations on ribonucleotide and deoxyribonucleotide pools in ovarian cancer cell lines

scientific article published on January 2003

Effect of polymorphisms in folate-related genes on in vitro methotrexate sensitivity in pediatric acute lymphoblastic leukemia

scientific article published on 29 March 2005

Effects of adenosine and deoxyadenosine on pha-stimulation of lymphocytes of man, horse and pig ⬇️

scientific article published on 01 January 1982

Effects of antifolates on the binding of 5-fluoro-2'-deoxyuridine monophosphate to thymidylate synthase

scientific article published in August 2002

Effects of gemcitabine on cis-platinum-DNA adduct formation and repair in a panel of gemcitabine and cisplatin-sensitive or -resistant human ovarian cancer cell lines.

scientific article published in January 2006

Effects of the modulating agent WR2721 on myelotoxicity and antitumour activity in carboplatin-treated mice

scientific article published on 01 January 1994

Efficacy of thioguanine treatment in inflammatory bowel disease: A systematic review.

scientific article published on October 2016

Efficacy, pharmacokinetic and pharmacodynamic evaluation of apaziquone in the treatment of non-muscle invasive bladder cancer

scientific article published on 21 June 2017

Elevation of thymidylate synthase following 5-fluorouracil treatment is prevented by the addition of leucovorin in murine colon tumors ⬇️

scientific article published on September 15, 1992

Elucidation of chemosensitization effect of acridones in cancer cell lines: Combined pharmacophore modeling, 3D QSAR, and molecular dynamics studies

scientific article

End-joining deficiency and radiosensitization induced by gemcitabine

scientific article published in February 2001

Enhanced activity of deoxycytidine kinase after pulsed low dose rate and single dose gamma irradiation.

scientific article published on January 2006

Enhanced efficacy of AKT and FAK kinase combined inhibition in squamous cell lung carcinomas with stable reduction in PTEN

scientific article published on 23 May 2017

Enhanced levels of deoxycytidine kinase and thymidine kinase 1 and 2 after pulsed low dose rate irradiation as an adaptive response to radiation

scientific article published on January 1, 2002

Enhanced therapeutic efficacy of 5'deoxy-5-fluorouridine in 5-fluorouracil resistant head and neck tumours in relation to 5-fluorouracil metabolising enzymes

scientific article

Enhancement of the antiproliferative activity of gemcitabine by modulation of c-Met pathway in pancreatic cancer

scientific article published on January 2013

Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors and Chemotherapy: A Glimmer of Hope?

scientific article

Epidermal growth factor receptor tyrosine kinase inhibitors: current status and future perspectives in the development of novel irreversible inhibitors for the treatment of mutant non-small cell lung cancer

scientific article published on January 2013

Epigenetic mechanisms of irinotecan sensitivity in colorectal cancer cell lines.

scientific article

Epithelial Transfer of the Tyrosine Kinase Inhibitors Erlotinib, Gefitinib, Afatinib, Crizotinib, Sorafenib, Sunitinib, and Dasatinib: Implications for Clinical Resistance

scientific article published on 10 November 2020

Erratum to: Glutamate and α-ketoglutarate: key players in glioma metabolism.

scientific article

Evaluation of immunohistochemical staining and activity of thymidylate synthase in cell lines

scientific article published on January 1993

Ex vivo resistance in childhood acute lymphoblastic leukemia: Correlations between BCRP, MRP1, MRP4 and MRP5 ABC transporter expression and intracellular methotrexate polyglutamate accumulation

scientific article published on 23 February 2019

Experimental drugs and drug combinations in pancreatic cancer

scientific article

Expression microarray analysis and oligo array comparative genomic hybridization of acquired gemcitabine resistance in mouse colon reveals selection for chromosomal aberrations

scientific article

Expression of deoxycytidine kinase in leukaemic cells compared with solid tumour cell lines, liver metastases and normal liver

scientific article (publication date: March 2003)

Expression of the nucleoside transporters hENT1 (SLC29) and hCNT1 (SLC28) in pediatric acute myeloid leukemia

scientific article published on 20 April 2020

FOLFIRINOX and translational studies: Towards personalized therapy in pancreatic cancer

scientific article

Fluctuations in phosphoribosyl pyrophosphate levels in monolayer tumor cell lines ⬇️

scientific article published on May 21, 1984

Fluoropyrimidine metabolism in human head and neck cancer xenografts and murine colon tumors

Fluorouracil (5FU) pharmacokinetics in 5FU prodrug formulations with a dihydropyrimidine dehydrogenase inhibitor

scientific article published in November 2001

Folate concentration dependent transport activity of the Multidrug Resistance Protein 1 (ABCC1).

scientific article published on April 2004

Folate depletion increases sensitivity of solid tumor cell lines to 5-fluorouracil and antifolates

scientific article published in September 2000

Folate deprivation induces BCRP (ABCG2) expression and mitoxantrone resistance in Caco-2 cells.

scientific article

Folate receptors and transporters: biological role and diagnostic/therapeutic targets in cancer and other diseases

scientific article published on 12 March 2019

Folates as adjuvants to anticancer agents: Chemical rationale and mechanism of action

scientific article

Folates provoke cellular efflux and drug resistance of substrates of the multidrug resistance protein 1 (MRP1).

scientific article published on 5 March 2014

Folylpolyglutamate synthetase splicing alterations in acute lymphoblastic leukemia are provoked by methotrexate and other chemotherapeutics and mediate chemoresistance

scientific article published on 6 November 2015

From 'Targeted Therapy' to Targeted Therapy

scientific article published on 01 July 2019

Functional activity of the reduced folate carrier in KB, MA104, and IGROV-I cells expressing folate-binding protein ⬇️

scientific article published on 01 September 1995

Functional inactivity and mutations of p53 differentially affect sensitivity to 5-fluorouracil and antifolate inhibitors of thymidylate synthase (TS) by altering TS levels in colorectal cancer cells

scientific article

Galectin-4 expression is associated with reduced lymph node metastasis and modulation of Wnt/β-catenin signalling in pancreatic adenocarcinoma

scientific article

Gemcitabine and paclitaxel: pharmacokinetic and pharmacodynamic interactions in patients with non-small-cell lung cancer

scientific article published on 01 July 1999

Gemcitabine chemoresistance in pancreatic cancer: molecular mechanisms and potential solutions

scientific article published on January 2009

Gemcitabine uptake in glioblastoma multiforme: potential as a radiosensitizer

scientific article

Gemcitabine-cisplatin: a schedule finding study.

scientific article

Gemcitabine-radiotherapy in patients with locally advanced pancreatic cancer.

scientific article

Gender, Cytidine Deaminase, and 5-Aza/Decitabine--Letter

scientific article published on 08 May 2013

Gene expression profiling of leukemia T-cells resistant to methotrexate and 7-hydroxymethotrexate reveals alterations that preserve intracellular levels of folate and nucleotide biosynthesis

scientific article

Glutamate and α-ketoglutarate: key players in glioma metabolism

scientific article

Gout and hyperuricemia in Japan: perspectives for international research on purines and pyrimidines in man.

scientific article published in December 2011

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

High inter-individual variability of serum xanthine oxidoreductase activity in IBD patients

scientific article published on 03 May 2018

High-dose 5-Fluorouracil with uridine-diphosphoglucose rescue increases thymidylate synthase inhibition but not 5-Fluorouracil incorporation into RNA in murine tumors.

scientific article

High-throughput microRNA (miRNAs) arrays unravel the prognostic role of MiR-211 in pancreatic cancer

scientific article

Highly sensitive determination of 5-fluorouracil in human plasma by capillary gas chromatography and negative ion chemical ionization mass spectrometry

scholarly article published 1 September 1985

How to overcome ATP-binding cassette drug efflux transporter-mediated drug resistance?

scholarly article published on 19 March 2018

Hypoxanthine-guanine phosphoribosyl-transferase in childhood leukemia: relation with immunophenotype, in vitro drug resistance and clinical prognosis

scientific article published on 01 May 1992

Identification of microRNA-21 as a biomarker for chemoresistance and clinical outcome following adjuvant therapy in resectable pancreatic cancer

scientific article published on 14 May 2010

Imidazo[2,1-b] [1,3,4]thiadiazoles with antiproliferative activity against primary and gemcitabine-resistant pancreatic cancer cells

scientific article published on 25 January 2020

Immunocytochemical detection of deoxycytidine kinase in pediatric malignancies in relation to in vitro cytarabine sensitivity

scientific article

Immunocytochemical detection of hENT1 and hCNT1 in normal tissues, lung cancer cell lines, and NSCLC patient samples

scientific article

Impact of cellular folate status and epidermal growth factor receptor expression on BCRP/ABCG2-mediated resistance to gefitinib and erlotinib.

scientific article published on 10 March 2009

Impact of cytidine deaminase polymorphisms on toxicity after gemcitabine: the question is still ongoing.

scientific article published on 29 March 2010

Impact of hypoxia on chemoresistance of mesothelioma mediated by the proton-coupled folate transporter, and preclinical activity of new anti-LDH-A compounds

scientific article published on 04 June 2020

Impact ofABCG2polymorphisms on the clinical outcome and toxicity of gefitinib in non-small-cell lung cancer patients

article

Importance of pharmacodynamics in the in vitro antiproliferative activity of the antifolates methotrexate and 10-ethyl-10-deazaaminopterin against human head and neck squamous cell carcinoma

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In vitro activity and mechanism of action of a duplex and multidrug of ethynylcytidine and 5-fluorodeoxyuridine

scientific article published on January 2008

In vitro and in vivo antitumor activity of methotrexate conjugated to human serum albumin in human cancer cells ⬇️

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In vitro and in vivo inhibition of thymidylate synthase of human colon cancer by 5-fluorouracil.

scientific article published in January 1989

In vitro antiproliferative effects, toxicity profiles in vivo in mice and antitumour activity in tumour-bearing mice of five organotin compounds

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In vitro antiproliferative effects, toxicity profiles in vivo in mice and antitumour activity in tumour-bearing mice of four diorganotin compounds ⬇️

scientific article published on 01 May 1996

In vitro biochemical and in vivo biological studies of the uridine 'rescue' of 5-fluorouracil ⬇️

scientific article published on March 1, 1988

In vitro chemosensitivity testing of multilayered microcultures

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In vitro optimization of non-small cell lung cancer activity with troxacitabine, L-1,3-dioxolane-cytidine, prodrugs

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In vitro sensitivity and cross-resistance to deoxynucleoside analogs in childhood acute leukemia

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In vitro sequence-dependent synergistic effect of suramin and camptothecin.

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In vivo and in vitro activity and mechanism of action of the multidrug cytarabine-L-glycerylyl-fluorodeoxyuridine

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In vivo induction of resistance to gemcitabine results in increased expression of ribonucleotide reductase subunit M1 as the major determinant

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In-vitro schedule-dependency of eo9 and miltefosine in comparison to standard drugs in colon-cancer cells ⬇️

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Inactivating PSMB5 mutations and P-glycoprotein (multidrug resistance-associated protein/ATP-binding cassette B1) mediate resistance to proteasome inhibitors: ex vivo efficacy of (immuno)proteasome inhibitors in mononuclear blood cells from patients

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Increased migration by stimulation of thymidine phosphorylase in endothelial cells of different origin

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Increased sensitivity to gemcitabine of P-gP and MRP overexpressing human non-small cell lung cancer cell lines

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Increased sensitivity to gemcitabine of P-glycoprotein and multidrug resistance-associated protein-overexpressing human cancer cell lines

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Induction of in vivo resistance against gemcitabine (dFdC, 2',2'-difluoro-deoxycytidine).

scientific article published on January 1998

Induction of resistance to 2',2'-difluorodeoxycytidine in the human ovarian cancer cell line A2780.

scientific article published on August 1995

Induction of resistance to the lipophilic cytarabine prodrug elacytarabine (CP-4055) in CEM leukemic cells

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Induction of resistance to the multitargeted antifolate Pemetrexed (ALIMTA) in WiDr human colon cancer cells is associated with thymidylate synthase overexpression

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Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism

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Influence of different types of diuresis on renal excretion of urea studied in the rat by means of renal micropunctures ⬇️

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Influence of polymorphisms on EGFR targeted therapy in non-small-cell lung cancer

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Inherited germline T790M mutation and somatic epidermal growth factor receptor mutations in non-small cell lung cancer patients.

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Inhibition of pyrimidine de novo synthesis by DUP-785 (NSC 368390)

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Inhibition of thymidylate synthase by 2',2'-difluoro-2'-deoxycytidine (Gemcitabine) and its metabolite 2',2'-difluoro-2'-deoxyuridine

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Integrating Collection of Biospecimens in Clinical Trials: The Approach of the European Organization for Research and Treatment of Cancer

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Interaction between celecoxib and docetaxel or cisplatin in human cell lines of ovarian cancer and colon cancer is independent of COX-2 expression levels

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Interaction between cisplatin and gemcitabine in vitro and in vivo.

scientific article published on August 1995

Interference of gemcitabine triphosphate with the measurements of deoxynucleotides using an optimized DNA polymerase elongation assay.

scientific article published in July 2001

Intermittent continuous infusion of 5-fluorouracil and low dose oral leucovorin in patients with gastrointestinal cancer: relationship between plasma concentrations and clinical parameters

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Interrelationship between miRNA and splicing factors in pancreatic ductal adenocarcinoma

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Intracellular thymidylate synthase inhibition by trifluorothymidine in FM3A cells

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Intracellular trafficking of MDR transporters and relevance of SNPs.

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Intrarenal distribution of urea in rat water diuresis

scientific article published on 01 January 1966

Intrarenal urea and electrolyte concentrations as influenced by water diuresis and by hydrochlorothiazide ⬇️

scientific article published on 01 March 1967

Intravesical administration of gemcitabine in superficial bladder cancer: a phase I study with pharmacodynamic evaluation.

scientific article published in March 2004

Irinotecan and oxaliplatin: an overview of the novel chemotherapeutic options for the treatment of advanced colorectal cancer

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Irinotecan-induced cytotoxicity to colon cancer cells in vitro is stimulated by pre-incubation with trifluorothymidine

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Is there a role for dacomitinib, a second-generation irreversible inhibitor of the epidermal-growth factor receptor tyrosine kinase, in advanced non-small cell lung cancer?

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Isolated Liver Perfusion Versus Hepatic Artery Infusion with 5-Fluorouracil in a Rat Model; Effects on Thymidylate Synthase ⬇️

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Issues of normal tissue toxicity in patient and animal studies--effect of carbogen breathing in rats after 5-fluorouracil treatment.

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Kinase Inhibitor Treatment of Patients with Advanced Cancer Results in High Tumor Drug Concentrations and in Specific Alterations of the Tumor Phosphoproteome

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Kinome profiling of non-canonical TRAIL signaling reveals RIP1-Src-STAT3-dependent invasion in resistant non-small cell lung cancer cells

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Leucovorin rescue of human cancer and bone marrow cells following edatrexate or methotrexate

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Limited intra-individual variability in hypoxanthine-Guanine phosphoribosyl transferase, thiopurine S-methyl transferase, and xanthine oxidase activity in inflammatory bowel disease patients during 6-thioguanine therapy

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Lipophilic prodrugs and formulations of conventional (deoxy)nucleoside and fluoropyrimidine analogs in cancer

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Loss of multidrug resistance protein 1 expression and folate efflux activity results in a highly concentrative folate transport in human leukemia cells

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Low folate conditions may enhance the interaction of trifluorothymidine with antifolates in colon cancer cells

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Lysosomal sequestration of sunitinib: a novel mechanism of drug resistance.

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MAPK p38 and JNK have opposing activities on TRAIL-induced apoptosis activation in NSCLC H460 cells that involves RIP1 and caspase-8 and is mediated by Mcl-1.

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MET as a potential target for the treatment of upper gastrointestinal cancers: characterization of novel c-Met inhibitors from bench to bedside

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MRP3, an organic anion transporter able to transport anti-cancer drugs

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Maintenance of ATP favours apoptosis over necrosis triggered by benzamide riboside

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Measurement of in vitro cellular pharmacokinetics of 5-fluorouracil in human and rat cancer cell lines and rat hepatocytes using a flow-through system

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Mechanism of trifluorothymidine potentiation of oxaliplatin-induced cytotoxicity to colorectal cancer cells

scientific article published on January 2007

Mechanisms of action of FdUMP[10]: metabolite activation and thymidylate synthase inhibition

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Mechanisms of synergism between cisplatin and gemcitabine in ovarian and non-small-cell lung cancer cell lines

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Mechanisms of synergism between gemcitabine and cisplatin

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Metabolism and accumulation of the lipophilic deoxynucleoside analogs elacytarabine and CP-4126

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Metabolism of phosphoribosylpyrophosphate in peripheral and phytohemagglutin-stimulated mammalian lymphocytes ⬇️

scientific article published on 01 January 1981

Metabolism of purine nucleosides and phosphoribosylpyrophosphate in thymocytes and splenocytes of various mammalian species ⬇️

scientific article published on 01 January 1982

Metabolism, mechanism of action and sensitivity profile of fluorocyclopentenylcytosine (RX-3117; TV-1360).

scientific article published on 19 September 2013

Methotrexate resistance in relapsed childhood acute lymphoblastic leukaemia

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Methotrexate resistance in relation to treatment outcome in childhood acute lymphoblastic leukemia

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Methylation specific PCR to characterize methylation of the promoter of deoxycytidine kinase

scientific article published on June 2010

Methylenetetrahydrofolate reductase (MTHFR) C677T and thymidylate synthase promoter (TSER) polymorphisms in Indonesian children with and without leukemia

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MiRNAs and Their Interference with the Main Molecular Mechanisms Responsible for Drug Resistance in Pancreatic Cancer

Micro-array analysis of resistance for gemcitabine results in increased expression of ribonucleotide reductase subunits

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MicroRNA-21 in pancreatic cancer: correlation with clinical outcome and pharmacologic aspects underlying its role in the modulation of gemcitabine activity.

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Micropuncture Techniques as a Tool in Renal Pharmacology ⬇️

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Modulation of cytarabine induced cytotoxicity using novel deoxynucleoside analogs in the HL60 cell line

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Modulation of cytotoxicity and metabolism of 5-fluorouracil in two intestine cell lines

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Modulation of fluorouracil toxicity with uridine

scientific article published on April 1, 1992

Modulation of folate uptake in cultured human colon adenocarcinoma Caco-2 cells by dietary compounds

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Modulation of metabolism and cytotoxicity of cytosine arabinoside with N-(phosphon)-acetyl-L-aspartate in human leukemic blast cells and cell lines

scientific article published on 01 February 1996

Modulation of resistance to ara-C by bryostatin in fresh blast cells from patients with AML.

scientific article published in April 1998

Modulation of signaling enhances the efficacy of the combination of satraplatin and erlotinib

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Modulation of the antitumour activity of cisplatin alone and in combination with 5-fluoro-2'-deoxyuridine by N-phosphonacetyl-l-aspartate in murine colon carcinoma no. 26 ⬇️

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Molecular basis of bortezomib resistance: proteasome subunit beta5 (PSMB5) gene mutation and overexpression of PSMB5 protein

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Molecular downstream events and induction of thymidylate synthase in mutant and wild-type p53 colon cancer cell lines after treatment with 5-fluorouracil and the thymidylate synthase inhibitor raltitrexed

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Molecular mechanism underlying the pharmacological interactions of the protein kinase C-β inhibitor enzastaurin and erlotinib in non-small cell lung cancer cells

scientific article published on April 2017

Molecular mechanism underlying the synergistic interaction between trifluorothymidine and the epidermal growth factor receptor inhibitor erlotinib in human colorectal cancer cell lines.

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Molecular mechanisms and modulation of key pathways underlying the synergistic interaction of sorafenib with erlotinib in non-small-cell-lung cancer (NSCLC) cells.

scientific article published on January 2013

Molecular mechanisms involved in the synergistic interaction of the EZH2 inhibitor 3-deazaneplanocin A with gemcitabine in pancreatic cancer cells

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Molecular mechanisms underlying the antitumor activity of 3-aminopropanamide irreversible inhibitors of the epidermal growth factor receptor in non-small cell lung cancer.

scientific article published on January 2013

Molecular mechanisms underlying the role of microRNAs (miRNAs) in anticancer drug resistance and implications for clinical practice.

scientific article published on 05 May 2011

Molecular mechanisms underlying the role of microRNAs in resistance to epidermal growth factor receptor-targeted agents and novel therapeutic strategies for treatment of non-small-cell lung cancer

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Molecular mechanisms underlying the synergistic interaction of erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor, with the multitargeted antifolate pemetrexed in non-small-cell lung cancer cells.

scientific article published on 10 January 2008

Molecular pathways involved in the synergistic interaction of the PKC beta inhibitor enzastaurin with the antifolate pemetrexed in non-small cell lung cancer cells

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Molecular targets of gemcitabine action: rationale for development of novel drugs and drug combinations

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Multicentre EORTC study 16997: feasibility and phase II trial of farnesyl transferase inhibitor & gemcitabine combination in salvage treatment of advanced urothelial tract cancers

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Multidrug resistance proteins and folate supplementation: therapeutic implications for antifolates and other classes of drugs in cancer treatment

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Multifactorial resistance to aminopeptidase inhibitor prodrug CHR2863 in myeloid leukemia cells: down-regulation of carboxylesterase 1, drug sequestration in lipid droplets and pro-survival activation ERK/Akt/mTOR.

scientific article published on 19 October 2015

Multiple mechanisms of resistance to methotrexate and novel antifolates in human CCRF-CEM leukemia cells and their implications for folate homeostasis.

scientific article published in January 2002

N-Hydroxyindole-based inhibitors of lactate dehydrogenase against cancer cell proliferation

scientific article published on 8 September 2011

NF-κB drives acquired resistance to a novel mutant-selective EGFR inhibitor

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NUC-1031 in biliary tract cancer: from bench to bedside and back?

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Never let it go: Stopping key mechanisms underlying metastasis to fight pancreatic cancer.

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New Imidazo[2,1-b][1,3,4]Thiadiazole Derivatives Inhibit FAK Phosphorylation and Potentiate the Antiproliferative Effects of Gemcitabine Through Modulation of the Human Equilibrative Nucleoside Transporter-1 in Peritoneal Mesothelioma

scientific article published on 01 September 2020

New developments in the management of non-small-cell lung cancer, focus on rociletinib: what went wrong?

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New developments in the treatment of metastatic melanoma: immune checkpoint inhibitors and targeted therapies

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New targets for pyrimidine antimetabolites for the treatment of solid tumours. 2: Deoxycytidine kinase

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New targets for pyrimidine antimetabolites in the treatment of solid tumours. 1: Thymidylate synthase

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New tricks for old biomarkers: thymidylate synthase expression as a predictor of pemetrexed activity in malignant mesothelioma

scientific article published on 5 May 2010

Nitric oxide releasing acridone carboxamide derivatives as reverters of doxorubicin resistance in MCF7/Dx cancer cells

scientific article published on 01 December 2015

No circadian variation of dihydropyrimidine dehydrogenase, uridine phosphorylase, beta-alanine, and 5-fluorouracil during continuous infusion of 5-fluorouracil

scientific article published on 01 January 1998

No evidence of gemcitabine accumulation during weekly administration.

scientific article

Non-canonical kinase signaling by the death ligand TRAIL in cancer cells: discord in the death receptor family

scientific article published on 12 April 2013

Novel approaches to selective treatments of human solid tumors: Laboratory and clinical correlation ⬇️

scientific article published on April 1, 1993

Novel cell death mechanisms of trifluorothymidine.

scientific article published on January 2008

Novel developments in metabolic disorders of purine and pyrimidine metabolism and therapeutic applications of their analogs

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Novel developments in the use of antimetabolites

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Novel targeted strategies to overcome resistance in small-cell lung cancer: focus on PARP inhibitors and rovalpituzumab tesirine

scientific article published on 31 May 2019

Nucleoside and nucleobase analogs in cancer treatment: not only sapacitabine, but also gemcitabine.

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O6-methylguanine-DNA-methyltransferase promoter demethylation is involved in basic fibroblast growth factor induced resistance against temozolomide in human melanoma cells

scientific article published in October 2007

Obituary to Lynette Fairbanks, PhD

scholarly article

On the pharmacogenetics of non-small cell lung cancer treatment

scientific article

On the use of pharmacogenetics in cancer treatment and clinical trials

scientific article published on 04 August 2014

On therapeutic drug monitoring of thiopurines in inflammatory bowel disease; pharmacology, pharmacogenomics, drug intolerance and clinical relevance

scientific article

Online fluorescent method to assess BCRP/ABCG2 activity in suspension cells

scientific article published in October 2004

Overcoming bortezomib resistance in human B cells by anti-CD20/rituximab-mediated complement-dependent cytotoxicity and epoxyketone-based irreversible proteasome inhibitors

scientific article published on 10 January 2013

Overcoming crizotinib resistance in ALK-rearranged NSCLC with the second-generation ALK-inhibitor ceritinib.

scientific article

Overexpression of MRP4 (ABCC4) and MRP5 (ABCC5) confer resistance to the nucleoside analogs cytarabine and troxacitabine, but not gemcitabine

scientific article published on 13 December 2014

Oxaliplatin activity in selected and unselected human ovarian and colorectal cancer cell lines

scientific article

Pancreatic cancer resistance conferred by stellate cells: looking for new preclinical models

scientific article published on 03 August 2020

Pegylated nanoliposomal cisplatin ameliorates chemotherapy-induced peripheral neuropathy

scholarly article

Pemetrexed induced thymidylate synthase inhibition in non-small cell lung cancer patients: a pilot study with 3'-deoxy-3'-[¹⁸F]fluorothymidine positron emission tomography

scientific article

Personalized medicine in rheumatoid arthritis: methotrexate polyglutamylation revisited

scholarly article

Pharmacogenetic study of patients with advanced non-small cell lung cancer (NSCLC) treated with second-line pemetrexed or pemetrexed-carboplatin.

scientific article published on 11 August 2012

Pharmacogenetics of conventional chemotherapy in non-small-cell lung cancer: a changing landscape?

scientific article published on July 2012

Pharmacogenetics of non-small cell lung cancer (NSCLC): time to "work it out"?

scientific article published on January 2014

Pharmacokinetic schedule finding study of the combination of gemcitabine and cisplatin in patients with solid tumors

scientific article published on 01 April 1999

Pharmacokinetics and pharmacogenetics of Gemcitabine as a mainstay in adult and pediatric oncology: an EORTC-PAMM perspective

scientific article

Pharmacologic modifications of renal tubular transport

scientific article published on 01 December 1976

Pharmacological aspects of the enzastaurin-pemetrexed combination in non-small cell lung cancer (NSCLC).

scientific article published on January 2010

Pharmacological factors affecting accumulation of gemcitabine's active metabolite, gemcitabine triphosphate.

scientific article published on 08 June 2017

Pharmacologically directed strategies in academic anticancer drug discovery based on the European NCI compounds initiative

scientific article published on 13 June 2017

Pharmacology of the paclitaxel-cisplatin, gemcitabine-cisplatin, and paclitaxel-gemcitabine combinations in patients with advanced non-small cell lung cancer.

scientific article published on 7 March 2006

Phase I Dose-Escalation Study of Once Weekly or Once Every Two Weeks Administration of High-Dose Sunitinib in Patients With Refractory Solid Tumors

Phase I clinical and pharmacokinetic study of oral S-1 in patients with advanced solid tumors

scientific article published on 01 July 2000

Phase I study of aerosolized SLIT cisplatin in the treatment of patients with carcinoma of the lung

scientific article published on 01 April 2007

Phase II study of cisplatin preceding gemcitabine in patients with advanced oesophageal cancer

scientific article

Phase II study of tailored chemotherapy for advanced colorectal cancer with either 5-fluouracil and leucovorin or oxaliplatin and irinotecan based on the expression of thymidylate synthase and dihydropyrimidine dehydrogenase

scientific article published on 26 October 2005

Phase II trial of cisplatin and gemcitabine in patients with advanced gastric cancer.

scientific article published in March 2004

Phospho-Akt overexpression is prognostic and can be used to tailor the synergistic interaction of Akt inhibitors with gemcitabine in pancreatic cancer

scientific article published on 06 January 2017

Physicochemical properties of novel protein kinase inhibitors in relation to their substrate specificity for drug transporters.

scientific article

Platinum-induced neurotoxicity and preventive strategies: past, present, and future

scientific article

Polymorphisms correlated with the clinical outcome of locally advanced or metastatic colorectal cancer patients treated with ALIRI vs. FOLFIRI

Polymorphisms in folate-related genes and risk of pediatric acute lymphoblastic leukemia

scientific article published on 19 November 2008

Polymorphisms in the enhancer region of the thymidylate synthase gene are associated with thymidylate synthase levels in normal tissues but not in malignant tissues of patients with colorectal cancer.

scientific article published in July 2009

Polymorphisms to predict outcome to the tyrosine kinase inhibitors gefitinib, erlotinib, sorafenib and sunitinib

scientific article published on January 2012

Positioning of aminopeptidase inhibitors in next generation cancer therapy

scientific article published on 03 January 2014

Positron emission tomography using 2-deoxy-2-[18F]-fluoro-D-glucose for response monitoring in locally advanced gastroesophageal cancer; a comparison of different analytical methods

scientific article published in September 2003

Postconfluent multilayered cell line cultures for selective screening of gemcitabine

scientific article published on May 1998

Potentiation of 5-fluorouracil induced inhibition of thymidylate synthase in human colon tumors by leucovorin is dose dependent

scientific article published on 01 January 1993

Potentiation of in vitro ara-C cytotoxicity by ribonucleotide reductase inhibitors, cyclin-dependent kinase modulators and the DNA repair inhibitor aphidicolin in paediatric acute myeloid leukaemia

scientific article

Preclinical combination therapy with gemcitabine and mechanisms of resistance

scientific article published on October 1996

Preclinical emergence of vandetanib as a potent antitumour agent in mesothelioma: molecular mechanisms underlying its synergistic interaction with pemetrexed and carboplatin

scientific article published on 4 October 2011

Predictive role of repair enzymes in the efficacy of Cisplatin combinations in pancreatic and lung cancer

scientific article published on January 2014

Predictive value of thymidylate synthase and dihydropyrimidine dehydrogenase protein expression on survival in adjuvantly treated stage III colon cancer patients

scientific article published on 12 July 2005

Preface

Preface to a supplement to Pharmacy World on the 5TH Symposium of the European Society for the Study of Purine & Pyrimidtne Metabolism in Man (ESSPPMM 1995)

Pretreatment deoxycytidine kinase levels predict in vivo gemcitabine sensitivity.

scientific article published in April 2002

Prognostic and Predictive Roles of Thymidylate Synthase Expression in Lung Cancer: The Debate Is Still Open

scientific article published on 28 December 2015

Prognostic factors in gemcitabine-cisplatin polychemotherapy regimens in pancreatic cancer: XPD-Lys751Gln polymorphism strikes back

scientific article published on 04 March 2013

Prolonged retention of high concentrations of 5-fluorouracil in human and murine tumors as compared with plasma

scientific article published on 01 January 1993

Proteasome inhibition and mechanism of resistance to a synthetic, library-based hexapeptide.

scientific article published on 14 February 2018

Proteasome-based mechanisms of intrinsic and acquired bortezomib resistance in non-small cell lung cancer.

scientific article

Protection by WR-2721 of the toxicity induced by the combination of cisplatin and 5-fluorouracil

scientific article published on January 1, 1992

Protection of Normal Tissues from the Cytotoxic Effects of Chemotherapy and Radiation by Amifostine (WR-2721): Preclinical Aspects ⬇️

scientific article published on January 1, 1995

Protective autophagy by thymidine causes resistance to rapamycin in colorectal cancer cells <i>in vitro</i>

scientific article published on 24 May 2021

Proton-coupled folate transporter as a biomarker of outcome to treatment for pleural mesothelioma

scientific article published on 19 June 2018

Purine Metabolism in Splenocytes and Thymocytes of Various Mammalian Species ⬇️

scientific article published on 01 January 1984

Purine Nucleotide Interconversion Enzymes in Childhood Leukemia: Relation with Cell Cycle and Clinical Outcome ⬇️

scientific article published on 01 January 1994

Purine and pyrimidine metabolism in peripheral blood lymphocytes ⬇️

scientific article published on January 1, 1983

Purine and pyrimidine metabolism in the fist decade of the 21st century--highlights and perspectives

scientific article published in June 2010

Purine and pyrimidine metabolism: still a black box?

scientific article published on 01 April 1994

Purine nucleosides as cell-specific modulators of 5-fluorouracil metabolism and cytotoxicity

scientific article published on 01 December 1987

Pyrimidine metabolism in lymphocytes and erythrocytes of man, horse and cattle ⬇️

scientific article published on January 1, 1979

Quantification of 5-fluorouracil incorporation into RNA of human and murine tumors as measured with a sensitive gas chromatography-mass spectrometry assay

scientific article published on 01 October 1995

Quantitative real time PCR of deoxycytidine kinase mRNA by Light Cycler PCR in relation to enzyme activity and gemcitabine sensitivity.

scientific article

RX-3117 (Fluorocyclopentenyl-Cytosine)-Mediated Down-Regulation of DNA Methyltransferase 1 Leads to Protein Expression of Tumor-Suppressor Genes and Increased Functionality of the Proton-Coupled Folate Carrier

scientific article published on 14 April 2020

RX-3117 (fluorocyclopentenyl cytosine): a novel specific antimetabolite for selective cancer treatment

scientific article published on 16 March 2019

Radiosensitization by thymidine phosphorylase inhibitor in thymidine phosphorylase negative and overexpressing bladder cancer cell lines

scientific article

Randomized phase 2 study of gemcitabine and cisplatin with or without vitamin supplementation in patients with advanced esophagogastric cancer.

scientific article published on 25 April 2018

Rapid Homogeneous Immunoassay to Quantify Gemcitabine in Plasma for Therapeutic Drug Monitoring.

scientific article

Rb, mcl-1 and p53 expression correlate with clinical outcome in patients with liver metastases from colorectal cancer

scientific article published in June 2001

Re-evaluation of Brequinar sodium, a dihydroorotate dehydrogenase inhibitor

scientific article published on 01 January 2018

Recent updates on purine and pyrimidine metabolism in physiological and pathological settings

scientific article published on 17 March 2020

Regulation of carrier-mediated transport of folates and antifolates in methotrexate-sensitive and-resistant leukemia cells

scientific article published on 01 January 1997

Regulation of deoxycytidine kinase expression and sensitivity to gemcitabine by micro-RNA 330 and promoter methylation in cancer cells.

scientific article

Relation of 5'-nucleotidase and phosphatase activities with immunophenotype, drug resistance and clinical prognosis in childhood leukemia

scientific article published on September 1, 1992

Reproducible gene expression measurement among multiple laboratories obtained in a blinded study using standardized RT (StaRT)-PCR

scientific article published on December 1, 2001

Research Highlights: Highlights from the Latest Articles in Pharmacogenomics of Irinotecan/Cisplatin Toxicity ⬇️

scientific article published on October 1, 2012

Resistance Mechanisms to AZD9291 and Rociletinib-Letter

scientific article published in July 2017

Resistance to differentiation affects ribo- and deoxyribonucleotide pools and sensitivity to pyrimidine metabolism antagonists in HL60 cells

scientific article published on 30 July 2020

Reversal of 5-fluorouracil-induced toxicity by oral administration of uridine

scientific article

Role of Akt signaling in resistance to DNA-targeted therapy

scientific article

Role of CYB5A in pancreatic cancer prognosis and autophagy modulation

scientific article published on 03 December 2013

Role of E3 ubiquitin ligases in lung cancer

scientific article published on August 2013

Role of c-MET Inhibitors in Overcoming Drug Resistance in Spheroid Models of Primary Human Pancreatic Cancer and Stellate Cells.

scientific article

Role of deoxycytidine kinase (dCK), thymidine kinase 2 (TK2), and deoxycytidine deaminase (dCDA) in the antitumor activity of gemcitabine (dFdC)

scientific article published on 01 January 1998

Role of genomic factors beyond thymidylate synthase in the prediction of response to 5-fluorouracil

scientific article

Role of platelet-derived endothelial cell growth factor/thymidine phosphorylase in fluoropyrimidine sensitivity

scientific article published on March 2003

Role of proton-coupled folate transporter in pemetrexed resistance of mesothelioma: clinical evidence and new pharmacological tools ⬇️

scientific article

Schedule dependence of sensitivity to 2',2'-difluorodeoxycytidine (Gemcitabine) in relation to accumulation and retention of its triphosphate in solid tumour cell lines and solid tumours

scientific article published on October 1994

Schedule-Dependent Synergy Between the Histone Deacetylase Inhibitor Belinostat and the Dihydrofolate Reductase Inhibitor Pralatrexate in T-and B-cell Lymphoma Cells in vitro

scientific article published on 09 October 2020

Schedule-dependent antitumor effect of gemcitabine in in vivo model system

scientific article published on 01 August 1995

Schedule-dependent pharmacodynamic effects of gemcitabine and cisplatin in mice bearing Lewis lung murine non-small cell lung tumours

scientific article published on 01 December 2000

Schedule-dependent therapeutic efficacy of the combination of gemcitabine and cisplatin in head and neck cancer xenografts

scientific article published on December 1995

Scheduling of gemcitabine and cisplatin in Lewis lung tumour bearing mice

scientific article published on 01 May 1999

Selection of the best blood compartment to measure cytidine deaminase activity to stratify for optimal gemcitabine or cytarabine treatment.

scientific article published in January 2014

Selective cell kill of the combination of gemcitabine and cisplatin in multilayered postconfluent tumor cell cultures.

scientific article published on June 1999

Selective protection by uridine of growth inhibition by 5-fluorouracil (5FU) mediated by 5FU incorporation into RNA, but not the thymidylate synthase mediated growth inhibition by 5FU-leucovorin.

scientific article

Sensitive liquid chromatography mass spectrometry (LC-MS) assay reveals novel insights on DNA methylation and incorporation of gemcitabine, its metabolite difluorodeoxyuridine, deoxyuridine, and RX-3117 into DNA.

scientific article published on December 2016

Sensitivity to ionizing radiation and chemotherapeutic agents in gemcitabine-resistant human tumor cell lines.

scientific article published on September 2002

Separation of 5-fluorouracil and uracil by ion-pair reversed-phase high-performance liquid chromatography on a column with porous polymeric packing

scientific article published on 01 May 1984

Separation of several 5-fluorouracil metabolites in various melanoma cell lines. Evidence for the synthesis of 5-fluorouracil-nucleotide sugars

scientific article published on 01 November 1984

Sequence dependent effect of paclitaxel on gemcitabine metabolism in relation to cell cycle and cytotoxicity in non-small-cell lung cancer cell lines.

scientific article published in October 2000

Sequence-dependent growth inhibition and DNA damage formation by the irinotecan-5-fluorouracil combination in human colon carcinoma cell lines

scientific article published on 01 December 1999

Severe toxicity of capecitabine following uncomplicated treatment with 5-fluorouracil/leucovorin

scientific article published on 22 June 2010

Should alectinib or ceritinib be given as first line therapy for ALK positive non-small cell lung cancer patients instead of crizotinib?

Similar changes were induced by Cladribine and by gemcitabine, in the deoxypyrimidine salvage, during short-term treatments

scientific article published on January 1998

Simple and selective method for the determination of various tyrosine kinase inhibitors used in the clinical setting by liquid chromatography tandem mass spectrometry

scientific article published on 15 March 2010

Single-nucleotide polymorphisms in the genes of CES2, CDA and enzymatic activity of CDA for prediction of the efficacy of capecitabine-containing chemotherapy in patients with metastatic breast cancer

scientific article published on 18 August 2017

Sorafenib administered using a high-dose, pulsatile regimen in patients with advanced solid malignancies: a phase I exposure escalation study

scientific article published on 09 April 2020

Splicing modulation as novel therapeutic strategy against diffuse malignant peritoneal mesothelioma

scientific article published on 20 December 2018

Statins Potentiate Aminopeptidase Inhibitor (pro)Drug Activity in Acute Myeloid Leukemia Cells ⬇️

scholarly article

Staurosporine increases toxicity of gemcitabine in non-small cell lung cancer cells: role of protein kinase C, deoxycytidine kinase and ribonucleotide reductase

scientific article

Steroids affect collateral sensitivity to gemcitabine of multidrug-resistant human lung cancer cells

scientific article

Study by micropuncture of urea excretion by rats overloaded with saline solutions

scientific article published on 01 January 1970

Study of apoptosis induction and deoxycytidine kinase/cytidine deaminase modulation in the synergistic interaction of a novel ceramide analog and gemcitabine in pancreatic cancer cells.

scientific article published on June 2010

Successful treatment of renal cell carcinoma with sorafenib after effective but hepatotoxic sunitinib exposure

scientific article published on 26 November 2012

Sulfasalazine down-regulates the expression of the angiogenic factors platelet-derived endothelial cell growth factor/thymidine phosphorylase and interleukin-8 in human monocytic-macrophage THP1 and U937 cells

scientific article

Synergistic Interaction between Cisplatin and Gemcitabine in Ovarian and Colon Cancer Cell Lines ⬇️

scientific article published on January 1, 1994

Synergistic interaction between cisplatin and gemcitabine in vitro.

scientific article

Synergistic interaction between trifluorothymidine and docetaxel is sequence dependent.

scientific article published on 18 October 2008

Synergistic interaction of novel lactate dehydrogenase inhibitors with gemcitabine against pancreatic cancer cells in hypoxia

scientific article published on 31 October 2013

Synthesis and biological activity of a gemcitabine phosphoramidate prodrug

scientific article published on 29 June 2007

Synthesis of 2-fluoro N(10)-substituted acridones and their cytotoxicity studies in sensitive and resistant cancer cell lines and their DNA intercalation studies

scientific article published on November 2009

Synthesis, in vitro cytotoxicity and in vivo anti-inflammatory activity of long chain 3-amino-1,2-diols

scientific article published on 01 March 1999

TAS-102: more than an antimetabolite.

scientific article

TFAP2E-DKK4and Chemoresistance in Colorectal Cancer ⬇️

scientific article published on 01 March 2012

Tailoring heated intraperitoneal mitomycin C for peritoneal metastases originating from colorectal carcinoma: a translational approach to improve survival

scientific article published on 10 February 2015

Targeting the Ribosome Biogenesis Key Molecule Fibrillarin to Avoid Chemoresistance

scientific article published on 01 January 2019

The Cytidine Analog Fluorocyclopentenylcytosine (RX-3117) Is Activated by Uridine-Cytidine Kinase 2.

scientific article

The EGFR pathway regulates BCRP expression in NSCLC cells: role of erlotinib

scientific article

The Hollow Fibre Assay as a model for in vivo pharmacodynamics of fluoropyrimidines in colon cancer cells

scientific article published on 19 December 2006

The MEK1/2 Inhibitor Pimasertib Enhances Gemcitabine Efficacy-Letter.

scientific article

The Role of MicroRNAs in Resistance to Current Pancreatic Cancer Treatment: Translational Studies and Basic Protocols for Extraction and PCR Analysis

scientific article published on January 2016

The Role of c-Met as a Biomarker and Player in Innate and Acquired Resistance in Non-Small-Cell Lung Cancer: Two New Mutations Warrant Further Studies

scientific article published on 04 December 2019

The Role of the Microbiome in Cancer and Therapy Efficacy: Focus on Lung Cancer

scientific article published on 01 September 2020

The activity of the lipophilic nucleoside derivatives elacytarabine and CP-4126 in a panel of tumor cell lines resistant to nucleoside analogues

scientific article published on June 2010

The allosteric AKT inhibitor MK2206 shows a synergistic interaction with chemotherapy and radiotherapy in glioblastoma spheroid cultures

scientific article

The association of aberrant folylpolyglutamate synthetase splicing with ex vivo methotrexate resistance and clinical outcome in childhood acute lymphoblastic leukemia

scientific article published on April 2016

The concentration of 5-phosphoribosyl 1-pyrophosphate in monolayer tumor cells and the effect of various pyrimidine antimetabolites

scientific article published on January 1985

The continuous rediscovery and the benefit-risk ratio of thioguanine, a comprehensive review

scientific article published on 24 February 2020

The determination of gemcitabine and 2'-deoxycytidine in human plasma and tissue by APCI tandem mass spectrometry

scientific article

The dichotomous role of the glycolytic metabolism pathway in cancer metastasis: Interplay with the complex tumor microenvironment and novel therapeutic strategies

scientific article published on 21 August 2019

The effect of G-CSF on the in vitro cytotoxicity of cytarabine and fludarabine in the FLAG combination in pediatric acute myeloid leukemia.

scientific article published in December 2004

The effect of allopurinol and low-dose thiopurine combination therapy on the activity of three pivotal thiopurine metabolizing enzymes: results from a prospective pharmacological study

scientific article published on 11 January 2013

The effect of different routes of administration of 5-fluorouracil on thymidylate synthase inhibition in the rat ⬇️

scientific article published on 01 January 1995

The effect of fluoropyrimidines with or without thymidine phosphorylase inhibitor on the expression of thymidine phosphorylase

scientific article published on May 2004

The effect of food on the pharmacokinetics of S-1 after single oral administration to patients with solid tumors

scientific article

The effect of schedule, protein binding and growth factors on the activity of suramin

scientific article published on July 1992

The good, the bad and the ugly: a tale of miR-101, miR-21 and miR-155 in pancreatic intraductal papillary mucinous neoplasms

scientific article

The human equilibrative nucleoside transporter 1 mediates in vitro cytarabine sensitivity in childhood acute myeloid leukaemia

scientific article published on December 2005

The human multidrug resistance protein MRP5 transports folates and can mediate cellular resistance against antifolates.

scientific article

The impact of folate status on the efficacy of colorectal cancer treatment.

scientific article published on December 2011

The interval between methotrexate and leucovorin determines the efficacy of 5-fluorouracil modulation in vitro and in vivo.

scientific article published on January 1993

The novel thymidylate synthase inhibitor trifluorothymidine (TFT) and TRAIL synergistically eradicate non-small cell lung cancer cells.

scientific article published on 18 April 2014

The potential of multi-compound nanoparticles to bypass drug resistance in cancer.

scientific article published on 8 September 2017

The radiosensitizing effect of fluorocyclopentenyl-cytosine (RX-3117) in ovarian and lung cancer cell lines

scientific article published on December 2016

The relation between deoxycytidine kinase activity and the radiosensitising effect of gemcitabine in eight different human tumour cell lines

scientific article published on 30 May 2006

The relation between inhibition of cell growth and of dihydroorotic acid dehydrogenase by brequinar sodium

scientific article

The relationship between dihydroorotic acid dehydrogenase and in vitro and in vivo cytostatic effects of brequinar sodium (DUP-785; NSC 368390).

scientific article

The ribonucleotide reductase inhibitor trimidox induces c-myc and apoptosis of human ovarian carcinoma cells

scientific article published in November 2000

The role of Eph receptors in cancer and how to target them: novel approaches in cancer treatment

scientific article published on 29 April 2020

The role of deoxycytidine kinase in gemcitabine cytotoxicity

scientific article published on 01 January 2000

The role of multidrug resistance proteins MRP1, MRP2 and MRP3 in cellular folate homeostasis

scientific article (publication date: March 2003)

The role of platelet-derived endothelial cell growth factor/thymidine phosphorylase in tumor behavior

scientific article published on June 2008

The role of the microbiome in drug resistance in gastrointestinal cancers

scientific article published on 28 October 2020

The role of thymidine kinase activity in murine colon tumours treated with 5-fluorouracil

scientific article published on January 1998

The role of thymidine phosphorylase and uridine phosphorylase in (fluoro)pyrimidine metabolism in peripheral blood mononuclear cells

scientific article

The semisynthetic flavonoid monoHER sensitises human soft tissue sarcoma cells to doxorubicin-induced apoptosis via inhibition of nuclear factor-κB.

scientific article published on 18 January 2011

The synergistic interaction of gemcitabine and cytosine arabinoside with the ribonucleotide reductase inhibitor triapine is schedule dependent

scientific article published on 21 January 2007

The use of capecitabine in daily practice: a study on adherence and patients' experiences

scientific article

The value of fludarabine in addition to ARA-C and G-CSF in the treatment of patients with high-risk myelodysplastic syndromes and AML in elderly patients

scientific article published on 4 December 2003

Therapeutic potential of TAS-102 in the treatment of gastrointestinal malignancies

scientific article

Therapeutic potential of the dual-targeted TAS-102 formulation in the treatment of gastrointestinal malignancies

scientific article

Therapy Related Disturbances in Nucleotides in Cancer Cells ⬇️

scientific article published on January 1, 1994

Thiopurines with low-dose allopurinol (ThiLDA)-a prospective clinical one-way crossover trial

scientific article published on 05 October 2019

Thymidine phoshorylase as a target for antiangiogenesis treatment

scientific article published on January 2008

Thymidine phosphorylase in angiogenesis and drug resistance. Homology with platelet-derived endothelial cell growth factor

scientific article published on January 1, 2000

Thymidine phosphorylase in cancer cells stimulates human endothelial cell migration and invasion by the secretion of angiogenic factors.

scientific article published on 8 March 2011

Thymidine phosphorylase: its role in sensitivity and resistance to anticancer drugs

scientific article

Thymidylate Synthase Inhibition Induces P53 Dependent and Independent Cell Death ⬇️

scientific article published on 01 January 2000

Thymidylate Synthase and Excision Repair Cross-Complementing Group-1 as Predictors of Responsiveness in Mesothelioma Patients Treated with Pemetrexed/Carboplatin

Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expression after administration of 5-fluorouracil to patients with colorectal cancer

scientific article published on 01 June 2007

Thymidylate synthase and drug resistance ⬇️

scientific article published on July 1, 1995

Thymidylate synthase as a target in cancer chemotherapy

scientific article published on 01 November 1995

Thymidylate synthase expression in patients with colorectal carcinoma using a polyclonal thymidylate synthase antibody in comparison to the TS 106 monoclonal antibody

scientific article published on 01 June 2000

Thymidylate synthase from untreated human colorectal cancer and colonic mucosa: Enzyme activity and inhibition by 5-fluoro-2′-deoxyuridine-5′-monophosphate ⬇️

scientific article published on 01 January 1991

Thymidylate synthase inhibition after administration of fluorouracil with or without leucovorin in colon cancer patients: implications for treatment with fluorouracil

scientific article published on 01 October 1994

Thymidylate synthase inhibitors

scientific article published on 01 January 2002

Thymidylate synthase inhibitors

scientific article published on 01 January 2003

Thymidylate synthase inhibitors for non-small cell lung cancer

scientific article published on 09 September 2011

Thymidylate synthase inhibitors for thoracic tumors

Time course of inhibition of thymidylate synthase in patients treated with fluorouracil and leucovorin

scientific article published on 01 April 1992

Tissue homogenization using a micro-dismembrator for the measurement of enzyme activities

scientific article published on 01 July 1986

To Combine or Not Combine: Drug Interactions and Tools for Their Analysis. Reflections from the EORTC-PAMM Course on Preclinical and Early-phase Clinical Pharmacology

scientific article published on 01 July 2019

Tolerability and Safety of Conventional Thiopurines Concomitantly With Allopurinol in IBD-Patients With a Skewed Thiopurine Metabolism

scholarly article published in May 2011

Toxicity and antitumor effect of 5-fluorouracil and its rescue by uridine

scientific article published on 01 January 1986

Transformation of mouse fibroblasts with the oncogenes H-ras OR trk is associated with pronounced changes in drug sensitivity and metabolism

scientific article published on May 1993

Transporter and Lysosomal Mediated (Multi)drug Resistance to Tyrosine Kinase Inhibitors and Potential Strategies to Overcome Resistance

Trifluorothymidine induces cell death independently of p53.

scientific article

Trifluorothymidine resistance is associated with decreased thymidine kinase and equilibrative nucleoside transporter expression or increased secretory phospholipase A2.

scientific article published on 6 April 2010

Tyrosine kinase inhibitors: Multi-targeted or single-targeted?

scientific article published in February 2011

USP1 deubiquitinase: cellular functions, regulatory mechanisms and emerging potential as target in cancer therapy ⬇️

scientific article published on August 10, 2013

Unraveling the complexity of autophagy: Potential therapeutic applications in Pancreatic Ductal Adenocarcinoma

scientific article published on 23 September 2015

Urea excretion during compensatory adaptation of renal functions

scientific article published on 01 January 1968

Uridine Cytidine Kinase 2 as a Potential Biomarker for Treatment with RX-3117 in Pancreatic Cancer

scientific article published on 01 July 2019

Uridine-induced hypothermia in mice and rats in relation to plasma and tissue levels of uridine and its metabolites

scientific article published on 01 January 1987

Variable pharmacodynamics of antifolates in squamous cell carcinoma of the head and neck.

scientific article published on January 1993

XIII International Charles Heidelberger Symposium and 50 Years of Fluoropyrimidines in Cancer Therapy Held on september 6 to 8, 2007 at New York University Cancer Institute, Smilow Conference Center

scientific article published on 05 May 2009

[18F]FDG and [18F]FLT uptake in human breast cancer cells in relation to the effects of chemotherapy: an in vitro study.

scientific article published on August 2008

c-Met as a Target for Personalized Therapy

scientific article

cMET Exon 14 Skipping: From the Structure to the Clinic.

scientific article published on 17 May 2016

hENT-1 Expression and Localization Predict Outcome After Adjuvant Gemcitabine in Resected Cholangiocarcinoma Patients

scientific article published on 2 November 2016

mRNA expression levels of methotrexate resistance-related proteins in childhood leukemia as determined by a standardized competitive template-based RT-PCR method

scientific article published on 01 December 2000

miR-211 modulates gemcitabine activity through downregulation of ribonucleotide reductase and inhibits the invasive behavior of pancreatic cancer cells

scientific article

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