Search filters

List of works by Colin W Taylor

2,5-Di-(tert-butyl)-1,4-benzohydroquinone mobilizes inositol 1,4,5-trisphosphate-sensitive and -insensitive Ca2+ stores.

scientific article published in November 1990

2-Position base-modified analogues of adenophostin A as high-affinity agonists of the D-myo-inositol trisphosphate receptor: in vitro evaluation and molecular modeling.

scientific article

A bead aggregation assay for detection of low-affinity protein-protein interactions reveals interactions between N-terminal domains of inositol 1,4,5-trisphosphate receptors

scientific article

A calmodulin antagonist reveals a calmodulin-independent interdomain interaction essential for activation of inositol 1,4,5-trisphosphate receptors.

scientific article

A genetically encoded toolkit of functionalized nanobodies against fluorescent proteins for visualizing and manipulating intracellular signalling

scientific article published on 23 May 2019

A guanine nucleotide-dependent regulatory protein couples substance P receptors to phospholipase C in rat parotid gland

scientific article published on 01 April 1986

A non-capacitative pathway activated by arachidonic acid is the major Ca2+ entry mechanism in rat A7r5 smooth muscle cells stimulated with low concentrations of vasopressin.

scientific article published on May 1999

A novel role for calmodulin: Ca2+-independent inhibition of type-1 inositol trisphosphate receptors

scientific article published on September 1998

A synthetic diphosphoinositol phosphate analogue of inositol trisphosphate.

scientific article published on 4 June 2018

ATP evokes Ca2+ signals in cultured foetal human cortical astrocytes entirely through G protein-coupled P2Y receptors.

scientific article published on 5 July 2017

Activation of IP3 receptors requires an endogenous 1-8-14 calmodulin-binding motif ⬇️

scientific article published on January 1, 2013

Adenophostin A and analogues modified at the adenine moiety: synthesis, conformational analysis and biological activity.

scientific article

Adenophostins: High-Affinity Agonists of IP(3) Receptors

scientific article published on 25 July 2010

All three IP receptor subtypes generate Ca puffs, the universal building blocks of IP-evoked Ca signals

scientific article published on 23 August 2018

An NAADP-gated two-pore channel targeted to the plasma membrane uncouples triggering from amplifying Ca2+ signals

scientific article

Analysis of protein-ligand interactions by fluorescence polarization

scientific article

Binding of inositol 1,4,5-trisphosphate (IP3) and adenophostin A to the N-terminal region of the IP3 receptor: thermodynamic analysis using fluorescence polarization with a novel IP3 receptor ligand.

scientific article

C-glycoside based mimics of D-myo-inositol 1,4,5-trisphosphate.

scientific article

Ca(2+) signalling by IP(3) receptors.

scientific article published on January 2012

Ca2+ entry through plasma membrane IP3 receptors.

scientific article

Ca2+ signals initiate at immobile IP3 receptors adjacent to ER-plasma membrane junctions

scientific article published on 15 November 2017

Ca2+ sparks a wave of excitement

scientific article published on 01 August 1994

Ca2+-calmodulin inhibits Ca2+ release mediated by type-1, -2 and -3 inositol trisphosphate receptors.

scientific article published on January 2000

CaBP1, a neuronal Ca2+ sensor protein, inhibits inositol trisphosphate receptors by clamping intersubunit interactions.

scientific article published on 6 May 2013

Caffeine-stimulated Ca2+ release from the intracellular stores of hepatocytes is not mediated by ryanodine receptors ⬇️

scientific article published on May 1, 1993

Calcium and inositol trisphosphate receptors.

scientific article

Calcium signalling: IP3 rises again...and again.

scientific article

Contribution of Phosphates and Adenine to the Potency of Adenophostins at the IP3 Receptor: Synthesis of All Possible Bisphosphates of Adenophostin A ⬇️

scientific article published on February 8, 2012

Contribution of the adenine base to the activity of adenophostin A investigated using a base replacement strategy.

scientific article

Controlling calcium entry.

scientific article

Cooperative activation of IP3 receptors by sequential binding of IP3 and Ca2+ safeguards against spontaneous activity.

scientific article published in July 1997

Cyclic AMP Recruits a Discrete Intracellular Ca2+ Store by Unmasking Hypersensitive IP3 Receptors

scientific article published on January 2017

DL-myo-inositol 1,4,5-trisphosphorothioate mobilizes intracellular calcium in Swiss 3T3 cells and Xenopus oocytes.

scientific article published on January 1988

Design and synthesis of 5'-deoxy-5'-phenyladenophostin A, a highly potent IP3 receptor ligand

scientific article published on 01 March 2006

Different receptors use inositol trisphosphate to mobilize Ca(2+) from different intracellular pools

scientific article

Differential distribution, clustering, and lateral diffusion of subtypes of the inositol 1,4,5-trisphosphate receptor

scientific journal article

Differential regulation of types-1 and -3 inositol trisphosphate receptors by cytosolic Ca2+

scientific article published in December 1997

Differentiation of BC3H1 smooth muscle cells changes the bivalent cation selectivity of the capacitative Ca2+ entry pathway.

scientific article published on June 1996

Dimers of D-myo-inositol 1,4,5-trisphosphate: design, synthesis, and interaction with Ins(1,4,5)P3 receptors.

scientific article published in March 2004

Disaccharide Polyphosphates Based upon Adenophostin A Activate Hepatic d-myo-Inositol 1,4,5-Trisphosphate Receptors ⬇️

scientific article published on October 21, 1997

Effect of an oxytocin receptor antagonist and rho kinase inhibitor on the [Ca++]i sensitivity of human myometrium

scientific article published on 01 January 2004

Effects of Ca2+ on phosphoinositide breakdown in exocrine pancreas.

scientific article published on September 1986

Effects of pertussis toxin on growth factor-stimulated inositol phosphate formation and DNA synthesis in Swiss 3T3 cells.

scientific article published on February 1988

Endogenous heavy metal ions perturb fura-2 measurements of basal and hormone-evoked Ca2+ signals.

scientific article published on August 1996

Endogenous signalling pathways and caged IP3 evoke Ca2+ puffs at the same abundant immobile intracellular sites.

scientific article published on 11 September 2017

Expression and distribution of InsP(3) receptor subtypes in proliferating vascular smooth muscle cells

scientific article published on 01 July 2000

Expression of inositol trisphosphate receptors.

scientific article

Fluorescence methods for analysis of interactions between Ca(2+) signaling, lysosomes, and endoplasmic reticulum

scientific article published on 16 January 2015

From parathyroid hormone to cytosolic Ca2+ signals.

scientific article published on February 2012

Functional properties of Drosophila inositol trisphosphate receptors

scientific article

GPN does not release lysosomal Ca but evokes Ca release from the ER by increasing the cytosolic pH independently of cathepsin C

scientific article published on 01 February 2019

Guanophostin A: Synthesis and evaluation of a high affinity agonist of the d-myo-inositol 1,4,5-trisphosphate receptor

scientific article published on 31 March 2006

Heparin and other polyanions uncouple alpha 1-adrenoceptors from G-proteins.

scientific article published on December 1991

High-throughput analyses of IP3 receptor behavior

scientific article published in October 2013

High-throughput fluorescence polarization assay of ligand binding to IP3 receptors

scientific article published on 01 October 2013

High-throughput functional assays of IP3-evoked Ca2+ release.

scientific article published in October 2013

IP Receptors Preferentially Associate with ER-Lysosome Contact Sites and Selectively Deliver Ca to Lysosomes

scientific article published on 01 December 2018

IP(3) receptors: the search for structure.

scientific article

IP(3) receptors: toward understanding their activation.

scientific article published on 27 October 2010

IP3 receptors - lessons from analyses ex cellula

scientific article published on 14 December 2018

IP3 receptors and Ca2+ entry

scientific article published on 15 November 2018

IP3 receptors and their regulation by calmodulin and cytosolic Ca2+.

scientific article

IP3 receptors: Take four IP3 to open.

scientific article

Identification and analysis of cation channel homologues in human pathogenic fungi

scientific article

Identification and analysis of putative homologues of mechanosensitive channels in pathogenic protozoa.

scientific article

Incremental Ca2+ mobilization by inositol trisphosphate receptors is unlikely to be mediated by their desensitization or regulation by luminal or cytosolic Ca2+.

scientific article published on August 1997

Inositol 1,4,5-trisphosphate receptors and their protein partners as signalling hubs.

scientific article published on 2 February 2016

Inositol 1,4,5-trisphosphorothioate, a stable analogue of inositol trisphosphate which mobilizes intracellular calcium.

scientific article published on May 1989

Interactions between inositol trisphosphate receptors and fluorescent Ca2+ indicators.

scientific article published in February 1999

Interactions of antagonists with subtypes of inositol 1,4,5-trisphosphate (IP3) receptor.

scientific article published on July 2014

Interactions of inositol 1,4,5-trisphosphate (IP(3)) receptors with synthetic poly(ethylene glycol)-linked dimers of IP(3) suggest close spacing of the IP(3)-binding sites.

scientific article published on 14 August 2002

Intracellular Ca(2+) channels - a growing community.

scientific article published on 25 August 2011

Kinetic analysis of inositol trisphosphate binding to pure inositol trisphosphate receptors using scintillation proximity assay

scientific article published on 01 April 1996

Long lasting inhibition of adenylyl cyclase selectively mediated by inositol 1,4,5-trisphosphate-evoked calcium release.

scientific article

Luminal Ca2+ increases the affinity of inositol 1,4,5-trisphosphate for its receptor.

scientific article published on June 1993

Luminal Ca2+ promoting spontaneous Ca2+ release from inositol trisphosphate-sensitive stores in rat hepatocytes

scientific article published on 01 September 1992

Luminal Ca2+ regulates passive Ca2+ efflux from the intracellular stores of hepatocytes.

scientific article published on September 1998

Lysosomes shape Ins(1,4,5)P3-evoked Ca2+ signals by selectively sequestering Ca2+ released from the endoplasmic reticulum.

scientific article

Membrane topology of NAADP-sensitive two-pore channels and their regulation by N-linked glycosylation.

scientific article

Microtubule-Associated Protein EB3 Regulates IP3 Receptor Clustering and Ca(2+) Signaling in Endothelial Cells.

scientific article published on 25 June 2015

Modulation of IP(3)-sensitive Ca(2+) release by 2,3-butanedione monoxime

scientific article published on 6 December 2002

Molecular target sizes of inositol 1,4,5-trisphosphate receptors in liver and cerebellum.

scientific article

Mutant IP3 receptors attenuate store-operated Ca2+ entry by destabilizing STIM-Orai interactions in Drosophila neurons.

scientific article published on 02 September 2016

Nuclear patch-clamp recording from inositol 1,4,5-trisphosphate receptors.

scientific article published on January 2010

Overshooting cytosolic Ca2+ signals evoked by capacitative Ca2+ entry result from delayed stimulation of a plasma membrane Ca2+ pump

scientific article published on 01 June 1999

P2Y receptor subtypes evoke different Ca2+ signals in cultured aortic smooth muscle cells

scientific article

Paclitaxel affects cytosolic calcium signals by opening the mitochondrial permeability transition pore

scientific article published on 27 November 2001

Parathyroid hormone controls the size of the intracellular Ca(2+) stores available to receptors linked to inositol trisphosphate formation.

scientific article

Parathyroid hormone increases the sensitivity of inositol trisphosphate receptors by a mechanism that is independent of cyclic AMP.

scientific article published on January 2003

Pharmacological analysis of intracellular Ca2+ signalling: problems and pitfalls

scientific article published on 01 September 1998

Plasma membrane IP3 receptors.

scientific article

Prostaglandin F2α increases the sensitivity of the contractile proteins to Ca2+ in human myometrium

scientific article published on 12 June 2006

Putative inositol 1,4,5-trisphosphate receptor localized to endoplasmic reticulum in Limulus photoreceptors ⬇️

scientific article published on September 1, 1998

Pyrophosphatase-induced Ca2+ release is unrelated to the spontaneous release from inositol 1,4,5-trisphosphate-sensitive Ca2+ stores

scientific article published on February 1992

Rapid Activation and Partial Inactivation of Inositol Trisphosphate Receptors by Inositol Trisphosphate ⬇️

scientific article published on August 18, 1998

Rapid functional assays of intracellular Ca2+ channels.

scientific article published on January 2006

Rapid functional assays of recombinant IP3 receptors.

scientific article published in July 2005

Rapid kinetic measurements of 45Ca2+ mobilization reveal that Ins(2,4,5)P3 is a partial agonist at hepatic InsP3 receptors.

scientific article published on February 1997

Rapid recycling of Ca2+ between IP3-sensitive stores and lysosomes

scientific article

Receptors linked to polyphosphoinositide hydrolysis stimulate Ca2+ extrusion by a phospholipase C-independent mechanism.

scientific article published on August 1999

Red fluorescent genetically encoded Ca2+ indicators for use in mitochondria and endoplasmic reticulum

scientific article

Regulation of IP3 receptors by cyclic AMP

scientific article

Reliable encoding of stimulus intensities within random sequences of intracellular Ca2+ spikes

scientific article

Remodeling of ER-plasma membrane contact sites but not STIM1 phosphorylation inhibits Ca2+ influx in mitosis.

scientific article published on 7 May 2019

Selective determinants of inositol 1,4,5-trisphosphate and adenophostin A interactions with type 1 inositol 1,4,5-trisphosphate receptors.

scientific article published on November 2010

Selective inhibition of histamine-evoked Ca2+ signals by compartmentalized cAMP in human bronchial airway smooth muscle cells.

scientific article published on 15 December 2017

Sigma1 receptors inhibit store-operated Ca2+ entry by attenuating coupling of STIM1 to Orai1

scientific article published on April 2016

Signalling from parathyroid hormone.

scientific article published on August 2006

Simplification of adenophostin A defines a minimal structure for potent glucopyranoside-based mimics of D-myo-inositol 1,4,5-trisphosphate

scientific article published on 01 February 1999

Solubilization of rat liver inositol 1,4,5-trisphosphate receptor

scientific article published on 01 January 1991

Spatial organization of intracellular Ca2+ signals.

scientific article published on 13 September 2011

Spontaneous calcium release from inositol trisphosphate-sensitive calcium stores.

scientific article published on July 1991

Stimulation of inositol 1,4,5-trisphosphate (IP3) receptor subtypes by analogues of IP3

scientific article

Store-operated Ca2+ entry: A STIMulating stOrai

scientific article published on 06 October 2006

Structural and functional conservation of key domains in InsP3 and ryanodine receptors

scientific article

Structural organization of signalling to and from IP3 receptors.

scientific article published on February 2014

Subtype-selective regulation of IP3 receptors by thimerosal via cysteine residues within the IP3-binding core and suppressor domain ⬇️

scientific article published on April 15, 2013

Sustained signalling by PTH modulates IP3 accumulation and IP3 receptors through cyclic AMP junctions

scientific article published on 27 November 2014

Synthesis of adenophostin A analogues conjugating an aromatic group at the 5'-position as potent IP3 receptor ligands.

scientific article published on September 2006

Synthesis of dimeric analogs of adenophostin A that potently evoke Ca2+ release through IP3 receptors

scientific article published on 5 September 2016

Synthesis of inositol phosphate-based competitive antagonists of inositol 1,4,5-trisphosphate receptors

scientific article

Synthesis of potent agonists of the D-myo-inositol 1,4, 5-trisphosphate receptor based on clustered disaccharide polyphosphate analogues of adenophostin A.

scientific article

Targeting and clustering of IP3 receptors: key determinants of spatially organized Ca2+ signals.

scientific article published on September 2009

Targeting and retention of type 1 ryanodine receptors to the endoplasmic reticulum

scientific article published on 25 May 2007

Targeting of inositol 1,4,5-trisphosphate receptors to the endoplasmic reticulum by multiple signals within their transmembrane domains

scientific article published on 19 March 2004

The endo-lysosomal system as an NAADP-sensitive acidic Ca(2+) store: role for the two-pore channels.

scientific article published on 06 May 2011

The role of G proteins in transmembrane signalling.

scientific article

The size of inositol 1,4,5-trisphosphate-sensitive Ca2+ stores depends on inositol 1,4,5-trisphosphate concentration

scientific article published on February 1990

Three-dimensional structure of recombinant type 1 inositol 1,4,5-trisphosphate receptor.

scientific article published on 27 May 2010

Time and space--novel aspects of hormone action

scientific article published on 01 February 1988

Timescales of IP(3)-evoked Ca(2+) spikes emerge from Ca(2+) puffs only at the cellular level

scientific article published in December 2011

Triazolophostins: a library of novel and potent agonists of IP3 receptors

scientific article published on June 2015

Two calcium-binding sites mediate the interconversion of liver inositol 1,4,5-trisphosphate receptors between three conformational states.

scientific article published on July 1994

Vasopressin stimulation of Ca2+ mobilization, two bivalent cation entry pathways and Ca2+ efflux in A7r5 rat smooth muscle cells ⬇️

scientific article published on June 1, 1995

What's in store for Ca2+ oscillations?

scientific article published on 11 November 2004

Why do hormones stimulate Ca2+ mobilization?

scientific article published on August 1995

Paulina is supported by:

About Paulina

Help