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List of works by Paul J Lehner

A 58-year-old woman with abdominal symptoms and elevated C-reactive protein.

scientific article

A Genetic Screen Identifies a Critical Role for the WDR81-WDR91 Complex in the Trafficking and Degradation of Tetherin.

scientific article

A genome-wide CRISPR screen reconciles the role of N-linked glycosylation in galectin-3 transport to the cell surface.

scientific article published on 03 August 2017

A non-canonical ESCRT pathway, including histidine domain phosphotyrosine phosphatase (HD-PTP), is used for down-regulation of virally ubiquitinated MHC class I.

scientific article published on 28 July 2015

A non-proteolytic role for ubiquitin in deadenylation of MHC-I mRNA by the RNA-binding E3-ligase MEX-3C.

scientific article

A novel post-transcriptional role for ubiquitin in the differential regulation of MHC class I allotypes ⬇️

scientific article published on November 7, 2012

A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export

scientific article published on 03 November 2020

ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex

scientific article published in October 2016

Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts tropism and fusogenicity

An Interferon-Driven Oxysterol-Based Defense against Tumor-Derived Extracellular Vesicles

scientific article published on 01 January 2019

An in vitro model for the regulation of human cytomegalovirus latency and reactivation in dendritic cells by chromatin remodelling

scientific article published on 01 November 2005

Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network

scientific article

Antagonism of PP2A is an independent and conserved function of HIV-1 Vif and causes cell cycle arrest

scientific article published on 15 April 2020

Antibody-free magnetic cell sorting of genetically modified primary human CD4+ T cells by one-step streptavidin affinity purification

scientific article

Antigen presentation: TAP dances with ATP

scientific article published on 01 November 1999

Antigen presentation: coming out gracefully

scientific article published on 01 August 1998

Antigen presentation: peptides and proteins scramble for the exit.

scientific article

CD8high(CD57+) T cells in normal, healthy individuals specifically suppress the generation of cytotoxic T lymphocytes to Epstein‐Barr virus‐transformed B cell lines ⬇️

scientific article published on November 1, 1994

CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity

scientific article published on 16 August 2017

Cell Surface Proteomic Map of HIV Infection Reveals Antagonism of Amino Acid Metabolism by Vpu and Nef.

scientific article

Cleavage by signal peptide peptidase is required for the degradation of selected tail-anchored proteins

scientific article

Control of immune ligands by members of a cytomegalovirus gene expansion suppresses natural killer cell activation

scientific article published on 10 February 2017

Cytomegalovirus: from evasion to suppression?

scientific article published in November 2001

Degradation of endocytosed epidermal growth factor and virally ubiquitinated major histocompatibility complex class I is independent of mammalian ESCRTII

scientific article

Dendritic cell stimulation by mycobacterial Hsp70 is mediated through CCR5.

scientific article published on October 2006

Differential viral accessibility (DIVA) identifies alterations in chromatin architecture through large-scale mapping of lentiviral integration sites

scientific article published on 01 January 2019

Down-regulation of NKG2D and NKp80 ligands by Kaposi's sarcoma-associated herpesvirus K5 protects against NK cell cytotoxicity

scholarly article

Downregulation of cell surface receptors by the K3 family of viral and cellular ubiquitin E3 ligases.

scientific article

ESCRT proteins and the regulation of endocytic delivery to lysosomes

scientific article published on 01 February 2009

Effective control of SARS-CoV-2 transmission between healthcare workers during a period of diminished community prevalence of COVID-19

scientific article published on 19 June 2020

Efficient internalization of MHC I requires lysine-11 and lysine-63 mixed linkage polyubiquitin chains.

scientific article published on 17 November 2009

Endosomal transport via ubiquitination ⬇️

scientific article published on September 28, 2011

Fat mass and obesity-related (FTO) shuttles between the nucleus and cytoplasm.

scientific article published on 22 October 2014

First report of Salmonella enterica serotype paratyphi A azithromycin resistance leading to treatment failure.

scientific article published on 13 October 2010

Fluorescence-based phenotypic selection allows forward genetic screens in haploid human cells

scientific article

Functional proteomic atlas of HIV infection in primary human CD4+ T cells

article

GENE SILENCING. Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells.

scientific article published on 28 May 2015

Genetic dissection of mammalian ERAD through comparative haploid and CRISPR forward genetic screens

scientific article published on 10 June 2016

Genome surveillance by HUSH-mediated silencing of intronless mobile elements

scientific article published on 18 November 2021

HCMV pUL135 remodels the actin cytoskeleton to impair immune recognition of infected cells

scientific article

HRD1 and UBE2J1 target misfolded MHC class I heavy chains for endoplasmic reticulum-associated degradation

scientific article

HSP70 peptide binding mutants separate antigen delivery from dendritic cell stimulation

scientific article published on 01 January 2004

Human Cytomegalovirus Infection Upregulates the Mitochondrial Transcription and Translation Machineries

scientific article published on 29 March 2016

Human cytomegalovirus: taking the strain

scientific article published on 17 April 2015

Human embryonic stem cell-derived cardiomyocyte platform screens inhibitors of SARS-CoV-2 infection

scientific article published on 29 July 2021

Hyperactivation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2.

scientific article published on 05 June 2017

Identification of a lysosomal pathway regulating degradation of the bone morphogenetic protein receptor type II.

scientific article published on 24 September 2010

Identifying the ERAD ubiquitin E3 ligases for viral and cellular targeting of MHC class I

scientific article

Inhibition of MHC class I-restricted antigen presentation by gamma 2-herpesviruses

scientific article published on July 2000

Jenner's irony: cowpox taps into T cell evasion

scientific article published on 01 November 2009

Kaposi's sarcoma-associated herpesvirus K3 and K5 proteins block distinct steps in transendothelial migration of effector memory CD4+ T cells by targeting different endothelial proteins.

scientific article

Latency-associated degradation of the MRP1 drug transporter during latent human cytomegalovirus infection

scientific article published on April 2013

Loss of function of a lupus-associated FcγRIIb polymorphism through exclusion from lipid rafts

scientific article published on 18 September 2005

MARCH-IX mediates ubiquitination and downregulation of ICAM-1.

scientific article

MARCH6 and TRC8 facilitate the quality control of cytosolic and tail-anchored proteins.

scientific article

MARCH9-mediated ubiquitination regulates MHC I export from the TGN.

scientific article published on 31 May 2017

MHC class I molecules are preferentially ubiquitinated on endoplasmic reticulum luminal residues during HRD1 ubiquitin E3 ligase-mediated dislocation.

scientific article published on 08 August 2013

Manipulation of immunometabolism by HIV-accessories to the crime?

scientific article

Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1α Stability in Aerobic Conditions.

scientific article published on 27 October 2016

Mobilization of MHC class I molecules from late endosomes to the cell surface following activation of CD34-derived human Langerhans cells.

scholarly article

Molecular studies of anti-HLA-A2 using light-chain shuffling: a structural model for HLA antibody binding.

scientific article published in April 2004

Multiple E2 ubiquitin-conjugating enzymes regulate human cytomegalovirus US2-mediated immunoreceptor downregulation

scientific article

NOTCH1 mediates a switch between two distinct secretomes during senescence.

scientific article

Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms

scientific article published on 13 February 2018

Notch2 controls non-autonomous Wnt-signalling in chronic lymphocytic leukaemia

scientific article published in Nature Communications

Orthotopic liver transplantation for subacute hepatic failure following partial treatment of isoniazid-resistant tuberculosis

scientific article published on 14 September 2007

Peptides complexed with the protein HSP70 generate efficient human cytolytic T-lymphocyte responses

scientific article published on 01 August 2004

Plasma membrane profiling defines an expanded class of cell surface proteins selectively targeted for degradation by HCMV US2 in cooperation with UL141

scientific article (publication date: April 2015)

Position-effect variegation revisited: HUSHing up heterochromatin in human cells.

scientific article published on 8 February 2016

Powering the peptide pump: TAP crosstalk with energetic nucleotides

scientific article published in September 2002

Quantitative temporal viromics: an approach to investigate host-pathogen interaction

scientific article

RNA-binding E3 ubiquitin ligases: novel players in nucleic acid regulation

scientific article published on 01 December 2010

Recent developments in MHC-class-I-mediated antigen presentation.

scientific article published on February 2004

Regulation of Human γδ T Cells by BTN3A1 Protein Stability and ATP-Binding Cassette Transporters.

scientific article published on 4 April 2018

Regulation of MHC class I heterodimer stability and interaction with TAP by tapasin ⬇️

scientific article published on January 1, 1997

Role for the obesity-related FTO gene in the cellular sensing of amino acids

scientific article published on 28 January 2013

Screening of healthcare workers for SARS-CoV-2 highlights the role of asymptomatic carriage in COVID-19 transmission

scientific article published on 11 May 2020

Soluble tapasin restores MHC class I expression and function in the tapasin-negative cell line .220.

scientific article

Solution structure of the Kaposi's sarcoma-associated herpesvirus K3 N-terminal domain reveals a Novel E2-binding C4HC3-type RING domain.

scientific article published on 30 September 2004

Stabilization of an E3 ligase-E2-ubiquitin complex increases cell surface MHC class I expression.

scientific article published on 12 May 2010

Sterol metabolism regulates neuroserpin polymer degradation in the absence of the unfolded protein response in the dementia FENIB.

scientific article published on 28 June 2013

Stromal cell protein kinase C-β inhibition enhances chemosensitivity in B cell malignancies and overcomes drug resistance

scientific article published on 01 January 2020

Structure and function: heat shock proteins and adaptive immunity.

scientific article published on August 2007

Studying ubiquitination of MHC class I molecules.

scientific article published in January 2013

Suppression of costimulation by human cytomegalovirus promotes evasion of cellular immune defenses.

scientific article published on 24 April 2018

TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control

scientific article published on 02 October 2020

TRIM5α requires Ube2W to anchor Lys63-linked ubiquitin chains and restrict reverse transcription.

scientific article

Tapasin is a facilitator, not an editor, of class I MHC peptide binding.

scientific article

Tapasin-related protein TAPBPR is an additional component of the MHC class I presentation pathway

scientific article

Tartrate-resistant acid phosphatase (Acp 5): identification in diverse human tissues and dendritic cells.

scientific article

Temporal Proteomic Analysis of BK Polyomavirus Infection Reveals Virus-Induced G2 Arrest and Highly Effective Evasion of Innate Immune Sensing

scientific article published on 30 July 2019

Temporal proteomic analysis of HIV infection reveals remodelling of the host phosphoproteome by lentiviral Vif variants

scientific article published on 30 September 2016

The ABC-transporter signature motif is required for peptide translocation but not peptide binding by TAP

scientific journal article

The HUSH complex cooperates with TRIM28 to repress young retrotransposons and new genes.

scientific article published on 4 May 2018

The RNA-binding E3 ubiquitin ligase MEX-3C links ubiquitination with MHC-I mRNA degradation

scientific article

The dominantly expressed class I molecule of the chicken MHC is explained by coevolution with the polymorphic peptide transporter (TAP) genes.

scientific article

The human cytomegalovirus US6 glycoprotein inhibits transporter associated with antigen processing-dependent peptide translocation.

scientific article

The human cytomegalovirus gene product US6 inhibits ATP binding by TAP

scientific article

The sterol-responsive RNF145 E3 ubiquitin ligase mediates the degradation of HMG-CoA reductase together with gp78 and Hrd1

scientific article published on 13 December 2018

The trafficking and regulation of membrane receptors by the RING-CH ubiquitin E3 ligases.

scientific article

The ubiquitin E3 ligase MARCH7 is differentially regulated by the deubiquitylating enzymes USP7 and USP9X

scientific article published on 11 April 2008

The varicellovirus UL49.5 protein blocks the transporter associated with antigen processing (TAP) by inhibiting essential conformational transitions in the 6+6 transmembrane TAP core complex

scientific journal article

Treatment of COVID-19 with remdesivir in the absence of humoral immunity: a case report

scientific article published on 14 December 2020

Two novel human cytomegalovirus NK cell evasion functions target MICA for lysosomal degradation

scientific article

UBE2L3 polymorphism amplifies NF-κB activation and promotes plasma cell development, linking linear ubiquitination to multiple autoimmune diseases.

scientific article

Ubiquitylation of MHC class I by the K3 viral protein signals internalization and TSG101-dependent degradation

scientific article published on May 2002

Viral avoidance and exploitation of the ubiquitin system.

scientific article published on May 2009

What Has the Study of the K3 and K5 Viral Ubiquitin E3 Ligases Taught Us about Ubiquitin-Mediated Receptor Regulation? ⬇️

scientific article published on January 28, 2011

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