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List of works by Gerd Hasenfuss

2015 ESC Guidelines for the Management of Acute Coronary Syndromes in Patients Presenting Without Persistent ST-segment Elevation

article

2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevati

scientific article published on 29 August 2015

A randomized controlled trial to evaluate the safety and efficacy of cardiac contractility modulation in patients with moderately reduced left ventricular ejection fraction and a narrow QRS duration: study rationale and design

scientific article

A rare cause of right heart failure

scientific article

A rare cause of sudden cardiac arrest: primary cardiac lymphoma

scientific article published on 5 June 2009

Abnormalities of calcium metabolism and myocardial contractility depression in the failing heart

scientific article published on December 2009

Accuracy of 64-multidetector computed tomography coronary angiography in patients with symptomatic atrial fibrillation prior to pulmonary vein isolation ⬇️

scientific article published on December 6, 2011

Adenovirus-mediated overexpression of diacylglycerol kinase-zeta inhibits endothelin-1-induced cardiomyocyte hypertrophy

scientific article published on 21 March 2005

Age-dependent changes in contractile function and passive elastic properties of myocardium from mice lacking muscle LIM protein (MLP).

scientific article published on 26 February 2012

Altered Na(+) currents in atrial fibrillation effects of ranolazine on arrhythmias and contractility in human atrial myocardium

scientific article published in May 2010

Amount or intensity? Potential targets of exercise interventions in patients with heart failure with preserved ejection fraction

scientific article

Antiarrhythmic effects of dantrolene in human diseased cardiomyocytes

scientific article published on 17 September 2016

Application of genomewide SNP arrays for detection of simulated susceptibility loci

scientific article published in June 2005

Arterial stiffness and elevated left ventricular filling pressure in patients at risk for the development or a previous diagnosis of HF-A subgroup analysis from the DIAST-CHF study

scientific article published on 27 March 2017

Association of NADPH oxidase polymorphisms with anthracycline-induced cardiotoxicity in the RICOVER-60 trial of patients with aggressive CD20(+) B-cell lymphoma

scientific article published in January 2015

Atrial overdrive pacing compared to CPAP in patients with obstructive sleep apnoea syndrome

scientific article published on 26 August 2005

Atrial overdrive pacing in patients with sleep apnea with implanted pacemaker

scientific article

Axial tubule junctions control rapid calcium signaling in atria

scientific article

BNP controls early load-dependent regulation of SERCA through calcineurin

scientific article

Benefit of heart rate reduction in heart failure

scientific article published on December 2010

Biomarker-based phenotyping of myocardial fibrosis identifies patients with heart failure with preserved ejection fraction resistant to the beneficial effects of spironolactone: results from the Aldo-DHF trial

scientific article published on 30 April 2018

Biventricular pacing improves the blunted force-frequency relation present during univentricular pacing in patients with heart failure and conduction delay

scientific article published on 13 February 2006

Blunted frequency-dependent upregulation of cardiac output is related to impaired relaxation in diastolic heart failure

scientific article published on December 2009

CCL5 deficiency reduces neointima formation following arterial injury and thrombosis in apolipoprotein E-deficient mice

scientific article published on 16 June 2016

Ca2+/calmodulin-dependent protein kinase II and protein kinase A differentially regulate sarcoplasmic reticulum Ca2+ leak in human cardiac pathology.

scientific article

Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channels

scientific article

CaMKII-dependent diastolic SR Ca2+ leak and elevated diastolic Ca2+ levels in right atrial myocardium of patients with atrial fibrillation

scientific article published on 7 January 2010

Calcium cycling in congestive heart failure

scientific article

Cardiac expression of neutrophil gelatinase-associated lipocalin in a model of cancer cachexia-induced cardiomyopathy

scientific article published on 26 October 2018

Cardiac inotropes: current agents and future directions ⬇️

scientific article published on 08 March 2011

Cardiac resident progenitor cells: evidence and functional significance ⬇️

scientific article published on July 10, 2012

Cardiac resynchronization therapy and atrial overdrive pacing for the treatment of central sleep apnoea

scientific article published on 12 January 2009

Cardiomyocyte proliferation prevents failure in pressure overload but not volume overload

scientific article published on 30 October 2017

Catecholamine-Dependent β-Adrenergic Signaling in a Pluripotent Stem Cell Model of Takotsubo Cardiomyopathy

scientific article published in August 2017

Celecoxib modulates hypertrophic signalling and prevents load-induced cardiac dysfunction

scientific article

Cellular repopulation of myocardial infarction in patients with sex-mismatched heart transplantation

scientific article published in May 2004

Circulating Endothelial Cells Expressing the Angiogenic Transcription Factor Krüppel-Like Factor 4 are Decreased in Patients with Coronary Artery Disease

scientific article

Clinical Features and Outcomes of Takotsubo (Stress) Cardiomyopathy

scientific article published on September 2015

Clinical Relevance of Patent Foramen Ovale and Atrial Septum Aneurysm in Stroke: Findings of a Single-Center Cross-Sectional Study

scientific article published on 28 September 2017

Comparative study of human-induced pluripotent stem cells derived from bone marrow cells, hair keratinocytes, and skin fibroblasts

scientific article published on 12 July 2012

Constitutively active phosphatase inhibitor-1 improves cardiac contractility in young mice but is deleterious after catecholaminergic stress and with aging

scientific article

Contribution of comorbidities to functional impairment is higher in heart failure with preserved than with reduced ejection fraction

scientific article

Differential PI3K signal transduction in obesity-associated cardiac hypertrophy and response to ischemia.

scientific article published on 30 August 2014

Differential cardiac remodeling in preload versus afterload

scientific article

Differential effects of theophylline on sympathetic excitation, hemodynamics, and breathing in congestive heart failure

scientific article published on 4 October 2004

Differential interaction of clinical characteristics with key functional parameters in heart failure with preserved ejection fraction--results of the Aldo-DHF trial

scientific article

Differential roles of nitric oxide synthase isozymes in cardiotoxicity and mortality following chronic doxorubicin treatment in mice

scientific article

Direct pro-arrhythmogenic effects of angiotensin II can be suppressed by AT1 receptor blockade in human atrial myocardium

scientific article

Do stem cells in the heart truly differentiate into cardiomyocytes?

scientific article published on 31 July 2007

Dystrophin-deficiency increases the susceptibility to doxorubicin-induced cardiotoxicity

scientific article published on 20 September 2007

Echocardiographic evaluation of diastolic function in mouse models of heart disease

scientific article published on 18 October 2017

Effect of spironolactone on diastolic function and exercise capacity in patients with heart failure with preserved ejection fraction: the Aldo-DHF randomized controlled trial

scientific article published on February 2013

Effects of "minimally invasive curricular surgery" - a pilot intervention study to improve the quality of bedside teaching in medical education

scientific article

Effects of adenovirus-mediated sorcin overexpression on excitation-contraction coupling in isolated rabbit cardiomyocytes

scientific article

Effects of calsequestrin over-expression on excitation-contraction coupling in isolated rabbit cardiomyocytes

scientific article published in September 2005

Effects of exercise training on different quality of life dimensions in heart failure with preserved ejection fraction: the Ex-DHF-P trial

scientific article published on 13 March 2014

Effects of long-term endurance and resistance training on diastolic function, exercise capacity, and quality of life in asymptomatic diastolic dysfunction vs. heart failure with preserved ejection fraction

scientific article published in September 2014

Effects of mild hypothermia on hemodynamics in cardiac arrest survivors and isolated failing human myocardium

scientific article

Effects of obesity and weight loss on the functional properties of early outgrowth endothelial progenitor cells

scientific article

Effects of the NO donor sodium nitroprusside on oxygen consumption and energetics in rabbit myocardium

scientific article published on 3 February 2009

Efficient generation of hepatic cells from multipotent adult mouse germ-line stem cells using an OP9 co-culture system

scientific article published on 31 December 2013

Elevated afterload, neuroendocrine stimulation, and human heart failure increase BNP levels and inhibit preload-dependent SERCA upregulation

scientific article published on 17 September 2008

Empagliflozin directly improves diastolic function in human heart failure

scientific article published on 17 October 2018

Endothelial deletion of protein tyrosine phosphatase-1B protects against pressure overload-induced heart failure in mice

scientific article published on 20 May 2016

Energetics of the Frank-Starling effect in rabbit myocardium: economy and efficiency depend on muscle length

scientific article

Enhanced detection of paroxysmal atrial fibrillation by early and prolonged continuous holter monitoring in patients with cerebral ischemia presenting in sinus rhythm

scientific article published on 21 October 2010

Enhanced expression of DYRK1A in cardiomyocytes inhibits acute NFAT activation but does not prevent hypertrophy in vivo

scientific article

Epigenetic balance of aberrant Rasal1 promoter methylation and hydroxymethylation regulates cardiac fibrosis

scientific article

Epsilon waves in giant-cell myocarditis

scientific article published on 29 August 2013

Evidence for altered interleukin 18 (IL)-18 pathway in human heart failure.

scientific article

Excessive sarcoplasmic/endoplasmic reticulum Ca2+-ATPase expression causes increased sarcoplasmic reticulum Ca2+ uptake but decreases myocyte shortening

scientific article published on 25 October 2004

Exercise intolerance and systemic manifestations of pulmonary emphysema in a mouse model

scientific article published on 28 January 2009

Exercise training improves exercise capacity and diastolic function in patients with heart failure with preserved ejection fraction: results of the Ex-DHF (Exercise training in Diastolic Heart Failure) pilot study

scientific article

Exercise training in Diastolic Heart Failure (Ex-DHF): rationale and design of a multicentre, prospective, randomized, controlled, parallel group trial

scientific article published on 17 May 2017

FKBP12.6 overexpression decreases Ca2+ spark amplitude but enhances [Ca2+]i transient in rat cardiac myocytes

scientific article

Frequency-dependence of the slow force response

scientific article published in May 2008

Galectin-3 in patients with heart failure with preserved ejection fraction: results from the Aldo-DHF trial

scientific article published on 24 November 2014

Generation of functional cardiomyocytes from adult mouse spermatogonial stem cells

scientific article published on 3 May 2007

Generation of functional murine cardiac myocytes from induced pluripotent stem cells

scientific article

Genetic background defines the regulation of postnatal cardiac growth by 17β-estradiol through a β-catenin mechanism

scientific article published on 14 April 2014

Guía ESC 2015 sobre el tratamiento de los síndromes coronarios agudos en pacientes sin elevación persistente del segmento ST

Guía ESC 2016 sobre el diagnóstico y tratamiento de la insuficiencia cardiaca aguda y crónica

Heart failure and kidney dysfunction: epidemiology, mechanisms and management

scientific article published on 30 August 2016

High Precision Quantitative Proteomics Using iTRAQ on an LTQ Orbitrap: A New Mass Spectrometric Method Combining the Benefits of All

scientific article

High-fidelity CRISPR/Cas9- based gene-specific hydroxymethylation rescues gene expression and attenuates renal fibrosis

scientific article published in Nature Communications

Higher plasma levels of MR-pro-atrial natriuretic peptide are linked to less anxiety: results from the observational DIAST-CHF study

scientific article

Highly sensitive troponin T assay in normotensive patients with acute pulmonary embolism

scientific article

Hydroxyl radical-induced acute diastolic dysfunction is due to calcium overload via reverse-mode Na(+)-Ca(2+) exchange

scientific article

Impact of baroreflex activation therapy on renal function--a pilot study

scientific article

Impact of the learning curve on outcomes after percutaneous mitral valve repair with MitraClip and lessons learned after the first 75 consecutive patients

scientific article published on 24 October 2011

Impaired physical quality of life in patients with diastolic dysfunction associates more strongly with neurohumoral activation than with echocardiographic parameters: quality of life in diastolic dysfunction

scientific article published in April 2011

Implementing a hospital-based smoking cessation programme: evidence for a learning effect

scientific article published on 26 November 2007

Improved systolic and diastolic myocardial function with intracoronary pyruvate in patients with congestive heart failure

scientific article published in March 2004

In vitro and in vivo effects of human monocytes and their subsets on new vessel formation

scientific article

In vivo model with targeted cAMP biosensor reveals changes in receptor-microdomain communication in cardiac disease

scientific article published on 28 April 2015

Increased myocardial NADPH oxidase activity in human heart failure

scientific article

Increased neuronal nitric oxide synthase-derived NO production in the failing human heart

scientific article published in April 2004

Increased sympathetic nerve activity in COPD is associated with morbidity and mortality.

scientific article

Increasing the use of nicotine replacement therapy by a simple intervention: an exploratory trial

scientific article published in February 2010

Influence of Pyruvate on Contractile Performance and Ca 2+ Cycling in Isolated Failing Human Myocardium ⬇️

scientific article published on January 15, 2002

Inhibition of Elevated Ca 2+ /Calmodulin-Dependent Protein Kinase II Improves Contractility in Human Failing Myocardium ⬇️

scientific article published on September 2, 2010

Inhibition of PI3K improves contractility in alpha1-adrenergically stimulated myocardium

scientific article published in May 2008

Interference of remote magnetic catheter navigation and ablation with implanted devices for pacing and defibrillation.

scientific article published in September 2010

Intracellular beta-blockade: overexpression of Galpha(i2) depresses the beta-adrenergic response in intact myocardium

scientific article

Intracoronary pyruvate in cardiogenic shock as an adjunctive therapy to catecholamines and intra-aortic balloon pump shows beneficial effects on hemodynamics ⬇️

scientific article published on December 4, 2010

Intrathoracic impedance monitoring to detect chronic heart failure deterioration: relationship to changes in NT-proBNP.

scientific article

Is modulation of sodium-calcium exchange a therapeutic option in heart failure?

scientific article

Isolation and cultivation of stem cells from adult mouse testes

scientific article published in January 2009

K201 improves aspects of the contractile performance of human failing myocardium via reduction in Ca2+ leak from the sarcoplasmic reticulum

scientific article

Knowledge gaps about smoking cessation in hospitalized patients and their doctors ⬇️

scientific article published on February 11, 2011

Laminin-alpha4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and endothelial cells

scientific article published on 23 July 2007

Late INa increases diastolic SR-Ca2+-leak in atrial myocardium by activating PKA and CaMKII.

scientific article published on 18 May 2015

Leptin enhances the potency of circulating angiogenic cells via src kinase and integrin (alpha)vbeta5: implications for angiogenesis in human obesity

scientific journal article

Leptin promotes neointima formation and smooth muscle cell proliferation via NADPH oxidase activation and signalling in caveolin-rich microdomains ⬇️

scientific article published on May 30, 2013

Limitations of FKBP12.6-directed treatment strategies for maladaptive cardiac remodeling and heart failure ⬇️

scientific article published on August 24, 2010

Local and systemic effects of angiotensin receptor blockade in an emphysema mouse model ⬇️

scientific article published on December 25, 2010

Longevity of implantable cardioverter-defibrillators in a single-center population

scientific article published on 8 August 2015

Low-energy control of electrical turbulence in the heart ⬇️

scientific article

Mechanical load-dependent regulation of gene expression in monocrotaline-induced right ventricular hypertrophy in the rat.

scientific article published on 3 July 2003

Medical students lack basic knowledge about smoking: findings from two European medical schools

scientific article

Molecular and structural transition mechanisms in long-term volume overload

scientific article published on 23 December 2015

Multipotent adult germline stem cells and embryonic stem cells have similar microRNA profiles

scientific article

Myocardial adaptation of energy metabolism to elevated preload depends on calcineurin activity : a proteomic approach

scientific article

NAD(P)H oxidase and multidrug resistance protein genetic polymorphisms are associated with doxorubicin-induced cardiotoxicity

scientific article

Na(+)-Ca(2+) exchanger overexpression predisposes to reactive oxygen species-induced injury

scientific article published in November 2003

Oral health status of patients with acute coronary syndrome – a case control study ⬇️

scientific article published on June 22, 2012

Partial compression of the right atrium caused by a haematoma after coronary artery bypass angioplasty

scientific article published on 3 April 2006

Phosphatase inhibitor-1-deficient mice are protected from catecholamine-induced arrhythmias and myocardial hypertrophy

scientific article published on 8 August 2008

Plasminogen activator inhibitor-1 from bone marrow-derived cells suppresses neointimal formation after vascular injury in mice

scientific article published on 2 March 2006

Pluripotency of spermatogonial stem cells from adult mouse testis

scientific article

Pluripotent stem cells are highly susceptible targets for syngeneic, allogeneic, and xenogeneic natural killer cells

scientific article

Postextrasystolic blood pressure potentiation predicts poor outcome of cardiac patients

scientific article

Potentiation of beta-adrenergic inotropic response by pyruvate in failing human myocardium ⬇️

scientific article published on January 1, 2002

Predictive value of the high-sensitivity troponin T assay and the simplified Pulmonary Embolism Severity Index in hemodynamically stable patients with acute pulmonary embolism: a prospective validation study

scientific article

Predictors of High Post-Procedural Gradients after Catheter-Based Aortic Valve Implantation Using Direct Flow Medical Bioprostheses

scientific article published on May 2016

Pressure overload and neurohumoral activation differentially affect the myocardial proteome

scientific journal article

Proteome changes in CaMKIIδC-overexpressing cardiac myocytes

scientific article published on 25 January 2010

Quantification of intra and inter-ventricular dyssynchrony in Ebstein's anomaly using cardiovascular magnetic resonance myocardial feature tracking.

scientific article published on 16 January 2014

Quantification of left atrial strain and strain rate using cardiovascular magnetic resonance myocardial feature tracking.

scientific article published on 3 February 2015

Quantitative assessment of left ventricular mechanical dyssynchrony using cine cardiovascular magnetic resonance imaging: inter-study reproducibility.

scientific article published on 27 January 2016

RAnoLazIne for the treatment of diastolic heart failure in patients with preserved ejection fraction: the RALI-DHF proof-of-concept study

scientific article published in April 2013

Randomized Clinical evaluatiON of wireless fluid monitoriNg and rEmote ICD managemenT using OptiVol alert-based predefined management to reduce cardiac decompensation and health care utilization: the CONNECT-OptiVol study

scientific article published on 13 October 2012

Ranolazine for the Treatment of Heart Failure With Preserved Ejection Fraction: Background, Aims, and Design of the RALI‐DHF Study ⬇️

scientific article published on April 27, 2011

Ranolazine improves diastolic dysfunction in isolated myocardium from failing human hearts--role of late sodium current and intracellular ion accumulation

scientific article published on 14 March 2008

Rate dependence of [Na+]i and contractility in nonfailing and failing human myocardium

scientific article

Rationale and Design of the Reduce Elevated Left Atrial Pressure in Patients With Heart Failure (Reduce LAP-HF) Trial

scientific article published on 6 June 2015

Rationale and design of the 'aldosterone receptor blockade in diastolic heart failure' trial: a double-blind, randomized, placebo-controlled, parallel group study to determine the effects of spironolactone on exercise capacity and diastolic function

scientific article published on 10 June 2010

Rationale and design of the treatment of hyponatremia based on lixivaptan in NYHA class III/IV cardiac patient evaluation (THE BALANCE) study

scientific article

Recent in vitro findings of negative inotropy of pantoprazole did not translate into clinically relevant effects on left ventricular function in healthy volunteers

scientific article published on 20 March 2009

Relationship between exercise intervention and NO pathway in patients with heart failure with preserved ejection fraction

scientific article published on 5 April 2018

Relevance of Na+-Ca2+ exchange in heart failure

scientific article

Relevance of brain natriuretic peptide in preload-dependent regulation of cardiac sarcoplasmic reticulum Ca2+ ATPase expression

scientific article

Remote magnetic catheter navigation for cavotricuspid isthmus ablation in patients with common-type atrial flutter

scientific article published on December 2009

Remote magnetic versus manual catheter navigation for circumferential pulmonary vein ablation in patients with atrial fibrillation ⬇️

scientific article published on June 25, 2011

Role of late sodium current as a potential arrhythmogenic mechanism in the progression of pressure-induced heart disease ⬇️

scientific article published on 06 April 2013

Sarcomeric cardiomyopathies: from bedside to bench and back

scientific article published on 13 February 2015

Serial assessment of left atrial deformation in patients undergoing pulmonary vein isolation: a cardiovascular magnetic resonance feasibility study.

scientific article published on 27 January 2016

Severe DCM phenotype of patient harboring RBM20 mutation S635A can be modeled by patient-specific induced pluripotent stem cell-derived cardiomyocytes

scientific article

Sex difference in appropriate shocks but not mortality during long-term follow-up in patients with implantable cardioverter-defibrillators

scientific article

Sex-dependent alterations of Ca2+ cycling in human cardiac hypertrophy and heart failure

scientific article published on 22 October 2015

Stage-dependent detection of CD14+ and CD16+ cells in the human heart after myocardial infarction ⬇️

scientific article published on July 20, 2013

Stimulated emission depletion live-cell super-resolution imaging shows proliferative remodeling of T-tubule membrane structures after myocardial infarction

scientific article

Summative assessments are more powerful drivers of student learning than resource intensive teaching formats ⬇️

scientific article published on March 5, 2013

Targeting altered calcium physiology in the heart: translational approaches to excitation, contraction, and transcription

scientific article published on October 2007

The German CPU Registry: Dyspnea independently predicts negative short-term outcome in patients admitted to German Chest Pain Units

scientific article published on 28 November 2014

The German CPU Registry: comparison of troponin positive to troponin negative patients.

scientific article published in April 2013

The combined effects of ranolazine and dronedarone on human atrial and ventricular electrophysiology

scientific article published on 4 April 2016

The functional consequences of sodium channel Na 1.8 in human left ventricular hypertrophy

scientific article published on 30 October 2018

The novel biomarker growth differentiation factor 15 in heart failure with normal ejection fraction ⬇️

scientific article published on September 13, 2010

The risk-to-benefit ratio of transcatheter aortic valve implantation in specific patient cohorts: a single-centre experience ⬇️

scientific article published on February 21, 2012

Transthoracic echocardiography to rule out paroxysmal atrial fibrillation as a cause of stroke or transient ischemic attack

scientific article published on 13 October 2011

Treatment of heart failure through stabilization of the cardiac ryanodine receptor

scientific article

ZBTB17 ( MIZ1 ) Is Important for the Cardiac Stress Response and a Novel Candidate Gene for Cardiomyopathy and Heart Failure

article

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