List of works - A. Thomas Look

A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish

scientific article

ARID1A loss in neuroblastoma promotes the adrenergic-to-mesenchymal transition by regulating enhancer-mediated gene expression

scientific article published on 15 July 2020

ATM-deficient thymic lymphoma is associated with aberrant tcrd rearrangement and gene amplification

scientific article

Absence of biallelic TCRgamma deletion predicts early treatment failure in pediatric T-cell acute lymphoblastic leukemia

scientific article

Activating mutations in ALK provide a therapeutic target in neuroblastoma

scientific article

Age-dependent prognostic effect by Mitosis-Karyorrhexis Index in neuroblastoma: a report from the Children's Oncology Group

scientific article

Anti-leukaemic activity of the TYK2 selective inhibitor NDI-031301 in T-cell acute lymphoblastic leukaemia.

scientific article published on 14 March 2017

Autocrine activation of the MET receptor tyrosine kinase in acute myeloid leukemia

scientific article

Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3.

scientific article

Clinicopathological characteristics of ganglioneuroma and ganglioneuroblastoma: a report from the CCG and COG.

scientific article published on October 2009

Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia.

scientific article

Cyclin C is a haploinsufficient tumour suppressor

scientific article

Discovery of a selective irreversible BMX inhibitor for prostate cancer.

scientific article published on 26 April 2013

Discovery of regulatory noncoding variants in individual cancer genomes by using cis-X

scientific article published on 06 July 2020

Disruption of asxl1 results in myeloproliferative neoplasms in zebrafish.

scientific article

EP300 Selectively Controls the Enhancer Landscape of MYCN-Amplified Neuroblastoma

scientific article published on 01 March 2022

Emi1 maintains genomic integrity during zebrafish embryogenesis and cooperates with p53 in tumor suppression.

scientific article published on 24 August 2009

High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia

scientific article published on 20 May 2009

Inactivation of LEF1 in T-cell acute lymphoblastic leukemia

scientific article

Interconnecting molecular pathways in the pathogenesis and drug sensitivity of T-cell acute lymphoblastic leukemia

scientific article

Interplay of pu.1 and gata1 determines myelo-erythroid progenitor cell fate in zebrafish

scientific article

JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia.

scientific article published on 25 June 2018

KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia.

scientific article published on 04 February 2013

Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kinetics

scientific article published on 5 January 2012

Loss of atrx cooperates with p53-deficiency to promote the development of sarcomas and other malignancies

article

MYC-family protein overexpression and prominent nucleolar formation represent prognostic indicators and potential therapeutic targets for aggressive high-MKI neuroblastomas: a report from the children's oncology group

scientific article published on 15 December 2017

Mechanisms underlying synergy between DNA topoisomerase I-targeted drugs and mTOR kinase inhibitors in NF1-associated malignant peripheral nerve sheath tumors

scientific article published on 23 August 2019

Neuroblastoma of undifferentiated subtype, prognostic significance of prominent nucleolar formation, and MYC/MYCN protein expression: a report from the Children's Oncology Group

scientific article

Oncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element

scientific article

PIDD death-domain phosphorylation by ATM controls prodeath versus prosurvival PIDDosome signaling

scientific article published on 30 July 2012

Peripheral neuroblastic tumors with genotype-phenotype discordance: a report from the Children's Oncology Group and the International Neuroblastoma Pathology Committee

scientific article

Phosphatase-dependent and -independent functions of Shp2 in neural crest cells underlie LEOPARD syndrome pathogenesis

scientific article published on May 2010

Repression of tumor suppressor miR-451 is essential for NOTCH1-induced oncogenesis in T-ALL.

scientific article

Ribonucleoprotein HNRNPA2B1 interacts with and regulates oncogenic KRAS in pancreatic ductal adenocarcinoma cells.

scientific article

SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction

scientific article

Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma

scientific article

Synergistic melanoma cell death mediated by inhibition of both MCL1 and BCL2 in high-risk tumors driven by NF1/PTEN loss

scientific article published on 30 July 2021

Synergy between loss of NF1 and overexpression of MYCN in neuroblastoma is mediated by the GAP-related domain.

scientific article published on 27 April 2016

Synthetic lethal targeting of TET2-mutant hematopoietic stem and progenitor cells (HSPCs) with TOP1-targeted drugs and PARP1 inhibitors

scientific article published on 22 June 2020

T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation.

scientific article

TYK2-STAT1-BCL2 pathway dependence in T-cell acute lymphoblastic leukemia

scientific article published on 7 March 2013

Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

scientific article

The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia

scientific article

The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia

scientific article published on 15 July 2013

The requirement for cyclin D function in tumor maintenance

scientific article

suz12 inactivation in p53 and nf1 deficient zebrafish accelerates the onset of MPNSTs and expands the spectrum of tumor types to include adenocarcinoma, leukemia, and soft tissue sarcoma

scientific article published on 10 July 2020

tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors

scientific article

List of works by A. Thomas Look

A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish

ARID1A loss in neuroblastoma promotes the adrenergic-to-mesenchymal transition by regulating enhancer-mediated gene expression

ATM-deficient thymic lymphoma is associated with aberrant tcrd rearrangement and gene amplification

Absence of biallelic TCRgamma deletion predicts early treatment failure in pediatric T-cell acute lymphoblastic leukemia

Activating mutations in ALK provide a therapeutic target in neuroblastoma

Age-dependent prognostic effect by Mitosis-Karyorrhexis Index in neuroblastoma: a report from the Children's Oncology Group

Anti-leukaemic activity of the TYK2 selective inhibitor NDI-031301 in T-cell acute lymphoblastic leukaemia.

Autocrine activation of the MET receptor tyrosine kinase in acute myeloid leukemia

Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3.

Clinicopathological characteristics of ganglioneuroma and ganglioneuroblastoma: a report from the CCG and COG.

Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia.

Cyclin C is a haploinsufficient tumour suppressor

Discovery of a selective irreversible BMX inhibitor for prostate cancer.

Discovery of regulatory noncoding variants in individual cancer genomes by using cis-X

Disruption of asxl1 results in myeloproliferative neoplasms in zebrafish.

EP300 Selectively Controls the Enhancer Landscape of MYCN-Amplified Neuroblastoma

Emi1 maintains genomic integrity during zebrafish embryogenesis and cooperates with p53 in tumor suppression.

High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia

Inactivation of LEF1 in T-cell acute lymphoblastic leukemia

Interconnecting molecular pathways in the pathogenesis and drug sensitivity of T-cell acute lymphoblastic leukemia

Interplay of pu.1 and gata1 determines myelo-erythroid progenitor cell fate in zebrafish

JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia.

KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia.

Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kinetics

Loss of atrx cooperates with p53-deficiency to promote the development of sarcomas and other malignancies

MYC-family protein overexpression and prominent nucleolar formation represent prognostic indicators and potential therapeutic targets for aggressive high-MKI neuroblastomas: a report from the children's oncology group

Mechanisms underlying synergy between DNA topoisomerase I-targeted drugs and mTOR kinase inhibitors in NF1-associated malignant peripheral nerve sheath tumors

Neuroblastoma of undifferentiated subtype, prognostic significance of prominent nucleolar formation, and MYC/MYCN protein expression: a report from the Children's Oncology Group

Oncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element

PIDD death-domain phosphorylation by ATM controls prodeath versus prosurvival PIDDosome signaling

Peripheral neuroblastic tumors with genotype-phenotype discordance: a report from the Children's Oncology Group and the International Neuroblastoma Pathology Committee

Phosphatase-dependent and -independent functions of Shp2 in neural crest cells underlie LEOPARD syndrome pathogenesis

Repression of tumor suppressor miR-451 is essential for NOTCH1-induced oncogenesis in T-ALL.

Ribonucleoprotein HNRNPA2B1 interacts with and regulates oncogenic KRAS in pancreatic ductal adenocarcinoma cells.

SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction

Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma

Synergistic melanoma cell death mediated by inhibition of both MCL1 and BCL2 in high-risk tumors driven by NF1/PTEN loss

Synergy between loss of NF1 and overexpression of MYCN in neuroblastoma is mediated by the GAP-related domain.

Synthetic lethal targeting of TET2-mutant hematopoietic stem and progenitor cells (HSPCs) with TOP1-targeted drugs and PARP1 inhibitors

T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation.

TYK2-STAT1-BCL2 pathway dependence in T-cell acute lymphoblastic leukemia

Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia

The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia

The requirement for cyclin D function in tumor maintenance

suz12 inactivation in p53 and nf1 deficient zebrafish accelerates the onset of MPNSTs and expands the spectrum of tumor types to include adenocarcinoma, leukemia, and soft tissue sarcoma

tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors