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List of works by James P. Allison

A Pilot Study of Preoperative Single-Dose Ipilimumab and/or Cryoablation in Women with Early-Stage Breast Cancer with Comprehensive Immune Profiling

scientific article published on 26 August 2016

A genetic library screen for signaling proteins that interact with phosphorylated T cell costimulatory receptors

scientific article published on 2 October 2006

A genetic mouse model recapitulates immune checkpoint inhibitor-associated myocarditis and supports a mechanism-based therapeutic intervention

scientific article published on 30 November 2020

A pilot trial of CTLA-4 blockade with human anti-CTLA-4 in patients with hormone-refractory prostate cancer

scientific article published in March 2007

ARID1A mutation plus CXCL13 expression act as combinatorial biomarkers to predict responses to immune checkpoint therapy in mUCC

scientific article published on 01 June 2020

Ablation of B7-H3 but Not B7-H4 Results in Highly Increased Tumor Burden in a Murine Model of Spontaneous Prostate Cancer

scientific article published on 29 June 2015

Aire-dependent thymic development of tumor-associated regulatory T cells

scientific article published on March 2013

Alternative activation is an innate response to injury that requires CD4+ T cells to be sustained during chronic infection

scientific article published on September 2007

Analysis of Immune Signatures in Longitudinal Tumor Samples Yields Insight into Biomarkers of Response and Mechanisms of Resistance to Immune Checkpoint Blockade

scientific article published on 14 June 2016

Anti-CTLA-4 Immunotherapy Does Not Deplete FOXP3+ Regulatory T Cells (Tregs) in Human Cancers-Response

scientific article published on 01 June 2019

Anti-CTLA-4 antibody therapy: immune monitoring during clinical development of a novel immunotherapy

scientific article published on October 2010

Anti-CTLA-4 immunotherapy does not deplete FOXP3+ regulatory T cells (Tregs) in human cancers

scientific article published on 27 July 2018

Anti-cytotoxic T lymphocyte antigen-4 (CTLA-4) immunotherapy for the treatment of prostate cancer

scientific article published on September 2006

Antibodies against the T cell receptor/CD3 complex interfere with distinct intra-thymic cell-cell interactionsin vivo: correlation with arrest of T cell differentiation

scholarly article by Bruno A. Kyewski et al published May 1989 in European Journal of Immunology

Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25.

scientific article

Attenuated T cell responses to a high-potency ligand in vivo

scientific article

Augmentation of T Cell Levels and Responses Induced by Androgen Deprivation

article

Augmented IL-15Rα expression by CD40 activation is critical in synergistic CD8 T cell-mediated antitumor activity of anti-CD40 antibody with IL-15 in TRAMP-C2 tumors in mice

scientific article

B cells and tertiary lymphoid structures promote immunotherapy response

scientific article published on 15 January 2020

B7 expression on T cells down-regulates immune responses through CTLA-4 ligation via T-T interactions [corrections].

scientific article published in January 2004

B7-1 and B7-2 selectively recruit CTLA-4 and CD28 to the immunological synapse

scientific article published in September 2004

B7-H3 and B7x are highly expressed in human prostate cancer and associated with disease spread and poor outcome

scholarly article

B7-H3 expression in donor T cells and host cells negatively regulates acute graft-versus-host disease lethality

scientific article published on 26 March 2015

B7x in the periphery abrogates pancreas-specific damage mediated by self-reactive CD8 T cells

scientific article

B7x: a widely expressed B7 family member that inhibits T cell activation

scientific article

BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1

scientific journal article

Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients

scholarly article

Biosynthesis and processing of murine T-cell antigen receptor.

scientific article

Blockade of CTLA-4 and PD-1 Enhances Adoptive T-cell Therapy Efficacy in an ICOS-Mediated Manner

scientific article published on 29 August 2019

Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies

scientific article

Breaking down the barriers to cancer immunotherapy

article

CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation

scientific article

CD28 disruption exacerbates inflammation in Tgf-beta1-/- mice: in vivo suppression by CD4+CD25+ regulatory T cells independent of autocrine TGF-beta1.

scientific article

CD28-B7 interactions allow the induction of CD8+ cytotoxic T lymphocytes in the absence of exogenous help.

scientific article

CD28-B7 interactions in T-cell activation.

scientific article

CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

scientific article (publication date: 16 April 1992)

CTLA-4 Overexpression Inhibits T Cell Responses through a CD28-B7-Dependent Mechanism

article

CTLA-4 blockade enhances polyfunctional NY-ESO-1 specific T cell responses in metastatic melanoma patients with clinical benefit

scholarly article

CTLA-4 blockade in combination with xenogeneic DNA vaccines enhances T-cell responses, tumor immunity and autoimmunity to self antigens in animal and cellular model systems

scientific article published on April 2004

CTLA-4 blockade increases antigen-specific CD8(+) T cells in prevaccinated patients with melanoma: three cases

scientific article published on 5 April 2011

CTLA-4 blockade synergizes with cryoablation to mediate tumor rejection

scientific article published on July 2012

CTLA-4 blockade synergizes with tumor-derived granulocyte-macrophage colony-stimulating factor for treatment of an experimental mammary carcinoma.

scientific article

CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells

scientific article

CTLA-4: new insights into its biological function and use in tumor immunotherapy

scientific article

CTLA4 blockade and GM-CSF combination immunotherapy alters the intratumor balance of effector and regulatory T cells

scientific article published on 15 June 2006

CTLA4 blockade expands FoxP3+ regulatory and activated effector CD4+ T cells in a dose-dependent fashion

scientific article published on 3 June 2008

Cancer

article

Cancer classification using the Immunoscore: a worldwide task force

scientific article

Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting

scientific article published on 08 February 2012

Cancer immunotherapy: breaking the barriers to harvest the crop

Cancer immunotherapy: co-stimulatory agonists and co-inhibitory antagonists.

scientific article published on 18 February 2009

Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma

scientific article

Cell intrinsic mechanisms of T-cell inhibition and application to cancer therapy

scientific article published on August 2008

Cell surface expression by adult rat hepatocytes of a non-collagen glycoprotein present in rat liver biomatrix

scientific article published on 01 June 1984

Characterization and Comparison of GITR Expression in Solid Tumors

scientific article published on 29 July 2019

Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens

scientific article

Checkpoint blockade in cancer immunotherapy

scientific article

Checkpoints

scientific article published in September 2015

Chemical and immunological characterization of developmentally expressed chicken erythroid surface membrane antigens

scientific article published on 01 June 1982

Clonal expansion of CD8 T cells in the systemic circulation precedes development of ipilimumab-induced toxicities

scientific article published on 03 October 2016

Co-occurring genomic alterations define major subsets of KRAS-mutant lung adenocarcinoma with distinct biology, immune profiles, and therapeutic vulnerabilities

scientific article

Co-stimulation in T cell responses.

scientific article published on June 1997

Co-stimulation via CD28 induces activation of a refractory subset of MRL-Ipr/Ipr T lymphocytes

scientific article published on 01 November 1993

Co-stimulatory pathways in lymphocyte regulation: the immunoglobulin superfamily

scientific article

Combination CTLA-4 blockade and 4-1BB activation enhances tumor rejection by increasing T-cell infiltration, proliferation, and cytokine production

scientific article (publication date: 29 April 2011)

Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony-stimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accomp

scientific article

Combining radiation and immunotherapy: a new systemic therapy for solid tumors?

scientific article

Comparison of immune infiltrates in melanoma and pancreatic cancer highlights VISTA as a potential target in pancreatic cancer

scientific article published on 11 January 2019

Comprehensive T cell repertoire characterization of non-small cell lung cancer

scientific article published on 30 January 2020

Concurrent OX40 and CD30 Ligand Blockade Abrogates the CD4-Driven Autoimmunity Associated with CTLA4 and PD1 Blockade while Preserving Excellent Anti-CD8 Tumor Immunity.

scientific article published on 23 June 2017

Correlation of clinical and immunological data in a metastatic melanoma patient with heterogeneous tumor responses to ipilimumab therapy

scientific article

Costimulatory regulation of T cell function.

scientific article

Cutting Edge: CTLA-4 on Effector T Cells Inhibits In Trans

Cutting edge: a crucial role for B7-CD28 in transmitting T help from APC to CTL.

scientific article published on October 2002

Cutting edge: chronic inflammatory liver disease in mice expressing a CD28-specific ligand

scientific article published on 17 December 2012

Cytotoxic T Lymphocyte Antigen 4 (CD152) Regulates Self-Reactive T cells in BALB/c but not in the Autoimmune NOD Mouse

Cytotoxic T lymphocyte antigen-4 (CTLA-4) limits the expansion of encephalitogenic T cells in experimental autoimmune encephalomyelitis (EAE)-resistant BALB/c mice

scientific article

Cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates the size, reactivity, and function of a primed pool of CD4+ T cells.

scientific article published in November 2000

Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength

scientific article

Cytotoxic T lymphocyte antigen-4 blockade enhances antitumor immunity by stimulating melanoma-specific T-cell motility

scientific article

Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulates the unfolding of autoimmune diabetes

scientific article

De-Risking Immunotherapy: Report of a Consensus Workshop of the Cancer Immunotherapy Consortium of the Cancer Research Institute.

scientific article published on April 2016

Deep Sequencing of T-cell Receptor DNA as a Biomarker of Clonally Expanded TILs in Breast Cancer after Immunotherapy

scientific article published on September 2016

Defining the critical hurdles in cancer immunotherapy

scientific article published on 14 December 2011

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival

scientific article

Development of ipilimumab: a novel immunotherapeutic approach for the treatment of advanced melanoma

scientific article published on 17 June 2013

Distinct Cellular Mechanisms Underlie Anti-CTLA-4 and Anti-PD-1 Checkpoint Blockade

scientific article published on 9 August 2017

Distinct clinical patterns and immune infiltrates are observed at time of progression on targeted therapy versus immune checkpoint blockade for melanoma

scientific article published on 2 February 2016

Distinct influences of peptide-MHC quality and quantity on in vivo T-cell responses

scientific article

Efficacy, Safety, and Biomarkers of Response to Azacitidine and Nivolumab in Relapsed/Refractory Acute Myeloid Leukemia: A Non-randomized, Open-label, Phase 2 Study

scientific article published on 08 November 2018

Elimination of residual metastatic prostate cancer after surgery and adjunctive cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) blockade immunotherapy.

scientific article published on December 1999

Elucidating the autoimmune and antitumor effector mechanisms of a treatment based on cytotoxic T lymphocyte antigen-4 blockade in combination with a B16 melanoma vaccine: comparison of prophylaxis and therapy

scientific article

Emerging mechanisms of immune regulation: the extended B7 family and regulatory T cells

scientific article

Engagement of NKG2D by cognate ligand or antibody alone is insufficient to mediate costimulation of human and mouse CD8+ T cells.

scientific article published on February 2005

Engagement of the ICOS pathway markedly enhances efficacy of CTLA-4 blockade in cancer immunotherapy

scientific article published on 31 March 2014

Enhancement of antitumor immunity by CTLA-4 blockade

scientific article

Enhancement of tumor-reactive cytotoxic CD4+ T cell responses after ipilimumab treatment in four advanced melanoma patients

scientific article published on October 2013

Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis

scientific article

Epitope landscape in breast and colorectal cancer

scientific article published in February 2008

Erratum: Correlationof clinical and immunological data in a metastatic melanoma patient with heterogeneous tumor responses to ipilimumab therapy.

scientific article

Erratum: anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25.

scientific article published in March 2015

Expression of Helios in Peripherally Induced Foxp3+ Regulatory T Cells

scientific article published on 23 December 2011

Expression of Ly-1 and Ly-2 on a spontaneous AKR B-cell lymphoma

scientific article published on 01 January 1983

Expression of a fetal γδ T-cell receptor in adult mice triggers a non-MHC-linked form of selective depletion ⬇️

scientific article published on April 1, 1991

Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma

scientific article

Friends not foes: CTLA-4 blockade and mTOR inhibition cooperate during CD8+ T cell priming to promote memory formation and metabolic readiness

scientific article published on 26 January 2015

Functional deficiencies of granulocyte-macrophage colony stimulating factor and interleukin-3 contribute to insulitis and destruction of beta cells

scientific article published on 4 May 2007

Gamma delta antigen receptors of Thy-1+ dendritic epidermal cells: implications for thymic differentiation.

scientific article published in January 1988

Gene therapy-mediated reprogramming tumor infiltrating T cells using IL-2 and inhibiting NF-κB signaling improves the efficacy of immunotherapy in a brain cancer model

scientific article

Genomic and immune heterogeneity are associated with differential responses to therapy in melanoma.

scientific article

Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity.

scientific article published on 30 August 2016

Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients.

scientific article published on 2 November 2017

HSP90 inhibition enhances cancer immunotherapy by upregulating interferon response genes

scientific article published on 6 September 2017

Hypomethylating agents in combination with immune checkpoint inhibitors in acute myeloid leukemia and myelodysplastic syndromes.

scientific article

ICOS Promotes the Function of CD4+ Effector T Cells during Anti-OX40-Mediated Tumor Rejection

scientific article published on 4 May 2016

Idarubicin, cytarabine, and nivolumab in patients with newly diagnosed acute myeloid leukaemia or high-risk myelodysplastic syndrome: a single-arm, phase 2 study

scientific article published on 07 August 2019

Identification of antigen receptor-associated structures on murine T cells

scientific article published in Nature

Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido.

scientific article published on 28 August 2011

Immune Checkpoint Blockade in Cancer Therapy: The 2015 Lasker-DeBakey Clinical Medical Research Award

scientific article published on 8 September 2015

Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential

scientific article published on April 2015

Immune modulation in cancer with antibodies

scientific article published on 30 October 2013

Immunologic Correlates of Pathologic Complete Response to Preoperative Immunotherapy in Hepatocellular Carcinoma

scientific article published on 09 July 2019

Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients

scholarly article

Immunologic correlates of the abscopal effect in a patient with melanoma

scientific article (publication date: 8 March 2012)

Immunological insights from patients undergoing surgery on ipilimumab for metastatic melanoma.

scientific article published on 17 May 2013

Immunotherapeutic strategies for high-risk bladder cancer

scientific article published on April 2007

In Support of a Patient-Driven Initiative and Petition to Lower the High Price of Cancer Drugs

scientific article published on 23 July 2015

In vivo blockade of CTLA-4 enhances the priming of responsive T cells but fails to prevent the induction of tumor antigen-specific tolerance.

scientific article published on September 1999

Increased frequency of ICOS+ CD4 T cells as a pharmacodynamic biomarker for anti-CTLA-4 therapy

scientific article published on 31 July 2013

Indoleamine 2,3-dioxygenase is a critical resistance mechanism in anti-tumor T cell immunotherapy targeting CTLA-4.

scientific article published on 7 November 2013

Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4.

scientific article published on 10 June 2013

Inducible costimulator is required for type 2 antibody isotype switching but not T helper cell type 2 responses in chronic nematode infection

scientific article

Inhibitors of B7-CD28 costimulation in urologic malignancies

scientific article

Insolubilization of L-asparaginase by covalent attachment to nylon tubing

scientific article published on 01 April 1972

Integrated NY-ESO-1 antibody and CD8+ T-cell responses correlate with clinical benefit in advanced melanoma patients treated with ipilimumab

scientific article

Integrated molecular analysis of tumor biopsies on sequential CTLA-4 and PD-1 blockade reveals markers of response and resistance.

scientific article

Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein ⬇️

scientific article published on August 19, 1997

Interdependent IL-7 and IFN-γ signalling in T-cell controls tumour eradication by combined α-CTLA-4+α-PD-1 therapy

scientific article published on 08 August 2016

Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity

scientific article published on 13 February 2017

Ipilimumab plus Lenalidomide after Allogeneic and Autologous Stem Cell Transplantation for Patients with Lymphoid Malignancies

scientific article

Itk Negatively Regulates Induction of T Cell Proliferation by CD28 Costimulation ⬇️

scientific article published on July 21, 1997

Lack of a role for transforming growth factor-beta in cytotoxic T lymphocyte antigen-4-mediated inhibition of T cell activation.

scholarly article

Limited tumor infiltration by activated T effector cells restricts the therapeutic activity of regulatory T cell depletion against established melanoma

scientific article published on 25 August 2008

Local secretion of anti-CTLA-4 enhances the therapeutic efficacy of a cancer immunotherapy with reduced evidence of systemic autoimmunity

scientific article published on 31 January 2008

Localized oncolytic virotherapy inflames distant tumors and synergizes with immune checkpoint blockade leading to systemic tumor rejection

scientific article published on 7 November 2013

Localized oncolytic virotherapy overcomes systemic tumor resistance to immune checkpoint blockade immunotherapy

scientific article

Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy

scientific article published on 09 September 2016

Lymphoproliferation in CTLA-4–Deficient Mice Is Mediated by Costimulation-Dependent Activation of CD4 + T Cells ⬇️

scientific article published on December 1, 1997

MHC class II-independent and -dependent T cell expansion and B cell hyperactivity in vivo in mice deficient in CD152 (CTLA-4).

scientific article published on 10 May 2004

Manipulation of T cell costimulatory and inhibitory signals for immunotherapy of prostate cancer ⬇️

scientific article published on July 22, 1997

Manipulation of costimulatory signals to enhance antitumor T-cell responses.

scientific article published on October 1995

Metastatic Melanoma Patient Had a Complete Response with Clonal Expansion after Whole Brain Radiation and PD-1 Blockade.

scientific article published on 6 January 2017

Modulation of EZH2 expression in T cells improves efficacy of anti-CTLA-4 therapy

article published in 2018

Murine Ia and human DR antigens: homology of amino-terminal sequences ⬇️

scientific article published on August 1, 1978

Negative regulators of T-cell activation: potential targets for therapeutic intervention in cancer, autoimmune disease, and persistent infections

scientific article published on May 2009

Neoadjuvant plus adjuvant dabrafenib and trametinib versus standard of care in patients with high-risk, surgically resectable melanoma: a single-centre, open-label, randomised, phase 2 trial

scientific article

Neoantigen responses, immune correlates, and favorable outcomes after ipilimumab treatment of patients with prostate cancer

scientific article published on 01 April 2020

Nivolumab for previously treated unresectable metastatic anal cancer (NCI9673): a multicentre, single-arm, phase 2 study

scientific article published on 17 February 2017

Nobels: Toll pioneers deserve recognition

scientific article published on 9 November 2011

Novel cancer immunotherapy agents with survival benefit: recent successes and next steps

scientific article

Optimization and validation of a robust human T-cell culture method for monitoring phenotypic and polyfunctional antigen-specific CD4 and CD8 T-cell responses

scientific article published on January 2009

PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors

scientific article (publication date: 2 March 2010)

PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells

scientific article

Phase I clinical trial of combination imatinib and ipilimumab in patients with advanced malignancies

scientific article

Phase II Trial of Ipilimumab with Stereotactic Radiation Therapy for Metastatic Disease: Outcomes, Toxicities, and Low-Dose Radiation-Related Abscopal Responses

scientific article published on 28 October 2019

Phenotypic and functional analysis of positive selection in the gamma/delta T cell lineage

scientific article

Pillars article: CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. The journal of experimental medicine. 1995. 182: 459-465

scientific article published on October 1, 2011

Pilot study of intratumoral (IT) cryoablation (cryo) in combination with systemic checkpoint blockade in patients with metastatic melanoma (MM).

scientific article published on 4 November 2015

Potent induction of tumor immunity by combining tumor cryoablation with anti-CTLA-4 therapy

scientific article published on 22 November 2011

Preoperative CTLA-4 blockade: tolerability and immune monitoring in the setting of a presurgical clinical trial

scientific article

Principles and use of anti-CTLA4 antibody in human cancer immunotherapy

scientific article

Programmed death-1 concentration at the immunological synapse is determined by ligand affinity and availability

scientific article

Prostate cancer progression correlates with increased humoral immune response to a human endogenous retrovirus GAG protein

scientific article published on 30 September 2013

Prostate cancer: advances in immunotherapy

scientific article

Recognition of a ubiquitous self antigen by prostate cancer-infiltrating CD8+ T lymphocytes

scientific article published on January 2008

Regulated costimulation in the thymus is critical for T cell development: dysregulated CD28 costimulation can bypass the pre-TCR checkpoint

scientific article

Regulation of CD4 T cell activation and effector function by inducible costimulator (ICOS).

scientific article published on 29 January 2010

Repertoire enhancement with adoptively transferred female lymphocytes controls the growth of pre-implanted murine prostate cancer ⬇️

scientific article

Repression of B7.2 on Self-reactive B Cells Is Essential to Prevent Proliferation and Allow Fas-mediated Deletion by CD4+ T Cells ⬇️

scientific article published on August 17, 1998

Response to "Ipilimumab (Yervoy) and the TGN1412 catastrophe".

scientific article

Restoring function in exhausted CD8 T cells during chronic viral infection

scientific article

Retrospective. Lloyd J. Old (1933-2011).

scientific article

Robust Antitumor Responses Result from Local Chemotherapy and CTLA-4 Blockade.

scientific article published on 16 January 2018

SPAS-1 (stimulator of prostatic adenocarcinoma-specific T cells)/SH3GLB2: A prostate tumor antigen identified by CTLA-4 blockade

scholarly article

Selective inhibition of autoimmune exacerbation while preserving the anti-tumor clinical benefit using IL-6 blockade in a patient with advanced melanoma and Crohn's disease: a case report

scientific article published on 5 September 2016

Serum-soluble B7x is elevated in renal cell carcinoma patients and is associated with advanced stage

scientific article

Shifting the equilibrium in cancer immunoediting: from tumor tolerance to eradication

scientific article published on May 2011

Simultaneous inhibition of two regulatory T-cell subsets enhanced Interleukin-15 efficacy in a prostate tumor model

scientific article published on 2 April 2012

Single dose of anti-CTLA-4 enhances CD8+ T-cell memory formation, function, and maintenance

scientific article

Single-institution experience with ipilimumab in advanced melanoma patients in the compassionate use setting: lymphocyte count after 2 doses correlates with survival

scientific article

Spatial computation of intratumoral T cells correlates with survival of patients with pancreatic cancer

scientific article published on 27 April 2017

Spatially resolved analyses link genomic and immune diversity and reveal unfavorable neutrophil activation in melanoma

scientific article published on 15 April 2020

Specific blockade of CTLA-4/B7 interactions results in exacerbated clinical and histologic disease in an actively-induced model of experimental allergic encephalomyelitis.

scientific article

Strategies for combining immunotherapy with radiation for anticancer therapy

scientific article (publication date: 2015)

Strength of TCR-peptide/MHC interactions and in vivo T cell responses

scientific article published on May 2011

Structural Differences in Envelope Glycoproteins Associated with Rat Leukaemia Virus Produced by Novikoff Hepatocellular Carcinoma and Spontaneously Transformed Wistar Rat Embryo Cells ⬇️

scientific article published on April 1, 1984

Suppression of Type I IFN Signaling in Tumors Mediates Resistance to Anti-PD-1 Treatment That Can Be Overcome by Radiotherapy

scientific article published on 7 November 2016

Systemic 4-1BB activation induces a novel T cell phenotype driven by high expression of Eomesodermin

scientific article published on April 2013

Systemic CTLA-4 blockade ameliorates glioma-induced changes to the CD4+ T cell compartment without affecting regulatory T-cell function

scientific article published in April 2007

T cell immunoglobulin mucin-3 crystal structure reveals a galectin-9-independent ligand-binding surface

scientific article

T cell receptor-triggered activation of intraepithelial lymphocytes in vitro

article

T cell surveillance of oncogene-induced prostate cancer is impeded by T cell-derived TGF-β1 cytokine

scientific article published on 14 July 2011

TCR Repertoire Intratumor Heterogeneity in Localized Lung Adenocarcinomas: An Association with Predicted Neoantigen Heterogeneity and Postsurgical Recurrence.

scientific article published on 21 July 2017

TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo

scientific article

Targeting Immunosupportive Cancer Therapies: Accentuate the Positive, Eliminate the Negative

The B7 family and cancer therapy: costimulation and coinhibition

scientific article published on September 2007

The Emerging Role of CTLA-4 as an Immune Attenuator ⬇️

scientific article published on October 1, 1997

The T-cell antigen receptor gamma gene: rearrangement and cell lineages.

scientific article published on January 1987

The congenic mutant B6.C-H-2bm−1 (H-2bm−1) serological response to the T-cell receptor on EL4

scientific article published on 01 September 1986

The distribution of T-cell subsets and the expression of immune checkpoint receptors and ligands in patients with newly diagnosed and relapsed acute myeloid leukemia

scientific article published on 30 November 2018

The emerging role of immune checkpoint based approaches in AML and MDS.

scientific article

The future of immune checkpoint therapy

scientific article

The gamma T-cell antigen receptor.

scientific article published on November 1987

The lymphoproliferative defect in CTLA-4-deficient mice is ameliorated by an inhibitory NK cell receptor

The major histocompatibility complex-restricted antigen receptor on T cells in mouse and man: Identification of constant and variable peptides

article

The mouse T cell receptor: structural heterogeneity of molecules of normal T cells defined by xenoantiserum

scientific article published in October 1983

The murine T cell antigen receptor and associated structures.

scientific article

The prioritization of cancer antigens: a national cancer institute pilot project for the acceleration of translational research

scientific article

The role of short homology repeats and TdT in generation of the invariant gamma delta antigen receptor repertoire in the fetal thymus.

scientific article published in October 1995

The role of tyrosine phosphorylation and PTP-1C in CTLA-4 signal transduction.

scientific article published in December 1996

The substrate specificity of L-asparaginase from Alcaligenes eutrophus

article

Thymocyte development is normal in CTLA-4-deficient mice ⬇️

scientific article published on August 19, 1997

Tissue-specific expression of B7x protects from CD4 T cell-mediated autoimmunity

scientific article

To be or not to be B7.

scientific article published on October 2006

Training Procedures and Task Difficulty in Brightness and Position Discriminations by Rats ⬇️

scientific article published on August 1, 1972

Tumor associated endothelial expression of B7-H3 predicts survival in ovarian carcinomas

scientific article

Tumor vaccines expressing flt3 ligand synergize with ctla-4 blockade to reject preimplanted tumors

scientific article published on 8 September 2009

Tumor-Expressed IDO Recruits and Activates MDSCs in a Treg-Dependent Manner

scientific article published on 22 September 2015

Tumor-reactive CD4(+) T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts

scientific article

Tumor-specific antigen of murine T-lymphoma defined with monoclonal antibody. 1982.

scientific article published in February 2005

Two distinct mechanisms of augmented antitumor activity by modulation of immunostimulatory/inhibitory signals.

scientific article

Unique potential of 4-1BB agonist antibody to promote durable regression of HPV+ tumors when combined with an E6/E7 peptide vaccine.

scientific article

VISTA is an inhibitory immune checkpoint that is increased after ipilimumab therapy in patients with prostate cancer

scientific article

Vaccination with tumor cells expressing IL-15 and IL-15Rα inhibits murine breast and prostate cancer.

scientific article published on 27 February 2014

[55] HLA antigens in serum

scientific article published on 01 January 1984

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