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List of works by Graham Packham

A combination of trastuzumab and BAG-1 inhibition synergistically targets HER2 positive breast cancer cells

scientific article

A cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells.

scientific article

A minimal Bcl-x promoter is activated by Brn-3a and repressed by p53

scientific article

A ribosome-related signature in peripheral blood CLL B cells is linked to reduced survival following treatment.

scientific article published on 02 June 2016

A role for eukaryotic initiation factor 4B overexpression in the pathogenesis of diffuse large B-cell lymphoma.

scientific article published on 18 October 2013

Annexin A3 is a mammary marker and a potential neoplastic breast cell therapeutic target

scientific article published on 4 June 2015

Anti-angiogenic effects of dietary isothiocyanates: Mechanisms of action and implications for human health

scientific article published on October 16, 2010

B-cell receptor dependent phagocytosis and presentation of particulate antigen by chronic lymphocytic leukemia cells

scientific article published on 01 February 2022

B-cell receptor signaling in chronic lymphocytic leukemia.

scientific article published on 3 August 2011

BAG-1 expression and function in human cancer

scientific article

BAG-1 immunostaining and survival in early breast cancer

scientific article published on 01 August 2001

BAG-1 in carcinogenesis.

scientific article published on 22 March 2004

BAG-1 is up-regulated in colorectal tumour progression and promotes colorectal tumour cell survival through increased NF-kappaB activity

scientific article published on 19 January 2008

BAG-1 proteins protect cardiac myocytes from simulated ischemia/reperfusion-induced apoptosis via an alternate mechanism of cell survival independent of the proteasome.

scientific article published on 20 February 2004

BAG-1: a multi-functional pro-survival molecule

scientific article published on 01 February 2005

BAG-1: a multifunctional regulator of cell growth and survival

scientific article

BAG-i expression in human breast cancer: interrelationship between BAG-1 RNA, protein, HSC70 expression and clinico-pathological data.

scientific article

BCR signaling contributes to autophagy regulation in chronic lymphocytic leukemia

scientific article published on 28 August 2019

BCR-signaling-induced cell death demonstrates dependency on multiple BH3-only proteins in a murine model of B-cell lymphoma.

scientific article

BTK-independent regulation of calcium signalling downstream of the B-cell receptor in malignant B-cells

Bodyguards and assassins: Bcl-2 family proteins and apoptosis control in chronic lymphocytic leukaemia.

scientific article

British Journal of Pharmacology

article

Brn-3a activates the expression of Bcl-x(L) and promotes neuronal survival in vivo as well as in vitro

scientific article published on 01 March 2001

CD40L/IL-4-stimulated CLL demonstrates variation in translational regulation of DNA damage response genes including ATM

article

Chronic lymphocytic leukaemia

article

Click JAHAs: conformationally restricted ferrocene-based histone deacetylase inhibitors

DC-SIGN binding to mannosylated B-cell receptors in follicular lymphoma down-modulates receptor signaling capacity

scientific article published on 03 June 2021

Development of PROTACs to address clinical limitations associated with BTK-targeted kinase inhibitors

scientific article published on 01 June 2020

Differential induction of apoptosis in human breast cancer cell lines by phenethyl isothiocyanate, a glutathione depleting agent.

scientific article published on 17 February 2012

Differential signaling via surface IgM is associated with VH gene mutational status and CD38 expression in chronic lymphocytic leukemia

scientific article published on 26 September 2002

Distinct promoters mediate constitutive and inducible Bcl-XL expression in malignant lymphocytes.

scientific article published on 18 September 2006

E-ring modified steroids as novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1.

scientific article published in September 2005

Enantioselective synthesis of tranylcypromine analogues as lysine demethylase (LSD1) inhibitors.

scientific article published on 13 February 2011

Engagement of the B-cell receptor of chronic lymphocytic leukemia cells drives global and MYC-specific mRNA translation.

scientific article published on 21 October 2015

Epidermal Growth Factor Receptor Family Inhibition Identifies P38 Mitogen-activated Protein Kinase as a Potential Therapeutic Target in Bladder Cancer.

scientific article published on 15 November 2017

Epigenetic modulators as therapeutic targets in prostate cancer

scientific article

FOXO3 expression during colorectal cancer progression: biomarker potential reflects a tumour suppressor role.

scientific article published on 04 July 2013

Fluorinated tranylcypromine analogues as inhibitors of lysine-specific demethylase 1 (LSD1, KDM1A).

scientific article published on 29 March 2017

Genomic disruption of the histone methyltransferase SETD2 in chronic lymphocytic leukaemia.

scientific article published on 10 June 2016

Glycosylation of surface Ig creates a functional bridge between human follicular lymphoma and microenvironmental lectins

scientific article

High throughput imaging cytometer with acoustic focussing.

scientific article published in October 2015

Higher levels of reactive oxygen species are associated with anergy in chronic lymphocytic leukemia.

scientific article published on 6 March 2015

IL-10 production by CLL cells is enhanced in the anergic IGHV mutated subset and associates with reduced DNA methylation of the IL10 locus

scientific article published on 28 November 2016

IL-4 enhances expression and function of surface IgM in CLL cells.

scientific article

Ibrutinib therapy releases leukemic surface IgM from antigen drive in chronic lymphocytic leukemia patients

scientific article published on 29 October 2018

Identification in CLL of circulating intraclonal subgroups with varying B-cell receptor expression and function

scientific article

Immunohistochemical analysis of the antiapoptotic Mcl-1 and Bcl-2 proteins in follicular lymphoma

scientific article published on 01 March 2006

Induction of cytosolic calcium flux by CD20 is dependent upon B Cell antigen receptor signaling.

scientific article published on 21 April 2008

Inhibition of hypoxia inducible factor by phenethyl isothiocyanate.

scientific article published on 17 April 2009

Inhibition of proteasomal degradation of Mcl-1 by cobalt chloride suppresses cobalt chloride-induced apoptosis in HCT116 colorectal cancer cells.

scientific article

Insertion of atypical glycans into the tumor antigen-binding site identifies DLBCLs with distinct origin and behavior

Investigational epigenetically targeted drugs in early phase trials for the treatment of haematological malignancies.

scientific article published on 26 May 2014

LSD1 inhibition attenuates androgen receptor V7 splice variant activation in castration resistant prostate cancer models.

scientific article

Lectin binding to surface Ig variable regions provides a universal persistent activating signal for follicular lymphoma cells.

scientific article published on 20 July 2015

Lectins from opportunistic bacteria interact with acquired variable-region glycans of surface immunoglobulin in follicular lymphoma

scientific article published on 17 March 2015

Macrolactamization versus macrolactonization: total synthesis of FK228, the depsipeptide histone deacetylase inhibitor.

scientific article

Mcl-1 is required for Akata6 B-lymphoma cell survival and is converted to a cell death molecule by efficient caspase-mediated cleavage.

scientific article published on June 2004

Mcl-1.

scientific article published in February 2005

Mechanisms and clinical significance of BIM phosphorylation in chronic lymphocytic leukemia.

scientific article

Mechanisms of cell death and disease: advances in therapeutic intervention

scientific article published on 01 June 2003

Metabolic targets of watercress and PEITC in MCF-7 and MCF-10A cells explain differential sensitisation responses to ionising radiation

scientific article published on 31 July 2018

MicroRNAs: key players in carcinogenesis and novel therapeutic targets.

scientific article published on 21 July 2008

Molecular profiling of the invasive tumor microenvironment in a 3-dimensional model of colorectal cancer cells and ex vivo fibroblasts

scientific article

Natural product-derived antitumor compound phenethyl isothiocyanate inhibits mTORC1 activity via TSC2

scientific article published on 18 May 2012

Nuclear BAG-1 expression inhibits apoptosis in colorectal adenoma-derived epithelial cells.

scientific article

PEITC-mediated inhibition of mRNA translation is associated with both inhibition of mTORC1 and increased eIF2α phosphorylation in established cell lines and primary human leukemia cells.

scientific article published on 27 August 2016

PI3Kδ inhibition elicits anti-leukemic effects through Bim-dependent apoptosis

scientific article

Pharmacological inhibitors of NF-κB accelerate apoptosis in chronic lymphocytic leukaemia cells

scientific article published on 21 August 2006

Pleiotropic actions of miR-21 highlight the critical role of deregulated stromal microRNAs during colorectal cancer progression

scientific article

Preclinical Evaluation of a Novel SHIP1 Phosphatase Activator for Inhibition of PI3K Signaling in Malignant B Cells

scientific article published on 12 December 2019

Protein recognition by short peptide reversible inhibitors of the chromatin-modifying LSD1/CoREST lysine demethylase

scientific article

Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma.

scientific article published on 21 December 2015

Regulation of tumour necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in Burkitt's lymphoma cell lines

scientific article published on 01 July 2003

Reply to 'Comment on 'BAG-1 as a biomarker in early breast cancer prognosis: a systematic review with meta-analyses''

Reversible anergy of sIgM-mediated signaling in the two subsets of CLL defined by VH-gene mutational status

scientific article published on 15 May 2007

S-adenosylhomocysteine hydrolase inhibition by 3-deazaneplanocin A analogues induces anti-cancer effects in breast cancer cell lines and synergy with both histone deacetylase and HER2 inhibition.

scientific article published on 17 June 2010

Shooting the messenger (RNA) in B-cell lymphoma

scientific article published on 01 February 2016

Short peptides derived from the BAG-1 C-terminus inhibit the interaction between BAG-1 and HSC70 and decrease breast cancer cell growth

scientific article

Spiruchostatin A Inhibits Proliferation and Differentiation of Fibroblasts from Patients with Pulmonary Fibrosis

scientific article published on January 12, 2012

Stimulation of surface IgM of chronic lymphocytic leukemia cells induces an unfolded protein response dependent on BTK and SYK.

scientific article

Stratifying risk of recurrence in stage II colorectal cancer using deregulated stromal and epithelial microRNAs

scientific article published on March 2015

Structural and functional features of the B-cell receptor in IgG-positive chronic lymphocytic leukemia

scientific article

Subcellular localisation of BAG-1 and its regulation of vitamin D receptor-mediated transactivation and involucrin expression in oral keratinocytes: implications for oral carcinogenesis

scientific article

Surface IgM expression and function are associated with clinical behavior, genetic abnormalities, and DNA methylation in CLL.

scientific article published on 14 June 2016

Surface IgM of CLL cells displays unusual glycans indicative of engagement of antigen in vivo

scientific article published on 17 March 2010

Surface IgM stimulation induces MEK1/2-dependent MYC expression in chronic lymphocytic leukemia cells.

scientific article

T-cell number and subtype influence the disease course of primary chronic lymphocytic leukaemia xenografts in alymphoid mice.

scientific article

TEL, a putative tumor suppressor, induces apoptosis and represses transcription of Bcl-XL.

scientific article published on 5 September 2003

Target-Based Screening against eIF4A1 Reveals the Marine Natural Product Elatol as a Novel Inhibitor of Translation Initiation with Antitumor Activity

scientific article published on 29 May 2018

Targeted inhibition of mRNA translation initiation factors as a novel therapeutic strategy for mature B-cell neoplasms

scientific article published on 01 February 2020

Targeting B-cell anergy in chronic lymphocytic leukemia.

scientific article published on 4 March 2013

The Dual Syk/JAK Inhibitor Cerdulatinib Antagonizes B-cell Receptor and Microenvironmental Signaling in Chronic Lymphocytic Leukemia

scientific article published on 3 October 2016

The IGHV1-69/IGHJ3 recombinations of unmutated CLL are distinct from those of normal B cells.

scientific article published on 10 January 2012

The Nrf2 transcription factor contributes to resistance to cisplatin in bladder cancer.

scientific article published on 16 May 2014

The PI3K/mTOR inhibitor PF-04691502 induces apoptosis and inhibits microenvironmental signaling in CLL and the Eµ-TCL1 mouse model

scientific article published on 8 May 2015

The anti-CD20 antibody rituximab augments the immunospecific therapeutic effectiveness of an anti-CD19 immunotoxin directed against human B-cell lymphoma.

scientific article

The clinical and biological significance of MIR-224 expression in colorectal cancer metastasis

scientific article

The desmoplastic reaction surrounding hepatic colorectal adenocarcinoma metastases aids tumor growth and survival via alphav integrin ligation.

scientific article published on October 2008

The effect of 2-methoxyoestrone-3-O-sulphamate on the growth of breast cancer cells and induced mammary tumours

scientific article published on 01 February 2000

The first biologically active synthetic analogues of FK228, the depsipeptide histone deacetylase inhibitor

scientific article

The histone deacetylase inhibitor, romidepsin, as a potential treatment for pulmonary fibrosis.

scientific article

The histone deacetylase inhibitors vorinostat and romidepsin downmodulate IL-10 expression in cutaneous T-cell lymphoma cells.

scientific article

The meaning and relevance of B-cell receptor structure and function in chronic lymphocytic leukemia.

scientific article

The normal IGHV1-69-derived B-cell repertoire contains stereotypic patterns characteristic of unmutated CLL.

scientific article published on 3 November 2009

The nuclear BAG-1 isoform, BAG-1L, enhances oestrogen-dependent transcription.

scientific article published in August 2003

The outcome of B-cell receptor signaling in chronic lymphocytic leukemia: proliferation or anergy

scientific article

The retinoblastoma protein interacts with Bag-1 in human colonic adenoma and carcinoma derived cell lines

scientific article published in September 2003

Thioflavin S (NSC71948) interferes with Bcl-2-associated athanogene (BAG-1)-mediated protein-protein interactions.

scientific article published on 18 August 2009

Total synthesis of largazole and analogues: HDAC inhibition, antiproliferative activity and metabolic stability.

scientific article published on 17 February 2011

Total synthesis of spiruchostatin A, a potent histone deacetylase inhibitor

scientific article published on 01 February 2004

Type I collagen promotes the malignant phenotype of pancreatic ductal adenocarcinoma.

scientific article

Variable induction of PRDM1 and differentiation in chronic lymphocytic leukemia is associated with anergy.

scientific article

Will histone deacetylase inhibitors require combination with other agents to fulfil their therapeutic potential?

scientific article published on 19 August 2008

miR-153 supports colorectal cancer progression via pleiotropic effects that enhance invasion and chemotherapeutic resistance

scientific article published on 15 August 2013

p53 pathway gene single nucleotide polymorphisms and chronic lymphocytic leukemia.

scientific article