List of works - Andreas Pichlmair

A Comprehensive Analysis of the Dynamic Response to Aphidicolin-Mediated Replication Stress Uncovers Targets for ATM and ATMIN.

scientific article

A novel interaction between dengue virus nonstructural protein 1 and the NS4A-2K-4B precursor is required for viral RNA replication but not for formation of the membranous replication organelle

scientific article published on 09 May 2019

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape

scientific article published on 04 March 2019

Activation of MDA5 requires higher-order RNA structures generated during virus infection

scientific article

An orthogonal proteomic survey uncovers novel Zika virus host factors

scientific article published in Nature

CD14 is a coreceptor of Toll-like receptors 7 and 9. ⬇️

scientific article

Chasing Intracellular Zika Virus Using Proteomics

scientific article published on 19 September 2019

Chemoenzymatic Total Synthesis of Sorbicatechol Structural Analogues and Evaluation of Their Antiviral Potential

scientific article published on 19 November 2019

Cross-species analysis of viral nucleic acid interacting proteins identifies TAOKs as innate immune regulators

scientific article published on 01 December 2021

Cytoplasmic sensing of viral nucleic acids

scientific article

Data, reagents, assays and merits of proteomics for SARS-CoV-2 research and testing

scientific article published on 26 June 2020

Discrimination of Self and Non-Self Ribonucleic Acids

scientific article published on May 2017

ER-shaping atlastin proteins act as central hubs to promote flavivirus replication and virion assembly

scientific article published on 21 October 2019

Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposing

scientific article published on 14 July 2020

Gambling with Flu: "All in" to Maximize Reward

scientific article

Genotoxic stress in constitutive trisomies induces autophagy and the innate immune response via the cGAS-STING pathway

scientific article published on 02 July 2021

Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection

scientific article

Human NLRP1 is a sensor for double-stranded RNA

scientific article published on 26 November 2020

Human cytomegalovirus-induced host protein citrullination is crucial for viral replication

scientific article published on 23 June 2021

IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA

scientific article

Influenza a Virus Infection Reactivates Human Endogenous Retroviruses Associated with Modulation of Antiviral Immunity

scientific article published on 22 July 2022

Inhibition of Beta interferon induction by severe acute respiratory syndrome coronavirus suggests a two-step model for activation of interferon regulatory factor 3.

scientific article

Inhibition of cellular RNA methyltransferase abrogates influenza virus capping and replication

scientific article published on 31 March 2023

Innate recognition of viruses

scientific article published on September 2007

Interferon-induced degradation of the persistent hepatitis B virus cccDNA form depends on ISG20

scientific article published on 09 May 2021

MDM2 Influences ACE2 Stability and SARS-CoV-2 Uptake

scientific article published in 2023

Molluscum Contagiosum Virus Protein MC005 Inhibits NF-κB Activation by Targeting NEMO-Regulated IκB Kinase Activation.

scientific article

Mucosal IFNλ1 mRNA-based immunomodulation effectively reduces SARS-CoV-2 induced mortality in mice

scientific article published in 2024

Multi-level proteomics reveals host-perturbation strategies of SARS-CoV-2 and SARS-CoV

scientific article published on 17 June 2020

Multi-omics characterization of the monkeypox virus infection

scientific article published in 2024

NSs Protein of Sandfly Fever Sicilian Phlebovirus Counteracts Interferon (IFN) Induction by Masking the DNA-Binding Domain of IFN Regulatory Factor 3

scholarly article by Jennifer Deborah Wuerth et al published 1 December 2018 in Journal of Virology

NSs protein of rift valley fever virus induces the specific degradation of the double-stranded RNA-dependent protein kinase

scientific article published on 11 February 2009

NUDT2 initiates viral RNA degradation by removal of 5'-phosphates

scientific article published on 25 November 2021

Oxeiptosis, a ROS-induced caspase-independent apoptosis-like cell-death pathway

scientific article published on 18 December 2017

Oxeiptosis-a cell death pathway to mitigate damage caused by radicals

scientific article published on 01 July 2018

Oxeiptosis: a discreet way to respond to radicals

scientific article published on 18 October 2018

Persistent Innate Immune Stimulation Results in IRF3-Mediated but Caspase-Independent Cytostasis

scientific article published on 11 June 2020

Phosphorylation of Serine 225 in Hepatitis C Virus NS5A Regulates Protein-Protein Interactions ⬇️

scientific article

Phosphorylation-Dependent Feedback Inhibition of RIG-I by DAPK1 Identified by Kinome-wide siRNA Screening

scientific article published on 14 January 2017

Poxvirus Protein MC132 from Molluscum Contagiosum Virus Inhibits NF-B Activation by Targeting p65 for Degradation.

scientific article published on 3 June 2015

Processing of Genome 5′ Termini as a Strategy of Negative-Strand RNA Viruses to Avoid RIG-I-Dependent Interferon Induction

scientific article

Protein kinase R contributes to immunity against specific viruses by regulating interferon mRNA integrity

scientific article

RIG-I detects viral genomic RNA during negative-strand RNA virus infection

scientific article

RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates

scientific article (publication date: 10 November 2006)

Reduced mitochondrial resilience enables non-canonical induction of apoptosis after TNF receptor signaling in virus-infected hepatocytes

scientific article published on 26 June 2020

Sequestration by IFIT1 impairs translation of 2'O-unmethylated capped RNA.

scientific article

Structural basis for viral 5'-PPP-RNA recognition by human IFIT proteins

scientific article

Structure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2'-O methylations

scientific article published on March 2017

System-Based Approaches to Delineate the Antiviral Innate Immune Landscape

scientific article published on 21 October 2020

The Cytomegalovirus Tegument Protein UL35 Antagonizes Pattern Recognition Receptor-Mediated Type I IFN Transcription

scientific article published on 26 May 2020

The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate Immunity

scientific journal article

The alternative cap-binding complex is required for antiviral defense in vivo

scientific article published on 19 December 2019

The antiviral effect of interferon-beta against SARS-coronavirus is not mediated by MxA protein

scientific article published in July 2004

The interferon-inducible GTPase MxB promotes capsid disassembly and genome release of herpesviruses

scientific article published on 27 April 2022

The lysine methyltransferase SMYD3 interacts with hepatitis C virus NS5A and is a negative regulator of viral particle production

scientific article

Thogoto virus lacking interferon-antagonistic protein ML is strongly attenuated in newborn Mx1-positive but not Mx1-negative mice

scientific article

Tubulovesicular structures within vesicular stomatitis virus G protein-pseudotyped lentiviral vector preparations carry DNA and stimulate antiviral responses via Toll-like receptor 9.

scientific article published on November 2006

Viperin is an iron-sulfur protein that inhibits genome synthesis of tick-borne encephalitis virus via radical SAM domain activity

scientific journal article

Viperin targets flavivirus virulence by inducing assembly of non-infectious capsid particles

scientific article published on 18 October 2017

Viral immune modulators perturb the human molecular network by common and unique strategies

scientific article

Viral targeting of TFIIB impairs de novo polymerase II recruitment and affects antiviral immunity.

scientific article published on 30 April 2018

Virulence factor NSs of rift valley fever virus recruits the F-box protein FBXO3 to degrade subunit p62 of general transcription factor TFIIH

scientific article

Virus-like particles expressing the nucleocapsid gene as an efficient vaccine against Rift Valley fever virus

scientific article published on October 2010

[The first answer to viral infections: type I interferon]

scientific article published on 01 July 2004

eIF2B as a Target for Viral Evasion of PKR-Mediated Translation Inhibition

scientific article published on 14 July 2020

mRNA export through an additional cap-binding complex consisting of NCBP1 and NCBP3

scientific article

List of works by Andreas Pichlmair

A Comprehensive Analysis of the Dynamic Response to Aphidicolin-Mediated Replication Stress Uncovers Targets for ATM and ATMIN.

A novel interaction between dengue virus nonstructural protein 1 and the NS4A-2K-4B precursor is required for viral RNA replication but not for formation of the membranous replication organelle

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape

Activation of MDA5 requires higher-order RNA structures generated during virus infection

An orthogonal proteomic survey uncovers novel Zika virus host factors

CD14 is a coreceptor of Toll-like receptors 7 and 9. ⬇️

Chasing Intracellular Zika Virus Using Proteomics

Chemoenzymatic Total Synthesis of Sorbicatechol Structural Analogues and Evaluation of Their Antiviral Potential

Cross-species analysis of viral nucleic acid interacting proteins identifies TAOKs as innate immune regulators

Cytoplasmic sensing of viral nucleic acids

Data, reagents, assays and merits of proteomics for SARS-CoV-2 research and testing

Discrimination of Self and Non-Self Ribonucleic Acids

ER-shaping atlastin proteins act as central hubs to promote flavivirus replication and virion assembly

Exploring the SARS-CoV-2 virus-host-drug interactome for drug repurposing

Gambling with Flu: "All in" to Maximize Reward

Genotoxic stress in constitutive trisomies induces autophagy and the innate immune response via the cGAS-STING pathway

Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection

Human NLRP1 is a sensor for double-stranded RNA

Human cytomegalovirus-induced host protein citrullination is crucial for viral replication

IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA

Influenza a Virus Infection Reactivates Human Endogenous Retroviruses Associated with Modulation of Antiviral Immunity

Inhibition of Beta interferon induction by severe acute respiratory syndrome coronavirus suggests a two-step model for activation of interferon regulatory factor 3.

Inhibition of cellular RNA methyltransferase abrogates influenza virus capping and replication

Innate recognition of viruses

Interferon-induced degradation of the persistent hepatitis B virus cccDNA form depends on ISG20

MDM2 Influences ACE2 Stability and SARS-CoV-2 Uptake

Molluscum Contagiosum Virus Protein MC005 Inhibits NF-κB Activation by Targeting NEMO-Regulated IκB Kinase Activation.

Mucosal IFNλ1 mRNA-based immunomodulation effectively reduces SARS-CoV-2 induced mortality in mice

Multi-level proteomics reveals host-perturbation strategies of SARS-CoV-2 and SARS-CoV

Multi-omics characterization of the monkeypox virus infection

NSs Protein of Sandfly Fever Sicilian Phlebovirus Counteracts Interferon (IFN) Induction by Masking the DNA-Binding Domain of IFN Regulatory Factor 3

NSs protein of rift valley fever virus induces the specific degradation of the double-stranded RNA-dependent protein kinase

NUDT2 initiates viral RNA degradation by removal of 5'-phosphates

Oxeiptosis, a ROS-induced caspase-independent apoptosis-like cell-death pathway

Oxeiptosis-a cell death pathway to mitigate damage caused by radicals

Oxeiptosis: a discreet way to respond to radicals

Persistent Innate Immune Stimulation Results in IRF3-Mediated but Caspase-Independent Cytostasis

Phosphorylation of Serine 225 in Hepatitis C Virus NS5A Regulates Protein-Protein Interactions ⬇️

Phosphorylation-Dependent Feedback Inhibition of RIG-I by DAPK1 Identified by Kinome-wide siRNA Screening

Poxvirus Protein MC132 from Molluscum Contagiosum Virus Inhibits NF-B Activation by Targeting p65 for Degradation.

Processing of Genome 5′ Termini as a Strategy of Negative-Strand RNA Viruses to Avoid RIG-I-Dependent Interferon Induction

Protein kinase R contributes to immunity against specific viruses by regulating interferon mRNA integrity

RIG-I detects viral genomic RNA during negative-strand RNA virus infection

RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates

Reduced mitochondrial resilience enables non-canonical induction of apoptosis after TNF receptor signaling in virus-infected hepatocytes

Sequestration by IFIT1 impairs translation of 2'O-unmethylated capped RNA.

Structural basis for viral 5'-PPP-RNA recognition by human IFIT proteins

Structure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2'-O methylations

System-Based Approaches to Delineate the Antiviral Innate Immune Landscape

The Cytomegalovirus Tegument Protein UL35 Antagonizes Pattern Recognition Receptor-Mediated Type I IFN Transcription

The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate Immunity

The alternative cap-binding complex is required for antiviral defense in vivo

The antiviral effect of interferon-beta against SARS-coronavirus is not mediated by MxA protein

The interferon-inducible GTPase MxB promotes capsid disassembly and genome release of herpesviruses

The lysine methyltransferase SMYD3 interacts with hepatitis C virus NS5A and is a negative regulator of viral particle production

Thogoto virus lacking interferon-antagonistic protein ML is strongly attenuated in newborn Mx1-positive but not Mx1-negative mice

Tubulovesicular structures within vesicular stomatitis virus G protein-pseudotyped lentiviral vector preparations carry DNA and stimulate antiviral responses via Toll-like receptor 9.

Viperin is an iron-sulfur protein that inhibits genome synthesis of tick-borne encephalitis virus via radical SAM domain activity

Viperin targets flavivirus virulence by inducing assembly of non-infectious capsid particles

Viral immune modulators perturb the human molecular network by common and unique strategies

Viral targeting of TFIIB impairs de novo polymerase II recruitment and affects antiviral immunity.

Virulence factor NSs of rift valley fever virus recruits the F-box protein FBXO3 to degrade subunit p62 of general transcription factor TFIIH

Virus-like particles expressing the nucleocapsid gene as an efficient vaccine against Rift Valley fever virus

[The first answer to viral infections: type I interferon]

eIF2B as a Target for Viral Evasion of PKR-Mediated Translation Inhibition

mRNA export through an additional cap-binding complex consisting of NCBP1 and NCBP3