List of works - Miguel Constancia

Adaptations in placental phenotype support fetal growth during undernutrition of pregnant mice.

scientific article published on 30 November 2009

Adipose tissue dysfunction as a central mechanism leading to dysmetabolic obesity triggered by chronic exposure to p,p'-DDE.

scientific article

Ageing is associated with molecular signatures of inflammation and type 2 diabetes in rat pancreatic islets

scientific article published on 23 December 2015

Allele loss in human gastric carcinomas - relation to tumor progression and differentiation

scientific article published on 01 November 1995

An intragenic methylated region in the imprinted Igf2 gene augments transcription.

scientific article

An obesogenic diet during mouse pregnancy modifies maternal nutrient partitioning and the fetal growth trajectory

scientific article published on 27 June 2013

An upstream repressor element plays a role in Igf2 imprinting

scientific article

Biomarkers of Aging: From Cellular Senescence to Age-Associated Diseases.

scientific article published on 2 August 2017

Child health, developmental plasticity, and epigenetic programming

scientific article

DNA methylation profiling at imprinted loci after periconceptional micronutrient supplementation in humans: results of a pilot randomized controlled trial.

scientific article

Developmental adaptations to increased fetal nutrient demand in mouse genetic models of Igf2-mediated overgrowth.

scientific article published on 31 January 2011

Dietary composition programmes placental phenotype in mice

article

Differential genomic imprinting regulates paracrine and autocrine roles of IGF2 in mouse adult neurogenesis

scientific article published on 15 September 2015

Disproportional effects of Igf2 knockout on placental morphology and diffusional exchange characteristics in the mouse.

scientific article published on 28 August 2008

Epigenetics and imprinting of the trophoblast -- a workshop report.

scientific article published on 3 April 2006

Extracardiac control of embryonic cardiomyocyte proliferation and ventricular wall expansion.

scientific article

Genome-wide oxidative bisulfite sequencing identifies sex-specific methylation differences in the human placenta.

scientific article published on 29 January 2018

How genome-wide approaches can be used to unravel the remaining secrets of the imprintome.

scientific article published on July 2010

IFPA Meeting 2009 workshops report

scientific article published on 12 January 2010

Igf2 imprinting in development and disease.

scientific article

Igf2 pathway dependency of the Trp53 developmental and tumour phenotypes.

scientific article

Impact on offspring methylation patterns of maternal gestational diabetes mellitus and intrauterine growth restraint suggest common genes and pathways linked to subsequent type 2 diabetes risk

scientific article published on 21 August 2014

Imprinted genes and the coordination of fetal and postnatal growth in mammals.

scientific article

Imprinted genes and the epigenetic regulation of placental phenotype.

scientific article

Imprinted genes, placental development and fetal growth

scientific article

Imprinting of IGF2 P0 transcript and novel alternatively spliced INS-IGF2 isoforms show differences between mouse and human.

scientific article

Increased placental glucose transport rates in pregnant mice carrying fetuses with targeted disruption of their placental-specific Igf2 transcripts are not associated with raised circulating glucose concentrations

scientific article

Intergenerational epigenetic inheritance in models of developmental programming of adult disease

scientific article published on 29 June 2015

Making sense or antisense?

scientific article published in Nature

Maternal diet amplifies the hepatic aging trajectory of Cidea in male mice and leads to the development of fatty liver.

scientific article published on 30 January 2014

Maternal diet and aging alter the epigenetic control of a promoter-enhancer interaction at the Hnf4a gene in rat pancreatic islets.

scientific article

Maternal diet, aging and diabetes meet at a chromatin loop.

scientific article

Maternal to offspring resource allocation in plants and mammals

scientific article published on 18 September 2012

Maternal-fetal resource allocation

scientific article published on 20 September 2012

Mechanisms of disease: the developmental origins of disease and the role of the epigenotype.

scientific article published on July 2007

Microsatellite instability at multiple loci in gastric carcinoma: Clinicopathologic implications and prognosis

scientific article published on 01 January 1996

Nucleotide sequence of a 28-kb mouse genomic region comprising the imprinted Igf2 gene.

scientific article published in October 1996

Periconceptional maternal micronutrient supplementation is associated with widespread gender related changes in the epigenome: a study of a unique resource in the Gambia

scientific article published on 3 February 2012

Placental adaptations to the maternal-fetal environment: implications for fetal growth and developmental programming ⬇️

scientific article published on 05 April 2012

Placental phenotype and the insulin-like growth factors: resource allocation to fetal growth.

scientific article published on 24 March 2017

Placental polyamine metabolism differs by fetal sex, fetal growth restriction, and preeclampsia

scientific article published on 12 July 2018

Placental programming of anxiety in adulthood revealed by Igf2-null models.

scientific article

Placental-specific IGF-II is a major modulator of placental and fetal growth.

scientific article

Placental-specific Igf2 deficiency alters developmental adaptations to undernutrition in mice.

scientific article published on 14 June 2011

Placental-specific Igf2 knockout mice exhibit hypocalcemia and adaptive changes in placental calcium transport.

scientific article

Programming placental nutrient transport capacity.

scientific article

Raised late pregnancy glucose concentrations in mice carrying pups with targeted disruption of H19delta13

scientific article

Regulation of Igf2 imprinting in development and disease.

scientific article published in January 1996

Regulation of supply and demand for maternal nutrients in mammals by imprinted genes.

scientific article

Sex differences in the intergenerational inheritance of metabolic traits

scientific article published in 2022

Tandem repeat hypothesis in imprinting: deletion of a conserved direct repeat element upstream of H19 has no effect on imprinting in the Igf2-H19 region

scientific article

List of works by Miguel Constancia

Adaptations in placental phenotype support fetal growth during undernutrition of pregnant mice.

Adipose tissue dysfunction as a central mechanism leading to dysmetabolic obesity triggered by chronic exposure to p,p'-DDE.

Ageing is associated with molecular signatures of inflammation and type 2 diabetes in rat pancreatic islets

Allele loss in human gastric carcinomas - relation to tumor progression and differentiation

An intragenic methylated region in the imprinted Igf2 gene augments transcription.

An obesogenic diet during mouse pregnancy modifies maternal nutrient partitioning and the fetal growth trajectory

An upstream repressor element plays a role in Igf2 imprinting

Biomarkers of Aging: From Cellular Senescence to Age-Associated Diseases.

Child health, developmental plasticity, and epigenetic programming

DNA methylation profiling at imprinted loci after periconceptional micronutrient supplementation in humans: results of a pilot randomized controlled trial.

Developmental adaptations to increased fetal nutrient demand in mouse genetic models of Igf2-mediated overgrowth.

Dietary composition programmes placental phenotype in mice

Differential genomic imprinting regulates paracrine and autocrine roles of IGF2 in mouse adult neurogenesis

Disproportional effects of Igf2 knockout on placental morphology and diffusional exchange characteristics in the mouse.

Epigenetics and imprinting of the trophoblast -- a workshop report.

Extracardiac control of embryonic cardiomyocyte proliferation and ventricular wall expansion.

Genome-wide oxidative bisulfite sequencing identifies sex-specific methylation differences in the human placenta.

How genome-wide approaches can be used to unravel the remaining secrets of the imprintome.

IFPA Meeting 2009 workshops report

Igf2 imprinting in development and disease.

Igf2 pathway dependency of the Trp53 developmental and tumour phenotypes.

Impact on offspring methylation patterns of maternal gestational diabetes mellitus and intrauterine growth restraint suggest common genes and pathways linked to subsequent type 2 diabetes risk

Imprinted genes and the coordination of fetal and postnatal growth in mammals.

Imprinted genes and the epigenetic regulation of placental phenotype.

Imprinted genes, placental development and fetal growth

Imprinting of IGF2 P0 transcript and novel alternatively spliced INS-IGF2 isoforms show differences between mouse and human.

Increased placental glucose transport rates in pregnant mice carrying fetuses with targeted disruption of their placental-specific Igf2 transcripts are not associated with raised circulating glucose concentrations

Intergenerational epigenetic inheritance in models of developmental programming of adult disease

Making sense or antisense?

Maternal diet amplifies the hepatic aging trajectory of Cidea in male mice and leads to the development of fatty liver.

Maternal diet and aging alter the epigenetic control of a promoter-enhancer interaction at the Hnf4a gene in rat pancreatic islets.

Maternal diet, aging and diabetes meet at a chromatin loop.

Maternal to offspring resource allocation in plants and mammals

Maternal-fetal resource allocation

Mechanisms of disease: the developmental origins of disease and the role of the epigenotype.

Microsatellite instability at multiple loci in gastric carcinoma: Clinicopathologic implications and prognosis

Nucleotide sequence of a 28-kb mouse genomic region comprising the imprinted Igf2 gene.

Periconceptional maternal micronutrient supplementation is associated with widespread gender related changes in the epigenome: a study of a unique resource in the Gambia

Placental adaptations to the maternal-fetal environment: implications for fetal growth and developmental programming ⬇️

Placental phenotype and the insulin-like growth factors: resource allocation to fetal growth.

Placental polyamine metabolism differs by fetal sex, fetal growth restriction, and preeclampsia

Placental programming of anxiety in adulthood revealed by Igf2-null models.

Placental-specific IGF-II is a major modulator of placental and fetal growth.

Placental-specific Igf2 deficiency alters developmental adaptations to undernutrition in mice.

Placental-specific Igf2 knockout mice exhibit hypocalcemia and adaptive changes in placental calcium transport.

Programming placental nutrient transport capacity.

Raised late pregnancy glucose concentrations in mice carrying pups with targeted disruption of H19delta13

Regulation of Igf2 imprinting in development and disease.

Regulation of supply and demand for maternal nutrients in mammals by imprinted genes.

Sex differences in the intergenerational inheritance of metabolic traits

Tandem repeat hypothesis in imprinting: deletion of a conserved direct repeat element upstream of H19 has no effect on imprinting in the Igf2-H19 region