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List of works by Karen Brown

A novel 14C-postlabeling assay using accelerator mass spectrometry for the detection of O6-methyldeoxy-guanosine adducts.

scientific article published in January 2006

APC10.1 cells as a model for assessing the efficacy of potential chemopreventive agents in the Apc(Min) mouse model in vivo.

scientific article

Accelerator mass spectrometry for biomedical research.

scientific article

An HPLC-UV method for the simultaneous quantification of curcumin and its metabolites in plasma and lung tissue: Potential for preclinical applications

scientific article published on 09 May 2018

Anthocyanin-rich red grape extract impedes adenoma development in the Apc(Min) mouse: pharmacodynamic changes and anthocyanin levels in the murine biophase

scientific article published on 7 January 2010

Anthocyans as tertiary chemopreventive agents in bladder cancer: anti-oxidant mechanisms and interaction with mitomycin C.

scientific article published on 17 April 2014

Applications of accelerator mass spectrometry for pharmacological and toxicological research.

scientific article

Assessing barriers to a rational chemoprevention trial design in young patients with familial adenomatous polyposis

scientific article

Breast cancer chemoprevention: risk-benefit effects of the antioestrogen tamoxifen.

scientific article

Cancer chemoprevention: Evidence of a nonlinear dose response for the protective effects of resveratrol in humans and mice

scientific article published on July 2015

Cancer chemoprevention: a rapidly evolving field.

scientific article published on 04 June 2013

Cancer chemoprevention: factors influencing attitudes towards chemopreventive agents in high-risk populations

scientific article published on November 2014

Characterization and propagation of tumor initiating cells derived from colorectal liver metastases: trials, tribulations and a cautionary note

scientific article

Characterization of a peptide adduct formed by N-acetoxy-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), a reactive intermediate of the food carcinogen PhIP.

scientific article

Chemoprevention of breast cancer by tamoxifen: risks and opportunities

scientific article

Circulating tumor DNA in patients with colorectal adenomas: assessment of detectability and genetic heterogeneity

scientific article published on 30 August 2018

Clinical pharmacology of resveratrol and its metabolites in colorectal cancer patients.

scientific article

Combining curcumin (C3-complex, Sabinsa) with standard care FOLFOX chemotherapy in patients with inoperable colorectal cancer (CUFOX): study protocol for a randomised control trial

scientific article

Correspondence regarding M. Sharma et al., “Antioxidant inhibits tamoxifen–DNA adducts in endometrial explant culture” ⬇️

scientific article published on October 31, 2003

Curcumin ameliorates oxaliplatin-induced chemoresistance in HCT116 colorectal cancer cells in vitro and in vivo

scientific article published on 03 November 2010

Curcumin inhibits cancer stem cell phenotypes in ex vivo models of colorectal liver metastases, and is clinically safe and tolerable in combination with FOLFOX chemotherapy.

scientific article published on 12 May 2015

Curcumin: the potential for efficacy in gastrointestinal diseases.

scientific article published on August 2011

DNA adducts formed from 4-hydroxytamoxifen are more mutagenic than those formed by alpha-acetoxytamoxifen in a shuttle vector target gene replicated in human Ad293 cells

scientific article published on July 2002

DNA adducts: mass spectrometry methods and future prospects.

scientific article

Detection of Plasma Curcuminoids from Dietary Intake of Turmeric-Containing Food in Human Volunteers

scientific article published on 10 July 2018

Determination of 3',4',5',5,7-pentamethoxyflavone in the plasma and intestinal mucosa of mice by HPLC with UV detection.

scientific article

Determination of anthocyanins in the urine of patients with colorectal liver metastases after administration of bilberry extract.

scientific article

Determination of endogenous and exogenously derived N7-(2-hydroxyethyl)guanine adducts in ethylene oxide-treated rats

scientific article published on 31 January 2007

Development of dietary phytochemical chemopreventive agents: biomarkers and choice of dose for early clinical trials.

scientific article published on 26 May 2009

Dietary intake of rosmarinic acid by Apc(Min) mice, a model of colorectal carcinogenesis: levels of parent agent in the target tissue and effect on adenoma development

scientific article

Direct molecular targets of resveratrol: identifying key interactions to unlock complex mechanisms.

scientific article published on 22 June 2015

Do not throw out the resveratrol with the bath water

scientific article published on 01 January 2015

Effects of a Grapevine Shoot Extract Containing Resveratrol and Resveratrol Oligomers on Intestinal Adenoma Development in Mice: In Vitro and In Vivo Studies.

scientific article published on 10 November 2017

Flavones as colorectal cancer chemopreventive agents--phenol-o-methylation enhances efficacy.

scientific article published on 28 July 2009

Further characterization of the DNA adducts formed in rat liver after the administration of tamoxifen, N-desmethyltamoxifen or N, N-didesmethyltamoxifen

scientific article published on 01 October 1999

General practitioner attitudes towards prescribing aspirin to carriers of Lynch Syndrome: findings from a national survey ⬇️

scientific article published on 22 April 2017

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

Hepatic DNA adduct dosimetry in rats fed tamoxifen: a comparison of methods.

scientific article

High prevalence of early-onset osteopenia/osteoporosis after allogeneic stem cell transplantation and improvement after bisphosphonate therapy.

scientific article published on 12 November 2007

Inhibition of prostate cancer cell growth by 3',4',5'-trimethoxyflavonol (TMFol).

scientific article published on 29 May 2015

In vivo relevant mixed urolithins and ellagic acid inhibit phenotypic and molecular colon cancer stem cell features: A new potentiality for ellagitannin metabolites against cancer.

scientific article

Is tamoxifen a genotoxic carcinogen in women?

scientific article published on 07 June 2009

Methods for the detection of DNA adducts.

scientific article

Mutagenicity of DNA adducts derived from ethylene oxide exposure in the pSP189 shuttle vector replicated in human Ad293 cells

scientific article (publication date: August 2009)

Mutation spectra induced by alpha-acetoxytamoxifen-DNA adducts in human DNA repair proficient and deficient (xeroderma pigmentosum complementation group A) cells

scientific article

New concepts and challenges in the clinical translation of cancer preventive therapies: the role of pharmacodynamic biomarkers

scientific article

Pharmacokinetics and metabolism of the putative cancer chemopreventive agent cyanidin-3-glucoside in mice

scientific article

Pharmacokinetics in mice and metabolism in murine and human liver fractions of the putative cancer chemopreventive agents 3',4',5',5,7-pentamethoxyflavone and tricin (4',5,7-trihydroxy-3',5'-dimethoxyflavone).

scientific article published on 4 April 2010

Phase I randomized, double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases--safety, pharmacokinetics, and pharmacodynamics

scientific article

Pilot study of oral anthocyanins for colorectal cancer chemoprevention.

scientific article published in July 2009

Preclinical colorectal cancer chemopreventive efficacy and p53-modulating activity of 3',4',5'-trimethoxyflavonol, a quercetin analogue.

scientific article

Prescribing tamoxifen in primary care for the prevention of breast cancer: a national online survey of GPs' attitudes ⬇️

scientific article

Prolonged biologically active colonic tissue levels of curcumin achieved after oral administration--a clinical pilot study including assessment of patient acceptability ⬇️

scientific article published on 11 December 2012

Randomized trial of a decision aid for BRCA1/BRCA2 mutation carriers: impact on measures of decision making and satisfaction

scientific article published on January 2009

Repeat Dose Study of the Cancer Chemopreventive Agent Resveratrol in Healthy Volunteers: Safety, Pharmacokinetics, and Effect on the Insulin-like Growth Factor Axis ⬇️

scientific article published on October 8, 2010

Response to comment on "Cancer chemoprevention: Evidence of a nonlinear dose response for the protective effects of resveratrol in humans and mice".

scientific article published in August 2016

Resveratrol in human cancer chemoprevention--choosing the 'right' dose.

scientific article published on 07 October 2011

Resveratrol in the management of human cancer: how strong is the clinical evidence? ⬇️

scientific article published on July 1, 2013

Resveratrol-sulfates provide an intracellular reservoir for generation of parent resveratrol, which induces autophagy in cancer cells.

scientific article published on 09 January 2014

Rituximab in combination with CHOP or fludarabine in low-grade lymphoma.

scientific article

Sensitivity of Colorectal Cancer to Arginine Deprivation Therapy is Shaped by Differential Expression of Urea Cycle Enzymes

scientific article published in Scientific Reports

Simultaneous detection of five different 2-hydroxyethyl-DNA adducts formed by ethylene oxide exposure, using a high-performance liquid chromatography/electrospray ionisation tandem mass spectrometry assay.

scientific article published in January 2008

Site-specific tamoxifen-DNA adduct formation: lack of correlation with mutational ability in Escherichia coli

scientific article published on 01 August 1999

Structural characterization of carcinogen-modified oligodeoxynucleotide adducts using matrix-assisted laser desorption/ionization mass spectrometry.

scientific article

Synthesis and biological evaluation of novel flavonols as potential anti-prostate cancer agents.

scientific article

Synthesis of the flavonoid 3',4',5'-trimethoxyflavonol and its determination in plasma and tissues of mice by HPLC with fluorescence detection.

scientific article published on 24 February 2009

Tamoxifen forms DNA adducts in human colon after administration of a single [14C]-labeled therapeutic dose

scientific article published on 01 July 2007

Targeting cancer stem-like cells using dietary-derived agents - Where are we now?

scientific article published on 6 April 2016

Techniques: the application of accelerator mass spectrometry to pharmacology and toxicology.

scientific article published in August 2004

The role of cancer stem cells in the anti‐carcinogenicity of curcumin ⬇️

scientific article published on July 31, 2013

The role of stromal fibroblasts in lung carcinogenesis: A target for chemoprevention?

scientific article

Tissue distribution and metabolism of the putative cancer chemopreventive agent 3',4',5'-trimethoxyflavonol (TMFol) in mice.

scientific article

Translating curcumin to the clinic for lung cancer prevention: evaluation of the preclinical evidence for its utility in primary, secondary, and tertiary prevention strategies.

scientific article

Understanding the importance of low-molecular weight (ethylene oxide- and propylene oxide-induced) DNA adducts and mutations in risk assessment: Insights from 15 years of research and collaborative discussions

scientific article published on 10 December 2018

What is new for an old molecule? Systematic review and recommendations on the use of resveratrol

scientific article

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