List of works - Yifan Zhan

A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production

scientific article

A microRNA expression atlas of mouse dendritic cell development.

scientific article

Anti-CD45RB antibody deters xenograft rejection by modulating T cell priming and homing.

scientific article published in August 2002

Anti-apoptotic proteins BCL-2, MCL-1 and A1 summate collectively to maintain survival of immune cell populations both in vitro and in vivo.

scientific article published on 31 March 2017

Antigen delivery via two molecules on the CD8- dendritic cell subset induces humoral immunity in the absence of conventional "danger".

scientific article published in October 2005

BIM Deficiency Protects NOD Mice From Diabetes by Diverting Thymocytes to Regulatory T Cells

scientific article published on 06 May 2015

Bcl-2 Antagonists Kill Plasmacytoid Dendritic Cells From Lupus-Prone Mice and Dampen Interferon-α Production

scientific article published on 01 March 2015

Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation

scientific article published on 01 February 2019

CCR2 enhances CD25 expression by FoxP3+ regulatory T cells and regulates their abundance independently of chemotaxis and CCR2+ myeloid cells

scientific article published on 11 December 2018

CD4 help-independent induction of cytotoxic CD8 cells to allogeneic P815 tumor cells is absolutely dependent on costimulation

scientific article published on 01 October 2000

Characterisation of mice lacking all functional isoforms of the pro-survival BCL-2 family member A1 reveals minor defects in the haematopoietic compartment.

scientific article published on 13 January 2017

Characterization of an immediate splenic precursor of CD8+ dendritic cells capable of inducing antiviral T cell responses

scientific article published in April 2009

Cognate antigen engagement on parenchymal cells stimulates CD8+ T cell proliferation in situ

scientific article

Cystatin C regulates major histocompatibility complex-II-peptide presentation and extracellular signal-regulated kinase-dependent polarizing cytokine production by bone marrow-derived dendritic cells

scientific article published on 15 October 2019

Cytokine production in the murine response to brucella infection or immunization with antigenic extracts.

scientific article

Cytokine response of T-cell subsets from Brucella abortus-infected mice to soluble Brucella proteins.

scientific article

Defects in the Bcl-2-regulated apoptotic pathway lead to preferential increase of CD25 low Foxp3+ anergic CD4+ T cells

scientific article

Deliberately provoking local inflammation drives tumors to become their own protective vaccine site.

scientific article published on 29 September 2008

Differential development of murine dendritic cells by GM-CSF versus Flt3 ligand has implications for inflammation and trafficking

scientific article published on 01 December 2007

Differential induction of macrophage-derived cytokines by live and dead intracellular bacteria in vitro

scientific article

Drosha controls dendritic cell development by cleaving messenger RNAs encoding inhibitors of myelopoiesis.

scientific article published on 5 October 2015

Either B7-1 or B7-2 is required for Listeria monocytogenes-specific production of gamma interferon and interleukin-2.

scientific article published on December 1996

Endogenous gamma interferon mediates resistance to Brucella abortus infection

scientific article

Endogenous interleukin-12 is involved in resistance to Brucella abortus infection.

scientific article

Functional cytotoxic T lymphocytes against IGRP206-214 predict diabetes in the non-obese diabetic mouse.

scientific article published on 29 April 2014

Functional deficiencies of peritoneal cells from gene-targeted mice lacking G-CSF or GM-CSF.

scientific article published in February 1999

Functional regulation of monocyte-derived dendritic cells by microRNAs

scientific article

GM-CSF Quantity Has a Selective Effect on Granulocytic vs. Monocytic Myeloid Development and Function

scientific article published on 28 August 2018

GM-CSF-responsive monocyte-derived dendritic cells are pivotal in Th17 pathogenesis.

scientific article published on 31 January 2014

Glucocorticoid receptor deficient thymic and peripheral T cells develop normally in adult mice

scientific article published in December 2002

Glucocorticoid-induced TNF receptor expression by T cells is reciprocally regulated by NF-kappaB and NFAT.

scientific article published in October 2008

Heterogeneity, functional specialization and differentiation of monocyte-derived dendritic cells.

scientific article

Homeostatic proliferation of intestinal intraepithelial lymphocytes precedes their migration to extra-intestinal sites

scientific article published on 01 August 2007

In vivo IL-1 potentiates both specific and non-specific arms of immune response to infection

scientific article published on 01 July 1990

Inflammation conditions mature dendritic cells to retain the capacity to present new antigens but with altered cytokine secretion function.

scientific article published on 8 September 2014

Influenza-induced, helper-independent CD8+ T cell responses use CD40 costimulation at the late phase of the primary response

scientific article published on 29 October 2012

Inhibition of PAK1 suppresses pancreatic cancer by stimulation of anti-tumour immunity through down-regulation of PD-L1

scientific article published on 16 December 2019

Innate Allorecognition Results in Rapid Accumulation of Monocyte-Derived Dendritic Cells.

scientific article published on 29 July 2016

Innate immune surveillance of spontaneous B cell lymphomas by natural killer cells and gammadelta T cells

scientific article

Interleukin-6 production during chronic experimental infection

scientific article published on 01 August 1993

Life and Death of Activated T Cells: How Are They Different from Naïve T Cells?

scientific article published on 13 December 2017

Local effector failure in mesothelioma is not mediated by CD4+ CD25+ T-regulator cells.

scientific article

Local production of anti-CD4 antibody by transgenic allogeneic grafts affords partial protection

scientific article published on 01 September 2000

Loss of c-Cbl RING finger function results in high-intensity TCR signaling and thymic deletion.

scientific article

Macrophages, rather than DCs, are responsible for inflammasome activity in the GM-CSF BMDC model

scientific article published on 11 February 2019

Maintaining dendritic cell viability in culture.

scientific article published on 28 July 2014

Migratory Dendritic Cells Transfer Antigen to a Lymph Node-Resident Dendritic Cell Population for Efficient CTL Priming

article

Monocyte-Derived Dendritic Cells Impair Early Graft Function Following Allogeneic Islet Transplantation.

scientific article published on 13 October 2016

Monocyte-Derived Dendritic Cells Promote Th Polarization, whereas Conventional Dendritic Cells Promote Th Proliferation.

scientific article

Mucosal Profiling of Pediatric-Onset Colitis and IBD Reveals Common Pathogenics and Therapeutic Pathways

scientific article published on 01 November 2019

NK cells promote peritoneal xenograft rejection through an IFN-gamma-dependent mechanism

scientific article published on November 2006

NKT cell stimulation with glycolipid antigen in vivo: costimulation-dependent expansion, Bim-dependent contraction, and hyporesponsiveness to further antigenic challenge

scientific article published in September 2005

Negative selection of semimature CD4(+)8(-)HSA+ thymocytes requires the BH3-only protein Bim but is independent of death receptor signaling

scientific article published on 26 April 2004

Plasmacytoid dendritic cells are short-lived: reappraising the influence of migration, genetic factors and activation on estimation of lifespan

scientific article published on 26 April 2016

Plasmacytoid dendritic cells from parent strains of the NZB/W F1 lupus mouse contribute different characteristics to autoimmune propensity

scientific article published on 05 February 2020

Predominant transgene expression in exocrine pancreas directed by the CMV promoter

scientific article published on 01 November 2000

Prolonged allograft survival in anti-CD4 antibody transgenic mice: lack of residual helper T cells compared with other CD4-deficient mice

scientific article published on 01 July 2000

Prosurvival Bcl-2 family members reveal a distinct apoptotic identity between conventional and plasmacytoid dendritic cells

scientific article

Rapid deletion and inactivation of CTLs upon recognition of a number of target cells over a critical threshold.

scientific article published on 9 September 2013

Reducing or increasing β-cell apoptosis without inflammation does not affect diabetes initiation in neonatal NOD mice

scientific article published on 04 July 2011

Resident and monocyte-derived dendritic cells become dominant IL-12 producers under different conditions and signaling pathways

scientific article published on 19 July 2010

Rotavirus infection induces transient pancreatic involution and hyperglycemia in weanling mice

scientific article

SOCS1 negatively regulates the production of Foxp3+ CD4+ T cells in the thymus.

scientific article published on 21 April 2009

Selected Toll-like receptor ligands and viruses promote helper-independent cytotoxic T cell priming by upregulating CD40L on dendritic cells

scientific article published on 05 February 2009

Selective Depletion of Cross-Presenting Dendritic Cells Enhances Islet Allograft Survival

scientific article published on 30 September 2010

Selective suicide of cross-presenting CD8+ dendritic cells by cytochrome c injection shows functional heterogeneity within this subset

scientific article

Sex-specific adipose tissue imprinting of regulatory T cells

scientific article published on 26 February 2020

T lymphocytes from granulocyte colony-stimulating factor-/- mice produce large quantities of interferon-gamma in a chronic infection model

scientific article published on 01 September 2000

TCR-mediated activation promotes GITR upregulation in T cells and resistance to glucocorticoid-induced death

scientific article published on 19 July 2004

Targeting CD45RB alters T cell migration and delays viral clearance.

scientific article published on 16 December 2005

Targeting the Gut Vascular Endothelium Induces Gut Effector CD8 T Cell Responses Via Cross-Presentation by Dendritic Cells

article

The Pleiotropic Effects of the GM-CSF Rheostat on Myeloid Cell Differentiation and Function: More Than a Numbers Game

scientific article published on 15 November 2019

The Rel subunit of NF-kappaB-like transcription factors is a positive and negative regulator of macrophage gene expression: distinct roles for Rel in different macrophage populations

scientific article published in December 1996

The closely related CD103+ dendritic cells (DCs) and lymphoid-resident CD8+ DCs differ in their inflammatory functions

scientific article

The life and death of immune cell types: the role of BCL-2 anti-apoptotic molecules.

scientific article

The linear range for accurately quantifying antigen-specific T-cell frequencies by tetramer staining during natural immune responses

scientific article published on 11 April 2011

The origin of thymic CD4+CD25+ regulatory T cells and their co-stimulatory requirements are determined after elimination of recirculating peripheral CD4+ cells.

scientific article published on 20 February 2007

The polycomb repressive complex 2 governs life and death of peripheral T cells

scientific article published on 20 June 2014

The regulation of the development and function of dendritic cell subsets by GM-CSF: more than a hematopoietic growth factor.

scientific article published on 14 May 2012

The role of microRNAs in lymphopoiesis.

scientific article

Transcription Factor PU.1 Promotes Conventional Dendritic Cell Identity and Function via Induction of Transcriptional Regulator DC-SCRIPT

scientific article published on 02 January 2019

Transgenic anti-CD4 monoclonal antibody secretion by mouse segmental pancreas allografts promotes long term survival

scientific article published on 01 November 2000

Tumor necrosis factor alpha and interleukin-12 contribute to resistance to the intracellular bacterium Brucella abortus by different mechanisms

scientific article published on July 1996

Unexpectedly, induction of cytotoxic T lymphocytes enhances the humoral response after DNA immunization

scientific article

Unlike CD4+ T-cell help, CD28 costimulation is necessary for effective primary CD8+ T-cell influenza-specific immunity

scientific article published on 14 June 2012

Without CD4 help, CD8 rejection of pig xenografts requires CD28 costimulation but not perforin killing

scientific article published on 01 December 2001

Without peripheral interference, thymic deletion is mediated in a cohort of double-positive cells without classical activation

scientific article published on 21 January 2003

XIAP Loss Triggers RIPK3- and Caspase-8-Driven IL-1β Activation and Cell Death as a Consequence of TLR-MyD88-Induced cIAP1-TRAF2 Degradation.

scientific article published on July 2017

List of works by Yifan Zhan

A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production

A microRNA expression atlas of mouse dendritic cell development.

Anti-CD45RB antibody deters xenograft rejection by modulating T cell priming and homing.

Anti-apoptotic proteins BCL-2, MCL-1 and A1 summate collectively to maintain survival of immune cell populations both in vitro and in vivo.

Antigen delivery via two molecules on the CD8- dendritic cell subset induces humoral immunity in the absence of conventional "danger".

BIM Deficiency Protects NOD Mice From Diabetes by Diverting Thymocytes to Regulatory T Cells

Bcl-2 Antagonists Kill Plasmacytoid Dendritic Cells From Lupus-Prone Mice and Dampen Interferon-α Production

Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation

CCR2 enhances CD25 expression by FoxP3+ regulatory T cells and regulates their abundance independently of chemotaxis and CCR2+ myeloid cells

CD4 help-independent induction of cytotoxic CD8 cells to allogeneic P815 tumor cells is absolutely dependent on costimulation

Characterisation of mice lacking all functional isoforms of the pro-survival BCL-2 family member A1 reveals minor defects in the haematopoietic compartment.

Characterization of an immediate splenic precursor of CD8+ dendritic cells capable of inducing antiviral T cell responses

Cognate antigen engagement on parenchymal cells stimulates CD8+ T cell proliferation in situ

Cystatin C regulates major histocompatibility complex-II-peptide presentation and extracellular signal-regulated kinase-dependent polarizing cytokine production by bone marrow-derived dendritic cells

Cytokine production in the murine response to brucella infection or immunization with antigenic extracts.

Cytokine response of T-cell subsets from Brucella abortus-infected mice to soluble Brucella proteins.

Defects in the Bcl-2-regulated apoptotic pathway lead to preferential increase of CD25 low Foxp3+ anergic CD4+ T cells

Deliberately provoking local inflammation drives tumors to become their own protective vaccine site.

Differential development of murine dendritic cells by GM-CSF versus Flt3 ligand has implications for inflammation and trafficking

Differential induction of macrophage-derived cytokines by live and dead intracellular bacteria in vitro

Drosha controls dendritic cell development by cleaving messenger RNAs encoding inhibitors of myelopoiesis.

Either B7-1 or B7-2 is required for Listeria monocytogenes-specific production of gamma interferon and interleukin-2.

Endogenous gamma interferon mediates resistance to Brucella abortus infection

Endogenous interleukin-12 is involved in resistance to Brucella abortus infection.

Functional cytotoxic T lymphocytes against IGRP206-214 predict diabetes in the non-obese diabetic mouse.

Functional deficiencies of peritoneal cells from gene-targeted mice lacking G-CSF or GM-CSF.

Functional regulation of monocyte-derived dendritic cells by microRNAs

GM-CSF Quantity Has a Selective Effect on Granulocytic vs. Monocytic Myeloid Development and Function

GM-CSF-responsive monocyte-derived dendritic cells are pivotal in Th17 pathogenesis.

Glucocorticoid receptor deficient thymic and peripheral T cells develop normally in adult mice

Glucocorticoid-induced TNF receptor expression by T cells is reciprocally regulated by NF-kappaB and NFAT.

Heterogeneity, functional specialization and differentiation of monocyte-derived dendritic cells.

Homeostatic proliferation of intestinal intraepithelial lymphocytes precedes their migration to extra-intestinal sites

In vivo IL-1 potentiates both specific and non-specific arms of immune response to infection

Inflammation conditions mature dendritic cells to retain the capacity to present new antigens but with altered cytokine secretion function.

Influenza-induced, helper-independent CD8+ T cell responses use CD40 costimulation at the late phase of the primary response

Inhibition of PAK1 suppresses pancreatic cancer by stimulation of anti-tumour immunity through down-regulation of PD-L1

Innate Allorecognition Results in Rapid Accumulation of Monocyte-Derived Dendritic Cells.

Innate immune surveillance of spontaneous B cell lymphomas by natural killer cells and gammadelta T cells

Interleukin-6 production during chronic experimental infection

Life and Death of Activated T Cells: How Are They Different from Naïve T Cells?

Local effector failure in mesothelioma is not mediated by CD4+ CD25+ T-regulator cells.

Local production of anti-CD4 antibody by transgenic allogeneic grafts affords partial protection

Loss of c-Cbl RING finger function results in high-intensity TCR signaling and thymic deletion.

Macrophages, rather than DCs, are responsible for inflammasome activity in the GM-CSF BMDC model

Maintaining dendritic cell viability in culture.

Migratory Dendritic Cells Transfer Antigen to a Lymph Node-Resident Dendritic Cell Population for Efficient CTL Priming

Monocyte-Derived Dendritic Cells Impair Early Graft Function Following Allogeneic Islet Transplantation.

Monocyte-Derived Dendritic Cells Promote Th Polarization, whereas Conventional Dendritic Cells Promote Th Proliferation.

Mucosal Profiling of Pediatric-Onset Colitis and IBD Reveals Common Pathogenics and Therapeutic Pathways

NK cells promote peritoneal xenograft rejection through an IFN-gamma-dependent mechanism

NKT cell stimulation with glycolipid antigen in vivo: costimulation-dependent expansion, Bim-dependent contraction, and hyporesponsiveness to further antigenic challenge

Negative selection of semimature CD4(+)8(-)HSA+ thymocytes requires the BH3-only protein Bim but is independent of death receptor signaling

Plasmacytoid dendritic cells are short-lived: reappraising the influence of migration, genetic factors and activation on estimation of lifespan

Plasmacytoid dendritic cells from parent strains of the NZB/W F1 lupus mouse contribute different characteristics to autoimmune propensity

Predominant transgene expression in exocrine pancreas directed by the CMV promoter

Prolonged allograft survival in anti-CD4 antibody transgenic mice: lack of residual helper T cells compared with other CD4-deficient mice

Prosurvival Bcl-2 family members reveal a distinct apoptotic identity between conventional and plasmacytoid dendritic cells

Rapid deletion and inactivation of CTLs upon recognition of a number of target cells over a critical threshold.

Reducing or increasing β-cell apoptosis without inflammation does not affect diabetes initiation in neonatal NOD mice

Resident and monocyte-derived dendritic cells become dominant IL-12 producers under different conditions and signaling pathways

Rotavirus infection induces transient pancreatic involution and hyperglycemia in weanling mice

SOCS1 negatively regulates the production of Foxp3+ CD4+ T cells in the thymus.

Selected Toll-like receptor ligands and viruses promote helper-independent cytotoxic T cell priming by upregulating CD40L on dendritic cells

Selective Depletion of Cross-Presenting Dendritic Cells Enhances Islet Allograft Survival

Selective suicide of cross-presenting CD8+ dendritic cells by cytochrome c injection shows functional heterogeneity within this subset

Sex-specific adipose tissue imprinting of regulatory T cells

T lymphocytes from granulocyte colony-stimulating factor-/- mice produce large quantities of interferon-gamma in a chronic infection model

TCR-mediated activation promotes GITR upregulation in T cells and resistance to glucocorticoid-induced death

Targeting CD45RB alters T cell migration and delays viral clearance.

Targeting the Gut Vascular Endothelium Induces Gut Effector CD8 T Cell Responses Via Cross-Presentation by Dendritic Cells

The Pleiotropic Effects of the GM-CSF Rheostat on Myeloid Cell Differentiation and Function: More Than a Numbers Game

The Rel subunit of NF-kappaB-like transcription factors is a positive and negative regulator of macrophage gene expression: distinct roles for Rel in different macrophage populations

The closely related CD103+ dendritic cells (DCs) and lymphoid-resident CD8+ DCs differ in their inflammatory functions

The life and death of immune cell types: the role of BCL-2 anti-apoptotic molecules.

The linear range for accurately quantifying antigen-specific T-cell frequencies by tetramer staining during natural immune responses

The origin of thymic CD4+CD25+ regulatory T cells and their co-stimulatory requirements are determined after elimination of recirculating peripheral CD4+ cells.

The polycomb repressive complex 2 governs life and death of peripheral T cells

The regulation of the development and function of dendritic cell subsets by GM-CSF: more than a hematopoietic growth factor.