List of works - Stephen Goodbourn

Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures

scientific article (publication date: 2008)

The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter

scientific article

mda-5, but not RIG-I, is a common target for paramyxovirus V proteins.

scientific article published on 16 October 2006

Viral immune modulators perturb the human molecular network by common and unique strategies

scientific article

The NPro Product of Bovine Viral Diarrhea Virus Inhibits DNA Binding by Interferon Regulatory Factor 3 and Targets It for Proteasomal Degradation

scientific article (publication date: December 2006)

Mechanism of mda-5 Inhibition by paramyxovirus V proteins.

scientific article

STAT2 deficiency and susceptibility to viral illness in humans

scientific journal article

Paramyxovirus V proteins interact with the RNA Helicase LGP2 to inhibit RIG-I-dependent interferon induction

scientific article

Variation in the ability of human influenza A viruses to induce and inhibit the IFN-beta pathway.

scientific article published on 27 December 2005

Single amino acid substitution in the V protein of simian virus 5 differentiates its ability to block interferon signaling in human and murine cells

scientific article

The regulation of type I interferon production by paramyxoviruses.

scientific article published on September 2009

NS1 proteins of avian influenza A viruses can act as antagonists of the human alpha/beta interferon response.

scientific article published on 20 December 2006

Heterocellular induction of interferon by negative-sense RNA viruses.

scientific article published on 15 September 2010

The Npro product of classical swine fever virus and bovine viral diarrhea virus uses a conserved mechanism to target interferon regulatory factor-3.

scientific article published on November 2007

LGP2 Plays a Critical Role in Sensitizing mda-5 to Activation by Double-Stranded RNA

scientific article published on May 9, 2013

In vitro and in vivo specificity of ubiquitination and degradation of STAT1 and STAT2 by the V proteins of the paramyxoviruses simian virus 5 and human parainfluenza virus type 2.

scientific article

Deep sequencing analysis of defective genomes of parainfluenza virus 5 and their role in interferon induction

scientific article published on 28 February 2013

Failure to activate the IFN-β promoter by a paramyxovirus lacking an interferon antagonist.

scientific article published on 22 April 2011

Sensitivity of African swine fever virus to type I interferon is linked to genes within multigene families 360 and 505.

scientific article published on April 2016

Catalytic turnover of STAT1 allows PIV5 to dismantle the interferon-induced anti-viral state of cells.

scientific article

Activation of the beta interferon promoter by paramyxoviruses in the absence of virus protein synthesis

scientific article published on November 2, 2011

Transcriptional activation by the human herpesvirus-8-encoded interferon regulatory factor

scientific article published on 01 August 1999

Signal transduction. Notch takes a short cut.

scientific article published in September 1995

Chicken interferome: avian interferon-stimulated genes identified by microarray and RNA-seq of primary chick embryo fibroblasts treated with a chicken type I interferon (IFN-α).

scientific article published on 5 August 2016

Mapuera virus, a rubulavirus that inhibits interferon signalling in a wide variety of mammalian cells without degrading STATs.

scientific article

Human IFIT1 Inhibits mRNA Translation of Rubulaviruses but Not Other Members of the Paramyxoviridae Family.

scientific article published on 10 August 2016

Targeting Pattern Recognition Receptors (PRR) for Vaccine Adjuvantation: From Synthetic PRR Agonists to the Potential of Defective Interfering Particles of Viruses.

scientific article

Genetic Screen of a Mutant Poxvirus Library Identifies an Ankyrin Repeat Protein Involved in Blocking Induction of Avian Type I Interferon

scientific article published on February 20, 2013

The classical swine fever virus Npro product is degraded by cellular proteasomes in a manner that does not require interaction with interferon regulatory factor 3.

scientific article

Control of the induction of type I interferon by Peste des petits ruminants virus

scientific article

Genetic screen of a library of chimeric poxviruses identifies an ankyrin repeat protein involved in resistance to the avian type I interferon response.

scientific article

Regulation of transcription of the Aedes albopictus cecropin A1 gene: A role for p38 mitogen-activated protein kinase.

scientific article published on 08 April 2011

Constitutively elevated levels of SOCS1 suppress innate responses in DF-1 immortalised chicken fibroblast cells

scientific article published on 13 December 2017

Activation of interferon-stimulated response element in huh-7 cells replicating hepatitis C virus subgenomic RNA.

scientific article published on September 2005

Identification of residues within the African swine fever virus DP71L protein required for dephosphorylation of translation initiation factor eIF2α and inhibiting activation of pro-apoptotic CHOP.

scientific article published on 08 February 2017

A missense mutation in TRAPPC6A leads to build-up of the protein, in patients with a neurodevelopmental syndrome and dysmorphic features.

scientific article published in February 2018

The switch between acute and persistent paramyxovirus infection caused by single amino acid substitutions in the RNA polymerase P subunit

scientific article published on 11 February 2019

Genome Sequence of the Parainfluenza Virus 5 Strain That Persistently Infects AGS Cells

scientific article published on 21 July 2016

The cellular localization of avian influenza virus PB1-F2 protein alters the magnitude of IFN2 promoter and NFκB-dependent promoter antagonism in chicken cells

scientific article published on 23 January 2019

List of works by Stephen Goodbourn

Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures

The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter

mda-5, but not RIG-I, is a common target for paramyxovirus V proteins.

Viral immune modulators perturb the human molecular network by common and unique strategies

The NPro Product of Bovine Viral Diarrhea Virus Inhibits DNA Binding by Interferon Regulatory Factor 3 and Targets It for Proteasomal Degradation

Mechanism of mda-5 Inhibition by paramyxovirus V proteins.

STAT2 deficiency and susceptibility to viral illness in humans

Paramyxovirus V proteins interact with the RNA Helicase LGP2 to inhibit RIG-I-dependent interferon induction

Variation in the ability of human influenza A viruses to induce and inhibit the IFN-beta pathway.

Single amino acid substitution in the V protein of simian virus 5 differentiates its ability to block interferon signaling in human and murine cells

The regulation of type I interferon production by paramyxoviruses.

NS1 proteins of avian influenza A viruses can act as antagonists of the human alpha/beta interferon response.

Heterocellular induction of interferon by negative-sense RNA viruses.

The Npro product of classical swine fever virus and bovine viral diarrhea virus uses a conserved mechanism to target interferon regulatory factor-3.

LGP2 Plays a Critical Role in Sensitizing mda-5 to Activation by Double-Stranded RNA

In vitro and in vivo specificity of ubiquitination and degradation of STAT1 and STAT2 by the V proteins of the paramyxoviruses simian virus 5 and human parainfluenza virus type 2.

Deep sequencing analysis of defective genomes of parainfluenza virus 5 and their role in interferon induction

Failure to activate the IFN-β promoter by a paramyxovirus lacking an interferon antagonist.

Sensitivity of African swine fever virus to type I interferon is linked to genes within multigene families 360 and 505.

Catalytic turnover of STAT1 allows PIV5 to dismantle the interferon-induced anti-viral state of cells.

Activation of the beta interferon promoter by paramyxoviruses in the absence of virus protein synthesis

Transcriptional activation by the human herpesvirus-8-encoded interferon regulatory factor

Signal transduction. Notch takes a short cut.

Chicken interferome: avian interferon-stimulated genes identified by microarray and RNA-seq of primary chick embryo fibroblasts treated with a chicken type I interferon (IFN-α).

Mapuera virus, a rubulavirus that inhibits interferon signalling in a wide variety of mammalian cells without degrading STATs.

Human IFIT1 Inhibits mRNA Translation of Rubulaviruses but Not Other Members of the Paramyxoviridae Family.

Targeting Pattern Recognition Receptors (PRR) for Vaccine Adjuvantation: From Synthetic PRR Agonists to the Potential of Defective Interfering Particles of Viruses.

Genetic Screen of a Mutant Poxvirus Library Identifies an Ankyrin Repeat Protein Involved in Blocking Induction of Avian Type I Interferon

The classical swine fever virus Npro product is degraded by cellular proteasomes in a manner that does not require interaction with interferon regulatory factor 3.

Control of the induction of type I interferon by Peste des petits ruminants virus

Genetic screen of a library of chimeric poxviruses identifies an ankyrin repeat protein involved in resistance to the avian type I interferon response.

Regulation of transcription of the Aedes albopictus cecropin A1 gene: A role for p38 mitogen-activated protein kinase.

Constitutively elevated levels of SOCS1 suppress innate responses in DF-1 immortalised chicken fibroblast cells

Activation of interferon-stimulated response element in huh-7 cells replicating hepatitis C virus subgenomic RNA.

Identification of residues within the African swine fever virus DP71L protein required for dephosphorylation of translation initiation factor eIF2α and inhibiting activation of pro-apoptotic CHOP.

A missense mutation in TRAPPC6A leads to build-up of the protein, in patients with a neurodevelopmental syndrome and dysmorphic features.

The switch between acute and persistent paramyxovirus infection caused by single amino acid substitutions in the RNA polymerase P subunit

Genome Sequence of the Parainfluenza Virus 5 Strain That Persistently Infects AGS Cells

The cellular localization of avian influenza virus PB1-F2 protein alters the magnitude of IFN2 promoter and NFκB-dependent promoter antagonism in chicken cells