List of works by Henne Holstege

A hidden layer of structural variation in transposable elements reveals potential genetic modifiers in human disease-risk loci

scientific article published on 24 March 2022

A high-throughput pharmaceutical screen identifies compounds with specific toxicity against BRCA2-deficient tumors

scientific article

A whole-genome mouse BAC microarray with 1-Mb resolution for analysis of DNA copy number changes by array comparative genomic hybridization

scientific article published in January 2004

ABCA7 p.G215S as potential protective factor for Alzheimer's disease

scientific article published on 20 April 2016

Activation of central melanocortin pathways by fenfluramine

scientific article

Alzheimer's disease risk variants modulate endophenotypes in mild cognitive impairment

scientific article

Analysis of C9orf72 repeat expansions in a large international cohort of dementia with Lewy bodies.

scientific article

BRD7 is a candidate tumour suppressor gene required for p53 function

scientific article

Centenarian controls increase variant effect sizes by an average twofold in an extreme case-extreme control analysis of Alzheimer's disease.

scientific article published on 26 September 2018

Characterization of pathogenic SORL1 genetic variants for association with Alzheimer's disease: a clinical interpretation strategy

scientific article published on 24 May 2017

Correction to: A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

scientific article published on 18 January 2020

Cross-species comparison of aCGH data from mouse and human BRCA1- and BRCA2-mutated breast cancers

scientific article

Dynamic clonal hematopoiesis and functional T-cell immunity in a supercentenarian

scientific article published on 12 November 2020

EIF2AK3 variants in Dutch patients with Alzheimer's disease

scientific article published on 24 August 2018

Extreme enrichment of VNTR-associated polymorphicity in human subtelomeres: genes with most VNTRs are predominantly expressed in the brain

scientific article published on 02 November 2020

Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases

scientific article published on 2 November 2015

Genome-wide significant risk factors for Alzheimer's disease: role in progression to dementia due to Alzheimer's disease among subjects with mild cognitive impairment

scientific article

High incidence of protein-truncating TP53 mutations in BRCA1-related breast cancer.

scientific article published on 31 March 2009

ICC-dementia (International Centenarian Consortium - dementia): an international consortium to determine the prevalence and incidence of dementia in centenarians across diverse ethnoracial and sociocultural groups

scientific article

Identification of cancer genes using a statistical framework for multiexperiment analysis of nondiscretized array CGH data

scientific article

Immune response and endocytosis pathways are associated with the resilience against Alzheimer's disease

scientific article published on 29 September 2020

Influence of genetic variants in SORL1 gene on the manifestation of Alzheimer's disease

scientific article published on 11 December 2014

KC-SMARTR: An R package for detection of statistically significant aberrations in multi-experiment aCGH data.

scientific article

Neuropathology and cognitive performance in self-reported cognitively healthy centenarians

scientific article published on 23 July 2018

Neuropsychological Test Performance of Cognitively Healthy Centenarians: Normative Data From the Dutch 100-Plus Study

scientific article published on 27 December 2018

PLD3 variants in population studies

scientific article published on April 2015

SUCLG2 identified as both a determinator of CSF Aβ1-42 levels and an attenuator of cognitive decline in Alzheimer's disease

scientific article

Selective inhibition of BRCA2-deficient mammary tumor cell growth by AZD2281 and cisplatin.

scientific article

Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer

scholarly article

Telomerase deletion limits progression of p53-mutant hepatocellular carcinoma with short telomeres in chronic liver disease

scientific article published on 26 January 2007

The 100-plus Study of cognitively healthy centenarians: rationale, design and cohort description

scientific article published on 25 October 2018

WISECONDOR: detection of fetal aberrations from shallow sequencing maternal plasma based on a within-sample comparison scheme.

scientific article published on 28 October 2013

Paulina is supported by:

About Paulina

Help