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List of works by Luke Alphey

A Drosophila homologue of oxysterol binding protein (OSBP)--implications for the role of OSBP.

scientific article published in January 1998

A dominant lethal genetic system for autocidal control of the Mediterranean fruitfly.

scientific article

A model framework to estimate impact and cost of genetics-based sterile insect methods for dengue vector control

scientific article (publication date: 2011)

Aedes aegypticontrol: the concomitant role of competition, space and transgenic technologies

article

Analyzing the control of mosquito-borne diseases by a dominant lethal genetic system

scholarly article

Appropriate regulation of GM insects.

scientific article

Assessment of the Impact of Potential Tetracycline Exposure on the Phenotype of Aedes aegypti OX513A: Implications for Field Use.

scientific article published on 13 August 2015

Biochemical characterization of recombinant Drosophila type 1 serine/threonine protein phosphatase (PP1c) produced in Pichia pastoris.

scientific article published in December 2001

CG15031/PPYR1 is an intrinsically unstructured protein that interacts with protein phosphatase Y.

scientific article published on 5 April 2006

CRISPR/Cas9 gene editing in the West Nile Virus vector, Culex quinquefasciatus Say

scientific article published on 12 November 2019

Can CRISPR-Cas9 gene drives curb malaria?

scientific article

Cas13b-dependent and Cas13b-independent RNA knockdown of viral sequences in mosquito cells following guide RNA expression

scientific article published on 31 July 2020

Cloning and expression of mars, a novel member of the guanylate kinase associated protein family in Drosophila

scientific article published on September 2004

Combining pest control and resistance management: synergy of engineered insects with Bt crops

scientific article published in April 2009

Comparison of life history characteristics of the genetically modified OX513A line and a wild type strain of Aedes aegypti

scientific article (publication date: 2011)

Complete reversions of a gypsy retrotransposon-induced cut locus mutation in Drosophila melanogaster involving jockey transposon insertions and flanking gypsy sequence deletions

scientific article published in January 1990

Conditions for success of engineered underdominance gene drive systems.

scientific article published on 17 July 2017

Considerations for homology-based DNA repair in mosquitoes: Impact of sequence heterology and donor template source

scientific article published on 18 February 2022

Control of the olive fruit fly using genetics-enhanced sterile insect technique

scientific article published on 19 June 2012

Core commitments for field trials of gene drive organisms

scientific article published on 01 December 2020

Cost of mating and insemination capacity of a genetically modified mosquito Aedes aegypti OX513A compared to its wild type counterpart

scientific article (publication date: 2011)

Criteria for identifying and evaluating candidate sites for open-field trials of genetically engineered mosquitoes

scientific article

Cross-utilisation of template RNAs by alphavirus replicases

scientific article published on 04 September 2020

Culex quinquefasciatus: status as a threat to island avifauna and options for genetic control

scientific article published in 2021

DengueTools: innovative tools and strategies for the surveillance and control of dengue

scientific article

Design and Use of Chikungunya Virus Replication Templates Utilizing Mammalian and Mosquito RNA Polymerase I-Mediated Transcription

scientific article published on 28 August 2019

Development of a population suppression strain of the human malaria vector mosquito, Anopheles stephensi

scientific article published on 26 April 2013

Dispersal of Engineered Male Aedes aegypti Mosquitoes

scientific article published on 10 November 2015

Dominant lethality and insect population control.

scientific article

Drosophila Uri, a PP1alpha binding protein, is essential for viability, maintenance of DNA integrity and normal transcriptional activity.

scientific article

DsRed2 transient expression in Culex quinquefasciatus mosquitoes

scientific article published on June 2013

Ectopic expression of inhibitors of protein phosphatase type 1 (PP1) can be used to analyze roles of PP1 in Drosophila development.

scientific article published on May 2003

Engineered action at a distance: Blood-meal-inducible paralysis in Aedes aegypti

scientific article published on 03 September 2019

Engineered anti-viral shRNAs are more effective than lhRNAs in transgenic Aedes aegypti

scientific article published in 2022

Engineered female-specific lethality for control of pest Lepidoptera

scientific article

Engineered repressible lethality for controlling the pink bollworm, a lepidopteran pest of cotton.

scientific article

Essential, overlapping and redundant roles of the Drosophila protein phosphatase 1 alpha and 1 beta genes.

scientific article published in May 2007

Estimation of Aedes aegypti (Diptera: Culicidae) population size and adult male survival in an urban area in Panama

scientific article

Expanding the CRISPR Toolbox in Culicine Mosquitoes: In Vitro Validation of Pol III Promoters

scientific article published on 04 March 2020

Female-specific flightless (fsRIDL) phenotype for control of Aedes albopictus

scientific article (publication date: 2012)

Female-specific flightless phenotype for mosquito control

scientific article

Female-specific insect lethality engineered using alternative splicing.

scientific article published on 18 February 2007

Field cage studies and progressive evaluation of genetically-engineered mosquitoes

scientific article

Field longevity of a fluorescent protein marker in an engineered strain of the pink bollworm, Pectinophora gossypiella (Saunders)

scientific article

Field performance of a genetically engineered strain of pink bollworm

scientific article (publication date: 2011)

Field performance of engineered male mosquitoes

scientific article

Fitness of transgenic mosquito Aedes aegypti males carrying a dominant lethal genetic system.

scientific article

Five things to know about genetically modified (GM) insects for vector control

scientific article

Flight performance and teneral energy reserves of two genetically-modified and one wild-type strain of the yellow fever mosquito Aedes aegypti

scientific article

Functional interaction between nuclear inhibitor of protein phosphatase type 1 (NIPP1) and protein phosphatase type 1 (PP1) in Drosophila: consequences of over-expression of NIPP1 in flies and suppression by co-expression of PP1.

scientific article published in December 2002

Genetic Biocontrol for Invasive Species ⬇️

scientific article published on 25 May 2020

Genetic control of Aedes aegypti: data-driven modelling to assess the effect of releasing different life stages and the potential for long-term suppression

scientific article

Genetic control of Aedes mosquitoes

scientific article published on June 2013

Genetic control of mosquitoes

scientific article published on 18 October 2013

Genetic control of vector populations: an imminent prospect.

scientific article published in April 2004

Genetic elimination of dengue vector mosquitoes.

scientific article

Genetic elimination of field-cage populations of Mediterranean fruit flies.

scientific article published in October 2014

Genetic pest management and the background genetics of release strains

scientific article published on 28 December 2020

Genetic sexing through the use of Y-linked transgenes

scientific article published on 19 July 2007

Germ line specific expression of a protein phosphatase Y interacting protein (PPYR1) in Drosophila

scientific article published on 10 March 2006

Germ-line transformation of the Mexican fruit fly.

scientific article published in October 2007

Germline transformation of the diamondback moth, Plutella xylostella L., using the piggyBac transposable element.

scientific article

High efficiency site-specific genetic engineering of the mosquito genome.

scientific article published on April 2006

Identification and characterization of the vasa gene in the diamondback moth, Plutella xylostella

scientific article published on 10 April 2020

Insect population control using a dominant, repressible, lethal genetic system.

scientific article published in March 2000

Insect population suppression using engineered insects

scientific article published on January 2008

Insect transformation with piggyBac: getting the number of injections just right.

scientific article published on 30 March 2016

Instability in the ctMR2 strain of Drosophila melanogaster: role of P element functions and structure of revertants

scientific article published on August 1989

Irritant and repellent behavioral responses of Aedes aegypti male populations developed for RIDL disease control strategies

scientific article published on November 2010

Is It Time for Synthetic Biodiversity Conservation?

scientific article

KLP38B: A Mitotic Kinesin-related Protein That Binds PP1 ⬇️

scientific article published on July 28, 1997

Late-acting dominant lethal genetic systems and mosquito control

scientific article

Malaria control with genetically manipulated insect vectors

scientific article published in October 2002

Managing Insecticide Resistance by Mass Release of Engineered Insects

scientific article published in October 2007

Managing insecticide resistance by mass release of engineered insects

scientific article published in October 2007

Mass production of genetically modified Aedes aegypti for field releases in Brazil.

scientific article

Mating compatibility and competitiveness of transgenic and wild type Aedes aegypti (L.) under contained semi-field conditions

scientific article

Mating competitiveness and life-table comparisons between transgenic and Indian wild-type Aedes aegypti L

scientific article

Modeling resistance to genetic control of insects

scientific article published on 12 November 2010

Modeling the mutation and reversal of engineered underdominance gene drives

scientific article published on 29 June 2019

Mosquito transgenesis: what is the fitness cost?

scientific article

Multiplex detection and SNP genotyping in a single fluorescence channel

scientific article (publication date: 2012)

Natural and engineered mosquito immunity

scientific article (publication date: 2009)

Ommochrome pathway genes kynurenine 3-hydroxylase and cardinal participate in eye pigmentation in Plutella xylostella

scientific article published on 11 September 2020

Open field release of genetically engineered sterile male Aedes aegypti in Malaysia

scientific article

Opinion: Standardizing the definition of gene drive

scientific article published on 18 November 2020

Oral ingestion of transgenic RIDL Ae. aegypti larvae has no negative effect on two predator Toxorhynchites species.

scientific article

PNUTS/PP1 regulates RNAPII-mediated gene expression and is necessary for developmental growth.

scientific article

PP1 binds Sara and negatively regulates Dpp signaling in Drosophila melanogaster

scientific article

PP1beta9C interacts with Trithorax in Drosophila wing development

scientific article published on 01 October 2004

Pest control and resistance management through release of insects carrying a male-selecting transgene

scientific article

Polymerase chain displacement reaction

scientific article published on February 2013

Population dynamics of engineered underdominance and killer-rescue gene drives in the control of disease vectors.

scientific article published on 23 March 2018

Population-level effects of fitness costs associated with repressible female-lethal transgene insertions in two pest insects

scientific article (publication date: May 2014)

Population-level multiplexing: A promising strategy to manage the evolution of resistance against gene drives targeting a neutral locus

scientific article published on 25 March 2020

Practical applications of insects' sexual development for pest control.

scientific article published on 03 January 2014

Proportions of different habitat types are critical to the fate of a resistance allele

scientific article published in 2008

Protein phosphatase 1beta is required for the maintenance of muscle attachments

scientific article published in March 2000

Re-engineering the sterile insect technique

scientific article

Recent advances in threshold-dependent gene drives for mosquitoes

article

SIT 2.0: 21st Century genetic technology for the screwworm sterile-insect program

scientific article

Sex separation strategies: past experience and new approaches

scientific article

Site-specific cassette exchange systems in the Aedes aegypti mosquito and the Plutella xylostella moth

scientific article

Split drive killer-rescue provides a novel threshold-dependent gene drive

scientific article published on 25 November 2020

Sterile-insect methods for control of mosquito-borne diseases: an analysis

scientific article

Successful suppression of a field mosquito population by sustained release of engineered male mosquitoes

scientific article

Suppression of a Field Population of Aedes aegypti in Brazil by Sustained Release of Transgenic Male Mosquitoes

scientific article

Targeting female flight for genetic control of mosquitoes

scientific article published on 03 December 2020

The essential role of PP1beta in Drosophila is to regulate nonmuscle myosin

scientific article published on 21 July 2004

The nonmuscle myosin phosphatase PP1beta (flapwing) negatively regulates Jun N-terminal kinase in wing imaginal discs of Drosophila

scientific article published on 4 February 2007

The orthologue of the fruitfly sex behaviour gene fruitless in the mosquito Aedes aegypti: evolution of genomic organisation and alternative splicing.

scientific article

The structure of protein phosphatase 2A is as highly conserved as that of protein phosphatase 1.

scientific article

Towards a comprehensive analysis of the protein phosphatase 1 interactome in Drosophila.

scientific article published on 7 September 2006

Towards the genetic control of invasive species. ⬇️

scientific article

Transcriptional and post-transcriptional control mechanisms coordinate the onset of spermatid differentiation with meiosis I in Drosophila ⬇️

scientific article published on January 1, 1998

Transcriptomics and disease vector control

scientific article published on 7 May 2010

Transgene-based, female-specific lethality system for genetic sexing of the silkworm, Bombyx mori

scientific article published on 8 April 2013

Transgenic Control of Vectors: The Effects of Interspecific Interactions

scientific article published in 2010

Transposon-free insertions for insect genetic engineering.

scientific article published on 25 June 2006

Trithorax interacts with type 1 serine/threonine protein phosphatase in Drosophila.

scientific article published on January 2003

Use of a regulatory mechanism of sex determination in pest insect control.

scientific article published in September 2010

Variation in adult sex ratio alters the association between courtship, mating frequency and paternity in the lek-forming fruitfly Ceratitis capitata.

scientific article published on 21 June 2012

Why RIDL is not SIT.

scientific article published on 12 June 2011

Yeast two-hybrid screens to identify Drosophila PP1-binding proteins.

scientific article

giant nuclei is essential in the cell cycle transition from meiosis to mitosis.

scientific article published in July 2003

piggybac- and PhiC31-mediated genetic transformation of the Asian tiger mosquito, Aedes albopictus (Skuse).

scientific article published on 17 August 2010

twine, a cdc25 homolog that functions in the male and female germline of Drosophila

scientific article

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