List of works by Jeremy W Tomlinson

"Cushing's disease of the omentum"--fact or fiction?

scientific article published on February 2004

11Beta-hydroxysteroid dehydrogenase type 1 in differentiating omental human preadipocytes: from de-activation to generation of cortisol

scientific article published in November 2002

11Beta-hydroxysteroid dehydrogenase type 1 in human disease: a novel therapeutic target.

scientific article

11beta-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of type 2 diabetes

scientific article

11beta-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle ⬇️

scientific article published on 12 August 2009

11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response

scientific article

11β-HSD1 Modulates the Set Point of Brown Adipose Tissue Response to Glucocorticoids in Male Mice ⬇️

scientific article

11β-HSD1 is the major regulator of the tissue-specific effects of circulating glucocorticoid excess

scientific article

11β-Hydroxysteroid dehydrogenase 1: translational and therapeutic aspects

scientific article published on 23 April 2013

11β-Hydroxysteroid dehydrogenase type 1 inhibition in idiopathic intracranial hypertension: a double-blind randomized controlled trial

scientific article published on 10 January 2020

11βHSD1 inhibition with AZD4017 improves lipid profiles and lean muscle mass in Idiopathic intracranial hypertension

scientific article published on 24 October 2020

5α-Reductase Type 2 Regulates Glucocorticoid Action and Metabolic Phenotype in Human Hepatocytes

scientific article published on 14 May 2015

A comparative quality assessment of evidence-based clinical guidelines in endocrinology

scientific article published on February 2013

A novel selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitor prevents human adipogenesis. ⬇️

scientific article published on May 2008

A potential role for hepcidin in obesity-driven colorectal tumourigenesis

scientific article published on 31 October 2017

A switch in hepatic cortisol metabolism across the spectrum of non alcoholic fatty liver disease ⬇️

scientific article

A unique androgen excess signature in idiopathic intracranial hypertension is linked to cerebrospinal fluid dynamics

scientific article published on 21 March 2019

AKR1C3-Mediated Adipose Androgen Generation Drives Lipotoxicity in Women With Polycystic Ovary Syndrome.

scientific article published on 22 June 2017

AKR1D1 is a novel regulator of metabolic phenotype in human hepatocytes and is dysregulated in non-alcoholic fatty liver disease

scientific article published on 19 July 2019

AKR1D1 knockout mice develop a sex-dependent metabolic phenotype

scientific article published in 2022

AKR1D1 regulates glucocorticoid availability and glucocorticoid receptor activation in human hepatoma cells

scientific article published on 12 February 2019

Abdominal subcutaneous adipose tissue insulin resistance and lipolysis in patients with non-alcoholic steatohepatitis

scientific article

Absence of Cushingoid phenotype in a patient with Cushing's disease due to defective cortisone to cortisol conversion

scientific article published in January 2002

Accurate non-invasive diagnosis and staging of non-alcoholic fatty liver disease using the urinary steroid metabolome

scientific article published on 16 April 2020

Acute Hypercortisolemia Exerts Depot-Specific Effects on Abdominal and Femoral Adipose Tissue Function

scientific article published on 16 February 2017

Adipocyte differentiation, mitochondrial gene expression and fat distribution: differences between zidovudine and tenofovir after 6 months

scientific article published in January 2009

Adrenal suppression in patients taking inhaled glucocorticoids is highly prevalent and management can be guided by morning cortisol ⬇️

scientific article published on 20 August 2015

Advanced non-alcoholic fatty liver disease and adipose tissue fibrosis in patients with Alström syndrome.

scientific article

Altered cortisol metabolism in individuals with HNF1A-MODY

scientific article published on 12 May 2020

Androgen generation in adipose tissue in women with simple obesity--a site-specific role for 17beta-hydroxysteroid dehydrogenase type 5.

scientific article published in November 2004

Association between hypercortisolaemia and adipose tissue blood flow in vivo

scientific article published in February 2015

Baseline morning cortisol level as a predictor of pituitary-adrenal reserve: a comparison across three assays

scientific article published on 12 September 2016

Care standards for non-alcoholic fatty liver disease in the United Kingdom 2016: a cross-sectional survey

scientific article published on 28 April 2017

Central hypoadrenalism.

scientific article

Cerebrospinal fluid corticosteroid levels and cortisol metabolism in patients with idiopathic intracranial hypertension: a link between 11beta-HSD1 and intracranial pressure regulation?

scientific article published on 8 September 2010

Characterisation of 11beta-hydroxysteroid dehydrogenase 1 in human orbital adipose tissue: a comparison with subcutaneous and omental fat. ⬇️

scientific article published on February 2007

Corticosteroids, 11beta-hydroxysteroid dehydrogenase isozymes and the rabbit choroid plexus.

scientific article

Cortisol metabolism, postnatal depression and weight changes in the first 12 months postpartum.

scientific article

Cortisol, 11 beta-hydroxysteroid dehydrogenase type 1 and central obesity

scientific article published in April 2002

Current therapeutic strategies in non-alcoholic fatty liver disease.

scientific article published on August 2011

Dehydroepiandrosterone exerts antiglucocorticoid action on human preadipocyte proliferation, differentiation, and glucose uptake ⬇️

scientific article published on 10 September 2013

Depot-specific prostaglandin synthesis in human adipose tissue: a novel possible mechanism of adipogenesis

scientific article published on 10 June 2006

Development of hepatocellular carcinoma in a murine model of nonalcoholic steatohepatitis induced by use of a high-fat/fructose diet and sedentary lifestyle

scientific article published on 17 March 2014

Diagnosis and management of adrenal insufficiency

scientific article published on 03 August 2014

Differential adipose tissue gene expression profiles in abacavir treated patients that may contribute to the understanding of cardiovascular risk: a microarray study

scientific article

Differential glucocorticoid metabolism in patients with persistent versus resolving inflammatory arthritis ⬇️

scientific article published on 14 May 2015

Diminished 11β-hydroxysteroid dehydrogenase type 2 activity is associated with decreased weight and weight gain across the first year of life

scientific article

Dual-5α-Reductase Inhibition Promotes Hepatic Lipid Accumulation in Man

scientific article

Dysregulation of 11beta-hydroxysteroid dehydrogenases: implications during pregnancy and beyond.

scientific article published on 28 March 2016

Early occurrence of new-onset diabetes after transplantation is related to type of liver graft and warm ischaemic injury.

scientific article published on 20 November 2014

Editorial: can urine-based metabolomics improve diagnosis of advanced fibrosis in NAFLD? Authors' reply

scientific article published on 01 June 2020

Effect of insulin on AKR1C3 expression in female adipose tissue: in-vivo and in-vitro study of adipose androgen generation in polycystic ovary syndrome.

scientific article published in February 2015

Effects of interventions in pregnancy on maternal weight and obstetric outcomes: meta-analysis of randomised evidence

scientific article

Effects of the 5-HT2C receptor agonist meta-chlorophenylpiperazine on appetite, food intake and emotional processing in healthy volunteers

scientific article

Electron interactions and transport between coupled quantum Hall edge states

scientific article published on 03 March 2005

Elevated cerebrospinal fluid (CSF) leptin in idiopathic intracranial hypertension (IIH): evidence for hypothalamic leptin resistance?

scientific article published on 2 September 2008

Evaluating the Fat Distribution in Idiopathic Intracranial Hypertension Using Dual-Energy X-ray Absorptiometry Scanning.

scientific article published on 20 June 2017

Evidence for a shift to anaerobic metabolism in adipose tissue in efavirenz-containing regimens for HIV with different nucleoside backbones

scientific article published on 13 December 2011

Extensive weight loss can reduce immune age by altering IgG N-glycosylation

scientific article published on 29 April 2020

Gender-Specific Differences in Skeletal Muscle 11β-HSD1 Expression Across Healthy Aging

scientific article published on 19 May 2015

Glucagon-like peptide 1 decreases lipotoxicity in non-alcoholic steatohepatitis.

scientific article

Glucocorticoid modulation of insulin signaling in human subcutaneous adipose tissue

scientific article published on 21 August 2007

Glucocorticoids and non-alcoholic fatty liver disease.

scientific article published on August 2015

Glucocorticoids fail to cause insulin resistance in human subcutaneous adipose tissue in vivo

scientific article published on 20 February 2013

Glucocorticoids regulate AKR1D1 activity in human liver in vitro and in vivo

scientific article published on 01 February 2020

Guidelines for liver transplantation for patients with non-alcoholic steatohepatitis

scientific article published on 10 January 2012

Hepatitis C virus infection is associated with hepatic and adipose tissue insulin resistance that improves after viral cure

scientific article published on 17 January 2019

Hexose-6-phosphate dehydrogenase confers oxo-reductase activity upon 11 beta-hydroxysteroid dehydrogenase type 1.

scientific article published in June 2005

Hormonal regulation of lipogenesis

scientific article published on January 2013

Hyperandrogenemia predicts metabolic phenotype in polycystic ovary syndrome: the utility of serum androstenedione

scientific article published on January 2014

IGFALS gene dosage effects on serum IGF-I and glucose metabolism, body composition, bone growth in length and width, and the pharmacokinetics of recombinant human IGF-I administration

scientific article published on 13 January 2014

Impaired glucose tolerance and insulin resistance are associated with increased adipose 11beta-hydroxysteroid dehydrogenase type 1 expression and elevated hepatic 5alpha-reductase activity ⬇️

scientific article published on 15 July 2008

Increased 5 alpha-reductase activity and adrenocortical drive in women with polycystic ovary syndrome

scientific article

Increased central adiposity and decreased subcutaneous adipose tissue 11β-hydroxysteroid dehydrogenase type 1 are associated with deterioration in glucose tolerance-A longitudinal cohort study

scientific article published on 17 April 2019

Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 activity in vivo limits glucocorticoid exposure to human adipose tissue and decreases lipolysis.

scientific article published on 2 January 2007

Lack of hexose-6-phosphate dehydrogenase impairs lipid mobilization from mouse adipose tissue

scientific article published on 24 January 2008

Lack of significant metabolic abnormalities in mice with liver-specific disruption of 11β-hydroxysteroid dehydrogenase type 1.

scientific article

Learning pharmacokinetic models for in vivo glucocorticoid activation

Liraglutide efficacy and action in non-alcoholic steatohepatitis (LEAN): study protocol for a phase II multicentre, double-blinded, randomised, controlled trial

scientific article (publication date: 4 November 2013)

Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study

scientific article published on 19 November 2015

Liver biochemical abnormalities in Turner syndrome: A comprehensive characterization of an adult population

scientific article published on 19 August 2018

Longitudinal changes in glucocorticoid metabolism are associated with later development of adverse metabolic phenotype

scientific article published on July 2014

Loss of 5α-reductase type 1 accelerates the development of hepatic steatosis but protects against hepatocellular carcinoma in male mice

scientific article

Low energy diet and intracranial pressure in women with idiopathic intracranial hypertension: prospective cohort study ⬇️

scientific article (publication date: 7 July 2010)

Low-dose growth hormone inhibits 11 beta-hydroxysteroid dehydrogenase type 1 but has no effect upon fat mass in patients with simple obesity

scientific article published in May 2003

Male 11β-HSD1 Knockout Mice Fed Trans-Fats and Fructose Are Not Protected From Metabolic Syndrome or Nonalcoholic Fatty Liver Disease ⬇️

scientific article published on 6 July 2016

Mechanisms of disease: Selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 as a novel treatment for the metabolic syndrome

scientific article published on December 2005

Mitotane Therapy in Adrenocortical Cancer Induces CYP3A4 and Inhibits 5α-Reductase, Explaining the Need for Personalized Glucocorticoid and Androgen Replacement

scientific article published on 16 November 2012

Modified-Release and Conventional Glucocorticoids and Diurnal Androgen Excretion in Congenital Adrenal Hyperplasia.

scientific article published in June 2017

Modulation of glucocorticoid action and the treatment of type-2 diabetes

scientific article published on December 2007

Mortality in patients with pituitary disease

scientific article published on 19 January 2010

Mutations in the genes encoding 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency

scientific article

Non-alcoholic fatty liver disease and diabetes

scientific article published on 11 January 2016

Nonalcoholic Fatty Liver Disease in Adults: Current Concepts in Etiology, Outcomes, and Management

scientific article published on 01 January 2020

Nonclassic lipoid congenital adrenal hyperplasia masquerading as familial glucocorticoid deficiency

scientific article

Of mice and men: Is there a future for metformin in the treatment of hepatic steatosis?

scientific article published on 21 December 2018

Optimizing human hepatocyte models for metabolic phenotype and function: effects of treatment with dimethyl sulfoxide (DMSO).

scientific article published on November 2016

Orlistat for overweight subjects with nonalcoholic steatohepatitis.

scientific article published in July 2009

PYY plays a key role in the resolution of diabetes following bariatric surgery in humans

scientific article published on 11 January 2019

Pathogenesis of non-alcoholic fatty liver disease.

scientific article

Peri-operative corticosteroid supplementation for patients on therapeutic glucocorticoids: a national survey

scientific article published on 25 June 2020

Plasma Renin Measurements are Unrelated to Mineralocorticoid Replacement Dose in Patients With Primary Adrenal Insufficiency

scientific article published on 01 January 2020

Prevalence and severity of non-alcoholic fatty liver disease are underestimated in clinical practice: impact of a dedicated screening approach at a large university teaching hospital.

scientific article published on 2 November 2017

Reduced 11beta-hydroxysteroid dehydrogenase type 1 activity in obese boys.

scientific article published in September 2007

Reduced glucocorticoid production rate, decreased 5alpha-reductase activity, and adipose tissue insulin sensitization after weight loss

scientific article

Regulation of lipid metabolism by glucocorticoids and 11β-HSD1 in skeletal muscle

scientific article published on 30 April 2013

Regulation of lipogenesis by glucocorticoids and insulin in human adipose tissue ⬇️

scientific article

Regulation--the real threat to clinical research.

scientific article published on 16 October 2008

Response to the Letter: "Dual-5α-Reductase Inhibition Promotes Hepatic Lipid Accumulation in Man"

scientific article published on 01 April 2016

SFRP2 Is Associated with Increased Adiposity and VEGF Expression ⬇️

scientific article

Safety and efficacy of liraglutide in patients with type 2 diabetes and elevated liver enzymes: individual patient data meta-analysis of the LEAD program.

scientific article

Selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 for patients with metabolic syndrome: is the target liver, fat, or both? ⬇️

scientific article published on January 2009

Severe asymptomatic non-alcoholic fatty liver disease in routine diabetes care; a multi-disciplinary team approach to diagnosis and management

scientific article published on 15 October 2013

Sex Differences in Hepatic Lipogenesis with Acute Fructose Feeding

Short- and long-term glucocorticoid treatment enhances insulin signalling in human subcutaneous adipose tissue. ⬇️

scientific article published on 31 January 2011

Special issue on Steroids in Obesity and Diabetes ⬇️

scientific article published on 01 October 2010

Steroid biomarkers and genetic studies reveal inactivating mutations in hexose-6-phosphate dehydrogenase in patients with cortisone reductase deficiency

scientific article

Steroid metabolome analysis reveals prevalent glucocorticoid excess in primary aldosteronism

scientific article

The 5-HT2C receptor agonist meta-chlorophenylpiperazine (mCPP) reduces palatable food consumption and BOLD fMRI responses to food images in healthy female volunteers

scientific article

The A-ring reduction of 11-ketotestosterone is efficiently catalysed by AKR1D1 and SRD5A2 but not SRD5A1

scientific article published on 03 July 2020

The Dehydrogenase Hypothesis

scientific article published on January 2015

The Endocrine and Metabolic Characteristics of a large Bardet-Biedl syndrome clinic population

scientific article published in February 2018

The Short Synacthen (Corticotropin) Test Can Be Used to Predict Recovery of Hypothalamo-Pituitary-Adrenal Axis Function

scientific article published on 01 August 2018

The long-term predictive accuracy of the short synacthen (corticotropin) stimulation test for assessment of the hypothalamic-pituitary-adrenal axis

scientific article

The role of 11 beta-hydroxysteroid dehydrogenase in central obesity and osteoporosis

scientific article published on 01 November 2000

The role of 11beta-hydroxysteroid dehydrogenase 1 in adipogenesis in thyroid-associated ophthalmopathy

scientific article published on 30 October 2009

Tissue specific regulation of glucocorticoids in severe obesity and the response to significant weight loss following bariatric surgery (BARICORT).

scientific article published on 20 January 2015

Treating hypertension in diabetic nephropathy

scientific article published in June 2003

Treatment with PBI-4050 in patients with Alström syndrome: study protocol for a phase 2, single-Centre, single-arm, open-label trial

scientific article published on 26 November 2018

Understanding androgen action in adipose tissue

scientific article published on 28 April 2014

Vascular adhesion protein-1 promotes liver inflammation and drives hepatic fibrosis

scientific article

Very low calorie diets are associated with transient ventricular impairment before reversal of diastolic dysfunction in obesity

scientific article published on 21 November 2018

Weight loss increases 11beta-hydroxysteroid dehydrogenase type 1 expression in human adipose tissue

scientific article

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