List of works - Stuart A Ralph

3,3'-Disubstituted 5,5'-Bi(1,2,4-triazine) Derivatives with Potent in Vitro and in Vivo Antimalarial Activity

scientific article published on 05 March 2019

A dual-targeted aminoacyl-tRNA synthetase in Plasmodium falciparum charges cytosolic and apicoplast tRNACys

scientific article (publication date: 15 March 2014)

A genome-wide chromatin-associated nuclear peroxiredoxin from the malaria parasite Plasmodium falciparum

scientific article (publication date: April 2011)

A serine-arginine-rich (SR) splicing factor modulates alternative splicing of over a thousand genes in Toxoplasma gondii.

scientific article published on 13 April 2015

A type II pathway for fatty acid biosynthesis presents drug targets in Plasmodium falciparum

scientific article

AMPK beta subunits display isoform specific affinities for carbohydrates

scientific article

Alternative Splicing in Apicomplexan Parasites

article published in 2019

Alternative splicing is required for stage differentiation in malaria parasites.

scientific article published in August 2019

Aminoacyl-tRNA synthetases as drug targets in eukaryotic parasites

scientific article

An EGF-like protein forms a complex with PfRh5 and is required for invasion of human erythrocytes by Plasmodium falciparum ⬇️

scientific article (publication date: September 2011)

An FtsH protease is recruited to the mitochondrion of Plasmodium falciparum

scientific article

An integrative bioinformatic predictor of protein sub-cellular localisation in malaria

scientific article published on 21 November 2011

Antigenic variation in Plasmodium falciparum is associated with movement of var loci between subnuclear locations

scientific article

Artemisinin Action and Resistance in Plasmodium falciparum

scientific article published in September 2016

Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome

scientific article published in Nature Communications

Biosynthesis, localization, and macromolecular arrangement of the Plasmodium falciparum translocon of exported proteins (PTEX)

scientific article (publication date: 9 March 2012)

Characterization of a hepatitis C virus-like particle vaccine produced in a human hepatocyte-derived cell line

scientific article published on 4 May 2016

Chronic arsenic exposure and microbial drug resistance

scientific article

Comparative genomics of the neglected human malaria parasite Plasmodium vivax

scientific article

Comparative transcriptomics of female and male gametocytes in Plasmodium berghei and the evolution of sex in alveolates

scientific article published on 18 September 2017

Cryo-electron tomography reveals four-membrane architecture of the Plasmodium apicoplast

scientific article

Deciphering apicoplast targeting signals--feature extraction from nuclear-encoded precursors of Plasmodium falciparum apicoplast proteins

scientific article (publication date: 12 December 2001)

Decreased K13 Abundance Reduces Hemoglobin Catabolism and Proteotoxic Stress, Underpinning Artemisinin Resistance

scientific article published on 01 November 2019

Delayed Death by Plastid Inhibition in Apicomplexan Parasites

scientific article published on 16 August 2019

Delayed death in the malaria parasite Plasmodium falciparum is caused by disruption of prenylation-dependent intracellular trafficking

scientific article published on 18 July 2019

Determination of protein subcellular localization in apicomplexan parasites

scientific article published on 17 September 2012

Differential sub-nuclear localisation of repressive and activating histone methyl modifications in P. falciparum

scientific article

Dissecting apicoplast targeting in the malaria parasite Plasmodium falciparum

scientific article published in January 2003

Drug target prediction and prioritization: using orthology to predict essentiality in parasite genomes

scientific article published in 2010

Dual targeting of aminoacyl-tRNA synthetases to the apicoplast and cytosol in Plasmodium falciparum

scientific article (publication date: February 2012)

Dynamin: the endosymbiosis ring of power?

scholarly article

Electron tomography of Plasmodium falciparum merozoites reveals core cellular events that underpin erythrocyte invasion

scientific article

Evolution of malaria parasite plastid targeting sequences

scholarly article

Evolutionary pressures on apicoplast transit peptides

scientific article

Expression of P. falciparum var genes involves exchange of the histone variant H2A.Z at the promoter

scientific article

Functional Characterization of the m

scientific article

Genome Sequence of Theileria parva, a Bovine Pathogen That Transforms Lymphocytes

scientific article

Genome sequence of the human malaria parasite Plasmodium falciparum

scientific article

Genomic-scale prioritization of drug targets: the TDR Targets database

scientific article

Identification of attractive drug targets in neglected-disease pathogens using an in silico approach

scientific article

In silico prediction of antimalarial drug target candidates

scientific article published on 17 July 2012

Independent translocation of two micronemal proteins in developing Plasmodium falciparum merozoites

scientific article

Integrative proteomics and bioinformatic prediction enable a high-confidence apicoplast proteome in malaria parasites

scientific article published on 13 September 2018

Interaction between Plasmodium falciparum apical membrane antigen 1 and the rhoptry neck protein complex defines a key step in the erythrocyte invasion process of malaria parasites ⬇️

scientific article

Interaction of apicoplast-encoded elongation factor (EF) EF-Tu with nuclear-encoded EF-Ts mediates translation in the Plasmodiumfalciparum plastid

scientific article (publication date: March 2011)

Investigation of the Plasmodium falciparum food vacuole through inducible expression of the chloroquine resistance transporter (PfCRT)

scientific article

Isolation of viable Plasmodium falciparum merozoites to define erythrocyte invasion events and advance vaccine and drug development ⬇️

scientific article

K13, the Cytostome, and Artemisinin Resistance

scientific article published on 17 April 2020

Large scale production of a mammalian cell derived quadrivalent hepatitis C virus like particle vaccine.

scientific article published on 29 June 2016

Malaria parasite signal peptide peptidase is an ER-resident protease required for growth but not for invasion

scientific article (publication date: November 2012)

Massively parallel sequencing and analysis of the Necator americanus transcriptome

scientific article published on 11 May 2010

Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis

scientific article

Membrane transporters in the relict plastid of malaria parasites

scientific article (publication date: 20 June 2006)

Metabolic Dysregulation Induced in Plasmodium falciparum by Dihydroartemisinin and Other Front-Line Antimalarial Drugs

scientific article published on 6 July 2015

Metabolomics-Based Screening of the Malaria Box Reveals both Novel and Established Mechanisms of Action

scientific article

Non-canonical metabolic pathways in the malaria parasite detected by isotope-tracing metabolomics.

scientific article

Novel vacuoles in Toxoplasma

scientific article published on 25 May 2010

Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles

scientific article published on 14 September 2016

Organellar proteomics reveals hundreds of novel nuclear proteins in the malaria parasite Plasmodium falciparum

scientific article

PfCERLI1 is a conserved rhoptry associated protein essential for Plasmodium falciparum merozoite invasion of erythrocytes ⬇️

scientific article published on 16 March 2020

Phenotypic variation of Plasmodium falciparum merozoite proteins directs receptor targeting for invasion of human erythrocytes ⬇️

scientific article (publication date: 3 March 2003)

Plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase is a potential drug target

scientific article (publication date: October 2015)

Plasmodium falciparum heterochromatin protein 1 marks genomic loci linked to phenotypic variation of exported virulence factors

scientific article published in September 2009

Plasmodium falciparum merozoite invasion is inhibited by antibodies that target the PfRh2a and b binding domains ⬇️

scientific article

Plasmodium sexual differentiation: how to make a female

scientific article published on 18 July 2019

Potential epigenetic regulatory proteins localise to distinct nuclear sub-compartments in Plasmodium falciparum

scientific article (publication date: 2010)

Properties and prediction of mitochondrial transit peptides from Plasmodium falciparum

scientific article (publication date: December 2003)

Protein translation in Plasmodium parasites.

scientific article published on 07 July 2011

REX1 and Pf62: are they one and the same?

scientific article published on April 2009

Recycling factors for ribosome disassembly in the apicoplast and mitochondrion of Plasmodium falciparum

scientific article (publication date: June 2013)

Reduced ribosomes of the apicoplast and mitochondrion of Plasmodium spp. and predicted interactions with antibiotics

scientific article (publication date: May 2014)

Reticulocyte-binding protein homologue 5 - an essential adhesin involved in invasion of human erythrocytes by Plasmodium falciparum

scientific article published on 25 October 2008

Selective inhibition of apicoplast tryptophanyl-tRNA synthetase causes delayed death in Plasmodium falciparum

scientific article (publication date: 9 June 2016)

Sir2 paralogues cooperate to regulate virulence genes and antigenic variation in Plasmodium falciparum

scientific article (publication date: 14 April 2009)

Spatial localisation of actin filaments across developmental stages of the malaria parasite

scientific article (publication date: 2012)

Stepwise dissection of Plasmodium falciparum merozoite invasion of the human erythrocyte ⬇️

Stepwise dissection of Plasmodium falciparum merozoite invasion of the human erythrocyte. ⬇️

scientific article

Steroid-sensitive nephrotic syndrome and vascular endothelial growth factor gene polymorphisms

scientific article published on 01 February 2003

Strange organelles--Plasmodium mitochondria lack a pyruvate dehydrogenase complex

scientific article published in January 2005

Subcellular multitasking - multiple destinations and roles for the Plasmodium falcilysin protease

scientific article published on 01 January 2007

Subcompartmentalisation of proteins in the rhoptries correlates with ordered events of erythrocyte invasion by the blood stage malaria parasite

scientific article (publication date: 2012)

Super-resolution dissection of coordinated events during malaria parasite invasion of the human erythrocyte

scientific article published in January 2011

TDR Targets: a chemogenomics resource for neglected diseases

scientific article published on 23 November 2011

Targeting Protein Translation in Organelles of the Apicomplexa

scientific article published on 25 October 2016

Targeting and function of proteins mediating translation initiation in organelles of Plasmodium falciparum

scientific article (publication date: May 2015)

Telomeric heterochromatin propagation and histone acetylation control mutually exclusive expression of antigenic variation genes in malaria parasites

scientific article (publication date: 8 April 2005)

The Plasmodium rhoptry associated protein complex is important for parasitophorous vacuole membrane structure and intraerythrocytic parasite growth

scientific article (publication date: 15 February 2017)

The apicoplast as an antimalarial drug target

scientific article (publication date: June 2001)

The cysteine protease dipeptidyl aminopeptidase 3 does not contribute to egress of Plasmodium falciparum from host red blood cells

scientific article published in PLoS ONE

The epigenetic control of antigenic variation in Plasmodium falciparum

scientific article

Theileria apicoplast as a target for chemotherapy

scientific article published on 15 December 2008

Transcriptome analysis of antigenic variation in Plasmodium falciparum--var silencing is not dependent on antisense RNA

scientific article

Tropical infectious diseases: metabolic maps and functions of the Plasmodium falciparum apicoplast

scientific article published in March 2004

List of works by Stuart A Ralph

3,3'-Disubstituted 5,5'-Bi(1,2,4-triazine) Derivatives with Potent in Vitro and in Vivo Antimalarial Activity

A dual-targeted aminoacyl-tRNA synthetase in Plasmodium falciparum charges cytosolic and apicoplast tRNACys

A genome-wide chromatin-associated nuclear peroxiredoxin from the malaria parasite Plasmodium falciparum

A serine-arginine-rich (SR) splicing factor modulates alternative splicing of over a thousand genes in Toxoplasma gondii.

A type II pathway for fatty acid biosynthesis presents drug targets in Plasmodium falciparum

AMPK beta subunits display isoform specific affinities for carbohydrates

Alternative Splicing in Apicomplexan Parasites

Alternative splicing is required for stage differentiation in malaria parasites.

Aminoacyl-tRNA synthetases as drug targets in eukaryotic parasites

An EGF-like protein forms a complex with PfRh5 and is required for invasion of human erythrocytes by Plasmodium falciparum ⬇️

An FtsH protease is recruited to the mitochondrion of Plasmodium falciparum

An integrative bioinformatic predictor of protein sub-cellular localisation in malaria

Antigenic variation in Plasmodium falciparum is associated with movement of var loci between subnuclear locations

Artemisinin Action and Resistance in Plasmodium falciparum

Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome

Biosynthesis, localization, and macromolecular arrangement of the Plasmodium falciparum translocon of exported proteins (PTEX)

Characterization of a hepatitis C virus-like particle vaccine produced in a human hepatocyte-derived cell line

Chronic arsenic exposure and microbial drug resistance

Comparative genomics of the neglected human malaria parasite Plasmodium vivax

Comparative transcriptomics of female and male gametocytes in Plasmodium berghei and the evolution of sex in alveolates

Cryo-electron tomography reveals four-membrane architecture of the Plasmodium apicoplast

Deciphering apicoplast targeting signals--feature extraction from nuclear-encoded precursors of Plasmodium falciparum apicoplast proteins

Decreased K13 Abundance Reduces Hemoglobin Catabolism and Proteotoxic Stress, Underpinning Artemisinin Resistance

Delayed Death by Plastid Inhibition in Apicomplexan Parasites

Delayed death in the malaria parasite Plasmodium falciparum is caused by disruption of prenylation-dependent intracellular trafficking

Determination of protein subcellular localization in apicomplexan parasites

Differential sub-nuclear localisation of repressive and activating histone methyl modifications in P. falciparum

Dissecting apicoplast targeting in the malaria parasite Plasmodium falciparum

Drug target prediction and prioritization: using orthology to predict essentiality in parasite genomes

Dual targeting of aminoacyl-tRNA synthetases to the apicoplast and cytosol in Plasmodium falciparum

Dynamin: the endosymbiosis ring of power?

Electron tomography of Plasmodium falciparum merozoites reveals core cellular events that underpin erythrocyte invasion

Evolution of malaria parasite plastid targeting sequences

Evolutionary pressures on apicoplast transit peptides

Expression of P. falciparum var genes involves exchange of the histone variant H2A.Z at the promoter

Functional Characterization of the m

Genome Sequence of Theileria parva, a Bovine Pathogen That Transforms Lymphocytes

Genome sequence of the human malaria parasite Plasmodium falciparum

Genomic-scale prioritization of drug targets: the TDR Targets database

Identification of attractive drug targets in neglected-disease pathogens using an in silico approach

In silico prediction of antimalarial drug target candidates

Independent translocation of two micronemal proteins in developing Plasmodium falciparum merozoites

Integrative proteomics and bioinformatic prediction enable a high-confidence apicoplast proteome in malaria parasites

Interaction between Plasmodium falciparum apical membrane antigen 1 and the rhoptry neck protein complex defines a key step in the erythrocyte invasion process of malaria parasites ⬇️

Interaction of apicoplast-encoded elongation factor (EF) EF-Tu with nuclear-encoded EF-Ts mediates translation in the Plasmodiumfalciparum plastid

Investigation of the Plasmodium falciparum food vacuole through inducible expression of the chloroquine resistance transporter (PfCRT)

Isolation of viable Plasmodium falciparum merozoites to define erythrocyte invasion events and advance vaccine and drug development ⬇️

K13, the Cytostome, and Artemisinin Resistance

Large scale production of a mammalian cell derived quadrivalent hepatitis C virus like particle vaccine.

Malaria parasite signal peptide peptidase is an ER-resident protease required for growth but not for invasion

Massively parallel sequencing and analysis of the Necator americanus transcriptome

Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis

Membrane transporters in the relict plastid of malaria parasites

Metabolic Dysregulation Induced in Plasmodium falciparum by Dihydroartemisinin and Other Front-Line Antimalarial Drugs

Metabolomics-Based Screening of the Malaria Box Reveals both Novel and Established Mechanisms of Action

Non-canonical metabolic pathways in the malaria parasite detected by isotope-tracing metabolomics.

Novel vacuoles in Toxoplasma

Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles

Organellar proteomics reveals hundreds of novel nuclear proteins in the malaria parasite Plasmodium falciparum

PfCERLI1 is a conserved rhoptry associated protein essential for Plasmodium falciparum merozoite invasion of erythrocytes ⬇️

Phenotypic variation of Plasmodium falciparum merozoite proteins directs receptor targeting for invasion of human erythrocytes ⬇️

Plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase is a potential drug target

Plasmodium falciparum heterochromatin protein 1 marks genomic loci linked to phenotypic variation of exported virulence factors

Plasmodium falciparum merozoite invasion is inhibited by antibodies that target the PfRh2a and b binding domains ⬇️

Plasmodium sexual differentiation: how to make a female

Potential epigenetic regulatory proteins localise to distinct nuclear sub-compartments in Plasmodium falciparum

Properties and prediction of mitochondrial transit peptides from Plasmodium falciparum

Protein translation in Plasmodium parasites.

REX1 and Pf62: are they one and the same?

Recycling factors for ribosome disassembly in the apicoplast and mitochondrion of Plasmodium falciparum

Reduced ribosomes of the apicoplast and mitochondrion of Plasmodium spp. and predicted interactions with antibiotics

Reticulocyte-binding protein homologue 5 - an essential adhesin involved in invasion of human erythrocytes by Plasmodium falciparum

Selective inhibition of apicoplast tryptophanyl-tRNA synthetase causes delayed death in Plasmodium falciparum

Sir2 paralogues cooperate to regulate virulence genes and antigenic variation in Plasmodium falciparum

Spatial localisation of actin filaments across developmental stages of the malaria parasite

Stepwise dissection of Plasmodium falciparum merozoite invasion of the human erythrocyte ⬇️

Stepwise dissection of Plasmodium falciparum merozoite invasion of the human erythrocyte. ⬇️

Steroid-sensitive nephrotic syndrome and vascular endothelial growth factor gene polymorphisms

Strange organelles--Plasmodium mitochondria lack a pyruvate dehydrogenase complex