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List of works by Thomas G Cotter

7-formyl-10-methylisoellipticine, a novel ellipticine derivative, induces mitochondrial reactive oxygen species (ROS) and shows anti-leukaemic activity in mice

scientific article published on 12 November 2015

A Critical role for Bim in retinal ganglion cell death

scientific article published on 17 April 2007

A cell surface differentiation antigen involved in human neutrophil chemotaxis and degranulation

scientific article published on 01 July 1983

A monoclonal antibody inhibiting human neutrophil chemotaxis and degranulation.

scientific article published in October 1981

A monoclonal antibody-inhibiting FMLP-induced chemotaxis of human neutrophils

scientific article published on 01 December 1981

A novel free radical scavenger rescues retinal cells in vivo

scientific article published on 25 May 2011

A stress survival response in retinal cells mediated through inhibition of the serine/threonine phosphatase PP2A.

scientific article published on 15 July 2010

Abl expression in human fetal and adult tissues, tumours, and tumour microvessels

scientific article published on 01 November 1997

Activation of SAPK/JNK by camptothecin sensitizes androgen-independent prostate cancer cells to Fas-induced apoptosis.

scientific article published in June 2000

Activation of a calcium magnesium independent endonuclease in human leukemic cell apoptosis

scientific article published on 01 September 1993

Activation of multiple pathways during photoreceptor apoptosis in the rd mouse.

scientific article published in October 2005

Age-dependent rat retinal ganglion cell susceptibility to apoptotic stimuli: implications for glaucoma

scientific article published on 04 April 2011

Age-dependent susceptibility of the retinal ganglion cell layer to cell death.

scientific article published in March 2006

Age-related differences in granulocyte chemotaxis and degranulation

scientific article published on 01 January 1986

Alterations to retinal architecture prior to photoreceptor loss in a mouse model of retinitis pigmentosa

scientific article published on 01 January 2016

Anisomycin activates JNK and sensitises DU 145 prostate carcinoma cells to Fas mediated apoptosis.

scientific article

Antibody-Targeted Cyclodextrin-Based Nanoparticles for siRNA Delivery in the Treatment of Acute Myeloid Leukemia: Physicochemical Characteristics, in Vitro Mechanistic Studies, and ex Vivo Patient Derived Therapeutic Efficacy

scientific article published on February 2017

Antioxidant-mediated inhibition of the heat shock response leads to apoptosis

scientific article published on 01 February 1999

Apoptosis and cancer.

scientific article

Apoptosis induced by Actinomycin D, Camptothecin or Aphidicolin can occur in all phases of the cell cycle

scientific article published on 01 February 1992

Apoptosis: Historical perspectives ⬇️

scientific article published on 01 January 2003

Apoptosis: a potential therapeutic target for retinal degenerations.

scientific article

Autocrine secretion of osteopontin results in degradation of I kappa B in Bcr-Abl-expressing cells.

scientific article published on March 2005

BCR-ABL regulates phosphatidylinositol 3-kinase-p110gamma transcription and activation and is required for proliferation and drug resistance.

scientific article

BCR-ABL: an anti-apoptosis gene in chronic myelogenous leukemia.

scientific article

Bcr-Abl reduces endoplasmic reticulum releasable calcium levels by a Bcl-2-independent mechanism and inhibits calcium-dependent apoptotic signaling

scientific article published on 09 February 2006

Bcr-Abl regulates osteopontin transcription via Ras, PI-3K, aPKC, Raf-1, and MEK.

scientific article

Bcr‐Abl upregulates cytosolic p21WAF‐1/CIP‐1 by a phosphoinositide‐3‐kinase (PI3K)‐independent pathway ⬇️

scientific article published on October 1, 2003

Between-group analysis of microarray data

scientific article

Bim expression indicates the pathway to retinal cell death in development and degeneration.

scientific article published in October 2007

Biochemical characterisation studies on a leukocyte alloantigen expressed with high frequency in leukaemia patients

scientific article published on 01 January 1990

Biochemical studies on a human leukaemia-associated antigen.

scientific article published on April 1990

Carbonylation of glycolytic proteins is a key response to drug-induced oxidative stress and apoptosis.

scientific article published in March 2004

Caspase-independent photoreceptor apoptosis in mouse models of retinal degeneration.

scientific article published on July 2003

Cell Death Analysis in Retinal Cultures

article

Cell death in the myeloid lineage.

scientific article

Cell shrinkage and apoptosis: a role for potassium and sodium ion efflux

scientific article published on 01 December 1997

Ceramide is the key mediator of oxidative stress-induced apoptosis in retinal photoreceptor cells.

scientific article published on September 2006

Chemotherapeutic drug-induced apoptosis in human leukaemic cells is independent of the Fas (APO-1/CD95) receptor/ligand system.

scientific article published on June 1998

Circulating granulocyte macrophage colony-stimulating factor in plasma of patients with the systemic inflammatory response syndrome delays neutrophil apoptosis through inhibition of spontaneous reactive oxygen species generation

Collapse of the inner mitochondrial transmembrane potential is not required for apoptosis of HL60 cells.

scientific article published on August 1999

Control of mitochondrial integrity by Bcl-2 family members and caspase-independent cell death.

scientific article published on March 2004

DUOX enzyme activity promotes AKT signalling in prostate cancer cells

scientific article published on December 1, 2012

Decreased expression of pro-apoptotic Bcl-2 family members during retinal development and differential sensitivity to cell death.

scientific article published on 19 January 2006

Decreased neutrophil cyclic AMP response to isoprenaline stimulation in the elderly.

scientific article published on August 1983

Defects in death-inducing signalling complex formation prevent JNK activation and Fas-mediated apoptosis in DU 145 prostate carcinoma cells

scientific article

Degradation of renal basement membrane by neutral proteinases from rabbit polymorphonuclear leucocytes [proceedings]

scientific article published on January 1, 1978

Deregulation of cell death (apoptosis): implications for tumor development.

scientific article published on August 2009

Detection of DNA fragmentation in retinal apoptosis by TUNEL.

scientific article published in January 2013

Detection of Molecular Events During Apoptosis by Flow Cytometry

scientific article published on 01 January 2000

Dicing with death: dissecting the components of the apoptosis machinery.

scientific article

Differential roles of ERK1/2 and JNK in retinal development and degeneration.

scientific article

Direct oxidative modifications of signalling proteins in mammalian cells and their effects on apoptosis.

scientific article

Disruption of microtubules induces an endogenous suicide pathway in human leukaemia HL-60 cells.

scientific article published in November 1990

Dose-dependent induction of apoptosis in human tumour cell lines by widely diverging stimuli.

scientific article

Downregulation of Bcr-Abl in K562 cells restores susceptibility to apoptosis: characterization of the apoptotic death.

scientific article published on February 1997

Effects of surgery on the cancer stem cell niche

scientific article

Elevations in cytosolic free Ca2+ are not required to trigger apoptosis in human leukaemia cells

scientific article published on March 1, 1992

Ellipticine derivative induces potent cytostatic effect in acute myeloid leukaemia cells

scientific article

Enhancing survival of photoreceptor cells in vivo using the synthetic progestin Norgestrel ⬇️

scientific article published on July 18, 2011

EphA3 is induced by CD28 and IGF-1 and regulates cell adhesion.

scientific article published in January 2004

Erythrocyte survival is promoted by plasma and suppressed by a Bak-derived BH3 peptide that interacts with membrane-associated Bcl-X(L).

scientific article published in May 2002

FLT3-driven redox-modulation of Ezrin regulates leukaemic cell migration ⬇️

scientific article published on October 16, 2012

Fractalkine-CX3CR1 signaling is critical for progesterone-mediated neuroprotection in the retina

scientific article published on 20 February 2017

Gene expression profiling in biliary atresia

scientific article published on 01 March 2003

Heat Shock Protein 70 Inhibits Caspase-Dependent and -Independent Apoptosis in Jurkat T Cells

scientific article published in May 2000

Heat shock proteins increase resistance to apoptosis.

scientific article published on February 1996

Heat shock proteins--modulators of apoptosis in tumour cells

scientific journal article

Histone deacetylase activity in conjunction with E2F-1 and p53 regulates Apaf-1 expression in 661W cells and the retina.

scientific article published on March 2009

Histone deacetylase activity regulates apaf-1 and caspase 3 expression in the developing mouse retina

scientific article published on 01 July 2006

Hydrogen peroxide as a cell-survival signaling molecule.

scientific article

Hydrogen peroxide: a Jekyll and Hyde signalling molecule ⬇️

scientific article published on 06 October 2011

IGF-I maintains calpastatin expression and attenuates apoptosis in several models of photoreceptor cell death.

scientific article

Identification of a leukocyte alloantigen with a high-frequency expression in leukemia patients

scientific article published on 01 February 1989

Imatinib and Nilotinib inhibit Bcr-Abl-induced ROS through targeted degradation of the NADPH oxidase subunit p22phox.

scientific article published on 3 December 2012

Induction of apoptosis (programmed cell death) in human leukemic HL-60 cells by inhibition of RNA or protein synthesis.

scientific article published on September 1990

Induction of apoptosis in cells of the immune system by cytotoxic stimuli

scientific article published on December 1, 1992

Inhibition of PI3-kinase sensitises HL60 human leukaemia cells to both chemotherapeutic drug- and Fas-induced apoptosis by a JNK independent pathway.

scientific article

Inhibition of protein-tyrosine phosphatase 1B (PTP1B) mediates ubiquitination and degradation of Bcr-Abl protein.

scientific article published on 27 July 2011

Intraoperative jet ventilation during aortic coarctation repair in an infant.

scientific article published in April 2004

Introduction: apoptosis in the immune system

scientific article published on December 1, 1992

Less stress, more success? Oncological implications of surgery-induced oxidative stress.

scientific article published on 06 December 2011

Leukocyte Bim deficiency does not impact atherogenesis in ldlr -/- mice, despite a pronounced induction of autoimmune inflammation

scientific article published on 8 June 2017

Light-induced Photoreceptor Apoptosis in vivo is Caspase Independent and Mediated by Nitric Oxide

scientific article published on 04 April 2001

Light-induced photoreceptor apoptosis in vivo requires neuronal nitric-oxide synthase and guanylate cyclase activity and is caspase-3-independent.

scientific article

Live and let die: regulatory mechanisms in Fas-mediated apoptosis.

scientific article published on November 2003

Mechanisms driving local breast cancer recurrence in a model of breast-conserving surgery.

scientific article published on 12 July 2008

Meeting Report: The high-tech aspect of death

scientific article published on 01 July 1994

Microfilament-disrupting agents prevent the formation of apoptotic bodies in tumor cells undergoing apoptosis ⬇️

scientific article published on February 15, 1992

Microglial-induced Müller cell gliosis is attenuated by progesterone in a mouse model of retinitis pigmentosa

scientific article published on 16 October 2017

Molecular and cellular biology of prostate cancer-the role of apoptosis as a target for therapy.

scientific article published in May 1999

Molecular mechanisms of programmed cell death

article

Molecular signals in anti-apoptotic survival pathways.

scientific article

Multiple death pathways in retina-derived 661W cells following growth factor deprivation: crosstalk between caspases and calpains.

scientific article published in July 2005

Mutant H-ras overexpression inhibits drug and U.V. induced apoptosis.

scientific article published on July 1996

NADPH oxidase-generated hydrogen peroxide induces DNA damage in mutant FLT3-expressing leukemia cells.

scientific article

NOX-driven ROS formation in cell transformation of FLT3-ITD-positive AML.

scientific article published on 22 September 2016

New Insight into the Role of Reactive Oxygen Species (ROS) in Cellular Signal-Transduction Processes.

scientific article published on August 2015

Norgestrel may be a potential therapy for retinal degenerations.

scientific article published in March 2012

Nuclear membrane-localised NOX4D generates pro-survival ROS in FLT3-ITD-expressing AML.

scientific article

Oxidative stress induces caspase-independent retinal apoptosis in vitro

scientific article published on 01 March 2000

Oxidative stress-induced apoptosis in retinal photoreceptor cells is mediated by calpains and caspases and blocked by the oxygen radical scavenger CR-6.

scientific article published on 21 June 2004

Preventing retinal apoptosis--is there a common therapeutic theme?

scientific article published on 13 February 2012

Pro-survival redox signalling in progesterone-mediated retinal neuroprotection

scientific article

Progesterone Attenuates Microglial-Driven Retinal Degeneration and Stimulates Protective Fractalkine-CX3CR1 Signaling.

scientific article

Progesterone analogue protects stressed photoreceptors via bFGF-mediated calcium influx.

scientific article published on 20 October 2016

Progesterone receptor signalling in retinal photoreceptor neuroprotection

scientific article published on 8 October 2015

Programmed cell death (apoptosis) in lymphoid and myeloid cell lines during zinc deficiency

scientific article published on 01 February 1991

Purification and characterisation of an 'elastase-like' enzyme from rabbit polymorphonuclear leucocytes

scientific article published on 01 October 1980

Purification and characterization of an antigen involved in neutrophil chemotaxis and degranulation using a monoclonal antibody

scientific article published on 01 July 1984

ROS signalling in the biology of cancer.

scientific article published on 3 June 2017

ROS signalling, NADPH oxidases and cancer.

scientific article

Rapid detection of rod photoreceptor apoptosis by flow cytometry

scientific article published on 01 September 1998

Reactive oxygen species as mediators of photoreceptor apoptosis in vitro

scientific article published on 01 May 1999

Reactive oxygen species regulate prosurvival ERK1/2 signaling and bFGF expression in gliosis within the retina.

scientific article

Recent advances in reactive oxygen species measurement in biological systems

scientific article published on 09 October 2013

Redox regulation of protein kinases

scientific article published on 21 March 2013

Redox survival signalling in retina-derived 661W cells.

scientific article

Redox-Regulated Growth Factor Survival Signaling ⬇️

scientific article published on January 15, 2013

Retinal ganglion cells: dying to survive.

scientific article published on January 2006

Role for c-myc in activation-induced apoptotic cell death in T cell hybridomas

scientific article published on July 10, 1992

Selective protection by hsp 70 against cytotoxic drug-, but not Fas-induced T-cell apoptosis

scientific article published in May 1999

Sensitisation of HL60 human leukaemic cells to cytotoxic drug-induced apoptosis by inhibition of PI3-kinase survival signals.

scientific article

Signalling apoptosis: a radical approach.

scientific article

Studies on the filtration properties of isolated renal basement membranes ⬇️

scientific article published on February 20, 1979

Subcellular localization of the FLT3-ITD oncogene plays a significant role in the production of NOX- and p22phox-derived reactive oxygen species in acute myeloid leukemia

scientific article published on 11 November 2016

Substrates modified by advanced glycation end-products cause dysfunction and death in retinal pericytes by reducing survival signals mediated by platelet-derived growth factor.

scientific article published on 22 October 2004

Targeting inflammatory diseases via apoptotic mechanisms.

scientific article

The Antioxidant 4b,5,9b,10-Tetrahydroindeno[1,2-b]indole Inhibits Apoptosis by Preventing Caspase Activation Following Mitochondrial Depolarization

scientific article published in November 1999

The Filtration of Protein Solutions across Films of Renal Basement Membrane in vitro ⬇️

scientific article published on January 1, 1978

The ability to cleave 28S ribosomal RNA during apoptosis is a cell-type dependent trait unrelated to DNA fragmentation

scientific article published on 01 May 1997

The abl oncogene family and apoptosis.

scientific article published in January 1994

The anticancer drug mithramycin A sensitises tumour cells to apoptosis induced by tumour necrosis factor (TNF).

scientific article published on May 2004

The degranulation response in differentiated HL-60 cells

scientific article published on 01 December 1988

The effects of proteinases on the filtration properties of isolated basement membranes

scientific article published on 01 January 1980

The induction of apoptosis by chemotherapeutic agents occurs in all phases of the cell cycle

scientific article published on May 1, 1992

The involvement of RNA and protein synthesis in programmed cell death (apoptosis) in human leukaemia HL-60 cells

scientific article published on 01 August 1990

The production of a reactive oxygen intermediate during the induction of apoptosis by cytotoxic insult.

scientific article

The radical scavenger CR-6 protects SH-SY5Y neuroblastoma cells from oxidative stress-induced apoptosis: effect on survival pathways.

scientific article published on 19 June 2006

The regulatory role of zinc in apoptosis in human tumour cell lines ⬇️

scientific article published on February 1, 1992

The repression of apoptosis by activated abl oncogenes in chronic myelogenous leukaemia.

scientific article

The role of oncogene products in neutrophil apoptosis

scientific article published on 01 August 1994

The synthetic progesterone Norgestrel is neuroprotective in stressed photoreceptor-like cells and retinal explants, mediating its effects via basic fibroblast growth factor, protein kinase A and glycogen synthase kinase 3β signalling.

scientific article published on 10 January 2016

The synthetic progestin norgestrel acts to increase LIF levels in the rd10 mouse model of retinitis pigmentosa

scientific article published on 25 March 2016

The synthetic progestin norgestrel modulates Nrf2 signaling and acts as an antioxidant in a model of retinal degeneration.

scientific article published on 04 October 2016

Use of flow cytometry techniques in studying mechanisms of apoptosis in leukemic cells ⬇️

scientific article published on October 1, 1997

Zinc inhibits UV radiation-induced apoptosis but fails to prevent subsequent cell death

scientific article published on 01 October 1994

bFGF promotes photoreceptor cell survival in vitro by PKA-mediated inactivation of glycogen synthase kinase 3beta and CREB-dependent Bcl-2 up-regulation.

scientific article published on 20 August 2007

bFGF-mediated redox activation of the PI3K/Akt pathway in retinal photoreceptor cells ⬇️

scientific article published on January 11, 2011

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