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List of works by James P Hewitson

A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells.

scientific article published on 23 November 2017

Antibodies and IL-3 support helminth-induced basophil expansion.

scientific article

Bone marrow remodeling supports hematopoiesis in response to immune thrombocytopenia progression in mice

scientific article published on 01 December 2021

CD40/CD154 interactions are required for the optimal maturation of skin-derived APCs and the induction of helminth-specific IFN-gamma but not IL-4.

scientific article published on September 2006

Chronic Gastrointestinal Nematode Infection Mutes Immune Responses to Mycobacterial Infection Distal to the Gut.

scientific article published on 27 January 2016

Commensal-pathogen interactions in the intestinal tract: lactobacilli promote infection with, and are promoted by, helminth parasites

scientific article published on July 2014

Concerted activity of IgG1 antibodies and IL-4/IL-25-dependent effector cells trap helminth larvae in the tissues following vaccination with defined secreted antigens, providing sterile immunity to challenge infection

scientific article (publication date: March 2015)

Heligmosomoides polygyrus Elicits a Dominant Nonprotective Antibody Response Directed against Restricted Glycan and Peptide Epitopes ⬇️

scientific article published on September 30, 2011

Heligmosomoides polygyrus: one species still

scientific article published on 14 December 2010

Helminth immunoregulation: the role of parasite secreted proteins in modulating host immunity.

scientific article published on 03 May 2009

Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-β pathway

scientific article

HpARI Protein Secreted by a Helminth Parasite Suppresses Interleukin-33

scientific article published on October 2017

IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1

scientific article published on 07 October 2013

Immune modulation and modulators in Heligmosomoides polygyrus infection.

scientific article published on 22 August 2011

Immunomodulation by helminth parasites: Defining mechanisms and mediators ⬇️

scientific article published on 03 January 2013

In the absence of CD154, administration of interleukin-12 restores Th1 responses but not protective immunity to Schistosoma mansoni

scientific article published on 7 May 2007

Innate and adaptive type 2 immune cell responses in genetically controlled resistance to intestinal helminth infection

scientific article

Low-level regulatory T-cell activity is essential for functional type-2 effector immunity to expel gastrointestinal helminths.

scientific article

Macrophage origin limits functional plasticity in helminth-bacterial co-infection

scientific article

Modulation of the host's immune response by schistosome larvae.

scientific article published on October 2005

MyD88 signaling inhibits protective immunity to the gastrointestinal helminth parasite Heligmosomoides polygyrus

scientific article

Myeloid Cell Phenotypes in Susceptibility and Resistance to Helminth Parasite Infections.

scientific article published on December 2016

Novel O-linked methylated glycan antigens decorate secreted immunodominant glycoproteins from the intestinal nematode Heligmosomoides polygyrus

scientific article published on 11 December 2015

Proteomic analysis of secretory products from the model gastrointestinal nematode Heligmosomoides polygyrus reveals dominance of venom allergen-like (VAL) proteins

scientific article published on 29 June 2011

S6K2-mediated regulation of TRBP as a determinant of miRNA expression in human primary lymphatic endothelial cells.

scientific article published on 12 July 2016

Schistosome larvae stimulate macrophage cytokine production through TLR4-dependent and -independent pathways.

scientific article

Secretion of protective antigens by tissue-stage nematode larvae revealed by proteomic analysis and vaccination-induced sterile immunity.

scientific article

Susceptibility and immunity to helminth parasites

scientific article published on 12 July 2012

TGF-β mimic proteins form an extended gene family in the murine parasite Heligmosomoides polygyrus.

scientific article published on 3 March 2018

The adult murine heart has a sparse, phagocytically active macrophage population that expands through monocyte recruitment and adopts an 'M2' phenotype in response to Th2 immunologic challenge.

scientific article published on 7 February 2015

The secreted triose phosphate isomerase of Brugia malayi is required to sustain microfilaria production in vivo

scientific article (publication date: February 2014)

The secretome of the filarial parasite, Brugia malayi: proteomic profile of adult excretory-secretory products.

scientific article

Vaccination against helminth parasite infections.

scientific article published on April 2014

miR-132 suppresses transcription of ribosomal proteins to promote protective Th1 immunity

scientific article published on 04 March 2019

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