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List of works by Dominic J Withers

5-HT inhibition of rat insulin 2 promoter Cre recombinase transgene and proopiomelanocortin neuron excitability in the mouse arcuate nucleus.

scientific article published on 14 December 2008

A link between FTO, ghrelin, and impaired brain food-cue responsivity

scientific article

AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons

scientific article

Ageing: Out with the old.

scientific article

Bio-informatics analysis of a gene co-expression module in adipose tissue containing the diet-responsive gene Nnat

scientific article

Brain deletion of insulin receptor substrate 2 disrupts hippocampal synaptic plasticity and metaplasticity

scientific article

Calcium Channel Ca2.3 Subunits Regulate Hepatic Glucose Production by Modulating Leptin-Induced Excitation of Arcuate Pro-opiomelanocortin Neurons

scientific article published in October 2018

Caloric restriction reveals a metabolomic and lipidomic signature in liver of male mice

scientific article

Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function

scientific article published on 26 April 2016

Comment on "Brain IRS2 signaling coordinates life span and nutrient homeostasis"

scientific article published on 01 May 2008

Common and unique transcriptional responses to dietary restriction and loss of insulin receptor substrate 1 (IRS1) in mice.

scientific article published in May 2018

Contrasting effects of IRS-1 versus IRS-2 gene disruption on carbohydrate and lipid metabolism in vivo.

scientific article published in December 2000

Coordinated multitissue transcriptional and plasma metabonomic profiles following acute caloric restriction in mice.

scientific article

Critical role for peptide YY in protein-mediated satiation and body-weight regulation

scientific article

Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice

scientific journal article

Deletion of Lkb1 in pro-opiomelanocortin neurons impairs peripheral glucose homeostasis in mice

scientific article

Deletion of the von Hippel-Lindau gene in pancreatic beta cells impairs glucose homeostasis in mice.

scientific article published on 08 December 2008

Diet and gastrointestinal bypass-induced weight loss: the roles of ghrelin and peptide YY. ⬇️

scientific article

Differential effects of laparoscopic sleeve gastrectomy and laparoscopic gastric bypass on appetite, circulating acyl-ghrelin, peptide YY3-36 and active GLP-1 levels in non-diabetic humans

scientific article published on February 2014

Differential pre-mRNA splicing regulates Nnat isoforms in the hypothalamus after gastric bypass surgery in mice

scientific article

Dominant role of the p110beta isoform of PI3K over p110alpha in energy homeostasis regulation by POMC and AgRP neurons

scientific article published on November 2009

Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice

scientific article

Evidence for neuromedin-B synthesis in the rat anterior pituitary gland

scientific article published on April 1, 1992

Evidence that S6K1, but not 4E-BP1, mediates skeletal muscle pathology associated with loss of A-type lamins.

scientific article

Evidence that hematopoietic stem cell function is preserved during aging in long-lived S6K1 mutant mice

scientific article

Evolutionary conservation of regulated longevity assurance mechanisms

scientific article published on January 2007

Experimental analysis of risk factors for ulcerative dermatitis in mice

scientific article published on 01 September 2012

Expression, Enzyme Activity, and Subcellular Localization of Mammalian Target of Rapamycin in Insulin-Responsive Cells ⬇️

scientific article published on December 29, 1997

Extrahypothalamic GABAergic nociceptin-expressing neurons regulate AgRP neuron activity to control feeding behavior

scientific article published on 01 January 2020

Fibroblasts derived from long-lived insulin receptor substrate 1 null mice are not resistant to multiple forms of stress

scientific article

Genetic deletion of S6k1 does not rescue the phenotypic deficits observed in the R6/2 mouse model of Huntington's disease

scientific article published on 06 November 2019

Genomic imprinting and its effects on postnatal growth and adult metabolism

scientific article published on 03 July 2019

Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production

scientific article

Inhibition of food intake in obese subjects by peptide YY3-36

scientific article (publication date: 4 September 2003)

Insulin receptor substrate 2 is a negative regulator of memory formation

scientific article

Insulin receptor substrate proteins and neuroendocrine function

scientific article

Insulin receptor substrate-2 is not necessary for insulin- and exercise-stimulated glucose transport in skeletal muscle

scientific article published on 01 July 1999

LKB1 is required for hepatic bile acid transport and canalicular membrane integrity in mice

scientific article published on February 2011

Leptin rapidly suppresses insulin release from insulinoma cells, rat and human islets and, in vivo, in mice ⬇️

scientific article published on December 1, 1997

Liver-specific deletion of insulin receptor substrate 2 does not impair hepatic glucose and lipid metabolism in mice.

scientific article published on 11 January 2006

Long-term p110α PI3K inactivation exerts a beneficial effect on metabolism

scientific article published on 11 March 2013

Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands

scientific article

Longevity of insulin receptor substrate1 null mice is not associated with increased basal antioxidant protection or reduced oxidative damage

scientific article published on 29 February 2012

Loss of AMP-activated protein kinase alpha2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia.

scientific article

Mammalian models of extended healthy lifespan

scientific article

Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.

scientific article published in December 1999

Melanocortins and agouti-related protein modulate the excitability of two arcuate nucleus neuron populations by alteration of resting potassium conductances

scientific article published on 26 October 2006

Metabotyping of Long-Lived Mice using 1H NMR Spectroscopy ⬇️

scientific article published on February 27, 2012

Modulation of SF1 Neuron Activity Coordinately Regulates Both Feeding Behavior and Associated Emotional States

scientific article published in December 2017

Neuronatin deletion causes postnatal growth restriction and adult obesity in 129S2/Sv mice

scientific article published on 15 September 2018

Neuronatin regulates pancreatic β cell insulin content and secretion

PINK1 deficiency in β-cells increases basal insulin secretion and improves glucose tolerance in mice

scientific article published on 7 May 2014

PYY modulation of cortical and hypothalamic brain areas predicts feeding behaviour in humans

scientific article published in Nature

Pancreatic deletion of insulin receptor substrate 2 reduces beta and alpha cell mass and impairs glucose homeostasis in mice

scientific article published on 29 March 2007

Peripheral activation of the Y2-receptor promotes secretion of GLP-1 and improves glucose tolerance

scientific article published on 14 March 2013

Pharmacogenetic stimulation of cholinergic pedunculopontine neurons reverses motor deficits in a rat model of Parkinson's disease

scientific article published on 23 September 2015

Phasic Stimulation of Midbrain Dopamine Neuron Activity Reduces Salt Consumption.

scientific article

Phosphoinositide signalling pathways in metabolic regulation

scientific article published on January 2010

Physiology: An atypical switch for metabolism and ageing.

scientific article

Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer

scientific article published on 01 April 2019

Regulation of anterior pituitary galanin and vasoactive intestinal peptide by oestrogen and prolactin status

scientific article published on 01 February 1997

Regulation of lifespan, metabolism, and stress responses by the Drosophila SH2B protein, Lnk

scientific article

Replication of Extended Lifespan Phenotype in Mice with Deletion of Insulin Receptor Substrate 1 ⬇️

scientific article published on January 25, 2011

Ribosomal S6K1 in POMC and AgRP Neurons Regulates Glucose Homeostasis but Not Feeding Behavior in Mice

scientific article published on 9 April 2015

Role of central nervous system and ovarian insulin receptor substrate 2 signaling in female reproductive function in the mouse

scientific article published on 28 February 2007

Sex and death: what is the connection?

scientific article

Stat6 and IRS-2 cooperate in interleukin 4 (IL-4)-induced proliferation and differentiation but are dispensable for IL-4-dependent rescue from apoptosis

scientific article

The hypoxia response pathway and β-cell function.

scientific article published on October 2010

Visualizing Changes in Cdkn1c Expression Links Early-Life Adversity to Imprint Mis-regulation in Adults

scientific article published on January 2017

mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype

scientific article

nNOS-Expressing Neurons in the Ventral Tegmental Area and Substantia Nigra Pars Compacta

scientific article published on 01 September 2018

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