List of works by Mohammed Akhter Hossain

2-nitroveratryl as a photocleavable thiol-protecting group for directed disulfide bond formation in the chemical synthesis of insulin

scientific article published on 24 June 2014

A One-Pot Chemically Cleavable Bis-Linker Tether Strategy for the Synthesis of Heterodimeric Peptides

scientific article published on 16 August 2016

A One-Pot Chemically Cleavable Bis-Linker Tether Strategy for the Synthesis of Heterodimeric Peptides

A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1

scientific article published on 26 February 2016

Amphipathic alpha-helical peptide, HP (2-20), and its analogues derived from Helicobacter pylori: pore formation mechanism in various lipid compositions

scientific article published on 2 October 2007

Amyloid Beta (Aβ) Peptide and Factors that Play Important Roles in Alzheimer's Disease

scientific article published on 28 February 2016

Antiviral Peptides as Promising Therapeutics against SARS-CoV-2

scientific article published on 23 October 2020

Atomic Force Microscopy Reveals the Mechanobiology of Lytic Peptide Action on Bacteria

scientific article published on 26 May 2015

B7-33 replicates the vasoprotective functions of human relaxin-2 (serelaxin).

scientific article published on 3 May 2017

Binding conformation and determinants of a single-chain peptide antagonist at the relaxin-3 receptor RXFP3

scientific article published on 21 August 2018

C-Terminal Modification and Multimerization Increase the Efficacy of a Proline-Rich Antimicrobial Peptide

scientific article published on 16 November 2016

C-terminus of the B-chain of relaxin-3 is important for receptor activity

scientific article

Cellular disulfide bond formation in bioactive peptides and proteins

scientific article

Central injection of relaxin-3 receptor (RXFP3) antagonist peptides reduces motivated food seeking and consumption in C57BL/6J mice.

scientific article published on 25 March 2014

Central relaxin-3 receptor (RXFP3) activation decreases anxiety- and depressive-like behaviours in the rat.

scientific article published on February 2013

Central relaxin-3 receptor (RXFP3) activation reduces elevated, but not basal, anxiety-like behaviour in C57BL/6J mice

scientific article published on 6 June 2015

Challenges in the design of insulin and relaxin/insulin-like peptide mimetics

scientific article

Chemical synthesis and biological evaluation of an antimicrobial peptide gonococcal growth inhibitor.

scientific article published on 4 May 2012

Chemical synthesis and orexigenic activity of rat/mouse relaxin-3.

scientific article

Chemically synthesized dicarba H2 relaxin analogues retain strong RXFP1 receptor activity but show an unexpected loss of in vitro serum stability

scientific article published on 14 September 2015

Chimeric relaxin peptides highlight the role of the A-chain in the function of H2 relaxin

scientific article published on 05 March 2012

Coatings Releasing the Relaxin Peptide Analogue B7-33 Reduce Fibrotic Encapsulation

scientific article published on 02 December 2019

Colokinetic effect of an insulin-like peptide 5-related agonist of the RXFP4 receptor

scientific article published on 27 January 2020

Correction to "Atomic Force Microscopy Reveals the Mechanobiology of Lytic Peptide Action on Bacteria"

scientific article published on 06 June 2016

Covalent conjugation of cationic antimicrobial peptides with a β-lactam antibiotic core

Cyclodecapeptides to mimic the radical site of tyrosyl-containing proteins

scholarly article by Mohammed Akhter Hossain published in January 2006

De novo design and synthesis of cyclic and linear peptides to mimic the binding cassette of human relaxin

scientific article published in April 2009

Design and development of analogues of dimers of insulin-like peptide 3 B-chain as high-affinity antagonists of the RXFP2 receptor

scientific article

Design, synthesis and characterization of a fluorescently labeled functional analog of full-length human ghrelin

scientific article published on 23 September 2020

Design, synthesis and pharmacological evaluation of cyclic mimetics of the insulin-like peptide 3 (INSL3) B-chain.

scientific article published on February 2007

Design, synthesis, and characterization of a single-chain peptide antagonist for the relaxin-3 receptor RXFP3.

scientific article published on 8 March 2011

Development of a Single-Chain Peptide Agonist of the Relaxin-3 Receptor Using Hydrocarbon Stapling

scientific article published on 27 July 2016

Direct Measurement of Pore Dynamics and Leakage Induced by a Model Antimicrobial Peptide in Single Vesicles and Cells

scientific article published on 9 June 2016

Distinct activation modes of the Relaxin Family Peptide Receptor 2 in response to insulin-like peptide 3 and relaxin

scientific article

Distinct but overlapping binding sites of agonist and antagonist at the relaxin family peptide 3 (RXFP3) receptor

scientific article published on 21 August 2018

Effect of dimerized melittin on gastric cancer cells and antibacterial activity

scientific article published on 16 May 2018

Effect of helix-promoting strategies on the biological activity of novel analogues of the B-chain of INSL3.

scientific article

Elucidation of relaxin-3 binding interactions in the extracellular loops of RXFP3.

scientific article published on 22 February 2013

Engineering of a Novel Simplified Human Insulin-Like Peptide 5 Agonist.

scientific article published on 29 January 2016

Enhancing proline-rich antimicrobial peptide action by homodimerization: influence of bifunctional linker

scientific article published in January 2022

Exploring the Use of Helicogenic Amino Acids for Optimising Single Chain Relaxin-3 Peptide Agonists

scientific article published on 14 October 2020

Fluorescence imaging of the interaction of amyloid beta 40 peptides with lives cells and model membrane

scientific article published on 2 February 2018

Fluorescence resonance energy transfer in a novel cyclodextrin-peptide conjugate for detecting steroid molecules

scientific article

H3 relaxin demonstrates antifibrotic properties via the RXFP1 receptor

scientific article published on 31 January 2011

Human relaxin-2: historical perspectives and role in cancer biology

scientific article published on 02 August 2012

Identification of key residues essential for the structural fold and receptor selectivity within the A-chain of human gene-2 (H2) relaxin

scientific article

Imaging the action of antimicrobial peptides on living bacterial cells

scientific article

Improved chemical synthesis and demonstration of the relaxin receptor binding affinity and biological activity of mouse relaxin.

scientific article published on 11 April 2007

Innentitelbild: A One-Pot Chemically Cleavable Bis-Linker Tether Strategy for the Synthesis of Heterodimeric Peptides (Angew. Chem. 47/2016)

Inside Cover: A One-Pot Chemically Cleavable Bis-Linker Tether Strategy for the Synthesis of Heterodimeric Peptides (Angew. Chem. Int. Ed. 47/2016)

Intramolecular acyl transfer in peptide and protein ligation and synthesis

scientific article

Investigation of interactions at the extracellular loops of the relaxin family peptide receptor 1 (RXFP1).

scientific article

Long-time-scale interaction dynamics between a model antimicrobial peptide and giant unilamellar vesicles

scientific article published on 14 November 2013

ML290 is a biased allosteric agonist at the relaxin receptor RXFP1.

scientific article

Melittin peptides exhibit different activity on different cells and model membranes

scientific article published on 9 September 2014

Membrane interactions of proline-rich antimicrobial peptide, Chex1-Arg20, multimers

scientific article

Minimum active structure of insulin-like peptide 5.

scientific article published on 21 November 2013

Modulation of hippocampal theta oscillations and spatial memory by relaxin-3 neurons of the nucleus incertus.

scientific article published on 30 October 2009

Multimerization of a Proline-Rich Antimicrobial Peptide, Chex-Arg20, Alters Its Mechanism of Interaction with the Escherichia coli Membrane

scientific article published on September 2015

Native Chemical Ligation to Minimize Aspartimide Formation during Chemical Synthesis of Small LDLa Protein

scientific article published on 27 November 2015

Novel Methods for the Chemical Synthesis of Insulin Superfamily Peptides and of Analogues Containing Disulfide Isosteres

scientific article published on 22 August 2017

Novel peptides bearing pyrene and coumarin units with or without beta-cyclodextrin in their side chains exhibit intramolecular fluorescence resonance energy transfer

scientific article

Phosphorylation of a full length amyloid-β peptide modulates its amyloid aggregation, cell binding and neurotoxic properties.

scientific article published on 23 June 2017

Probing the functional domains of relaxin-3 and the creation of a selective antagonist for RXFP3/GPCR135 over relaxin receptor RXFP1/LGR7.

scientific article

R3(BDelta23 27)R/I5 chimeric peptide, a selective antagonist for GPCR135 and GPCR142 over relaxin receptor LGR7: in vitro and in vivo characterization.

scientific article published on 2 July 2007

Rapid Photolysis-Mediated Folding of Disulfide-Rich Peptides

scientific article published on 22 May 2019

Real-time examination of cAMP activity at relaxin family peptide receptors using a BRET-based biosensor

scientific article published on 24 September 2018

Relaxin family peptides: structure-activity relationship studies.

scientific article published on 6 December 2016

Relaxin-3 innervation of the intergeniculate leaflet of the rat thalamus - neuronal tract-tracing and in vitro electrophysiological studies

scientific article

Relaxin-3/RXFP3 system regulates alcohol-seeking

scientific article

Sequential formation of regioselective disulfide bonds in synthetic peptides with multiple disulfide bonds

scientific article published in January 2013

Signal transduction pathways activated by insulin-like peptide 5 at the relaxin family peptide RXFP4 receptor.

scientific article published on 31 May 2016

Signalling profiles of H3 relaxin, H2 relaxin and R3(BΔ23-27)R/I5 acting at the relaxin family peptide receptor 3 (RXFP3)

scientific article

Single chain peptide agonists of relaxin receptors

scientific article published on 11 January 2019

Site of fluorescent label modifies interaction of melittin with live cells and model membranes

scientific article published on 4 June 2015

Site-specific conjugation of a lanthanide chelator and its effects on the chemical synthesis and receptor binding affinity of human relaxin-2 hormone

scientific article published on 07 March 2012

Slow insertion kinetics during interaction of a model antimicrobial peptide with unilamellar phospholipid vesicles

scientific article published on 22 December 2011

Solid Phase Synthesis of an Analogue of Insulin, A0:R glargine, That Exhibits Decreased Mitogenic Activity

Solid phase synthesis and structural analysis of novel A-chain dicarba analogs of human relaxin-3 (INSL7) that exhibit full biological activity

scientific article published on 24 February 2009

Solid-phase synthesis of europium-labeled human INSL3 as a novel probe for the study of ligand-receptor interactions

scientific article

Solution structure, aggregation behavior, and flexibility of human relaxin-2

scientific article

Structural dynamics of a lytic peptide interacting with a supported lipid bilayer

scientific article published on March 2011

Structural insights into the function of relaxins

scientific article

Structural properties of relaxin chimeras.

scientific article

Structure and activity in the relaxin family of peptides

scientific article published in April 2009

Structure and function relationship of murine insulin-like peptide 5 (INSL5): free C-terminus is essential for RXFP4 receptor binding and activation

scientific article published on 08 September 2011

Structure of human insulin-like peptide 5 and characterization of conserved hydrogen bonds and electrostatic interactions within the relaxin framework

scientific article

Structure of the R3/I5 Chimeric Relaxin Peptide, a Selective GPCR135 and GPCR142 Agonist

scientific article

Synthesis of fluorescent analogs of relaxin family peptides and their preliminary in vitro and in vivo characterization

scientific article

Synthesis, conformational analysis and biological properties of a dicarba derivative of the antimicrobial peptide, brevinin-1BYa

scientific article published on 11 February 2011

Synthetic covalently linked dimeric form of H2 relaxin retains native RXFP1 activity and has improved in vitro serum stability.

scientific article

Synthetic relaxins

scientific article published on October 2014

The A-chain of human relaxin family peptides has distinct roles in the binding and activation of the different relaxin family peptide receptors

scientific article published on 22 April 2008

The C-terminus of the B-chain of human insulin-like peptide 5 is critical for cognate RXFP4 receptor activity

scientific article published on 11 December 2015

The Effect of Selective D- or Nα-Methyl Arginine Substitution on the Activity of the Proline-Rich Antimicrobial Peptide, Chex1-Arg20.

scientific article published on 19 January 2017

The Importance of Tryptophan B28 in H2 Relaxin for RXFP2 Binding and Activation

The actions of relaxin family peptides on signal transduction pathways activated by the relaxin family peptide receptor RXFP4.

scientific article published on 26 November 2016

The chemical synthesis of relaxin and related peptides

scientific article published on 01 April 2009

The chemically synthesized human relaxin-2 analog, B-R13/17K H2, is an RXFP1 antagonist

scientific article

The complex binding mode of the peptide hormone H2 relaxin to its receptor RXFP1

scientific article published on 18 April 2016

The minimal active structure of human relaxin-2

scientific article

The relaxin peptide family--structure, function and clinical applications

scientific article published on March 2011

The relaxin receptor as a therapeutic target - perspectives from evolution and drug targeting

scientific article published on 16 February 2018

The roles of the A- and B-chains of human relaxin-2 and -3 on their biological activity

scientific article published on December 2010

The structural and functional role of the B-chain C-terminal arginine in the relaxin-3 peptide antagonist, R3(BDelta23-27)R/I5.

scientific article published in January 2009

Total Chemical Synthesis of a Nonfibrillating Human Glycoinsulin

scientific article published on 09 January 2020

Total Chemical Synthesis of an Intra-A-Chain Cystathionine Human Insulin Analogue with Enhanced Thermal Stability

scientific article published on 20 October 2016

Total Chemical Synthesis of an Intra-A-Chain Cystathionine Human Insulin Analogue with Enhanced Thermal Stability

Total Solid-Phase Synthesis of Biologically Active Drosophila Insulin-Like Peptide 2 (DILP2).

scientific article published on 12 December 2016

Total chemical synthesis of a heterodimeric interchain bis-lactam-linked Peptide: application to an analogue of human insulin-like Peptide 3.

scientific article published on 28 October 2013

Use of a temporary "solubilizing" peptide tag for the Fmoc solid-phase synthesis of human insulin glargine via use of regioselective disulfide bond formation.

scientific article published in July 2009

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