Search filters

List of works by Bon-Kyoung Koo

A Protocol for Multiple Gene Knockout in Mouse Small Intestinal Organoids Using a CRISPR-concatemer

scientific article published on 12 July 2017

A critical role for the Wnt effector Tcf4 in adult intestinal homeostatic self-renewal

scientific article

A crucial role of WW45 in developing epithelial tissues in the mouse

scientific journal article

A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis

scientific article published on 15 September 2020

A video protocol of retroviral infection in primary intestinal organoid culture

scientific article published on 11 August 2014

Adult gastric stem cells and their niches

scientific article published on 3 January 2017

Adult stem cell lineage tracing and deep tissue imaging

scientific article

An obligatory role of mind bomb-1 in notch signaling of mammalian development

scientific article

Ascl2 acts as an R-spondin/Wnt-responsive switch to control stemness in intestinal crypts

scientific article

Clonal Evolution of Stem Cells in the Gastrointestinal Tract

scientific article

Controlled gene expression in primary Lgr5 organoid cultures

scientific article

Crif1 is a novel transcriptional coactivator of STAT3

scientific article

Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation

scientific article published on 25 August 2016

DNA Methylation and Transcription Patterns in Intestinal Epithelial Cells From Pediatric Patients With Inflammatory Bowel Diseases Differentiate Disease Subtypes and Associate With Outcome.

scientific article

DNA methylation defines regional identity of human intestinal epithelial organoids and undergoes dynamic changes during development.

scientific article

Defective Notch activation in microenvironment leads to myeloproliferative disease

scientific article published on 25 September 2008

Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium

scientific article

Divergent Routes toward Wnt and R-spondin Niche Independency during Human Gastric Carcinogenesis

scientific article published on 01 August 2018

ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response

scientific article published on 28 March 2013

Essential role of CR6-interacting factor 1 (Crif1) in E74-like factor 3 (ELF3)-mediated intestinal development

scientific article

Expression of an ASCL2 related stem cell signature and IGF2 in colorectal cancer liver metastases with 11p15.5 gain.

scientific article published on 17 May 2010

Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients

scientific article

Gastric organoids-an in vitro model system for the study of gastric development and road to personalized medicine

scientific article published on 22 November 2020

Generation of BAC transgenic epithelial organoids

scientific article

Generation of FLIP and FLIP-FlpE Targeting Vectors for Biallelic Conditional and Reversible Gene Knockouts in Mouse and Human Cells

article

Genetic engineering in organoids

scientific article published in 2021

How to create state-of-the-art genetic model systems: strategies for optimal CRISPR-mediated genome editing

scientific article published on 01 July 2018

Human gastric cancer modelling using organoids

scientific article published on 27 April 2018

Human organoids: model systems for human biology and medicine

scientific article published on 07 July 2020

Human primary liver cancer-derived organoid cultures for disease modeling and drug screening

scientific article published on 13 November 2017

Inactivation of Notch signaling in the renal collecting duct causes nephrogenic diabetes insipidus in mice

scientific article published on 12 October 2009

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

scientific article

Long-term, hormone-responsive organoid cultures of human endometrium in a chemically defined medium

scientific article published on 10 April 2017

Mind bomb 1 in the lymphopoietic niches is essential for T and marginal zone B cell development

scientific article published on 29 September 2008

Mind bomb 1 is essential for generating functional Notch ligands to activate Notch

scientific journal article

Mind bomb 1-expressing intermediate progenitors generate notch signaling to maintain radial glial cells

scientific article published on May 2008

Mind bomb-1 is essential for intraembryonic hematopoiesis in the aortic endothelium and the subaortic patches

scientific article

Mind bomb-2 is an E3 ligase for Notch ligand

scientific journal article

Modeling mouse and human development using organoid cultures

scientific article

Morphological alterations of cultured human colorectal matched tumour and healthy organoids.

scientific article published on 19 January 2018

Neuralized-2 regulates a Notch ligand in cooperation with Mind bomb-1

scientific journal article

Notch signaling promotes the generation of EphrinB1-positive intestinal epithelial cells

scientific article published on 28 March 2009

Notch1 counteracts WNT/β-catenin signaling through chromatin modification in colorectal cancer

scientific article

One-step generation of conditional and reversible gene knockouts

scientific article published on 30 January 2017

Organoids: A new in vitro model system for biomedical science and disease modelling and promising source for cell-based transplantation

scientific article published on 27 October 2016

Porcupine inhibitor suppresses paracrine Wnt-driven growth of Rnf43;Znrf3-mutant neoplasia

scientific article published on 28 May 2015

RNF43 truncations trap CK1 to drive niche-independent self-renewal in cancer

scientific article published on 10 August 2020

RNF43/ZNRF3 loss predisposes to hepatocellular-carcinoma by impairing liver regeneration and altering the liver lipid metabolic ground-state

scientific article published on 17 January 2022

Receptor activator of NF-kappaB ligand regulates the proliferation of mammary epithelial cells via Id2

scientific article

Retroviral gene expression control in primary organoid cultures

scientific article published on 13 November 2013

Simultaneous paralogue knockout using a CRISPR-concatemer in mouse small intestinal organoids

scientific article published on 27 October 2016

Snx5, as a Mind bomb-binding protein, is expressed in hematopoietic and endothelial precursor cells in zebrafish

scientific journal article

Stem Cells in Repair of Gastrointestinal Epithelia

scientific article

Stem cells marked by the R-spondin receptor LGR5.

scientific article published on 21 May 2014

Survival and differentiation of mammary epithelial cells in mammary gland development require nuclear retention of Id2 due to RANK signaling

scientific article published on 26 September 2011

Tales from the crypt: intestinal niche signals in tissue renewal, plasticity and cancer

article by Maureen Spit et al published 12 September 2018 in Open Biology

The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers

scientific article published on 12 June 2012

The WNT antagonist Dickkopf2 promotes angiogenesis in rodent and human endothelial cells

scientific article

Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors

scientific article published on 30 August 2012

ZNRF3 functions in mammalian sex determination by inhibiting canonical WNT signaling.

scientific article published on 7 May 2018

Paulina is supported by:

About Paulina

Help