List of works - Yasuyuki Fujiwara

AU-1 from Agavaceae plants causes transient increase in p21/Cip1 expression in renal adenocarcinoma ACHN cells in an miR-34-dependent manner

scientific article published on 7 July 2016

Accumulation of p53 via down-regulation of UBE2D family genes is a critical pathway for cadmium-induced renal toxicity

scientific article published on 25 February 2016

Alteration of DNA binding activity of transcription factors in NRK-52E rat proximal tubular cells treated with cadmium

scientific article published on 01 January 2014

Arsenite but not arsenate inhibits general proteoglycan synthesis in cultured arterial smooth muscle cells.

scientific article published in October 2008

Attenuation of cadmium-induced testicular injury in metallothionein-III null mice.

scientific article published on 17 September 2010

Basic fibroblast growth factor-induced glycosaminoglycan production in cultured vascular endothelial cells results from enhanced protein synthesis mediated by the lipoxygenase pathway

scientific article published on 01 January 1997

Biglycan Intensifies ALK5-Smad2/3 Signaling by TGF-β1 and Downregulates Syndecan-4 in Cultured Vascular Endothelial Cells

scientific article published in September 2016

Bismuth induces metallothionein but does not protect against cadmium cytotoxicity in cultured vascular endothelial cells

scientific article published on 01 April 1996

Bismuth protects against arsenite-induced inhibition of proteoglycan synthesis in cultured vascular endothelial cells

scientific article published on 01 January 2012

Cadmium induces the production of high molecular weight heparan sulfate proteoglycan molecules in cultured vascular endothelial cells.

scientific article published in July 1997

Cadmium renal toxicity via apoptotic pathways.

scientific article published on January 2012

Cadmium toxicity is caused by accumulation of p53 through the down-regulation of Ube2d family genes in vitro and in vivo.

scientific article published on April 2011

Cell density-dependent regulation of proteoglycan synthesis by transforming growth factor-beta(1) in cultured bovine aortic endothelial cells

scientific article published on 01 January 2000

Cell-density-dependent methylmercury susceptibility of cultured human brain microvascular pericytes.

scientific article published on 22 December 2009

Characterization of chondroitin/dermatan sulfate proteoglycans synthesized by bovine retinal pericytes in culture.

scientific article published on November 2004

Cilostazol induces metallothionein expression in vascular cells

scientific article published in November 2009

Comparative cytotoxicity of exogenous cadmium-metallothionein and cadmium ion in cultured vascular endothelial cells

scientific article published on 01 April 1995

Comparative photodynamic therapy cytotoxicity of mannose-conjugated chlorin and talaporfin sodium in cultured human and rat cells.

scientific article

Concomitant treatment with temozolomide enhances apoptotic cell death in glioma cells induced by photodynamic therapy with talaporfin sodium.

scientific article published on 28 September 2014

Copper diethyldithiocarbamate as an activator of Nrf2 in cultured vascular endothelial cells

scientific article

Cyclic AMP-dependent pathway that mediates suppressive regulation of glycosaminoglycan production in cultured vascular endothelial cells

scientific article published on 01 June 1996

DNA microarray analysis of human coronary artery endothelial cells exposed to cadmium.

scientific article published on January 2011

DNA microarray analysis of normal rat kidney epithelial cells treated with cadmium.

scientific article published on January 2011

DNA microarray expression analysis of mouse kidney following cadmium exposure for 12 months.

scientific article published on January 2013

Different Regulation of p53 Expression by Cadmium Exposure in Kidney, Liver, Intestine, Vasculature, and Brain Astrocytes

scientific article published on 31 January 2016

Differential effects of cadmium on proteoglycan synthesis of arterial smooth muscle cells: increase in small dermatan sulfate proteoglycans, biglycan and decorin, in the extracellular matrix at low cell density.

scientific article published in January 2002

Effect of dental amalgam on gene expression profiles in rat cerebrum, cerebellum, liver and kidney.

scientific article

Effect of talaporfin sodium-mediated photodynamic therapy on cell death modalities in human glioblastoma T98G cells.

scientific article

Galacto-N-biose is neuroprotective against glutamate-induced excitotoxicity in vitro.

scientific article

Gene expression analysis using DNA microarray in HK-2 human proximal tubular cells treated with cadmium

scientific article published on January 2013

Gene expression differences in the duodenum of 129/Sv and DBA/2 mice compared with that of C57BL/6J mice

scientific article published on 01 February 2014

Gene expression profiles in the dorsal root ganglia of methylmercury-exposed rats

scientific article published on 01 January 2019

Heparan sulfate chains potentiate cadmium cytotoxicity in cultured vascular endothelial cells

scientific article published on 25 November 2014

Identification and functions of chondroitin sulfate in the milieu of neural stem cells.

scientific article published on 22 December 2005

Induction of Syndecan-4 by Organic-Inorganic Hybrid Molecules with a 1,10-Phenanthroline Structure in Cultured Vascular Endothelial Cells.

scientific article published on 08 February 2017

Induction of chemokine CCL3 by NF-κB reduces methylmercury toxicity in C17.2 mouse neural stem cells

scientific article published on 24 June 2019

Induction of metallothionein by thrombin in cultured vascular endothelial and smooth muscle cells

scientific article published on 01 September 1995

Induction of metallothionein isoforms by copper diethyldithiocarbamate in cultured vascular endothelial cells.

scientific article published on January 2016

Inhibition of cultured bovine aortic endothelial cell proliferation by sodium spirulan, a new sulfated polysaccharide isolated from Spirulina platensis.

scientific article published in June 2002

Inhibitory effect of lead on the proliferation of cultured vascular endothelial cells

scientific article published on 01 January 1995

Inhibitory effect of lead on the repair of wounded monolayers of cultured vascular endothelial cells

scientific article published on 01 February 1997

Inorganic arsenic induces apoptosis through downregulation of Ube2d genes and p53 accumulation in rat proximal tubular cells

scientific article published on January 2013

Interaction between cadmium and zinc in the production and sulfation of glycosaminoglycans in cultured bovine vascular endothelial cells

scientific article published on 01 February 1996

Involvement of ubiquitin-coding genes in cadmium-induced protein ubiquitination in human proximal tubular cells.

scientific article published on January 2015

Lead inhibits the core protein synthesis of a large heparan sulfate proteoglycan perlecan by proliferating vascular endothelial cells in culture.

scientific article

Lead-induced alteration of heparan sulfate proteoglycans in cultured vascular endothelial cells

scientific article published on 01 March 1997

Methylmercury induces the expression of chemokine CCL4 via SRF activation in C17.2 mouse neural stem cells

scientific article published on 15 March 2019

Methylmercury-induced neural degeneration in rat dorsal root ganglion is associated with the accumulation of microglia/macrophages and the proliferation of Schwann cells

scientific article published on 01 January 2019

Microarray analysis of the liver in metallothionein-III null mice treated with cadmium.

scientific article published in April 2010

Novel Photosensitizer β-Mannose-Conjugated Chlorin e6 as a Potent Anticancer Agent for Human Glioblastoma U251 Cells

scientific article published on 16 October 2020

Nucleolin Acts as a Scavenger Receptor for Acetylated Low-Density Lipoprotein on Macrophages.

scientific article published on January 2015

Phorbol 12-myristate 13-acetate stimulates the release of glycosaminoglycans from cultured vascular endothelial cells: possible involvement of protein kinase C activation

scientific article published on 01 June 1996

Phosphodiesterase-III inhibitor prevents hemorrhagic transformation induced by focal cerebral ischemia in mice treated with tPA

scientific article

Photodynamic therapy using talaporfin sodium induces concentration-dependent programmed necroptosis in human glioblastoma T98G cells.

scientific article published on 25 June 2015

Photodynamic therapy using talaporfin sodium induces heme oxygenase-1 expression in rat malignant meningioma KMY-J cells.

scientific article

Photodynamic therapy with talaporfin sodium induces dose- and time-dependent apoptotic cell death in malignant meningioma HKBMM cells

scientific article published on 31 October 2018

Possible mechanism for lead inhibition of vascular endothelial cell proliferation: a lower response to basic fibroblast growth factor through inhibition of heparan sulfate synthesis

scientific article published on 01 April 1999

Possible mechanisms underlying transcriptional induction of metallothionein isoforms by tris(pentafluorophenyl)stibane, tris(pentafluorophenyl)arsane, and tris(pentafluorophenyl)phosphane in cultured bovine aortic endothelial cells

scientific article published on 01 January 2019

Promotion of cultured vascular smooth muscle cell proliferation by low levels of cadmium

scientific article published on 01 February 1998

Protective effect of copper against cadmium cytotoxicity on cultured vascular endothelial cells

scientific article published on 01 October 1992

Protective effect of pretreatment with cilostazol on cytotoxicity of cadmium and arsenite in cultured vascular endothelial cells.

scientific article published on April 2011

Proteoglycan as a key molecule in atherosclerosis progression: characteristics of the structure and regulation of the synthesis

scientific article

Proteoglycans synthesized by cultured bovine aortic smooth muscle cells after exposure to lead: lead selectively inhibits the synthesis of versican, a large chondroitin sulfate proteoglycan

scientific article published on 01 November 2000

Repair of wounded monolayers of cultured vascular endothelial cells after simultaneous exposure to lead and zinc.

scientific article published in February 1998

Resistance of human brain microvascular endothelial cells in culture to methylmercury: cell-density-dependent defense mechanisms.

scientific article published in June 2010

Sensitive response of cultured vascular smooth-muscle cells to cadmium cytotoxicity: comparison with cultured vascular endothelial cells and kidney epithelial LLC-PK1 cells

scientific article published on 01 December 1996

Stimulation by zinc of cultured vascular endothelial cell proliferation: possible involvement of endogenous basic fibroblast growth factor

scientific article published on 01 January 1994

Stimulation of cultured vascular smooth muscle cell proliferation by thrombospondin is potentiated by zinc

scientific article published on 01 September 1995

Stimulatory effect of lead on the proliferation of cultured vascular smooth-muscle cells.

scientific article published in April 1995

Suppression of fibroblast growth factor-2 expression: possible mechanism underlying methylmercury-induced inhibition of the repair of wounded monolayers of cultured human brain microvascular endothelial cells.

scientific article published in October 2009

Synthesis and anticancer activity of bis(2-arylimidazo[1,2-a]pyridin-3-yl) selenides and diselenides: the copper-catalyzed tandem C-H selenation of 2-arylimidazo[1,2-a]pyridine with selenium

scientific article published on 20 May 2020

Synthesis, antitumor activity, and cytotoxicity of 4-substituted 1-benzyl-5-diphenylstibano-1H-1,2,3-triazoles

scientific article

Tolerance to cadmium cytotoxicity is induced by zinc through non-metallothionein mechanisms as well as metallothionein induction in cultured cells

scientific article published on 01 March 1997

Transcriptional Induction of Metallothionein by Tris(pentafluorophenyl)stibane in Cultured Bovine Aortic Endothelial Cells

scientific article

Transforming Growth Factor-β1 Modulates the Expression of Syndecan-4 in Cultured Vascular Endothelial Cells in a Biphasic Manner.

scientific article published on 26 December 2016

Vascular smooth muscle cells in culture are highly sensitive to cadmium cytotoxicity without species-related differences: comparison with Chang liver cells.

scientific article

[Molecular toxicology led by young scientists 5-biological systems to determine the sensitivity to chemicals]

scientific article published on 01 March 2011

List of works by Yasuyuki Fujiwara

AU-1 from Agavaceae plants causes transient increase in p21/Cip1 expression in renal adenocarcinoma ACHN cells in an miR-34-dependent manner

Accumulation of p53 via down-regulation of UBE2D family genes is a critical pathway for cadmium-induced renal toxicity

Alteration of DNA binding activity of transcription factors in NRK-52E rat proximal tubular cells treated with cadmium

Arsenite but not arsenate inhibits general proteoglycan synthesis in cultured arterial smooth muscle cells.

Attenuation of cadmium-induced testicular injury in metallothionein-III null mice.

Basic fibroblast growth factor-induced glycosaminoglycan production in cultured vascular endothelial cells results from enhanced protein synthesis mediated by the lipoxygenase pathway

Biglycan Intensifies ALK5-Smad2/3 Signaling by TGF-β1 and Downregulates Syndecan-4 in Cultured Vascular Endothelial Cells

Bismuth induces metallothionein but does not protect against cadmium cytotoxicity in cultured vascular endothelial cells

Bismuth protects against arsenite-induced inhibition of proteoglycan synthesis in cultured vascular endothelial cells

Cadmium induces the production of high molecular weight heparan sulfate proteoglycan molecules in cultured vascular endothelial cells.

Cadmium renal toxicity via apoptotic pathways.

Cadmium toxicity is caused by accumulation of p53 through the down-regulation of Ube2d family genes in vitro and in vivo.

Cell density-dependent regulation of proteoglycan synthesis by transforming growth factor-beta(1) in cultured bovine aortic endothelial cells

Cell-density-dependent methylmercury susceptibility of cultured human brain microvascular pericytes.

Characterization of chondroitin/dermatan sulfate proteoglycans synthesized by bovine retinal pericytes in culture.

Cilostazol induces metallothionein expression in vascular cells

Comparative cytotoxicity of exogenous cadmium-metallothionein and cadmium ion in cultured vascular endothelial cells

Comparative photodynamic therapy cytotoxicity of mannose-conjugated chlorin and talaporfin sodium in cultured human and rat cells.

Concomitant treatment with temozolomide enhances apoptotic cell death in glioma cells induced by photodynamic therapy with talaporfin sodium.

Copper diethyldithiocarbamate as an activator of Nrf2 in cultured vascular endothelial cells

Cyclic AMP-dependent pathway that mediates suppressive regulation of glycosaminoglycan production in cultured vascular endothelial cells

DNA microarray analysis of human coronary artery endothelial cells exposed to cadmium.

DNA microarray analysis of normal rat kidney epithelial cells treated with cadmium.

DNA microarray expression analysis of mouse kidney following cadmium exposure for 12 months.

Different Regulation of p53 Expression by Cadmium Exposure in Kidney, Liver, Intestine, Vasculature, and Brain Astrocytes

Differential effects of cadmium on proteoglycan synthesis of arterial smooth muscle cells: increase in small dermatan sulfate proteoglycans, biglycan and decorin, in the extracellular matrix at low cell density.

Effect of dental amalgam on gene expression profiles in rat cerebrum, cerebellum, liver and kidney.

Effect of talaporfin sodium-mediated photodynamic therapy on cell death modalities in human glioblastoma T98G cells.

Galacto-N-biose is neuroprotective against glutamate-induced excitotoxicity in vitro.

Gene expression analysis using DNA microarray in HK-2 human proximal tubular cells treated with cadmium

Gene expression differences in the duodenum of 129/Sv and DBA/2 mice compared with that of C57BL/6J mice

Gene expression profiles in the dorsal root ganglia of methylmercury-exposed rats

Heparan sulfate chains potentiate cadmium cytotoxicity in cultured vascular endothelial cells

Identification and functions of chondroitin sulfate in the milieu of neural stem cells.

Induction of Syndecan-4 by Organic-Inorganic Hybrid Molecules with a 1,10-Phenanthroline Structure in Cultured Vascular Endothelial Cells.

Induction of chemokine CCL3 by NF-κB reduces methylmercury toxicity in C17.2 mouse neural stem cells

Induction of metallothionein by thrombin in cultured vascular endothelial and smooth muscle cells

Induction of metallothionein isoforms by copper diethyldithiocarbamate in cultured vascular endothelial cells.

Inhibition of cultured bovine aortic endothelial cell proliferation by sodium spirulan, a new sulfated polysaccharide isolated from Spirulina platensis.

Inhibitory effect of lead on the proliferation of cultured vascular endothelial cells

Inhibitory effect of lead on the repair of wounded monolayers of cultured vascular endothelial cells

Inorganic arsenic induces apoptosis through downregulation of Ube2d genes and p53 accumulation in rat proximal tubular cells

Interaction between cadmium and zinc in the production and sulfation of glycosaminoglycans in cultured bovine vascular endothelial cells

Involvement of ubiquitin-coding genes in cadmium-induced protein ubiquitination in human proximal tubular cells.

Lead inhibits the core protein synthesis of a large heparan sulfate proteoglycan perlecan by proliferating vascular endothelial cells in culture.

Lead-induced alteration of heparan sulfate proteoglycans in cultured vascular endothelial cells

Methylmercury induces the expression of chemokine CCL4 via SRF activation in C17.2 mouse neural stem cells

Methylmercury-induced neural degeneration in rat dorsal root ganglion is associated with the accumulation of microglia/macrophages and the proliferation of Schwann cells

Microarray analysis of the liver in metallothionein-III null mice treated with cadmium.

Novel Photosensitizer β-Mannose-Conjugated Chlorin e6 as a Potent Anticancer Agent for Human Glioblastoma U251 Cells

Nucleolin Acts as a Scavenger Receptor for Acetylated Low-Density Lipoprotein on Macrophages.

Phorbol 12-myristate 13-acetate stimulates the release of glycosaminoglycans from cultured vascular endothelial cells: possible involvement of protein kinase C activation

Phosphodiesterase-III inhibitor prevents hemorrhagic transformation induced by focal cerebral ischemia in mice treated with tPA

Photodynamic therapy using talaporfin sodium induces concentration-dependent programmed necroptosis in human glioblastoma T98G cells.

Photodynamic therapy using talaporfin sodium induces heme oxygenase-1 expression in rat malignant meningioma KMY-J cells.

Photodynamic therapy with talaporfin sodium induces dose- and time-dependent apoptotic cell death in malignant meningioma HKBMM cells

Possible mechanism for lead inhibition of vascular endothelial cell proliferation: a lower response to basic fibroblast growth factor through inhibition of heparan sulfate synthesis

Possible mechanisms underlying transcriptional induction of metallothionein isoforms by tris(pentafluorophenyl)stibane, tris(pentafluorophenyl)arsane, and tris(pentafluorophenyl)phosphane in cultured bovine aortic endothelial cells

Promotion of cultured vascular smooth muscle cell proliferation by low levels of cadmium

Protective effect of copper against cadmium cytotoxicity on cultured vascular endothelial cells

Protective effect of pretreatment with cilostazol on cytotoxicity of cadmium and arsenite in cultured vascular endothelial cells.

Proteoglycan as a key molecule in atherosclerosis progression: characteristics of the structure and regulation of the synthesis

Proteoglycans synthesized by cultured bovine aortic smooth muscle cells after exposure to lead: lead selectively inhibits the synthesis of versican, a large chondroitin sulfate proteoglycan

Repair of wounded monolayers of cultured vascular endothelial cells after simultaneous exposure to lead and zinc.

Resistance of human brain microvascular endothelial cells in culture to methylmercury: cell-density-dependent defense mechanisms.

Sensitive response of cultured vascular smooth-muscle cells to cadmium cytotoxicity: comparison with cultured vascular endothelial cells and kidney epithelial LLC-PK1 cells

Stimulation by zinc of cultured vascular endothelial cell proliferation: possible involvement of endogenous basic fibroblast growth factor

Stimulation of cultured vascular smooth muscle cell proliferation by thrombospondin is potentiated by zinc

Stimulatory effect of lead on the proliferation of cultured vascular smooth-muscle cells.

Suppression of fibroblast growth factor-2 expression: possible mechanism underlying methylmercury-induced inhibition of the repair of wounded monolayers of cultured human brain microvascular endothelial cells.

Synthesis and anticancer activity of bis(2-arylimidazo[1,2-a]pyridin-3-yl) selenides and diselenides: the copper-catalyzed tandem C-H selenation of 2-arylimidazo[1,2-a]pyridine with selenium

Synthesis, antitumor activity, and cytotoxicity of 4-substituted 1-benzyl-5-diphenylstibano-1H-1,2,3-triazoles

Tolerance to cadmium cytotoxicity is induced by zinc through non-metallothionein mechanisms as well as metallothionein induction in cultured cells

Transcriptional Induction of Metallothionein by Tris(pentafluorophenyl)stibane in Cultured Bovine Aortic Endothelial Cells

Transforming Growth Factor-β1 Modulates the Expression of Syndecan-4 in Cultured Vascular Endothelial Cells in a Biphasic Manner.

Vascular smooth muscle cells in culture are highly sensitive to cadmium cytotoxicity without species-related differences: comparison with Chang liver cells.

[Molecular toxicology led by young scientists 5-biological systems to determine the sensitivity to chemicals]