List of works by Simon Jones

12/15-Lipoxygenase regulates the inflammatory response to bacterial products in vivo

scientific article

A comparison of post-receptor signal transduction events in Jurkat cells transfected with either IL-8R1 or IL-8R2. Chemokine mediated activation of p42/p44 MAP-kinase (ERK-2).

scientific article published on May 1995

A quantifiable proliferative burst of tissue macrophages restores homeostatic macrophage populations after acute inflammation.

scientific article published in August 2011

A role for IL-27p28 as an antagonist of gp130-mediated signaling

scientific article

A unique transcription factor for the A alpha fibrinogen gene is related to the mitochondrial single-stranded DNA binding protein P16

scientific article published on 01 December 1997

Activation of liver X receptors inhibits experimental fibrosis by interfering with interleukin-6 release from macrophages

scientific article published on 11 March 2014

Activation of naïve CD4+ T cells re-tunes STAT1 signaling to deliver unique cytokine responses in memory CD4+ T cells

scientific article published on 19 March 2019

Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signaling function of neutrophils

scientific article published on 13 June 2007

C-reactive protein: a physiological activator of interleukin 6 receptor shedding.

scientific article published on February 1999

Chemokine antagonists that discriminate between interleukin-8 receptors. Selective blockers of CXCR2.

scientific article

Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes

scientific article

Circulating neutrophils maintain physiological blood pressure by suppressing bacteria and IFNgamma-dependent iNOS expression in the vasculature of healthy mice.

scientific article published on 15 February 2008

Classic interleukin-6 receptor signaling and interleukin-6 trans-signaling differentially control angiotensin II-dependent hypertension, cardiac signal transducer and activator of transcription-3 activation, and vascular hypertrophy in vivo

scientific article published in July 2007

Cytomegalovirus-Specific IL-10-Producing CD4+ T Cells Are Governed by Type-I IFN-Induced IL-27 and Promote Virus Persistence

scientific article

Differential dependencies of monocytes and neutrophils on dectin-1, dectin-2 and complement for the recognition of fungal particles in inflammation

scientific article

Directing transition from innate to acquired immunity: defining a role for IL-6.

scientific article

Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation

scientific article published on January 2013

Dynamic expression of IL-6 trans-signalling molecules in the lungs of preterm baboons undergoing mechanical ventilation

scientific article published on 02 March 2011

Enhanced neutrophil migratory activity following major blunt trauma.

scientific article

Esterified eicosanoids are acutely generated by 5-lipoxygenase in primary human neutrophils and in human and murine infection

scientific article

Expression of high- and low-affinity receptors for C3a on the human mast cell line, HMC-1.

scientific article

Foxp3⁺ Treg cells in the inflamed CNS are insensitive to IL-6-driven IL-17 production.

scientific article published in May 2012

Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis

article

Granulocyte chemotactic protein 2 acts via both IL-8 receptors, CXCR1 and CXCR2

scientific article published on 01 January 1998

Hoxb8 conditionally immortalised macrophage lines model inflammatory monocytic cells with important similarity to dendritic cells

scientific article published on 11 January 2011

Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling.

scientific article

IL-10 differentially controls the infiltration of inflammatory macrophages and antigen-presenting cells during inflammation

scientific article published on 05 July 2016

IL-27 - a double agent in the IL-6 family

scientific article published on 13 February 2018

IL-6 Trans-Signaling Links Inflammation with Angiogenesis in the Peritoneal Membrane.

scientific article published on 11 November 2016

IL-6 and its soluble receptor augment aggrecanase-mediated proteoglycan catabolism in articular cartilage

scientific article

IL-6 as a keystone cytokine in health and disease

scientific article published on May 2015

IL-6 regulates neutrophil trafficking during acute inflammation via STAT3

scientific article published on 01 August 2008

IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation.

scientific article

IL-6 transsignaling: the in vivo consequences

scientific article

Implications of the serine protease HtrA1 in amyloid precursor protein processing

scientific article

In vivo functional analysis and genetic modification of in vitro-derived mouse neutrophils

scientific article published on 2 March 2011

Inactivation of IL-6 and soluble IL-6 receptor by neutrophil derived serine proteases in cystic fibrosis

scientific article published on 7 May 2010

Inhibition of classic signaling is a novel function of soluble glycoprotein 130 (sgp130), which is controlled by the ratio of interleukin 6 and soluble interleukin 6 receptor

scientific article published on 11 October 2011

Interferon-gamma inhibits interleukin-1beta-induced matrix metalloproteinase production by synovial fibroblasts and protects articular cartilage in early arthritis.

scientific article

Interferon-gamma protects against the development of structural damage in experimental arthritis by regulating polymorphonuclear neutrophil influx into diseased joints

scientific article published on 01 July 2007

Interleukin 6 (IL-6) deficiency delays lupus nephritis in MRL-Faslpr mice: the IL-6 pathway as a new therapeutic target in treatment of autoimmune kidney disease in systemic lupus erythematosus.

scientific article

Interleukin-10 regulates the inflammasome-driven augmentation of inflammatory arthritis and joint destruction

scientific article published on 30 August 2014

Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer

scientific article

Interleukin-6 limits influenza-induced inflammation and protects against fatal lung pathology

scientific article published on 12 August 2013

Interleukin-6 signaling drives fibrosis in unresolved inflammation

scientific article published on 09 January 2014

Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation

scientific journal article

LAB/NTAL facilitates fungal/PAMP-induced IL-12 and IFN-γ production by repressing β-catenin activation in dendritic cells

scientific article

Loss of CD4+ T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells.

scientific article published on 18 January 2010

Macrophage heterogeneity and acute inflammation

scientific article

Myeloid 12/15-LOX regulates B cell numbers and innate immune antibody levels in vivo

scientific article published on 04 January 2017

Networks of enzymatically oxidized membrane lipids support calcium-dependent coagulation factor binding to maintain hemostasis.

scientific article

Neutrophils recruited by IL-22 in peripheral tissues function as TRAIL-dependent antiviral effectors against MCMV.

scientific article published on April 2014

On-going Mechanical Damage from Mastication Drives Homeostatic Th17 Cell Responses at the Oral Barrier

scientific article published on 6 January 2017

Paracetamol reduces influenza-induced immunopathology in a mouse model of infection without compromising virus clearance or the generation of protective immunity

scientific article

Phosphatidylethanolamine-esterified eicosanoids in the mouse: tissue localization and inflammation-dependent formation in Th-2 disease

scientific article published on 15 June 2009

Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer

scientific article published on 01 December 2018

Regulation of pre-B cell colony-enhancing factor by STAT-3-dependent interleukin-6 trans-signaling: implications in the pathogenesis of rheumatoid arthritis.

scientific article

Regulatory B cells are induced by gut microbiota-driven interleukin-1β and interleukin-6 production

scientific article

STAT3 acts as a co-activator of glucocorticoid receptor signaling

scientific article

Secretion of oncostatin M by infiltrating neutrophils: regulation of IL-6 and chemokine expression in human mesothelial cells

scientific article published on 01 November 2002

Sleep enhances IL-6 trans-signaling in humans

scientific article published on 15 August 2006

Soluble IL-6 Receptor Governs IL-6 Activity in Experimental Arthritis: Blockade of Arthritis Severity by Soluble Glycoprotein 130

scientific article published on 01 September 2003

Suppression of leukocyte infiltration and cartilage degradation by selective inhibition of pre-B cell colony-enhancing factor/visfatin/nicotinamide phosphoribosyltransferase: Apo866-mediated therapy in human fibroblasts and murine collagen-induced a

scientific article published on 01 July 2011

TH17 cells require ongoing classic IL-6 receptor signaling to retain transcriptional and functional identity

scientific article published on 01 July 2020

The antiviral restriction factor IFN-induced transmembrane protein 3 prevents cytokine-driven CMV pathogenesis

scientific article

The interleukin-6 receptor Asp358Ala single nucleotide polymorphism rs2228145 confers increased proteolytic conversion rates by ADAM proteases.

scientific article

The problem of choice: current biologic agents and future prospects in RA.

scientific article published on 19 February 2013

The response of interleukin-6 and soluble interleukin-6 receptor isoforms following intermittent high intensity and continuous moderate intensity cycling

scientific article

The role of human HtrA1 in arthritic disease

scientific article

The role of soluble receptors in cytokine biology: the agonistic properties of the sIL-6R/IL-6 complex

scientific article

The transcription factor Gata6 links tissue macrophage phenotype and proliferative renewal

scientific article

Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling

scientific article

Therapeutic targeting of IL-6 trans signaling counteracts STAT3 control of experimental inflammatory arthritis

scientific article

Tracking Competent Host Defence to Chronic Inflammation: An In Vivo Model of Peritonitis.

scientific article published in January 2018

Transgenic blockade of interleukin 6 transsignaling abrogates inflammation

scientific article published on 7 November 2007

Viral IL-6 Blocks Neutrophil Infiltration during Acute Inflammation

scientific article published on 01 September 2005

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