List of works - Nicole L La Gruta

A correlation between function and selected measures of T cell avidity in influenza virus-specific CD8+ T cell responses

scientific article

A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis

scientific article

A question of self-preservation: immunopathology in influenza virus infection.

scientific article

A trans-Golgi network golgin is required for the regulated secretion of TNF in activated macrophages in vivo

scholarly article

A virus-specific CD8+ T cell immunodominance hierarchy determined by antigen dose and precursor frequencies

scientific article

Age-Related Decline in Primary CD8+ T Cell Responses Is Associated with the Development of Senescence in Virtual Memory CD8+ T Cells

article

Altered CD8(+) T cell immunodominance after vaccinia virus infection and the naive repertoire in inbred and F(1) mice.

scientific article

Antigen Specificity of Type I NKT Cells Is Governed by TCR β-Chain Diversity.

scientific article published on 30 September 2015

Architectural changes in the TCR:CD3 complex induced by MHC:peptide ligation.

scientific article published in March 2004

CD4+CD8β+ double-positive T cells in skin-draining lymph nodes respond to inflammatory signals from the skin

scientific article published on 21 June 2017

Cell cycle-related acquisition of cytotoxic mediators defines the progressive differentiation to effector status for virus-specific CD8+ T cells

scientific article published in September 2008

Characterisation of clinical and immune reactivity to barley and rye ingestion in children with coeliac disease

scientific article published on 28 August 2019

Characterization of CD8+ T cell repertoire diversity and persistence in the influenza A virus model of localized, transient infection

scientific article published on June 2004

Clonally diverse CD38+HLA-DR+CD8+ T cells persist during fatal H7N9 disease.

scientific article published on 26 February 2018

Consistency in polyclonal T-cell responses to gluten between children and adults with celiac disease.

scientific article published on 27 July 2015

Contribution of T cell receptor affinity to overall avidity for virus-specific CD8+ T cell responses

scientific article

Corrigendum to ''Modelling cross-reactivity and memory in the cellular adaptive immune response to influenza infection in the host'' [J.Theor. Biol. 413 (2017) 34-49].

scientific article published in April 2017

Dendritic cell preactivation impairs MHC class II presentation of vaccines and endogenous viral antigens

scholarly article

Differential regulation of gastric tumor growth by cytokines that signal exclusively through the coreceptor gp130.

scientific article

Differential tumor necrosis factor receptor 2-mediated editing of virus-specific CD8+ effector T cells

scholarly article

Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells

scientific article published on 3 May 2017

Ecological analysis of antigen-specific CTL repertoires defines the relationship between naïve and immune T-cell populations ⬇️

scientific article (publication date: 29 January 2013)

Effect of MHC class I diversification on influenza epitope-specific CD8+ T cell precursor frequency and subsequent effector function

scientific article

Effector CD8+ T cells recovered from an influenza pneumonia differentiate to a state of focused gene expression

scientific article

Epitope-specific TCR repertoire diversity imparts no functional advantage on the CD8+ T cell response to cognate viral peptides

scientific article

Establishment and recall of CD8+ T-cell memory in a model of localized transient infection

scientific article published on June 2006

Extrinsically derived TNF is primarily responsible for limiting antiviral CD8+ T cell response magnitude

scientific article published on 8 September 2017

Fixed expression of single influenza virus-specific TCR chains demonstrates the capacity for TCR α- and β-chain diversity in the face of peptide-MHC class I specificity

scientific article published on 22 December 2014

Forewarned is forearmed

scientific article published in July 2010

Functional implications of T cell receptor diversity

scientific article published on 11 June 2009

Heightened self-reactivity associated with selective survival, but not expansion, of naïve virus-specific CD8+ T cells in aged mice

scientific article published on 19 January 2016

Hierarchies in cytokine expression profiles for acute and resolving influenza virus-specific CD8+ T cell responses: correlation of cytokine profile and TCR avidity

scientific article published in May 2004

IL-18, but not IL-12, is required for optimal cytokine production by influenza virus-specific CD8+ T cells

scientific article published in February 2007

Immunopathogenesis, loss of T cell tolerance and genetics of autoimmune gastritis

scientific article

Influenza epitope-specific CD8+ T cell avidity, but not cytokine polyfunctionality, can be determined by TCRβ clonotype

scientific article

Influenza-induced, helper-independent CD8+ T cell responses use CD40 costimulation at the late phase of the primary response

scientific article published on 29 October 2012

Interrogating the relationship between naïve and immune antiviral T cell repertoires

scientific article published on 10 July 2013

Killer T cells in influenza

scientific article published on 28 August 2008

Lack of prominent peptide-major histocompatibility complex features limits repertoire diversity in virus-specific CD8+ T cell populations

scientific article published on 27 February 2005

Metabolic characteristics of CD8+ T cell subsets in young and aged individuals are not predictive of functionality

scientific article published on 05 June 2020

Modelling cross-reactivity and memory in the cellular adaptive immune response to influenza infection in the host. ⬇️

scientific article

Most viral peptides displayed by class I MHC on infected cells are immunogenic

scientific article

Multiplexed combinatorial tetramer staining in a mouse model of virus infection.

scientific article published on 15 June 2010

Overlapping Peptides Elicit Distinct CD8+ T Cell Responses following Influenza A Virus Infection

scientific article published on 31 August 2020

PTPN2 attenuates T-cell lymphopenia-induced proliferation

scientific article published in Nature Communications

Paired TCRαβ analysis of virus-specific CD8(+) T cells exposes diversity in a previously defined 'narrow' repertoire

scientific article

Precursor frequency and competition dictate the HLA-A2-restricted CD8+ T cell responses to influenza A infection and vaccination in HLA-A2.1 transgenic mice.

scientific article published on 15 July 2011

Primary CTL response magnitude in mice is determined by the extent of naive T cell recruitment and subsequent clonal expansion

scientific article

Protective Efficacy of Cross-Reactive CD8+ T Cells Recognising Mutant Viral Epitopes Depends on Peptide-MHC-I Structural Interactions and T Cell Activation Threshold

scientific article

Publisher Correction: Metabolic characteristics of CD8+ T cell subsets in young and aged individuals are not predictive of functionality

scientific article published on 09 July 2020

Quantifiable predictive features define epitope-specific T cell receptor repertoires

scientific article published on 21 June 2017

Quantification of epitope abundance reveals the effect of direct and cross-presentation on influenza CTL responses

scientific article published on 28 June 2019

Recognition of the Major Histocompatibility Complex (MHC) Class Ib Molecule H2-Q10 by the Natural Killer Cell Receptor Ly49C.

scientific article published on 6 July 2016

Reproducible selection of high avidity CD8+ T-cell clones following secondary acute virus infection

scientific article published on 13 January 2014

Reversed T Cell Receptor Docking on a Major Histocompatibility Class I Complex Limits Involvement in the Immune Response

scientific article

Role of CD8(+) T-cell immunity in influenza infection: potential use in future vaccine development

scientific article published in October 2009

Simulation modelling for immunologists

scientific article published on 05 December 2019

Sizing up the key determinants of the CD8(+) T cell response

scientific article published on 09 October 2015

Structural basis for enabling T-cell receptor diversity within biased virus-specific CD8+ T-cell responses

scientific article

T cell mediated immunity to influenza: mechanisms of viral control

scientific article published on 16 July 2014

T cell receptor recognition of hybrid insulin peptides bound to HLA-DQ8

scientific article published on 25 August 2021

T cells recognizing a 11mer influenza peptide complexed to H-2D(b) show promiscuity for peptide length.

scientific article

T-cell receptor recognition of HLA-DQ2-gliadin complexes associated with celiac disease

scientific article

Targeted deletion of Traf2 allows immunosuppression-free islet allograft survival in mice.

scientific article published on 6 January 2017

Terminal deoxynucleotidyltransferase is required for the establishment of private virus-specific CD8+ TCR repertoires and facilitates optimal CTL responses

scientific article published on August 2008

The Impact of MHC Class I Dose on Development and Maintenance of the Polyclonal Naive CD8+ T Cell Repertoire

scientific article published on 27 April 2020

The influenza virus-specific CTL immunodominance hierarchy in mice is determined by the relative frequency of high-avidity T cells

scientific article published on 2 April 2014

The linear range for accurately quantifying antigen-specific T-cell frequencies by tetramer staining during natural immune responses

scientific article published on 11 April 2011

The role of natural killer cells in the induction of autoimmune gastritis

scientific article published on 01 January 2001

The structural basis for autonomous dimerization of the pre-T-cell antigen receptor

scientific article published on 14 October 2010

Thymic expression of a gastritogenic epitope results in positive selection of self-reactive pathogenic T cells

scientific article published in May 2004

Tracking phenotypically and functionally distinct T cell subsets via T cell repertoire diversity

scientific article published on 24 August 2007

Ubiquitin ligase MARCH 8 cooperates with CD83 to control surface MHC II expression in thymic epithelium and CD4 T cell selection

scientific article published on 08 August 2016

Understanding the drivers of MHC restriction of T cell receptors

scientific article published on 01 July 2018

Unlike CD4+ T-cell help, CD28 costimulation is necessary for effective primary CD8+ T-cell influenza-specific immunity

scientific article published on 14 June 2012

Visualizing CTL activity for different CD8+ effector T cells supports the idea that lower TCR/epitope avidity may be advantageous for target cell killing.

scientific article published on 9 January 2009

List of works by Nicole L La Gruta

A correlation between function and selected measures of T cell avidity in influenza virus-specific CD8+ T cell responses

A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis

A question of self-preservation: immunopathology in influenza virus infection.

A trans-Golgi network golgin is required for the regulated secretion of TNF in activated macrophages in vivo

A virus-specific CD8+ T cell immunodominance hierarchy determined by antigen dose and precursor frequencies

Age-Related Decline in Primary CD8+ T Cell Responses Is Associated with the Development of Senescence in Virtual Memory CD8+ T Cells

Altered CD8(+) T cell immunodominance after vaccinia virus infection and the naive repertoire in inbred and F(1) mice.

Antigen Specificity of Type I NKT Cells Is Governed by TCR β-Chain Diversity.

Architectural changes in the TCR:CD3 complex induced by MHC:peptide ligation.

CD4+CD8β+ double-positive T cells in skin-draining lymph nodes respond to inflammatory signals from the skin

Cell cycle-related acquisition of cytotoxic mediators defines the progressive differentiation to effector status for virus-specific CD8+ T cells

Characterisation of clinical and immune reactivity to barley and rye ingestion in children with coeliac disease

Characterization of CD8+ T cell repertoire diversity and persistence in the influenza A virus model of localized, transient infection

Clonally diverse CD38+HLA-DR+CD8+ T cells persist during fatal H7N9 disease.

Consistency in polyclonal T-cell responses to gluten between children and adults with celiac disease.

Contribution of T cell receptor affinity to overall avidity for virus-specific CD8+ T cell responses

Corrigendum to ''Modelling cross-reactivity and memory in the cellular adaptive immune response to influenza infection in the host'' [J.Theor. Biol. 413 (2017) 34-49].

Dendritic cell preactivation impairs MHC class II presentation of vaccines and endogenous viral antigens

Differential regulation of gastric tumor growth by cytokines that signal exclusively through the coreceptor gp130.

Differential tumor necrosis factor receptor 2-mediated editing of virus-specific CD8+ effector T cells

Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells

Ecological analysis of antigen-specific CTL repertoires defines the relationship between naïve and immune T-cell populations ⬇️

Effect of MHC class I diversification on influenza epitope-specific CD8+ T cell precursor frequency and subsequent effector function

Effector CD8+ T cells recovered from an influenza pneumonia differentiate to a state of focused gene expression

Epitope-specific TCR repertoire diversity imparts no functional advantage on the CD8+ T cell response to cognate viral peptides

Establishment and recall of CD8+ T-cell memory in a model of localized transient infection

Extrinsically derived TNF is primarily responsible for limiting antiviral CD8+ T cell response magnitude

Fixed expression of single influenza virus-specific TCR chains demonstrates the capacity for TCR α- and β-chain diversity in the face of peptide-MHC class I specificity

Forewarned is forearmed

Functional implications of T cell receptor diversity

Heightened self-reactivity associated with selective survival, but not expansion, of naïve virus-specific CD8+ T cells in aged mice

Hierarchies in cytokine expression profiles for acute and resolving influenza virus-specific CD8+ T cell responses: correlation of cytokine profile and TCR avidity

IL-18, but not IL-12, is required for optimal cytokine production by influenza virus-specific CD8+ T cells

Immunopathogenesis, loss of T cell tolerance and genetics of autoimmune gastritis

Influenza epitope-specific CD8+ T cell avidity, but not cytokine polyfunctionality, can be determined by TCRβ clonotype

Influenza-induced, helper-independent CD8+ T cell responses use CD40 costimulation at the late phase of the primary response

Interrogating the relationship between naïve and immune antiviral T cell repertoires

Killer T cells in influenza

Lack of prominent peptide-major histocompatibility complex features limits repertoire diversity in virus-specific CD8+ T cell populations

Metabolic characteristics of CD8+ T cell subsets in young and aged individuals are not predictive of functionality

Modelling cross-reactivity and memory in the cellular adaptive immune response to influenza infection in the host. ⬇️

Most viral peptides displayed by class I MHC on infected cells are immunogenic

Multiplexed combinatorial tetramer staining in a mouse model of virus infection.

Overlapping Peptides Elicit Distinct CD8+ T Cell Responses following Influenza A Virus Infection

PTPN2 attenuates T-cell lymphopenia-induced proliferation

Paired TCRαβ analysis of virus-specific CD8(+) T cells exposes diversity in a previously defined 'narrow' repertoire

Precursor frequency and competition dictate the HLA-A2-restricted CD8+ T cell responses to influenza A infection and vaccination in HLA-A2.1 transgenic mice.

Primary CTL response magnitude in mice is determined by the extent of naive T cell recruitment and subsequent clonal expansion

Protective Efficacy of Cross-Reactive CD8+ T Cells Recognising Mutant Viral Epitopes Depends on Peptide-MHC-I Structural Interactions and T Cell Activation Threshold

Publisher Correction: Metabolic characteristics of CD8+ T cell subsets in young and aged individuals are not predictive of functionality

Quantifiable predictive features define epitope-specific T cell receptor repertoires

Quantification of epitope abundance reveals the effect of direct and cross-presentation on influenza CTL responses

Recognition of the Major Histocompatibility Complex (MHC) Class Ib Molecule H2-Q10 by the Natural Killer Cell Receptor Ly49C.

Reproducible selection of high avidity CD8+ T-cell clones following secondary acute virus infection

Reversed T Cell Receptor Docking on a Major Histocompatibility Class I Complex Limits Involvement in the Immune Response

Role of CD8(+) T-cell immunity in influenza infection: potential use in future vaccine development

Simulation modelling for immunologists

Sizing up the key determinants of the CD8(+) T cell response

Structural basis for enabling T-cell receptor diversity within biased virus-specific CD8+ T-cell responses

T cell mediated immunity to influenza: mechanisms of viral control

T cell receptor recognition of hybrid insulin peptides bound to HLA-DQ8

T cells recognizing a 11mer influenza peptide complexed to H-2D(b) show promiscuity for peptide length.

T-cell receptor recognition of HLA-DQ2-gliadin complexes associated with celiac disease

Targeted deletion of Traf2 allows immunosuppression-free islet allograft survival in mice.

Terminal deoxynucleotidyltransferase is required for the establishment of private virus-specific CD8+ TCR repertoires and facilitates optimal CTL responses

The Impact of MHC Class I Dose on Development and Maintenance of the Polyclonal Naive CD8+ T Cell Repertoire

The influenza virus-specific CTL immunodominance hierarchy in mice is determined by the relative frequency of high-avidity T cells

The linear range for accurately quantifying antigen-specific T-cell frequencies by tetramer staining during natural immune responses

The role of natural killer cells in the induction of autoimmune gastritis

The structural basis for autonomous dimerization of the pre-T-cell antigen receptor

Thymic expression of a gastritogenic epitope results in positive selection of self-reactive pathogenic T cells

Tracking phenotypically and functionally distinct T cell subsets via T cell repertoire diversity

Ubiquitin ligase MARCH 8 cooperates with CD83 to control surface MHC II expression in thymic epithelium and CD4 T cell selection

Understanding the drivers of MHC restriction of T cell receptors

Unlike CD4+ T-cell help, CD28 costimulation is necessary for effective primary CD8+ T-cell influenza-specific immunity

Visualizing CTL activity for different CD8+ effector T cells supports the idea that lower TCR/epitope avidity may be advantageous for target cell killing.