List of works - David H Dockrell

52-year-old man with shortness of breath

scientific article published on 01 April 2000

A cardinal role for cathepsin d in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci.

scientific article

A decoy receptor 3 analogue reduces localised defects in phagocyte function in pneumococcal pneumonia ⬇️

scientific article published on June 26, 2012

Acceleration of human neutrophil apoptosis by TRAIL.

scientific article

Alveolar Macrophage Apoptosis Contributes to Pneumococcal Clearance in a Resolving Model of Pulmonary Infection ⬇️

scientific article published on November 15, 2003

Alveolar Macrophage Apoptosis-associated Bacterial Killing Helps Prevent Murine Pneumonia

scientific article published on 01 July 2019

Analysis of histone post translational modifications in primary monocyte derived macrophages using reverse phase×reverse phase chromatography in conjunction with porous graphitic carbon stationary phase.

scientific article published on 07 May 2016

Apoptosis in HIV-1 infection.

scientific article

Apoptotic cell death in the pathogenesis of infectious diseases.

scientific article

Bacterial size matters: Multiple mechanisms controlling septum cleavage and diplococcus formation are critical for the virulence of the opportunistic pathogen Enterococcus faecalis.

scientific article

CD4 regulates susceptibility to Fas ligand- and tumor necrosis factor-mediated apoptosis

scientific article

Clostridium difficile infection in HIV-seropositive individuals and transplant recipients.

scientific article published on 09 December 2011

Contrasting roles for reactive oxygen species and nitric oxide in the innate response to pulmonary infection with Streptococcus pneumoniae

scientific article published on 20 September 2006

Decreased alveolar macrophage apoptosis is associated with increased pulmonary inflammation in a murine model of pneumococcal pneumonia

scientific article published on 01 November 2006

Deficiency of tumour necrosis factor-related apoptosis-inducing ligand exacerbates lung injury and fibrosis.

scientific article

Differential Effects of p38, MAPK, PI3K or Rho Kinase Inhibitors on Bacterial Phagocytosis and Efferocytosis by Macrophages in COPD.

scientific article

Distinct cell death programs in monocytes regulate innate responses following challenge with common causes of invasive bacterial disease.

scientific article published on 23 July 2010

Dynamic changes in Mcl-1 expression regulate macrophage viability or commitment to apoptosis during bacterial clearance

scientific article

Editorial: RSV: a new box of delights for an old enemy.

scientific article published in December 2014

Eosinophilia in returning travellers and migrants from the tropics: UK recommendations for investigation and initial management

scientific article published in January 2010

Epstein‐Barr Virus‐Induced T Cell Lymphoma in Solid Organ Transplant Recipients ⬇️

scientific article published on January 1, 1998

Facing new challenges to promote long-term health for people living with HIV.

scientific article published on 10 November 2016

Gamma interferon enhances internalization and early nonoxidative killing of Salmonella enterica serovar Typhimurium by human macrophages and modifies cytokine responses.

scientific article published on June 2005

Group G streptococcal bacteraemia: an opportunistic infection associated with immune senescence

scientific article published on 01 January 2002

HIV and bone disease ⬇️

scientific article published on November 1, 2010

HIV gp120 in Lungs of ART-treated Individuals Impairs Alveolar Macrophage Responses To Pneumococci

scientific article published on 24 January 2018

Human Rhinovirus Inhibits Macrophage Phagocytosis of Bacteria in Chronic Obstructive Pulmonary Disease. More Than a Common Cold

scientific article published on 01 June 2019

Human herpesvirus 6: molecular biology and clinical features.

scientific article

Human skin commensals augment Staphylococcus aureus pathogenesis

scientific article published on 16 July 2018

Hypercalcemia in a Patient With Hypoparathyroidism and Nocardia asteroides Infection: A Novel Observation ⬇️

scientific article published on August 1, 1997

Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation

scientific article published on 27 May 2022

Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish.

scientific article

Immune-mediated phagocytosis and killing of Streptococcus pneumoniae are associated with direct and bystander macrophage apoptosis.

scientific article published on 24 August 2001

Immunogenicity of three Haemophilus influenzae type b protein conjugate vaccines in HIV seropositive adults and analysis of predictors of vaccine response.

scientific article

Impaired Mitochondrial Microbicidal Responses in Chronic Obstructive Pulmonary Disease Macrophages

scientific article published on 30 May 2017

Impairment of apoptotic cell engulfment by pyocyanin, a toxic metabolite of Pseudomonas aeruginosa.

scientific article published on 4 October 2007

Improved outcomes associated with advances in therapy for invasive fungal infections in immunocompromised hosts.

scientific article published on 13 August 2007

In vivo analysis of Fas/FasL interactions in HIV-infected patients.

scientific article

Inability to sustain intraphagolysosomal killing of Staphylococcus aureus predisposes to bacterial persistence in macrophages

scientific article published on 6 August 2015

Inhibition of ErbB kinase signalling promotes resolution of neutrophilic inflammation

scientific article published on 15 October 2019

Invasive pneumococcal disease and the potential for prevention by vaccination in the United Kingdom

scientific article published on 17 October 2006

Low concordance with HIV testing guidelines in a retrospective review of intensive care practice.

scientific article published on 07 March 2013

Macrophage phenotype is associated with disease severity in preterm infants with chronic lung disease.

scientific article

Mechanistic links between acute respiratory tract infections and acute coronary syndromes.

scientific article

Monocyte and macrophage dysfunction as a cause of HIV-1 induced dysfunction of innate immunity.

scientific article

Monocytes Regulate the Mechanism of T-cell Death by Inducing Fas-Mediated Apoptosis during Bacterial Infection ⬇️

scientific article published on July 19, 2012

Nitric oxide levels regulate macrophage commitment to apoptosis or necrosis during pneumococcal infection.

scientific article

Opsonic Phagocytosis in Chronic Obstructive Pulmonary Disease is Enhanced by Nrf2 Agonists.

scientific article

Phagosomal Acidification Is Required to Kill Streptococcus pneumoniae in a Zebrafish Model

scientific article published in 2022

Platelet P2Y12 Inhibitors Reduce Systemic Inflammation and Its Prothrombotic Effects in an Experimental Human Model.

scientific article

Pneumococcal pneumonia: mechanisms of infection and resolution.

scientific article published on August 2012

Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses

scientific article published on 14 August 2017

Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice

scientific article published on 7 February 2011

Proteomic evaluation and validation of cathepsin D regulated proteins in macrophages exposed to Streptococcus pneumoniae

scientific article

Reactive oxygen species regulate neutrophil recruitment and survival in pneumococcal pneumonia

scientific article published on 17 January 2008

Regulation of phagocyte lifespan in the lung during bacterial infection.

scientific article

Roles of neutrophils in the regulation of the extent of human inflammation through delivery of IL-1 and clearance of chemokines

scientific article

Salvage therapy for invasive aspergillosis.

scientific article published on January 2008

Seroconversion to human herpesvirus 6 following liver transplantation is a marker of cytomegalovirus disease

scientific article published on 01 November 1997

Streptococcus pneumoniae-associated human macrophage apoptosis after bacterial internalization via complement and Fcgamma receptors correlates with intracellular bacterial load.

scientific article published on 10 October 2003

Streptococcus pneumoniae: the role of apoptosis in host defense and pathogenesis.

scientific article published on 15 June 2006

Streptococcus pneumoniaeworsens cerebral ischemia via interleukin 1 and platelet glycoprotein Ibα

scientific article published on 14 April 2014

Successful use of Fendrix in HIV-infected non-responders to standard hepatitis B vaccines.

scientific article published on 31 December 2013

Targeting the networks that underpin contiguous immunity in asthma and chronic obstructive pulmonary disease.

scientific article published on 30 November 2006

The economic cost of invasive pneumococcal disease and the potential for reduction by vaccination in an adult population in South Yorkshire

scientific article published on 01 May 2006

The expression of Fas Ligand by macrophages and its upregulation by human immunodeficiency virus infection.

scientific article

The identification of markers of macrophage differentiation in PMA-stimulated THP-1 cells and monocyte-derived macrophages

scientific article

The multiple roles of Fas ligand in the pathogenesis of infectious diseases.

scientific article published on August 2003

The role of macrophages in the innate immune response to Streptococcus pneumoniae and Staphylococcus aureus: mechanisms and contrasts

scientific article

The role of the macrophage in lung disease mediated by bacteria.

scientific article published on December 2007

The therapeutic potential of epigenetic manipulation during infectious diseases.

scientific article published on 9 August 2016

Toll-like receptors in health and disease: complex questions remain.

scientific article

Variability in parvovirus B19 IgG levels in intravenous immunoglobulin samples

scientific article published on 01 November 1996

Virulence factors in pneumococcal respiratory pathogenesis.

scientific article published on April 2008

List of works by David H Dockrell

52-year-old man with shortness of breath

A cardinal role for cathepsin d in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci.

A decoy receptor 3 analogue reduces localised defects in phagocyte function in pneumococcal pneumonia ⬇️

Acceleration of human neutrophil apoptosis by TRAIL.

Alveolar Macrophage Apoptosis Contributes to Pneumococcal Clearance in a Resolving Model of Pulmonary Infection ⬇️

Alveolar Macrophage Apoptosis-associated Bacterial Killing Helps Prevent Murine Pneumonia

Analysis of histone post translational modifications in primary monocyte derived macrophages using reverse phase×reverse phase chromatography in conjunction with porous graphitic carbon stationary phase.

Apoptosis in HIV-1 infection.

Apoptotic cell death in the pathogenesis of infectious diseases.

Bacterial size matters: Multiple mechanisms controlling septum cleavage and diplococcus formation are critical for the virulence of the opportunistic pathogen Enterococcus faecalis.

CD4 regulates susceptibility to Fas ligand- and tumor necrosis factor-mediated apoptosis

Clostridium difficile infection in HIV-seropositive individuals and transplant recipients.

Contrasting roles for reactive oxygen species and nitric oxide in the innate response to pulmonary infection with Streptococcus pneumoniae

Decreased alveolar macrophage apoptosis is associated with increased pulmonary inflammation in a murine model of pneumococcal pneumonia

Deficiency of tumour necrosis factor-related apoptosis-inducing ligand exacerbates lung injury and fibrosis.

Differential Effects of p38, MAPK, PI3K or Rho Kinase Inhibitors on Bacterial Phagocytosis and Efferocytosis by Macrophages in COPD.

Distinct cell death programs in monocytes regulate innate responses following challenge with common causes of invasive bacterial disease.

Dynamic changes in Mcl-1 expression regulate macrophage viability or commitment to apoptosis during bacterial clearance

Editorial: RSV: a new box of delights for an old enemy.

Eosinophilia in returning travellers and migrants from the tropics: UK recommendations for investigation and initial management

Epstein‐Barr Virus‐Induced T Cell Lymphoma in Solid Organ Transplant Recipients ⬇️

Facing new challenges to promote long-term health for people living with HIV.

Gamma interferon enhances internalization and early nonoxidative killing of Salmonella enterica serovar Typhimurium by human macrophages and modifies cytokine responses.

Group G streptococcal bacteraemia: an opportunistic infection associated with immune senescence

HIV and bone disease ⬇️

HIV gp120 in Lungs of ART-treated Individuals Impairs Alveolar Macrophage Responses To Pneumococci

Human Rhinovirus Inhibits Macrophage Phagocytosis of Bacteria in Chronic Obstructive Pulmonary Disease. More Than a Common Cold

Human herpesvirus 6: molecular biology and clinical features.

Human skin commensals augment Staphylococcus aureus pathogenesis

Hypercalcemia in a Patient With Hypoparathyroidism and Nocardia asteroides Infection: A Novel Observation ⬇️

Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation

Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish.

Immune-mediated phagocytosis and killing of Streptococcus pneumoniae are associated with direct and bystander macrophage apoptosis.

Immunogenicity of three Haemophilus influenzae type b protein conjugate vaccines in HIV seropositive adults and analysis of predictors of vaccine response.

Impaired Mitochondrial Microbicidal Responses in Chronic Obstructive Pulmonary Disease Macrophages

Impairment of apoptotic cell engulfment by pyocyanin, a toxic metabolite of Pseudomonas aeruginosa.

Improved outcomes associated with advances in therapy for invasive fungal infections in immunocompromised hosts.

In vivo analysis of Fas/FasL interactions in HIV-infected patients.

Inability to sustain intraphagolysosomal killing of Staphylococcus aureus predisposes to bacterial persistence in macrophages

Inhibition of ErbB kinase signalling promotes resolution of neutrophilic inflammation

Invasive pneumococcal disease and the potential for prevention by vaccination in the United Kingdom

Low concordance with HIV testing guidelines in a retrospective review of intensive care practice.

Macrophage phenotype is associated with disease severity in preterm infants with chronic lung disease.

Mechanistic links between acute respiratory tract infections and acute coronary syndromes.

Monocyte and macrophage dysfunction as a cause of HIV-1 induced dysfunction of innate immunity.

Monocytes Regulate the Mechanism of T-cell Death by Inducing Fas-Mediated Apoptosis during Bacterial Infection ⬇️

Nitric oxide levels regulate macrophage commitment to apoptosis or necrosis during pneumococcal infection.

Opsonic Phagocytosis in Chronic Obstructive Pulmonary Disease is Enhanced by Nrf2 Agonists.

Phagosomal Acidification Is Required to Kill Streptococcus pneumoniae in a Zebrafish Model

Platelet P2Y12 Inhibitors Reduce Systemic Inflammation and Its Prothrombotic Effects in an Experimental Human Model.

Pneumococcal pneumonia: mechanisms of infection and resolution.

Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses

Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice

Proteomic evaluation and validation of cathepsin D regulated proteins in macrophages exposed to Streptococcus pneumoniae

Reactive oxygen species regulate neutrophil recruitment and survival in pneumococcal pneumonia

Regulation of phagocyte lifespan in the lung during bacterial infection.

Roles of neutrophils in the regulation of the extent of human inflammation through delivery of IL-1 and clearance of chemokines

Salvage therapy for invasive aspergillosis.

Seroconversion to human herpesvirus 6 following liver transplantation is a marker of cytomegalovirus disease

Streptococcus pneumoniae-associated human macrophage apoptosis after bacterial internalization via complement and Fcgamma receptors correlates with intracellular bacterial load.

Streptococcus pneumoniae: the role of apoptosis in host defense and pathogenesis.

Streptococcus pneumoniaeworsens cerebral ischemia via interleukin 1 and platelet glycoprotein Ibα

Successful use of Fendrix in HIV-infected non-responders to standard hepatitis B vaccines.

Targeting the networks that underpin contiguous immunity in asthma and chronic obstructive pulmonary disease.

The economic cost of invasive pneumococcal disease and the potential for reduction by vaccination in an adult population in South Yorkshire

The expression of Fas Ligand by macrophages and its upregulation by human immunodeficiency virus infection.

The identification of markers of macrophage differentiation in PMA-stimulated THP-1 cells and monocyte-derived macrophages

The multiple roles of Fas ligand in the pathogenesis of infectious diseases.

The role of macrophages in the innate immune response to Streptococcus pneumoniae and Staphylococcus aureus: mechanisms and contrasts

The role of the macrophage in lung disease mediated by bacteria.

The therapeutic potential of epigenetic manipulation during infectious diseases.

Toll-like receptors in health and disease: complex questions remain.

Variability in parvovirus B19 IgG levels in intravenous immunoglobulin samples

Virulence factors in pneumococcal respiratory pathogenesis.