List of works - John H Bushweller

1H, 13C and 15N NMR resonance assignments of vaccinia glutaredoxin-1 in the fully reduced form

scientific article published on 01 August 1998

3D 13C-15N-heteronuclear two-spin coherence spectroscopy for polypeptide backbone assignments in 13C-15N-double-labeled proteins.

scientific article published in January 1993

A PCR-based method for uniform 13C/15N labeling of long DNA oligomers

scientific article published on 01 October 1998

A tool compound targeting the core binding factor Runt domain to disrupt binding to CBFβ in leukemic cells

scientific article published on 18 December 2017

Allosteric Inhibition of the Protein-Protein Interaction between the Leukemia-Associated Proteins Runx1 and CBFβ

scientific article

Allosteric activation of protein phosphatase 2C by D-chiro-inositol-galactosamine, a putative mediator mimetic of insulin action.

scientific article

An optimized PCR-based procedure for production of 13C/15N-labeled DNA.

scientific article published in June 2001

Application of fragment-based drug discovery to membrane proteins: identification of ligands of the integral membrane enzyme DsbB

scientific article

Assignment of 1H, 13C and 15N resonances of the N-terminal microtubule-binding domain of human doublecortin

scientific article published on 01 January 2003

Bacillus anthracis Peptidoglycan Integrity Is Disrupted by the Chemokine CXCL10 through the FtsE/X Complex.

scientific article

Binding specificity and mechanistic insight into glutaredoxin-catalyzed protein disulfide reduction

scientific article

Biosynthetic 15N and 13C isotope labelling of glutathione in the mixed disulfide with Escherichia coli glutaredoxin documented by sequence-specific NMR assignments

scientific article published on 01 December 1993

CBFβ-SMMHC Inhibition Triggers Apoptosis by Disrupting MYC Chromatin Dynamics in Acute Myeloid Leukemia

article

CBFβ-SMMHC Inhibition Triggers Apoptosis by Disrupting MYC Chromatin Dynamics in Acute Myeloid Leukemia

scientific article published on 01 August 2018

Charged gels as orienting media for measurement of residual dipolar couplings in soluble and integral membrane proteins.

scientific article

Chemical biology. A small-molecule inhibitor of the aberrant transcription factor CBFβ-SMMHC delays leukemia in mice

scientific article

Complete heteronuclear NMR resonance assignments and secondary structure of core binding factor beta (1-141).

scientific article

Corrigendum to: "Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers" [EBioMedicine 8 (2016) 117-131].

scientific article published on 31 October 2017

Degree of recruitment of DOT1L to MLL-AF9 defines level of H3K79 Di- and tri-methylation on target genes and transformation potential.

scientific article

Disease mutations in RUNX1 and RUNX2 create nonfunctional, dominant-negative, or hypomorphic alleles.

scientific article

Energetic contribution of residues in the Runx1 Runt domain to DNA binding.

scientific article

Functional specificity of CpG DNA-binding CXXC domains in mixed lineage leukemia.

scientific article

Hepatoma derived growth factor is a nuclear targeted mitogen

scientific article (publication date: July 2003)

High resolution structure of the HDGF PWWP domain: a potential DNA binding domain.

scientific article

Importance of a specific amino acid pairing for murine MLL leukemias driven by MLLT1/3 or AFF1/4

scientific article

Increasing the accuracy of solution NMR structures of membrane proteins by application of residual dipolar couplings. High-resolution structure of outer membrane protein A.

scientific article

KIX domain determines a selective tumor-promoting role for EP300 and its vulnerability in small cell lung cancer

scientific article published on 16 February 2022

Leukemia fusion target AF9 is an intrinsically disordered transcriptional regulator that recruits multiple partners via coupled folding and binding.

scientific article

MAPK/ERK2 phosphorylates ERG at serine 283 in leukemic cells and promotes stem cell signatures and cell proliferation.

scientific article

MLL protects CpG clusters from methylation within the Hoxa9 gene, maintaining transcript expression.

scientific article

MQ-hCN-based pulse sequences for the measurement of 13C1'-1H1', 13C1'-15N, 1H1'-15N, 13C1'-13C2', 1H1'-13C2',13C6/8-1H6/8, 13C6/8-15N, 1H6/8-15N, 13C6-13C5, 1H6-13C5 dipolar couplings in 13C, 15N-labeled DNA (and RNA).

scientific article

Membrane structures of the hemifusion-inducing fusion peptide mutant G1S and the fusion-blocking mutant G1V of influenza virus hemagglutinin suggest a mechanism for pore opening in membrane fusion

scientific article published in September 2005

Mitotic gene bookmarking by RUNX1 contributes to stabilization of the normal mammary epithelial phenotype

article

Molecular Basis and Targeted Inhibition of CBFβ-SMMHC Acute Myeloid Leukemia

scientific article

Mutagenesis of the Runt domain defines two energetic hot spots for heterodimerization with the core binding factor beta subunit

scientific journal article

On the mechanism of autoinhibition of the RhoA-specific nucleotide exchange factor PDZRhoGEF.

scientific article

Optimal mutation sites for PRE data collection and membrane protein structure prediction.

scientific article

Overexpression, Purification, and Biophysical Characterization of the Heterodimerization Domain of the Core-binding Factor β Subunit ⬇️

scientific article published on January 23, 1998

Preparation, characterization, and complete heteronuclear NMR resonance assignments of the glutaredoxin (C14S)-ribonucleotide reductase B1 737-761 (C754S) mixed disulfide

scientific article published on 01 April 1998

RUNX proteins desensitize multiple myeloma to lenalidomide via protecting IKZFs from degradation

scientific article published on 13 February 2019

RUNX1 is required for oncogenic Myb and Myc enhancer activity in T-cell acute lymphoblastic leukemia

scientific article published on 8 August 2017

RUNX1-targeted therapy for AML expressing somatic or germline mutation in RUNX1

scientific article published on 25 April 2019

Site-directed parallel spin-labeling and paramagnetic relaxation enhancement in structure determination of membrane proteins by solution NMR spectroscopy.

scientific article

Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers

scientific article

Small molecule inhibition of the CBFβ/RUNX interaction decreases ovarian cancer growth and migration through alterations in genes related to epithelial-to-mesenchymal transition

scientific article published on 15 March 2018

Solution structure and elevator mechanism of the membrane electron transporter CcdA.

scientific article

Structural and functional characterization of Runx1, CBF beta, and CBF beta-SMMHC.

scientific article

Structural and functional characterization of the mutant Escherichia coli glutaredoxin (C14----S) and its mixed disulfide with glutathione

scientific article published on September 29, 1992

Structural basis for recognition of SMRT/N-CoR by the MYND domain and its contribution to AML1/ETO's activity

scientific article

Structure and Biophysics of CBFβ/RUNX and Its Translocation Products.

scientific article

Structure of outer membrane protein A transmembrane domain by NMR spectroscopy

scientific article

Structure of the AML1-ETO eTAFH domain-HEB peptide complex and its contribution to AML1-ETO activity.

scientific article

Structure of the MLL CXXC domain-DNA complex and its functional role in MLL-AF9 leukemia.

scientific article

Synthesis and evaluation of substituted 4-aryloxy- and 4-arylsulfanyl-phenyl-2-aminothiazoles as inhibitors of human breast cancer cell proliferation.

scientific article

Targeting transcription factors in cancer - from undruggable to reality

scientific article published on 11 September 2019

The NMR solution structure of human glutaredoxin in the fully reduced form

scientific article

The NOESY jigsaw: automated protein secondary structure and main-chain assignment from sparse, unassigned NMR data.

scientific article

The PHD3 Domain of MLL Acts as a CYP33-Regulated Switch between MLL-Mediated Activation and Repression, ⬇️

scientific article published on August 10, 2010

The binding of the PDZ tandem of syntenin to target proteins.

scientific article

The nuclear magnetic resonance solution structure of the mixed disulfide between Escherichia coli glutaredoxin(C14S) and glutathione.

scientific article

The role of CBFbeta in AML1-ETO's activity

scientific article published on 01 September 2009

The solution structure and dynamics of the DH-PH module of PDZRhoGEF in isolation and in complex with nucleotide-free RhoA.

scientific article

The tetramer structure of the Nervy homology two domain, NHR2, is critical for AML1/ETO's activity

scientific article

Tom1 Modulates Binding of Tollip to Phosphatidylinositol 3-Phosphate via a Coupled Folding and Binding Mechanism

scientific article

List of works by John H Bushweller

1H, 13C and 15N NMR resonance assignments of vaccinia glutaredoxin-1 in the fully reduced form

3D 13C-15N-heteronuclear two-spin coherence spectroscopy for polypeptide backbone assignments in 13C-15N-double-labeled proteins.

A PCR-based method for uniform 13C/15N labeling of long DNA oligomers

A tool compound targeting the core binding factor Runt domain to disrupt binding to CBFβ in leukemic cells

Allosteric Inhibition of the Protein-Protein Interaction between the Leukemia-Associated Proteins Runx1 and CBFβ

Allosteric activation of protein phosphatase 2C by D-chiro-inositol-galactosamine, a putative mediator mimetic of insulin action.

An optimized PCR-based procedure for production of 13C/15N-labeled DNA.

Application of fragment-based drug discovery to membrane proteins: identification of ligands of the integral membrane enzyme DsbB

Assignment of 1H, 13C and 15N resonances of the N-terminal microtubule-binding domain of human doublecortin

Bacillus anthracis Peptidoglycan Integrity Is Disrupted by the Chemokine CXCL10 through the FtsE/X Complex.

Binding specificity and mechanistic insight into glutaredoxin-catalyzed protein disulfide reduction

Biosynthetic 15N and 13C isotope labelling of glutathione in the mixed disulfide with Escherichia coli glutaredoxin documented by sequence-specific NMR assignments

CBFβ-SMMHC Inhibition Triggers Apoptosis by Disrupting MYC Chromatin Dynamics in Acute Myeloid Leukemia

CBFβ-SMMHC Inhibition Triggers Apoptosis by Disrupting MYC Chromatin Dynamics in Acute Myeloid Leukemia

Charged gels as orienting media for measurement of residual dipolar couplings in soluble and integral membrane proteins.

Chemical biology. A small-molecule inhibitor of the aberrant transcription factor CBFβ-SMMHC delays leukemia in mice

Complete heteronuclear NMR resonance assignments and secondary structure of core binding factor beta (1-141).

Corrigendum to: "Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers" [EBioMedicine 8 (2016) 117-131].

Degree of recruitment of DOT1L to MLL-AF9 defines level of H3K79 Di- and tri-methylation on target genes and transformation potential.

Disease mutations in RUNX1 and RUNX2 create nonfunctional, dominant-negative, or hypomorphic alleles.

Energetic contribution of residues in the Runx1 Runt domain to DNA binding.

Functional specificity of CpG DNA-binding CXXC domains in mixed lineage leukemia.

Hepatoma derived growth factor is a nuclear targeted mitogen

High resolution structure of the HDGF PWWP domain: a potential DNA binding domain.

Importance of a specific amino acid pairing for murine MLL leukemias driven by MLLT1/3 or AFF1/4

Increasing the accuracy of solution NMR structures of membrane proteins by application of residual dipolar couplings. High-resolution structure of outer membrane protein A.

KIX domain determines a selective tumor-promoting role for EP300 and its vulnerability in small cell lung cancer

Leukemia fusion target AF9 is an intrinsically disordered transcriptional regulator that recruits multiple partners via coupled folding and binding.

MAPK/ERK2 phosphorylates ERG at serine 283 in leukemic cells and promotes stem cell signatures and cell proliferation.

MLL protects CpG clusters from methylation within the Hoxa9 gene, maintaining transcript expression.

MQ-hCN-based pulse sequences for the measurement of 13C1'-1H1', 13C1'-15N, 1H1'-15N, 13C1'-13C2', 1H1'-13C2',13C6/8-1H6/8, 13C6/8-15N, 1H6/8-15N, 13C6-13C5, 1H6-13C5 dipolar couplings in 13C, 15N-labeled DNA (and RNA).

Membrane structures of the hemifusion-inducing fusion peptide mutant G1S and the fusion-blocking mutant G1V of influenza virus hemagglutinin suggest a mechanism for pore opening in membrane fusion

Mitotic gene bookmarking by RUNX1 contributes to stabilization of the normal mammary epithelial phenotype

Molecular Basis and Targeted Inhibition of CBFβ-SMMHC Acute Myeloid Leukemia

Mutagenesis of the Runt domain defines two energetic hot spots for heterodimerization with the core binding factor beta subunit

On the mechanism of autoinhibition of the RhoA-specific nucleotide exchange factor PDZRhoGEF.

Optimal mutation sites for PRE data collection and membrane protein structure prediction.

Overexpression, Purification, and Biophysical Characterization of the Heterodimerization Domain of the Core-binding Factor β Subunit ⬇️

Preparation, characterization, and complete heteronuclear NMR resonance assignments of the glutaredoxin (C14S)-ribonucleotide reductase B1 737-761 (C754S) mixed disulfide

RUNX proteins desensitize multiple myeloma to lenalidomide via protecting IKZFs from degradation

RUNX1 is required for oncogenic Myb and Myc enhancer activity in T-cell acute lymphoblastic leukemia

RUNX1-targeted therapy for AML expressing somatic or germline mutation in RUNX1

Site-directed parallel spin-labeling and paramagnetic relaxation enhancement in structure determination of membrane proteins by solution NMR spectroscopy.

Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers

Small molecule inhibition of the CBFβ/RUNX interaction decreases ovarian cancer growth and migration through alterations in genes related to epithelial-to-mesenchymal transition

Solution structure and elevator mechanism of the membrane electron transporter CcdA.

Structural and functional characterization of Runx1, CBF beta, and CBF beta-SMMHC.

Structural and functional characterization of the mutant Escherichia coli glutaredoxin (C14----S) and its mixed disulfide with glutathione

Structural basis for recognition of SMRT/N-CoR by the MYND domain and its contribution to AML1/ETO's activity

Structure and Biophysics of CBFβ/RUNX and Its Translocation Products.

Structure of outer membrane protein A transmembrane domain by NMR spectroscopy

Structure of the AML1-ETO eTAFH domain-HEB peptide complex and its contribution to AML1-ETO activity.

Structure of the MLL CXXC domain-DNA complex and its functional role in MLL-AF9 leukemia.

Synthesis and evaluation of substituted 4-aryloxy- and 4-arylsulfanyl-phenyl-2-aminothiazoles as inhibitors of human breast cancer cell proliferation.

Targeting transcription factors in cancer - from undruggable to reality

The NMR solution structure of human glutaredoxin in the fully reduced form

The NOESY jigsaw: automated protein secondary structure and main-chain assignment from sparse, unassigned NMR data.

The PHD3 Domain of MLL Acts as a CYP33-Regulated Switch between MLL-Mediated Activation and Repression, ⬇️

The binding of the PDZ tandem of syntenin to target proteins.

The nuclear magnetic resonance solution structure of the mixed disulfide between Escherichia coli glutaredoxin(C14S) and glutathione.

The role of CBFbeta in AML1-ETO's activity

The solution structure and dynamics of the DH-PH module of PDZRhoGEF in isolation and in complex with nucleotide-free RhoA.

The tetramer structure of the Nervy homology two domain, NHR2, is critical for AML1/ETO's activity

Tom1 Modulates Binding of Tollip to Phosphatidylinositol 3-Phosphate via a Coupled Folding and Binding Mechanism