List of works - Patrice Le Pape

A Decade of Antifungal Leads from Natural Products: 2010-2019

scientific article published on 12 December 2019

A One Health Perspective to Recognize Fusarium as Important in Clinical Practice

scientific article published on 20 October 2020

A glycoprotein isolated from the sponge, Pachymatisma johnstonii, has anti-leishmanial activity

scientific article published on 01 January 2000

Amino acid substitutions at the major insertion loop of Candida albicans sterol 14alpha-demethylase are involved in fluconazole resistance.

scientific article

Answer to May 2016 Photo Quiz.

scientific article published on May 2016

Antileishmanial activities and mechanisms of action of indole-based azoles

scientific article published on 01 June 2006

Antileishmanial and antifungal activities of xanthanolides isolated from Xanthium macrocarpum.

scientific article published in June 2005

Aspergillus fumigatus endocarditis of the mitral valve in a heart transplant recipient: a case report.

scientific article

Azole Resistance in Aspergillus fumigatus in Patients with Cystic Fibrosis: A Matter of Concern?

scientific article

Azole-resistant Aspergillus fumigatus harboring TR34/L98H, TR46/Y121F/T289A and TR53 mutations related to flower fields in Colombia.

scientific article published on 30 March 2017

Benzofuro[3,2-d]pyrimidines inspired from cercosporamide CaPkc1 inhibitor: Synthesis and evaluation of fluconazole susceptibility restoration.

scientific article

Biological exploration of a novel 1,2,4-triazole-indole hybrid molecule as antifungal agent

scientific article published on 01 December 2020

Deciphering azole resistance mechanisms with a focus on transcription factor-encoding genes TAC1, MRR1 and UPC2 in a set of fluconazole-resistant clinical isolates of Candida albicans

scientific article published on 29 August 2013

Design of new antifungal agents: synthesis and evaluation of 1-[(1H-indol-5-ylmethyl)amino]-2-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-2-ols.

scientific article published on 31 August 2009

Design, synthesis and biological evaluation of novel 4-alkapolyenylpyrrolo[1,2-a]quinoxalines as antileishmanial agents--part III

scientific article published on 14 May 2014

Design, synthesis and evaluation of 3-(imidazol- 1-ylmethyl)indoles as antileishmanial agents. Part II.

scientific article published in October 2009

Design, synthesis, and evaluation of 1-(N-benzylamino)-2-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-2-ols as antifungal agents

scientific article published on 14 February 2008

Development of new antileishmanial drugs--current knowledge and future prospects

scientific article published in October 2008

Discovery of a novel broad-spectrum antifungal agent derived from albaconazole.

scientific article

Disseminated Mucormycosis With Cerebral Involvement Owing to Rhizopus Microsporus in a Kidney Recipient Treated With Combined Liposomal Amphotericin B and Posaconazole Therapy.

scientific article published on 30 September 2014

Disseminated mucormycosis due to Lichtheimia corymbifera during ibrutinib treatment for relapsed chronic lymphocytic leukaemia: a case report

scientific article published on 26 October 2018

Econazole imprinted textiles with antifungal activity.

scientific article published on 13 February 2016

Effects of seawater on growth and gliotoxin excretion of marine strains of Aspergillus fumigatus Fres.

scientific article published on 30 October 2007

Emergence of Aspergillus fumigatus azole resistance in azole-naïve patients with chronic obstructive pulmonary disease and their homes.

scientific article published on 30 October 2017

Epidemiology, risk factor, species distribution, antifungal resistance and outcome of Candidemia at a single French hospital: a 7-year study.

scientific article

Evaluation of a new multiplex PCR assay (ParaGENIE G-Amoeba Real-Time PCR kit) targeting Giardia intestinalis, Entamoeba histolytica and Entamoeba dispar/Entamoeba moshkovskii from stool specimens: evidence for the limited performances of microscopy

scientific article published on 15 February 2018

Fatal invasive infection with fungemia due to Microascus cirrosus after heart and lung transplantation in a patient with cystic fibrosis

scientific article published on 4 May 2011

First Human Model of In Vitro Candida albicans Persistence within Granuloma for the Reliable Study of Host-Fungi Interactions ⬇️

scientific article published on June 29, 2012

First report of sporadic cases of Candida auris in Colombia

scientific article published on 5 February 2018

Fungicide-driven alterations in azole-resistant Aspergillus fumigatus are related to vegetable crops in Colombia, South America

scientific article published on 21 March 2019

Gene flow contributes to diversification of the major fungal pathogen Candida albicans.

scientific article

High prevalence of triazole resistance in Aspergillus fumigatus, especially mediated by TR/L98H, in a French cohort of patients with cystic fibrosis.

scientific article

Home Environment as a Source of Life-Threatening Azole-Resistant Aspergillus fumigatus in Immunocompromised Patients.

scientific article published on 28 September 2016

Identification of cryptic Candida species by MALDI-TOF mass spectrometry, not all MALDI-TOF systems are the same: focus on the C. parapsilosis species complex.

scientific article

In vitro immune responses of human PBMCs against Candida albicans reveals fungal and leucocyte phenotypes associated with fungal persistence

scientific article published on 10 April 2020

Infectivity of Leishmania mexicana is associated with differential expression of protein kinase C-like triggered during a cell-cell contact

scientific article

Is procalcitonin increased in cases of invasive amoebiasis? A retrospective, observational study

scientific article published on 28 August 2015

Is real-time PCR-based diagnosis similar in performance to routine parasitological examination for the identification of Giardia intestinalis, Cryptosporidium parvum/Cryptosporidium hominis and Entamoeba histolytica from stool samples? Evaluation of

scientific article

Isoquinolines from the roots of Thalictrum flavum L. and their evaluation as antiparasitic compounds ⬇️

scientific article published on 16 September 2010

Molecular basis of antifungal drug resistance in yeasts

scientific article published on 29 June 2017

Multicenter Comparison of the Etest and EUCAST Methods for Antifungal Susceptibility Testing of Candida Isolates to Micafungin.

scientific article published on 13 June 2016

Multifocal phaeohyphomycosis caused by Exophiala xenobiotica in a kidney transplant recipient

scientific article published on 5 February 2015

Multilocus sequence typing of Pneumocystis jirovecii from clinical samples: how many and which loci should be used?

scientific article published on 19 June 2013

Multiple Fungicide-Driven Alterations in Azole-Resistant Aspergillus fumigatus, Colombia, 2015.

scientific article published on January 2016

Multiplexed infectious protein microarray immunoassay suitable for the study of the specificity of monoclonal immunoglobulins ⬇️

scientific article published on October 26, 2012

Multivalent fucosides with nanomolar affinity for the Aspergillus fumigatus lectin FleA prevent spore adhesion to pneumocytes

scientific article published on 26 November 2018

PCR-based detection of Aspergillus fumigatus and absence of azole resistance due to TR34 /L98H in a french multicenter cohort of 137 patients with fungal rhinosinusitis.

scientific article published on 18 September 2017

Photo Quiz: A Cutaneous Lesion in a 66-Year-Old Traveler Returning from Thailand.

scientific article published on May 2016

Potential application of plant lipid transfer proteins for drug delivery.

scientific article

Prevalence of the reversed halo sign in neutropenic patients compared with non-neutropenic patients: Data from a single-centre study involving 27 patients with pulmonary mucormycosis (2003-2016).

scientific article

Prevalence, geographic risk factor, and development of a standardized protocol for fungal isolation in cystic fibrosis: Results from the international prospective study "MFIP"

scientific article published on 20 October 2018

Prototheca Infections and Ecology from a One Health Perspective

scientific article published on 30 April 2022

Rapid diagnostic tests relying on antigen detection from stool as an efficient point of care testing strategy for giardiasis and cryptosporidiosis? Evaluation of a new immunochromatographic duplex assay

scientific article published on 25 July 2018

Saksenaea erythrospora infection after medical tourism for esthetic breast augmentation surgery

scientific article published on 4 June 2016

Screening for amino acid substitutions in the Candida albicans Erg11 protein of azole-susceptible and azole-resistant clinical isolates: new substitutions and a review of the literature.

scientific article published on April 2010

Synthesis and antifungal activities of new fluconazole analogues with azaheterocycle moiety

scientific article published on 19 April 2007

Synthesis, antileishmanial activity and cytotoxicity of 2,3-diaryl- and 2,3,8-trisubstituted imidazo[1,2-a]pyrazines.

scientific article published on 9 September 2015

Systemic immune presentations of Coxiella burnetii infection (Q Fever).

scientific article published on 24 December 2008

Use of an Itraconazole/allopurinol combination for the treatment of visceral leishmaniasis in a patient with AIDS

scientific article published on 01 November 1995

[Contribution of molecular biology and Aspergillus galactomannan antigen assay for the diagnosis of histoplasmosis]

scientific article published on 28 November 2009

[Identification of three Candida africana strains in Senegal].

scientific article

[Prevalence of Candida parapsilosis, C. orthopsilosis and C. metapsilosis in candidemia over a 5-year period at Nantes hospital and in vitro susceptibility to three echinocandins by E-test®]

scientific article published on 15 September 2010

List of works by Patrice Le Pape

A Decade of Antifungal Leads from Natural Products: 2010-2019

A One Health Perspective to Recognize Fusarium as Important in Clinical Practice

A glycoprotein isolated from the sponge, Pachymatisma johnstonii, has anti-leishmanial activity

Amino acid substitutions at the major insertion loop of Candida albicans sterol 14alpha-demethylase are involved in fluconazole resistance.

Answer to May 2016 Photo Quiz.

Antileishmanial activities and mechanisms of action of indole-based azoles

Antileishmanial and antifungal activities of xanthanolides isolated from Xanthium macrocarpum.

Aspergillus fumigatus endocarditis of the mitral valve in a heart transplant recipient: a case report.

Azole Resistance in Aspergillus fumigatus in Patients with Cystic Fibrosis: A Matter of Concern?

Azole-resistant Aspergillus fumigatus harboring TR34/L98H, TR46/Y121F/T289A and TR53 mutations related to flower fields in Colombia.

Benzofuro[3,2-d]pyrimidines inspired from cercosporamide CaPkc1 inhibitor: Synthesis and evaluation of fluconazole susceptibility restoration.

Biological exploration of a novel 1,2,4-triazole-indole hybrid molecule as antifungal agent

Deciphering azole resistance mechanisms with a focus on transcription factor-encoding genes TAC1, MRR1 and UPC2 in a set of fluconazole-resistant clinical isolates of Candida albicans

Design of new antifungal agents: synthesis and evaluation of 1-[(1H-indol-5-ylmethyl)amino]-2-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-2-ols.

Design, synthesis and biological evaluation of novel 4-alkapolyenylpyrrolo[1,2-a]quinoxalines as antileishmanial agents--part III

Design, synthesis and evaluation of 3-(imidazol- 1-ylmethyl)indoles as antileishmanial agents. Part II.

Design, synthesis, and evaluation of 1-(N-benzylamino)-2-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-2-ols as antifungal agents

Development of new antileishmanial drugs--current knowledge and future prospects

Discovery of a novel broad-spectrum antifungal agent derived from albaconazole.

Disseminated Mucormycosis With Cerebral Involvement Owing to Rhizopus Microsporus in a Kidney Recipient Treated With Combined Liposomal Amphotericin B and Posaconazole Therapy.

Disseminated mucormycosis due to Lichtheimia corymbifera during ibrutinib treatment for relapsed chronic lymphocytic leukaemia: a case report

Econazole imprinted textiles with antifungal activity.

Effects of seawater on growth and gliotoxin excretion of marine strains of Aspergillus fumigatus Fres.

Emergence of Aspergillus fumigatus azole resistance in azole-naïve patients with chronic obstructive pulmonary disease and their homes.

Epidemiology, risk factor, species distribution, antifungal resistance and outcome of Candidemia at a single French hospital: a 7-year study.

Evaluation of a new multiplex PCR assay (ParaGENIE G-Amoeba Real-Time PCR kit) targeting Giardia intestinalis, Entamoeba histolytica and Entamoeba dispar/Entamoeba moshkovskii from stool specimens: evidence for the limited performances of microscopy

Fatal invasive infection with fungemia due to Microascus cirrosus after heart and lung transplantation in a patient with cystic fibrosis

First Human Model of In Vitro Candida albicans Persistence within Granuloma for the Reliable Study of Host-Fungi Interactions ⬇️

First report of sporadic cases of Candida auris in Colombia

Fungicide-driven alterations in azole-resistant Aspergillus fumigatus are related to vegetable crops in Colombia, South America

Gene flow contributes to diversification of the major fungal pathogen Candida albicans.

High prevalence of triazole resistance in Aspergillus fumigatus, especially mediated by TR/L98H, in a French cohort of patients with cystic fibrosis.

Home Environment as a Source of Life-Threatening Azole-Resistant Aspergillus fumigatus in Immunocompromised Patients.

Identification of cryptic Candida species by MALDI-TOF mass spectrometry, not all MALDI-TOF systems are the same: focus on the C. parapsilosis species complex.

In vitro immune responses of human PBMCs against Candida albicans reveals fungal and leucocyte phenotypes associated with fungal persistence

Infectivity of Leishmania mexicana is associated with differential expression of protein kinase C-like triggered during a cell-cell contact

Is procalcitonin increased in cases of invasive amoebiasis? A retrospective, observational study

Is real-time PCR-based diagnosis similar in performance to routine parasitological examination for the identification of Giardia intestinalis, Cryptosporidium parvum/Cryptosporidium hominis and Entamoeba histolytica from stool samples? Evaluation of

Isoquinolines from the roots of Thalictrum flavum L. and their evaluation as antiparasitic compounds ⬇️

Molecular basis of antifungal drug resistance in yeasts

Multicenter Comparison of the Etest and EUCAST Methods for Antifungal Susceptibility Testing of Candida Isolates to Micafungin.

Multifocal phaeohyphomycosis caused by Exophiala xenobiotica in a kidney transplant recipient

Multilocus sequence typing of Pneumocystis jirovecii from clinical samples: how many and which loci should be used?

Multiple Fungicide-Driven Alterations in Azole-Resistant Aspergillus fumigatus, Colombia, 2015.

Multiplexed infectious protein microarray immunoassay suitable for the study of the specificity of monoclonal immunoglobulins ⬇️

Multivalent fucosides with nanomolar affinity for the Aspergillus fumigatus lectin FleA prevent spore adhesion to pneumocytes

PCR-based detection of Aspergillus fumigatus and absence of azole resistance due to TR34 /L98H in a french multicenter cohort of 137 patients with fungal rhinosinusitis.

Photo Quiz: A Cutaneous Lesion in a 66-Year-Old Traveler Returning from Thailand.

Potential application of plant lipid transfer proteins for drug delivery.

Prevalence of the reversed halo sign in neutropenic patients compared with non-neutropenic patients: Data from a single-centre study involving 27 patients with pulmonary mucormycosis (2003-2016).

Prevalence, geographic risk factor, and development of a standardized protocol for fungal isolation in cystic fibrosis: Results from the international prospective study "MFIP"

Prototheca Infections and Ecology from a One Health Perspective

Rapid diagnostic tests relying on antigen detection from stool as an efficient point of care testing strategy for giardiasis and cryptosporidiosis? Evaluation of a new immunochromatographic duplex assay

Saksenaea erythrospora infection after medical tourism for esthetic breast augmentation surgery

Screening for amino acid substitutions in the Candida albicans Erg11 protein of azole-susceptible and azole-resistant clinical isolates: new substitutions and a review of the literature.

Synthesis and antifungal activities of new fluconazole analogues with azaheterocycle moiety

Synthesis, antileishmanial activity and cytotoxicity of 2,3-diaryl- and 2,3,8-trisubstituted imidazo[1,2-a]pyrazines.

Systemic immune presentations of Coxiella burnetii infection (Q Fever).

Use of an Itraconazole/allopurinol combination for the treatment of visceral leishmaniasis in a patient with AIDS

[Contribution of molecular biology and Aspergillus galactomannan antigen assay for the diagnosis of histoplasmosis]

[Identification of three Candida africana strains in Senegal].

[Prevalence of Candida parapsilosis, C. orthopsilosis and C. metapsilosis in candidemia over a 5-year period at Nantes hospital and in vitro susceptibility to three echinocandins by E-test®]