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List of works by Laure Elens

A New CYP3A5*3 and CYP3A4*22 Cluster Influencing Tacrolimus Target Concentrations: A Population Approach

scientific article published on 3 January 2017

A new functional CYP3A4 intron 6 polymorphism significantly affects tacrolimus pharmacokinetics in kidney transplant recipients.

scientific article published on 8 September 2011

A population pharmacokinetic model to predict the individual starting dose of tacrolimus in adult renal transplant recipients

article

ABCB1 1199G>A genetic polymorphism (Rs2229109) influences the intracellular accumulation of tacrolimus in HEK293 and K562 recombinant cell lines

scientific article (publication date: 2014)

ABCB1 1199G>A polymorphism (rs2229109) affects the transport of imatinib, nilotinib and dasatinib.

scientific article published on 7 June 2016

Acute intoxication with nevirapine in an HIV-1-infected patient: clinical and pharmacokinetic follow up.

scientific article

Advanced cancer pain: the search for genetic factors correlated with interindividual variability in opioid requirement

scientific article published on 26 July 2017

Association between ABCC2 polymorphism and lopinavir accumulation in peripheral blood mononuclear cells of HIV-infected patients.

scientific article published in October 2009

Association of CYP3A variants with kidney transplant outcomes

scientific article published on 03 February 2015

CYP2C9*2 allele increases risk for hypoglycemia in POR*1/*1 type 2 diabetic patients treated with sulfonylureas

scientific article published on 24 January 2014

CYP3A4 Intron 6 C>T SNP ( CYP3A4*22 ) Encodes Lower CYP3A4 Activity in Cancer Patients, as Measured with Probes Midazolam and Erythromycin ⬇️

scientific article published on January 1, 2013

CYP3A4*22 : Promising Newly Identified CYP3A4 Variant Allele for Personalizing Pharmacotherapy ⬇️

scientific article published on January 1, 2013

CYP3A4*22 genotype and systemic exposure affect paclitaxel-induced neurotoxicity.

scientific article published on 02 May 2013

CYP3A5 and ABCB1 Polymorphisms and Tacrolimus Pharmacokinetics in Renal Transplant Candidates: Guidelines from an Experimental Study

scientific article published on 01 November 2006

CYP3A5 and ABCB1 polymorphisms influence tacrolimus concentrations in peripheral blood mononuclear cells after renal transplantation.

scientific article published in May 2010

Clinical implementation of pharmacogenetics in kidney transplantation: calcineurin inhibitors in the starting blocks.

scientific article published on April 2014

Cytochrome P450 genotype and aggressive behavior on selective serotonin reuptake inhibitors

scientific article published on 31 August 2018

Dental Apical Papilla as Therapy for Spinal Cord Injury

scientific article published on 4 September 2015

Detection of a rare CYP3A4 variant in a transplant patient characterized by a tacrolimus poor metabolizer phenotype.

scientific article

Effect of ABCB1 genetic polymorphisms on the transport of rivaroxaban in HEK293 recombinant cell lines.

scientific article published on 12 July 2018

Effect of UGT2B7 -900G>A (-842G>A; rs7438135) on morphine glucuronidation in preterm newborns: results from a pilot cohort.

scientific article

Effect of a new functionalCYP3A4polymorphism on calcineurin inhibitors’ dose requirements and trough blood levels in stable renal transplant patients

scientific article published on 08 September 2011

Exploration of Reduced Doses and Short-Cycle Therapy for Darunavir/Cobicistat in Patients with HIV Using Population Pharmacokinetic Modeling and Simulations

scientific article published on 22 July 2020

Functional defect caused by the 4544G>A SNP in ABCC2: potential impact for drug cellular disposition

scientific article published on December 2011

Genetic Predisposition to Poor Opioid Response in Preterm Infants: Impact of KCNJ6 and COMT Polymorphisms on Pain Relief After Endotracheal Intubation.

scientific article published on 17 March 2016

Genetic variation in the ABCC2 gene is associated with dose decreases or switches to other cholesterol-lowering drugs during simvastatin and atorvastatin therapy ⬇️

scientific article published on December 20, 2011

Genetic variation in the PPARA gene is associated with simvastatin-mediated cholesterol reduction in the Rotterdam Study.

scientific article published in August 2013

Genotype-based tacrolimus dosing guidelines: with or without CYP3A4*22?

scientific article published on 02 November 2017

Gut microbiome modulates tacrolimus pharmacokinetics through the transcriptional regulation of ABCB1

scientific article published on 6 July 2023

HYGIEIA: HYpothesizing the Genesis of Infectious Diseases and Epidemics through an Integrated Systems Biology Approach

scientific article published on 24 June 2022

Impact of ABCB1 1236C > T-2677G > T-3435C > T polymorphisms on the anti-proliferative activity of imatinib, nilotinib, dasatinib and ponatinib

scientific article published on 12 July 2016

Impact of CYP3A4*22 allele on tacrolimus pharmacokinetics in early period after renal transplantation: toward updated genotype-based dosage guidelines.

scientific article published in October 2013

Impact of POR*28 on the clinical pharmacokinetics of CYP3A phenotyping probes midazolam and erythromycin.

scientific article

Impact of POR*28 on the pharmacokinetics of tacrolimus and cyclosporine A in renal transplant patients

scientific article

Impact of UGT1A1 polymorphisms on Raltegravir and its glucuronide plasma concentrations in a cohort of HIV-1 infected patients

scientific article

Influence of donor-recipient CYP3A4/5 genotypes, age and fluconazole on tacrolimus pharmacokinetics in pediatric liver transplantation: a population approach

scientific article published on 01 June 2014

Influence of host genetic factors on efavirenz plasma and intracellular pharmacokinetics in HIV-1-infected patients

scientific article

Interaction between Darunavir and Etravirine Is Partly Mediated by CYP3A5 Polymorphism

scientific article

Lack of association of the p450 oxidoreductase *28 single nucleotide polymorphism with the lipid-lowering effect of statins in hypercholesterolemic patients

scientific article published on 01 June 2014

Mycophenolic acid-related anemia and leucopenia in renal transplant recipients are related to genetic polymorphisms in CYP2C8

scientific article published on 01 May 2012

No effect of CYP3A4 intron 6 C>T polymorphism (CYP3A4*22) on lipid-lowering response to statins in Greek patients with primary hypercholesterolemia.

scientific article

Optimal sampling strategies for darunavir and external validation of the underlying population pharmacokinetic model

scientific article published on 11 November 2020

POR*28 SNP is associated with lipid response to atorvastatin in children and adolescents with familial hypercholesterolemia.

scientific article published in December 2014

Pharmacogenetic associations with cytochrome P450 in antiretroviral therapy: what does the future hold?

scientific article published on 28 May 2018

Pharmacogenetics in kidney transplantation: recent updates and potential clinical applications.

scientific article published on December 2012

Quantification of 8 HIV-protease inhibitors and 2 nonnucleoside reverse transcriptase inhibitors by ultra-performance liquid chromatography with diode array detection.

scientific article published on 21 November 2008

Quantification of darunavir and etravirine in human peripheral blood mononuclear cells using high performance liquid chromatography tandem mass spectrometry (LC-MS/MS), clinical application in a cohort of 110 HIV-1 infected patients and evidence of

scientific article published on 29 December 2015

Rescue morphine in mechanically ventilated newborns associated with combined OPRM1 and COMT genotype

scientific article published on 01 July 2014

Rivaroxaban plasma levels in patients admitted for bleeding events: insights from a prospective study

scientific article published on 12 November 2018

SLC22A1/OCT1 Genotype Affects O-desmethyltramadol Exposure in Newborn Infants

scientific article published on 01 August 2016

Single-nucleotide polymorphisms in P450 oxidoreductase and peroxisome proliferator-activated receptor-α are associated with the development of new-onset diabetes after transplantation in kidney transplant recipients treated with tacrolimus

scientific article published on December 2013

Tacrolimus Updated Guidelines through popPK Modeling: How to Benefit More from CYP3A Pre-emptive Genotyping Prior to Kidney Transplantation

scientific article published on 8 June 2017

The CYP3A4*22 C>T single nucleotide polymorphism is associated with reduced midazolam and tacrolimus clearance in stable renal allograft recipients.

scientific article

The CYP3A4*22 allele affects the predictive value of a pharmacogenetic algorithm predicting tacrolimus predose concentrations

scientific article published on June 2013

The Val158Met polymorphism of the COMT gene is associated with increased pain sensitivity in morphine-treated patients undergoing a painful procedure after cardiac surgery.

scientific article published on June 2013

The combination of CYP3A4*22 and CYP3A5*3 single-nucleotide polymorphisms determines tacrolimus dose requirement after kidney transplantation

scientific article published on 01 September 2017

The new CYP3A4 intron 6 C>T polymorphism (CYP3A4*22) is associated with an increased risk of delayed graft function and worse renal function in cyclosporine-treated kidney transplant patients.

scientific article published in May 2012

The role of pharmacogenetics in the disposition of and response to tacrolimus in solid organ transplantation.

scientific article published on February 2014

Validation and clinical application of a high performance liquid chromatography tandem mass spectrometry (LC-MS/MS) method for the quantitative determination of 10 anti-retrovirals in human peripheral blood mononuclear cells.

scientific article published on 13 May 2009

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