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List of works by Santiago Vazquez

3-Azatetracyclo[5.2.1.1(5,8).0(1,5)]undecane derivatives: from wild-type inhibitors of the M2 ion channel of influenza A virus to derivatives with potent activity against the V27A mutant.

scientific article published on 15 November 2013

A Novel NMDA Receptor Antagonist Protects against Cognitive Decline Presented by Senescent Mice

scientific article published on 22 March 2020

Alternative syntheses of the new D2d symmetric tetramethyl tricyclo- [3.3.0.0(3,7)]octane-1,3,5,7-tetracarboxylate.

scientific article published in October 2003

Aniline-based inhibitors of influenza H1N1 virus acting on hemagglutinin-mediated fusion.

scientific article published on 8 December 2017

Antibacterial activity of novel benzopolycyclic amines

scientific article published on 3 December 2014

Azapropellanes with anti-influenza a virus activity.

scientific article

Design, synthesis and in vivo study of novel pyrrolidine-based 11β-HSD1 inhibitors for age-related cognitive dysfunction

scientific article published on 4 August 2017

Dimerization of pyramidalized 3,4,8,9-tetramethyltetracyclo [4.4.0.0(3,9).0(4,8)]dec-1(6)-ene to a hydrocarbon featuring four cyclohexane rings in boat conformations

scientific article published on 16 June 2014

Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer's Disease

scientific article published on 10 March 2022

Easily accessible polycyclic amines that inhibit the wild-type and amantadine-resistant mutants of the M2 channel of influenza A virus

scientific article published on 30 June 2014

Escape from adamantane: Scaffold optimization of novel P2X7 antagonists featuring complex polycycles. ⬇️

scientific article published on 16 January 2017

Exploring N-acyl-4-azatetracyclo[5.3.2.02,6.08,10]dodec-11-enes as 11β-HSD1 Inhibitors.

scientific article

Generation and reactions of two new functionalized tricyclo[3.3.0.0 3,7]oct-1(5)-ene derivatives.

scientific article

Inhibition of Soluble Epoxide Hydrolase Ameliorates Phenotype and Cognitive Abilities in a Murine Model of Niemann Pick Type C Disease

scientific article published on 26 March 2021

Mechanism of the Pseudoirreversible Binding of Amantadine to the M2 Proton Channel

scientific article

New polycyclic dual inhibitors of the wild type and the V27A mutant M2 channel of the influenza A virus with unexpected binding mode.

scientific article published on 14 April 2015

Novel 11β-HSD1 inhibitors: C-1 versus C-2 substitution and effect of the introduction of an oxygen atom in the adamantane scaffold

scientific article published in October 2015

Novel Quinazolinone Inhibitors of ALK2 Flip between Alternate Binding Modes: Structure-Activity Relationship, Structural Characterization, Kinase Profiling, and Cellular Proof of Concept

scientific article published on 07 August 2018

Novel benzopolycyclic amines with NMDA receptor antagonist activity

scientific article published on 24 March 2014

Palladium-catalyzed cocyclotrimerization of arynes with a pyramidalized alkene

scientific article published on 01 June 2018

Pentafluorosulfanyl-containing Triclocarban Analogs with Potent Antimicrobial Activity

scientific article published on 02 November 2018

Pharmacological and Electrophysiological Characterization of Novel NMDA Receptor Antagonists

scientific article published on 01 June 2018

Polycyclic N-benzamido imides with potent activity against vaccinia virus.

scientific article published on December 2010

Role of the viral hemagglutinin in the anti-influenza virus activity of newly synthesized polycyclic amine compounds.

scientific article published on 22 June 2013

Searching for novel applications of the benzohomoadamantane scaffold in medicinal chemistry: Synthesis of novel 11β-HSD1 inhibitors

scientific article published in December 2015

Slow but Steady Wins the Race: Dissimilarities among New Dual Inhibitors of the Wild-Type and the V27A Mutant M2 Channels of Influenza A Virus

scientific article published on 18 April 2017

Soluble Epoxide Hydrolase Inhibition to Face Neuroinflammation in Parkinson's Disease: A New Therapeutic Strategy

scientific article published on 01 May 2020

Synthesis and Anti-influenza A Virus Activity of 2,2-Dialkylamantadines and Related Compounds.

scientific article

Synthesis and pharmacological evaluation of (2-oxaadamant-1-yl)amines.

scientific article published on 13 February 2009

Synthesis of benzopolycyclic cage amines: NMDA receptor antagonist, trypanocidal and antiviral activities.

scientific article published on 2 December 2011

Towards a Novel Class of Multitarget-Directed Ligands: Dual P2X7-NMDA Receptor Antagonists

scientific article

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