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List of works by Richard M Wynn

A Novel Inhibitor of Pyruvate Dehydrogenase Kinase Stimulates Myocardial Carbohydrate Oxidation in Diet-Induced Obesity.

scientific article

A novel branched-chain amino acid metabolon. Protein-protein interactions in a supramolecular complex

scientific article published on 21 February 2007

A synchronized substrate-gating mechanism revealed by cubic-core structure of the bovine branched-chain alpha-ketoacid dehydrogenase complex

scientific article

Anation of laccase type 2 copper by azide and thiocyanate ions

scientific article published on 01 August 1982

Benzothiophene carboxylate derivatives as novel allosteric inhibitors of branched-chain α-ketoacid dehydrogenase kinase

scientific article (publication date: 25 July 2014)

Crystal structure of pyruvate dehydrogenase kinase 3 bound to lipoyl domain 2 of human pyruvate dehydrogenase complex

scientific article

Determination of protein complex stoichiometry through multisignal sedimentation velocity experiments.

scientific article

Development of Dihydroxyphenyl Sulfonylisoindoline Derivatives as Liver-Targeting Pyruvate Dehydrogenase Kinase Inhibitors.

scientific article published on 13 January 2017

Expression and characterization of branched-chain alpha-ketoacid dehydrogenase kinase from the rat. Is it a histidine-protein kinase?

scientific journal article

GM130 Regulates Golgi-Derived Spindle Assembly by Activating TPX2 and Capturing Microtubules

scientific article

Green algal cytochrome b6-f complexes: isolation and characterization from Dunaliella saline, Chlamydomonas reinhardtii and Scenedesmus obliquus ⬇️

scientific article published on September 14, 1988

GroEL/GroES promote dissociation/reassociation cycles of a heterodimeric intermediate during alpha(2)beta(2) protein assembly. Iterative annealing at the quaternary structure level

scientific article published on 01 January 2000

GroEL/GroES-dependent reconstitution of alpha2 beta2 tetramers of humanmitochondrial branched chain alpha-ketoacid decarboxylase. Obligatory interaction of chaperonins with an alpha beta dimeric intermediate

scientific article published on 01 April 1999

Identification of the components of a putative cytochrome bc1 complex in Rhodopseudomonas viridis

scientific article published on 01 May 1985

Identification of the ferredoxin interaction sites on ferredoxin-dependent glutamate synthase from Synechocystis sp. PCC 6803.

scientific article published on 3 October 2017

Impaired assembly of E1 decarboxylase of the branched-chain alpha-ketoacid dehydrogenase complex in type IA maple syrup urine disease

scientific article published on 01 May 1998

Interaction of plastocyanin with photosystem I: a chemical cross-linking study of the polypeptide that binds plastocyanin.

scientific article published in August 1988

Interactions of GroEL/GroES with a heterodimeric intermediate during alpha 2beta 2 assembly of mitochondrial branched-chain alpha-ketoacid dehydrogenase. cis capping of the native-like 86-kDa intermediate by GroES

scientific article published on 01 July 2000

Isolation of cytochrome bc 1 complexes from the photosynthetic bacteria Rhodopseudomonas viridis and Rhodospirillum rubrum.

scientific article published in January 1986

Metabolite Regulation of Nuclear Localization of Carbohydrate-response Element-binding Protein (ChREBP): ROLE OF AMP AS AN ALLOSTERIC INHIBITOR

scientific article published on 16 March 2016

Metabolite regulation of nucleo-cytosolic trafficking of carbohydrate response element-binding protein (ChREBP): role of ketone bodies.

scientific article published on 05 August 2013

Molecular and biochemical basis of intermediate maple syrup urine disease. Occurrence of homozygous G245R and F364C mutations at the E1 alpha locus of Hispanic-Mexican patients

scientific article

Phenylbutyrate therapy for maple syrup urine disease ⬇️

scientific article published on November 23, 2010

Pyruvate dehydrogenase kinase-4 structures reveal a metastable open conformation fostering robust core-free basal activity

scientific article

Reduction of laccase type 1 copper by 3,4-dihydroxyphenylalanine and other catechol derivatives

scientific article published on 01 June 1983

Regulation of nuclear import/export of carbohydrate response element-binding protein (ChREBP): interaction of an alpha-helix of ChREBP with the 14-3-3 proteins and regulation by phosphorylation.

scientific article

Structural and Thermodynamic Basis for Weak Interactions between Dihydrolipoamide Dehydrogenase and Subunit-binding Domain of the Branched-chain  -Ketoacid Dehydrogenase Complex

scientific article

Structural and biochemical basis for novel mutations in homozygous Israeli maple syrup urine disease patients: a proposed mechanism for the thiamin-responsive phenotype.

scientific article published on 23 January 2004

Structural characterization of a unique interface between carbohydrate response element-binding protein (ChREBP) and 14-3-3β protein.

scientific article

Structural characterization of heme sites in spinach cytochrome b6f complexes: a resonance Raman study

scientific article published on 01 August 1991

Structure of rat BCKD kinase: Nucleotide-induced domain communication in a mitochondrial protein kinase

scientific article

Structure-guided Development of Specific Pyruvate Dehydrogenase Kinase Inhibitors Targeting the ATP-binding Pocket

scientific article

Subunit and catalytic component stoichiometries of an in vitro reconstituted human pyruvate dehydrogenase complex

scientific article

Targeting BCAA Catabolism to Treat Obesity-Associated Insulin Resistance

scientific article published on 05 June 2019

Targeting hepatic pyruvate dehydrogenase kinases restores insulin signaling and mitigates ChREBP-mediated lipogenesis in diet-induced obese mice.

scientific article published on 31 March 2018

The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase.

scientific article

Use of designer recombinant mitochondrial antigens in the diagnosis of primary biliary cirrhosis

scientific article published on March 1, 1992

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