List of works by Luke Whitesell

17AAG: low target binding affinity and potent cell activity--finding an explanation

scientific article published in February 2003

2,3-Dihydrowithaferin A-3beta-O-sulfate, a new potential prodrug of withaferin A from aeroponically grown Withania somnifera

scientific article

A Fungal-Selective Cytochrome bc1 Inhibitor Impairs Virulence and Prevents the Evolution of Drug Resistance

scientific article published on 6 August 2016

A new dihydroxanthenone from a plant-associated strain of the fungus Chaetomium globosum demonstrates anticancer activity

scientific article published on 10 August 2006

A rhizosphere fungus enhances Arabidopsis thermotolerance through production of an HSP90 inhibitor

scientific article published on 13 July 2007

A small molecule produced by Lactobacillus species blocks Candida albicans filamentation by inhibiting a DYRK1-family kinase

scientific article published on 22 October 2021

Actin microfilament aggregation induced by withaferin A is mediated by annexin II.

scientific article published on 11 December 2005

Adaptive laboratory evolution in S. cerevisiae highlights role of transcription factors in fungal xenobiotic resistance

scientific article published on 11 February 2022

Altered Hsp90 function in cancer: a unique therapeutic opportunity.

scientific article published in August 2004

Biomimetic kinetic resolution: highly enantio- and diastereoselective transfer hydrogenation of aglain ketones to access flavagline natural products

scientific article

Calcineurin determines toxic versus beneficial responses to α-synuclein

scientific article

Chaperones as thermodynamic sensors of drug-target interactions reveal kinase inhibitor specificities in living cells

scientific article published on 30 June 2013

Cytotoxic constituents of Aspergillus terreus from the rhizosphere of Opuntia versicolor of the Sonoran Desert

scientific article published on December 2003

Design of quinolinedione-based geldanamycin analogues

scientific article published in September 2003

Endothelial Thermotolerance Impairs Nanoparticle Transport in Tumors.

scientific article

Evidence for a Novel, Caspase-8-Independent, Fas Death Domain-Mediated Apoptotic Pathway

scientific article

Expression of a unique drug-resistant Hsp90 ortholog by the nematode Caenorhabditis elegans

scientific article published on January 2003

FKBP12 contributes to α-synuclein toxicity by regulating the calcineurin-dependent phosphoproteome

scientific article published on 11 December 2017

Fitness trade-offs restrict the evolution of resistance to amphotericin B

scientific article (publication date: October 2013)

Geopyxins A-E, ent-kaurane diterpenoids from endolichenic fungal strains Geopyxis aff. majalis and Geopyxis sp. AZ0066: structure-activity relationships of geopyxins and their analogues ⬇️

scientific article

HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers

scientific article

HSP90 Shapes the Consequences of Human Genetic Variation

scientific article published on 16 February 2017

HSP90 as a platform for the assembly of more effective cancer chemotherapy

scientific article published on 24 December 2011

HSP90 empowers evolution of resistance to hormonal therapy in human breast cancer models

scientific article

HSP90: a rising star on the horizon of anticancer targets

scientific article

Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease

scholarly article

Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis

scientific article

Heat shock protein 90: a unique chemotherapeutic target

scientific article published on August 2006

High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer

scientific article published on 31 October 2011

Hormone-refractory breast cancer remains sensitive to the antitumor activity of heat shock protein 90 inhibitors.

scientific article

Hsp90 inhibitors deplete key anti-apoptotic proteins in pediatric solid tumor cells and demonstrate synergistic anticancer activity with cisplatin

scientific article published in January 2005

Hsp90 is essential in the filarial nematode Brugia pahangi

scientific article published on 19 March 2005

Hsp90: an emerging target for breast cancer therapy

scientific article published in August 2004

Inhibiting GPI anchor biosynthesis in fungi stresses the endoplasmic reticulum and enhances immunogenicity

scientific article

Inhibiting mitochondrial phosphate transport as an unexploited antifungal strategy

scientific article published on 11 December 2017

Inhibiting the oncogenic translation program is an effective therapeutic strategy in multiple myeloma.

scientific article

Isolation, optimization of production and structure-activity relationship studies of monocillin I, the cytotoxic constituent of Paraphaeosphaeria quadriseptata ⬇️

scientific article

Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis

scientific article

ML212: A small-molecule probe for investigating fluconazole resistance mechanisms in Candida albicans

scientific article

Methods to validate Hsp90 inhibitor specificity, to identify off-target effects, and to rethink approaches for further clinical development

scientific article published in February 2018

Nontoxic antimicrobials that evade drug resistance

scientific article published on June 2015

Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles

scientific article

Piperazinyl quinolines as chemosensitizers to increase fluconazole susceptibility of Candida albicans clinical isolates

scientific article

Ponicidin and oridonin are responsible for the antiangiogenic activity of Rabdosia rubescens, a constituent of the herbal supplement PC SPES.

scientific article

Rebalancing Protein Homeostasis Enhances Tumor Antigen Presentation

scientific article published on 18 June 2019

Search for Hsp90 inhibitors with potential anticancer activity: isolation and SAR studies of radicicol and monocillin I from two plant-associated fungi of the Sonoran desert

scientific article published on February 2006

Susan Lindquist (1949-2016).

scientific article

Synthesis and biological evaluation of novobiocin analogues as potential heat shock protein 90 inhibitors

scientific article published on 27 June 2013

Synthesis of Aza-Rocaglates via ESIPT-Mediated (3+2) Photocycloaddition

scientific article published on 24 June 2016

The Stress Response: Implications for the Clinical Development of Hsp90 Inhibitors ⬇️

scientific article published on October 1, 2003

The anticancer activity of the fungal metabolite terrecyclic acid A is associated with modulation of multiple cellular stress response pathways

scientific article published on October 2005

The reprogramming of tumor stroma by HSF1 is a potent enabler of malignancy

scientific article

Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state

scientific article

Two cases of pediatric neuroblastoma with tumor thrombus in the inferior vena cava.

scientific article published in June 2002

Using the heat-shock response to discover anticancer compounds that target protein homeostasis

scientific article published on 30 November 2011

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