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List of works by Motoyuki Otsuka

A simple combination of serum type IV collagen and prothrombin time to diagnose cirrhosis in patients with chronic active hepatitis C

scientific article published on 01 December 2004

Aberrant expression of a novel circular RNA in pancreatic cancer

scientific article published on 03 September 2020

Absence of tyrosine kinase mutations in Japanese colorectal cancer patients.

scientific article published on 2 October 2006

Activation of intracellular signaling by hepatitis B and C viruses: C-viral core is the most potent signal inducer.

scientific article published in August 2000

Acyclic retinoid inhibits human hepatoma cell growth by suppressing fibroblast growth factor-mediated signaling pathways.

scientific article

Altered composition of fatty acids exacerbates hepatotumorigenesis during activation of the phosphatidylinositol 3-kinase pathway.

scientific article published on 19 May 2011

CPT2 downregulation adapts HCC to lipid-rich environment and promotes carcinogenesis via acylcarnitine accumulation in obesity.

scientific article published on 6 February 2018

Calcineurin negatively regulates TLR-mediated activation pathways

scientific article published on 01 October 2007

Cell surface 4-1BBL mediates sequential signaling pathways 'downstream' of TLR and is required for sustained TNF production in macrophages.

scientific article published on 13 May 2007

Circulating RNAs as new biomarkers for detecting pancreatic cancer

scientific article

Current status of miRNA-targeting therapeutics and preclinical studies against gastroenterological carcinoma

scientific article

DHX9 regulates production of hepatitis B virus-derived circular RNA and viral protein levels.

scientific article

Decreased miR122 in hepatocellular carcinoma leads to chemoresistance with increased arginine.

scientific article published on April 2015

Development of a screening method to identify regulators of MICA shedding.

scientific article published on 20 August 2015

Diagnostic and therapeutic application of noncoding RNAs for hepatocellular carcinoma.

scientific article

Direct differentiation of hepatic cells from human induced pluripotent stem cells using a limited number of cytokines

scientific article published on 06 February 2011

Distinct effects of p38alpha deletion in myeloid lineage and gut epithelia in mouse models of inflammatory bowel disease.

scientific article

Epithelial p38alpha controls immune cell recruitment in the colonic mucosa.

scientific article

Expression of circular RNA CDR1‑AS in colon cancer cells increases cell surface PD‑L1 protein levels

scientific article published on 19 July 2019

Extracellular vesicles secreted by HBV-infected cells modulate HBV persistence in hydrodynamic HBV transfection mouse model

scientific article published on 10 July 2020

Gene expressions associated with chemosensitivity in human hepatoma cells.

scientific article published on March 2007

Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma

scientific article published on 17 April 2011

Hepatitis C virus core protein inhibits apoptosis via enhanced Bcl-xL expression.

scientific article

Histone demethylase KDM4C regulates sphere formation by mediating the cross talk between Wnt and Notch pathways in colonic cancer cells.

scientific article published on 22 May 2013

IL28B minor allele is associated with a younger age of onset of hepatocellular carcinoma in patients with chronic hepatitis C virus infection.

scientific article published on 22 May 2013

ISGF3 with reduced phosphorylation is associated with constitutive expression of interferon-induced genes in aging cells

article

Identifying genes with differential expression in gemcitabine-resistant pancreatic cancer cells using comprehensive transcriptome analysis.

scientific article published on November 2005

Impact of PNPLA3 polymorphisms on the development of hepatocellular carcinoma in patients with chronic hepatitis C virus infection.

scientific article published on 8 January 2014

Impact of histone demethylase KDM3A-dependent AP-1 transactivity on hepatotumorigenesis induced by PI3K activation.

scientific article published on 10 July 2017

Improved liver function in patients with cirrhosis due to chronic hepatitis C virus who achieve sustained virologic response is not accompanied by increased liver volume

scientific article published on 20 April 2020

Inhibition of HBV Transcription From cccDNA With Nitazoxanide by Targeting the HBx-DDB1 Interaction

scientific article published on 24 October 2018

Inhibition of microRNA122 decreases SREBP1 expression by modulating suppressor of cytokine signaling 3 expression.

scientific article published on 24 July 2013

Interferon-beta is activated by hepatitis C virus NS5B and inhibited by NS4A, NS4B, and NS5A.

scientific article published on June 2007

Interleukin-1beta gene polymorphisms associated with hepatocellular carcinoma in hepatitis C virus infection.

scientific article published in January 2003

Large isoform of hepatitis delta antigen activates serum response factor-associated transcription.

scientific article published on December 2000

Large-scale search of single nucleotide polymorphisms for hepatocellular carcinoma susceptibility genes in patients with hepatitis C

scientific article published on 01 October 2005

Liver chip and gene shaving.

scientific article

Liver stiffness measurements in chronic hepatitis C: treatment evaluation and risk assessment

scientific article published on 07 December 2018

Loss of histone demethylase KDM6B enhances aggressiveness of pancreatic cancer through downregulation of C/EBPα.

scientific article

Macrophage deletion of p38alpha partially impairs lipopolysaccharide-induced cellular activation.

scientific article published in April 2008

MicroRNA-140 acts as a liver tumor suppressor by controlling NF-κB activity by directly targeting DNA methyltransferase 1 (Dnmt1) expression.

scientific article

MicroRNA-22 and microRNA-140 suppress NF-κB activity by regulating the expression of NF-κB coactivators.

scientific article

MicroRNA122 is a key regulator of α-fetoprotein expression and influences the aggressiveness of hepatocellular carcinoma.

scientific article published on 7 June 2011

MicroRNAs and liver disease

scientific article published on 26 May 2016

Mutual antagonism between hepatitis B viral mRNA and host microRNA let-7.

scientific article published on 16 March 2016

NF-kappaB and ERK-signaling pathways contribute to the gene expression induced by cag PAI-positive-Helicobacter pylori infection.

scientific article published on October 2005

No mutations in the tyrosine kinases of human hepatic, pancreatic, and gastric cancer cell lines.

scientific article

Novel therapeutic approaches for hepatitis B virus covalently closed circular DNA

scientific article

Nucleotide change of codon 38 in the X gene of hepatitis B virus genotype C is associated with an increased risk of hepatocellular carcinoma.

scientific article

Pevonedistat, a Neuronal Precursor Cell-Expressed Developmentally Down-Regulated Protein 8-Activating Enzyme Inhibitor, Is a Potent Inhibitor of Hepatitis B Virus

scientific article published on 13 March 2019

ROCK inhibition enhances microRNA function by promoting deadenylation of targeted mRNAs via increasing PAIP2 expression

scientific article

Receptor for activated protein kinase C: requirement for efficient microRNA function and reduced expression in hepatocellular carcinoma.

scientific article

Reduced expression of RAS protein activator like-1 in gastric cancer

scientific article published on 01 March 2011

Regulation of NKT cell-mediated immune responses to tumours and liver inflammation by mitochondrial PGAM5-Drp1 signalling.

scientific article

Regulation of the expression of the liver cancer susceptibility gene MICA by microRNAs.

scientific article published on January 2013

Relevance network between chemosensitivity and transcriptome in human hepatoma cells.

scientific article published in February 2003

Repression of MicroRNA Function Mediates Inflammation-associated Colon Tumorigenesis

scientific article published on 5 November 2016

Satellite RNA Increases DNA Damage and Accelerates Tumor Formation in Mouse Models of Pancreatic Cancer

scientific article published on 10 May 2018

Satellite RNAs promote pancreatic oncogenic processes via the dysfunction of YBX1.

scientific article published on 26 September 2016

Should Level of HBV RNA be Used to Determine When Patients Should Stop Treatment With Nucleos(t)ide Analogues

scientific article published on 29 August 2019

TNF-alpha stimulation inhibits siRNA-mediated RNA interference through a mechanism involving poly-(A) tail stabilization.

scientific article published on April 2008

The evaluation of putative virulence factors of Helicobacter pylori for gastroduodenal disease by use of a short-term Mongolian gerbil infection model

scientific article published on 17 January 2002

The flavonoid apigenin improves glucose tolerance through inhibition of microRNA maturation in miRNA103 transgenic mice.

scientific article published on January 2013

The flavonoid apigenin inhibits hepatitis C virus replication by decreasing mature microRNA122 levels.

scientific article

The role of microRNAs in hepatocarcinogenesis: current knowledge and future prospects.

scientific article

Transcriptional activation of the MICA gene with an engineered CRISPR-Cas9 system

scientific article

Unique haploinsufficient role of the microRNA-processing molecule Dicer1 in a murine colitis-associated tumorigenesis model.

scientific article

Vitamin K2 binds 17beta-hydroxysteroid dehydrogenase 4 and modulates estrogen metabolism.

scientific article

cDNA microarray analysis of Helicobacter pylori-mediated alteration of gene expression in gastric cancer cells

article by S Maeda et al published 1 June 2001 in Biochemical and Biophysical Research Communications

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