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List of works by Markus Hecker

A Cross-species Quantitative Adverse Outcome Pathway for Activation of the Aryl Hydrocarbon Receptor Leading to Early Life Stage Mortality in Birds and Fishes

scientific article published on 19 June 2018

A combined hydraulic and toxicological approach to assess re-suspended sediments during simulated flood events. Part I–multiple biomarkers in rainbow trout

article by Markus Brinkmann et al published 17 July 2010 in Journal of Soils and Sediments

A combined hydraulic and toxicological approach to assess re-suspended sediments during simulated flood events—part II: an interdisciplinary experimental methodology

article by Catrina Cofalla et al published 3 February 2012 in Journal of Soils and Sediments

A comparison of statistical methods for deriving freshwater quality criteria for the protection of aquatic organisms

scientific article published on 15 January 2013

A new approach to investigate the interactions between sediment transport and ecotoxicological processes during flood events

scientific article published in 2011

A rapid and sensitive fluorometric method for determination of aldehyde oxidase activity.

scientific article published on 9 January 2018

Accumulation and biotransformation of BDE-47 by zebrafish larvae and teratogenicity and expression of genes along the hypothalamus-pituitary-thyroid axis.

scientific article

Acid mine drainage affects the diversity and metal resistance gene profile of sediment bacterial community along a river

article

Acute toxicity of copper, lead, cadmium, and zinc to early life stages of white sturgeon (Acipenser transmontanus) in laboratory and Columbia River water

scientific article

Advanced fluorescence in situ hybridization to localize and quantify gene expression in Japanese medaka (Oryzias latipes) exposed to endocrine-disrupting compounds.

scientific article published in September 2009

Advancing the adverse outcome pathway framework-An international horizon scanning approach

scientific article published on June 2017

Adverse health effects and histological changes in white sturgeon (Acipenser transmontanus) exposed to dietary selenomethionine

scientific article published on 3 December 2015

Adverse outcome pathway (AOP) development I: strategies and principles

scientific article

Adverse outcome pathway development II: best practices.

scientific article

Adverse outcome pathways and ecological risk assessment: Bridging to population‐level effects ⬇️

scientific article published on January 1, 2011

Alteration of steroidogenesis in H295R cells by organic sediment contaminants and relationships to other endocrine disrupting effects

scientific article published on 2 May 2006

Aquatic toxicology: History and future

scientific article published on 03 October 2019

Aryl hydrocarbon receptor nuclear translocators (ARNT1, ARNT2, and ARNT3) of white sturgeon (Acipenser transmontanus): Sequences, tissue-specific expressions, and response to β-naphthoflavone

scientific article published on 17 February 2020

Assessing the toxicity of naphthenic acids using a microbial genome wide live cell reporter array system

scientific article

Assessment of chemical effects on aromatase activity using the H295R cell line

scientific article

Assessment of the sensitivity of three North American fish species to disruptors of steroidogenesis using in vitro tissue explants

scientific article published on 19 April 2014

Attenuation of the cortisol response to stress in female rainbow trout chronically exposed to dietary selenomethionine

scientific article published on 14 September 2011

BioDoser: Improved dose-estimation software for biological radiation dosimetry ⬇️

scientific article published on April 14, 2012

Bioaccumulation, biotransformation, and toxicity of BDE-47, 6-OH-BDE-47, and 6-MeO-BDE-47 in early life-stages of zebrafish (Danio rerio).

scientific article published on 21 January 2015

Bioactivation of Quinolines in a Recombinant Estrogen Receptor Transactivation Assay Is Catalyzed by N-Methyltransferases

scientific article published on 28 March 2019

Bioanalytical and instrumental screening of the uptake of sediment-borne, dioxin-like compounds in roach (Rutilus rutilus).

scientific article published on 11 March 2016

Birds

March 2013 scholarly article

Bisphenol A disrupts steroidogenesis in human H295R cells

scientific article published on 6 April 2011

Challenges in assigning endocrine-specific modes of action: Recommendations for researchers and regulators

scientific article published on 15 December 2016

Characterisation of transcriptional responses to dioxins and dioxin-like contaminants in roach (Rutilus rutilus) using whole transcriptome analysis

scientific article

Chronic exposure to dietary selenomethionine increases gonadal steroidogenesis in female rainbow trout

scientific article published on 16 July 2011

Classification of chemicals based on concentration-dependent toxicological data using ToxClust

scientific article published in May 2009

Combined Transcriptomic and Proteomic Approach to Identify Toxicity Pathways in Early Life Stages of Japanese Medaka (Oryzias latipes) Exposed to 1,2,5,6-Tetrabromocyclooctane (TBCO).

scientific article published on 20 June 2016

Combining High-Throughput Sequencing of sedaDNA and Traditional Paleolimnological Techniques To Infer Historical Trends in Cyanobacterial Communities

scientific article published on 05 June 2018

Comparative analyses of oxidative stress response and metallothionein induction in white sturgeon and rainbow trout during acute waterborne copper exposure

scientific article published on 07 February 2020

Comparison of fathead minnow ovary explant and H295R cell-based steroidogenesis assays for identifying endocrine-active chemicals

scientific article published on 20 April 2007

Comparison of the sensitivity of four native Canadian fish species to 17-α ethinylestradiol, using an in vitro liver explant assay

scientific article published on 26 August 2015

Contribution of priority PAHs and POPs to Ah receptor-mediated activities in sediment samples from the River Elbe Estuary, Germany

scientific article (publication date: 2013)

Cross-species comparison of relative potencies and relative sensitivities of fishes to dibenzo-p-dioxins, dibenzofurans, and polychlorinated biphenyls in vitro

scientific article

Development and optimization of a Q-RT PCR method to quantify CYP19 mRNA expression in testis of male adult Xenopus laevis: comparisons with aromatase enzyme activity

scientific article published on 21 February 2006

Differences in activation of aryl hydrocarbon receptors of white sturgeon relative to lake sturgeon are predicted by identities of key amino acids in the ligand binding domain

scientific article published on 23 March 2015

Differences in the subcellular distribution of cadmium and copper in the gills and liver of white sturgeon (Acipenser transmontanus) and rainbow trout (Oncorhynchus mykiss)

scientific article published on 01 December 2020

Differential effects and potential adverse outcomes of ionic silver and silver nanoparticles in vivo and in vitro

scientific article published on 31 March 2014

Differential modulation of expression of nuclear receptor mediated genes by tris(2-butoxyethyl) phosphate (TBOEP) on early life stages of zebrafish (Danio rerio).

scientific article published on 30 October 2015

Differential responses of gut microbiota of male and female fathead minnow (Pimephales promelas) to a short-term environmentally-relevant, aqueous exposure to benzo[a]pyrene

scientific article published on 12 March 2020

Distribution of petroleum degrading genes and factor analysis of petroleum contaminated soil from the Dagang Oilfield, China

scientific article published on 18 June 2015

Effect of ozonation on the estrogenicity and androgenicity of oil sands process-affected water

scientific article published on 29 June 2011

Effect of perinatal and postnatal bisphenol A exposure to the regulatory circuits at the hypothalamus-pituitary-gonadal axis of CD-1 mice.

scientific article published on 21 December 2010

Effect of pyrolysis temperature on potential toxicity of biochar if applied to the environment.

scientific article published on 15 August 2016

Effect-directed analysis (EDA) in aquatic ecotoxicology: state of the art and future challenges

scientific article published on 25 August 2009

Effects of 17α-ethynylestradiol on sexual differentiation and development of the African clawed frog (Xenopus laevis).

scientific article

Effects of 20 PBDE metabolites on steroidogenesis in the H295R cell line

scientific article published on 8 December 2007

Effects of Columbia River water on early life-stages of white sturgeon (Acipenser transmontanus)

scientific article published on 09 January 2014

Effects of a non-steroidal aromatase inhibitor on ovarian function in cattle

scientific article published on 01 January 2012

Effects of atrazine on CYP19 gene expression and aromatase activity in testes and on plasma sex steroid concentrations of male African clawed frogs (Xenopus laevis).

scientific article published on 18 May 2005

Effects of atrazine on metamorphosis, growth, and gonadal development in the green frog (Rana clamitans).

scientific article

Effects of atrazine on metamorphosis, growth, laryngeal and gonadal development, aromatase activity, and sex steroid concentrations in Xenopus laevis

scientific article published on 8 January 2005

Effects of chronic exposure to dietary selenomethionine on the physiological stress response in juvenile white sturgeon (Acipenser transmontanus).

scientific article published on 3 February 2017

Effects of exposure to 17α-ethynylestradiol during larval development on growth, sexual differentiation, and abundances of transcripts in the liver of the wood frog (Lithobates sylvaticus).

scientific article

Effects of exposure to 17α-ethynylestradiol during sexual differentiation on the transcriptome of the African clawed frog (Xenopus laevis).

scientific article published on 25 April 2013

Effects of fifteen PBDE metabolites, DE71, DE79 and TBBPA on steroidogenesis in the H295R cell line

scientific article

Effects of fluorotelomer alcohol 8:2 FTOH on steroidogenesis in H295R cells: targeting the cAMP signalling cascade

scientific article published on 6 July 2010

Effects of prochloraz or propylthiouracil on the cross-talk between the HPG, HPA, and HPT axes in zebrafish

scientific article published on 15 December 2010

Effects of subchronic exposure of early life stages of white sturgeon (Acipenser transmontanus) to copper, cadmium, and zinc.

scientific article published on 27 September 2011

Effects of triphenyltin on growth and development of the wood frog (Lithobates sylvaticus).

scientific article published on 6 October 2013

Effects of tris (2-butoxyethyl) phosphate (TBOEP) on endocrine axes during development of early life stages of zebrafish (Danio rerio).

scientific article published on 4 November 2015

Endocrine disrupting, mutagenic, and teratogenic effects of upper Danube River sediments using effect-directed analysis

scientific article

Endocrine disruptor screening: regulatory perspectives and needs

scientific article published in 2011

Environmental and health challenges of the global growth of electronic waste

scientific article

Erratum to: The OECD validation program of the H295R steroidogenesis assay: Phase 3. Final inter-laboratory validation study

scientific article published on 23 October 2017

Expression stability and selection of optimal reference genes for gene expression normalization in early life stage rainbow trout exposed to cadmium and copper

scientific article published on 24 July 2017

Factors Affecting the Perception of New Approach Methodologies (NAMs) in the Ecotoxicology Community

scientific article published on 24 February 2020

Factors associated with blooms of cyanobacteria in a large shallow lake, China

article

Fishing for contaminants: identification of three mechanism specific transcriptome signatures using Danio rerio embryos

scientific article

Fluorescence in situ hybridization techniques (FISH) to detect changes in CYP19a gene expression of Japanese medaka (Oryzias latipes).

scientific article published on 2 July 2008

Functionality of aryl hydrocarbon receptors (AhR1 and AhR2) of white sturgeon (Acipenser transmontanus) and implications for the risk assessment of dioxin-like compounds

scientific article published on 2 July 2014

Generalized concentration addition accurately predicts estrogenic potentials of mixtures and environmental samples containing partial agonists

scientific article published on 21 October 2017

Genomic instability in adult men involved in processing electronic waste in Northern China

scientific article published on 01 May 2018

Hepatic P450 enzyme activity, tissue morphology and histology of mink (Mustela vison) exposed to polychlorinated dibenzofurans

scientific article published on 21 May 2009

High Conservation in Transcriptomic and Proteomic Response of White Sturgeon to Equipotent Concentrations of 2,3,7,8-TCDD, PCB 77, and Benzo[a]pyrene

scientific article published on 25 April 2016

How flood events affect rainbow trout: evidence of a biomarker cascade in rainbow trout after exposure to PAH contaminated sediment suspensions.

scientific article

Human adrenocarcinoma (H295R) cells for rapid in vitro determination of effects on steroidogenesis: hormone production

scientific article published on 29 July 2006

Identification and expression of aryl hydrocarbon receptors (AhR1 and AhR2) provide insight in an evolutionary context regarding sensitivity of white sturgeon (Acipenser transmontanus) to dioxin-like compounds

scientific article published on 25 February 2014

Identification and response to metals of metallothionein in two ancient fishes: white sturgeon (Acipenser transmontanus) and lake sturgeon (Acipenser fulvescens).

scientific article published on 18 March 2015

Identification of molecular toxicity pathways across early life-stages of zebrafish exposed to PCB126 using a whole transcriptomics approach

scientific article published on 11 December 2020

Impact of Predator Cues on Responses to Silver Nanoparticles in Daphnia carinata

scientific article published on 5 June 2015

In search for the ecological and toxicological relevance of sediment re-mobilisation and transport during flood events

In vitro bioassays for detecting dioxin-like activity--application potentials and limits of detection, a review

scientific article published on 22 April 2014

In vitro characterization of the effectiveness of enhanced sewage treatment processes to eliminate endocrine activity of hospital effluents

scientific article published on 19 December 2012

In vitro endocrine disruption and TCDD-like effects of three novel brominated flame retardants: TBPH, TBB, & TBCO.

scientific article published on 21 September 2013

In vitro tools for the toxicological evaluation of sediments and dredged materials: intra- and inter-laboratory comparisons of chemical and bioanalytical methods

scientific article

In vitro-in vivo and cross-life stage extrapolation of uptake and biotransformation of benzo[a]pyrene in the fathead minnow (Pimephales promelas)

scientific article published on 15 September 2020

Induction of cytochrome P4501A in African brown house snake (Lamprophis fuliginosus) primary hepatocytes

scientific article published in February 2006

Interconversion of hydroxylated and methoxylated polybrominated diphenyl ethers in Japanese medaka

scientific article published on November 2010

Intrafollicular thyroid hormone staining in whole-mount zebrafish (Danio rerio) embryos for the detection of thyroid hormone synthesis disruption

scientific article published on 22 March 2018

Investigating the Role of Ionoregulatory Processes in the Species- and Life-Stage-Specific Differences in Sensitivity of Rainbow Trout and White Sturgeon to Cadmium

scientific article published on 25 October 2018

Investigation of potential endocrine disrupting effects of mosquito larvicidal Bacillus thuringiensis israelensis (Bti) formulations

scientific article published on 4 August 2015

Is hepatic oxidative stress a main driver of dietary selenium toxicity in white sturgeon (Acipenser transmontanus)?

scientific article published on 2 August 2016

Linking Oxidative Stress and Magnitude of Compensatory Responses with Life-Stage Specific Differences in Sensitivity of White Sturgeon (Acipenser transmontanus) to Copper or Cadmium.

scientific article published on 10 August 2016

Mechanisms of pH-dependent uptake of ionizable organic chemicals by fish from oil sands process-affected water (OSPW)

scientific article published on 08 July 2020

Mechanisms of toxicity of triphenyltin chloride (TPTC) determined by a live cell reporter array

scientific article

Metals and PFAS in stormwater and surface runoff in a semi-arid Canadian city subject to large variations in temperature among seasons

scientific article published on 16 March 2020

Modulation of steroidogenesis by coastal waters and sewage effluents of Hong Kong, China, using the H295R assay

scientific article

Modulation of steroidogenic gene expression and hormone production of H295R cells by pharmaceuticals and other environmentally active compounds

scientific article published on 3 August 2007

Modulation of steroidogenic gene expression and hormone synthesis in H295R cells exposed to PCP and TCP.

scientific article published on 4 February 2011

Multi-species comparison of the mechanism of biotransformation of MeO-BDEs to OH-BDEs in fish

scientific article published on 01 March 2012

Novel trends in endocrine disruptor testing: the H295R Steroidogenesis Assay for identification of inducers and inhibitors of hormone production

scientific article published on January 2008

Origin of Hydroxylated Brominated Diphenyl Ethers: Natural Compounds or Man-Made Flame Retardants?

scientific article published on 01 October 2009

Ozonation attenuates the steroidogenic disruptive effects of sediment free oil sands process water in the H295R cell line

scientific article

Parasitism in fish--an endocrine modulator of ecological relevance?

scientific article published in April 2005

Plasma biomarkers in fish provide evidence for endocrine modulation in the Elbe River, Germany

scientific article published in June 2002

Plasma concentrations of estradiol and testosterone, gonadal aromatase activity and ultrastructure of the testis in Xenopus laevis exposed to estradiol or atrazine

scientific article published in May 2005

Plasma sex steroid concentrations and gonadal aromatase activities in African clawed frogs (Xenopus laevis) from South Africa

scientific article published in August 2004

Polybrominated diphenyl ethers and their hydroxylated/methoxylated analogs: environmental sources, metabolic relationships, and relative toxicities

scientific article published on 24 March 2011

Polychlorinated naphthalenes and other dioxin-like compounds in Elbe River sediments

scientific article published on March 2008

Predicting the sensitivity of fishes to dioxin-like compounds: possible role of the aryl hydrocarbon receptor (AhR) ligand binding domain

scientific article published on 11 October 2012

Project house water: a novel interdisciplinary framework to assess the environmental and socioeconomic consequences of flood-related impacts

scientific article

Quantitative RT-PCR methods for evaluating toxicant-induced effects on steroidogenesis using the H295R cell line

scientific article

Real-time PCR array to study effects of chemicals on the Hypothalamic-Pituitary-Gonadal axis of the Japanese medaka.

scientific article published on 24 April 2008

Recommended approaches to the scientific evaluation of ecotoxicological hazards and risks of endocrine-active substances.

scientific article

Responses of the Medaka HPG Axis PCR Array and Reproduction to Prochloraz and Ketoconazole

article

Responses of the medaka HPG axis PCR array and reproduction to prochloraz and ketoconazole

scientific article

Sensitivity of early life stages of white sturgeon, rainbow trout, and fathead minnow to copper

scientific article

Sensitivity of white sturgeon and rainbow trout to waterborne copper exposure: A comparative study of copper-induced disruption of sodium homeostasis

scientific article published on 21 August 2019

Sequencing and characterization of mixed function monooxygenase genes CYP1A1 and CYP1A2 of Mink (Mustela vison) to facilitate study of dioxin-like compounds

scientific article published on 11 November 2008

Shape-dependent toxicity of alumina nanoparticles in rat astrocytes

scientific article published on 02 July 2019

Simultaneous quantification of multiple classes of phenolic compounds in blood plasma by liquid chromatography-electrospray tandem mass spectrometry

scientific article published on 3 December 2009

Species and life-stage specific differences in cadmium accumulation and cadmium induced oxidative stress, metallothionein and heat shock protein responses in white sturgeon and rainbow trout

scientific article published on 08 April 2019

Species-specific considerations in using the fish embryo test as an alternative to identify endocrine disruption

scientific article published on 20 June 2014

Studying the effects of genistein on gene expression of fish embryos as an alternative testing approach for endocrine disruption

scientific article published on 24 September 2012

Suppression of aromatase activity in populations of bream (Abramis brama) from the river Elbe, Germany.

scientific article published on 24 July 2006

Terminology of gonadal anomalies in fish and amphibians resulting from chemical exposures.

scientific article published on January 2006

The H295R system for evaluation of endocrine-disrupting effects

scientific article published on 28 August 2006

The OECD validation program of the H295R steroidogenesis assay: Phase 3. Final inter-laboratory validation study

scientific article published on 3 October 2010

The Role of Omics in the Application of Adverse Outcome Pathways for Chemical Risk Assessment

scientific article

The dioRAMA project: assessment of dioxin-like activity in sediments and fish (Rutilus rutilus) in support of the ecotoxicological characterization of sediments

The endocrine disrupting potential of sediments from the Upper Danube River (Germany) as revealed by in vitro bioassays and chemical analysis

scientific article published on 5 September 2010

Time-dependent transcriptional profiles of genes of the hypothalamic-pituitary-gonadal axis in medaka (Oryzias latipes) exposed to fadrozole and 17beta-trenbolone

scientific article published in December 2008

Tissue specificity of aryl hydrocarbon receptor (AhR) mediated responses and relative sensitivity of white sturgeon (Acipenser transmontanus) to an AhR agonist

scientific article published on 22 February 2012

Toward understanding the impacts of sediment contamination on a native fish species: transcriptional effects, EROD activity, and biliary PAH metabolites

scientific article

Toxicity of untreated and ozone-treated oil sands process-affected water (OSPW) to early life stages of the fathead minnow (Pimephales promelas).

scientific article

Transcriptional changes in African clawed frogs (Xenopus laevis) exposed to 17α-ethynylestradiol during early development

scientific article

Transcriptional responses of male fathead minnows exposed to oil sands process-affected water

scientific article

Untargeted Identification of Organo-Bromine Compounds in Lake Sediments by Ultrahigh-Resolution Mass Spectrometry with the Data-Independent Precursor Isolation and Characteristic Fragment Method.

scientific article

Untargeted Screening and Distribution of Organo-Bromine Compounds in Sediments of Lake Michigan

scientific article published on 30 November 2015

Untargeted Screening and Distribution of Organo-Iodine Compounds in Sediments from Lake Michigan and the Arctic Ocean

scientific article published on 9 September 2016

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