List of works - Onofrio Laselva

Anti-Infectives Restore ORKAMBI® Rescue of F508del-CFTR Function in Human Bronchial Epithelial Cells Infected with Clinical Strains of P. aeruginosa

scientific article published on 19 February 2020

CFTR interactome mapping using the mammalian membrane two-hybrid high-throughput screening system

scientific article published on 01 February 2022

Cholesterol Interaction Directly Enhances Intrinsic Activity of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)

scientific article published on 31 July 2019

Comprehensive mapping of cystic fibrosis mutations to CFTR protein identifies mutation clusters and molecular docking predicts corrector binding site.

scientific article published on 23 March 2018

Correctors of mutant CFTR enhance subcortical cAMP-PKA signaling through modulating ezrin phosphorylation and cytoskeleton organization.

scientific article

Correctors of the major Cystic Fibrosis mutant interact through membrane spanning domains.

scientific article published on 4 April 2018

Functional rescue of c.3846G>A (W1282X) in patient-derived nasal cultures achieved by inhibition of nonsense mediated decay and protein modulators with complementary mechanisms of action

scientific article published on 09 December 2019

Molecular Mechanism of Action of Trimethylangelicin Derivatives as CFTR Modulators.

scientific article published on 4 July 2018

ORKAMBI-Mediated Rescue of Mucociliary Clearance in Cystic Fibrosis Primary Respiratory Cultures Is Enhanced by Arginine Uptake, Arginase Inhibition, and Promotion of Nitric Oxide Signaling to the Cystic Fibrosis Transmembrane Conductance Regulator

scientific article published on 19 August 2019

Orkambi® and amplifier co-therapy improves function from a rare CFTR mutation in gene-edited cells and patient tissue.

scientific article

Preclinical Studies of a Rare CF-Causing Mutation in the Second Nucleotide Binding Domain (c.3700A>G) Show Robust Functional Rescue in Primary Nasal Cultures by Novel CFTR Modulators

scientific article published on 05 November 2020

Rescue of multiple class II CFTR mutations by elexacaftor+ tezacaftor+ivacaftor mediated in part by the dual activities of Elexacaftor as both corrector and potentiator

scientific article published on 10 December 2020

The era of CFTR modulators: improvements made and remaining challenges

scientific article published on 01 June 2020

The investigational Cystic Fibrosis drug Trimethylangelicin directly modulates CFTR by stabilizing the first membrane-spanning domain.

scientific article published on 7 September 2016

The preclinical discovery and development of the combination of ivacaftor + tezacaftor used to treat cystic fibrosis

scientific article published on 15 April 2020

Trimethylangelicin promotes the functional rescue of mutant F508del CFTR protein in cystic fibrosis airway cells.

scientific article published on 9 May 2014

List of works by Onofrio Laselva