List of works by Richard J Vickers

A novel method for imaging the pharmacological effects of antibiotic treatment on Clostridium difficile.

scientific article

A randomised phase 1 study to investigate safety, pharmacokinetics and impact on gut microbiota following single and multiple oral doses in healthy male subjects of SMT19969, a novel agent for Clostridium difficile infections.

scientific article

Antimicrobial susceptibility and ribotypes of Clostridium difficile isolates from a Phase 2 clinical trial of ridinilazole (SMT19969) and vancomycin

scientific article published on 01 August 2018

Asymmetric synthesis and applications of beta-amino Weinreb amides: asymmetric synthesis of (S)-coniine.

scientific article

Asymmetric synthesis of substituted 1-aminocyclopropane-1-carboxylic acids via diketopiperazine methodology.

scientific article published in July 2003

Automated large-scale culture and medium-throughput chemical screen for modulators of proliferation and viability of human induced pluripotent stem cell-derived neuroepithelial-like stem cells.

scientific article

Combating resistance while maintaining innovation: the future of antimicrobial stewardship

scientific article published on 17 September 2019

Diastereoselective synthesis of quaternary alpha-amino acids from diketopiperazine templates.

scientific article published on 29 May 2007

Discovery and SAR of 2-arylbenzotriazoles and 2-arylindazoles as potential treatments for Duchenne muscular dystrophy

scientific article published on 17 June 2011

Discovery of 2-arylbenzoxazoles as upregulators of utrophin production for the treatment of Duchenne muscular dystrophy.

scientific article published on 15 April 2011

Efficacy and safety of ridinilazole compared with vancomycin for the treatment of Clostridium difficile infection: a phase 2, randomised, double-blind, active-controlled, non-inferiority study ⬇️

scientific article

Enhanced preservation of the human intestinal microbiota by ridinilazole, a novel Clostridium difficile-targeting antibacterial, compared to vancomycin

scientific article published in PLoS ONE

Identification of arylamine N-acetyltransferase inhibitors as an approach towards novel anti-tuberculars

scientific article (publication date: 2010)

Imaging-based chemical screens using normal and glioma-derived neural stem cells

scientific article

In vitro susceptibility of Clostridium difficile to SMT19969 and comparators, as well as the killing kinetics and post-antibiotic effects of SMT19969 and comparators against C. difficile ⬇️

scientific article published on 3 February 2015

In vivo assessment of SMT19969 in a hamster model of clostridium difficile infection.

scientific article

Ridinilazole: a novel therapy for Clostridium difficile infection ⬇️

scientific article

SMT19969 as a treatment for Clostridium difficile infection: an assessment of antimicrobial activity using conventional susceptibility testing and an in vitro gut model ⬇️

scientific article published on 3 September 2014

SMT19969 for Clostridium difficile infection (CDI): in vivo efficacy compared with fidaxomicin and vancomycin in the hamster model of CDI.

scientific article published on 3 February 2015

Susceptibility of Clostridium difficile Isolates of Varying Antimicrobial Resistance Phenotypes to SMT19969 and 11 Comparators ⬇️

scientific article

Synthesis and evaluation of the 2,4-diaminoquinazoline series as anti-tubercular agents

scientific article published on 22 October 2014

Synthesis and in vitro evaluation of novel small molecule inhibitors of bacterial arylamine N-acetyltransferases (NATs).

scientific article

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