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List of works by Stephanie Hughes

250. Protection Against Huntington's Diease Progression: AAV-Mediated Delivery of Biotherapeutics

scholarly article by Adrian P. Kells et al published 2006 in Molecular Therapy

451. AAV-BDNF Augments Neurogenesis in Both the Normal Adult Rat Brain and the Quinolinic Acid Lesion Model of Huntington's Disease

scholarly article by Rebecca A. Henry et al published 2006 in Molecular Therapy

A C-terminal peptide from secreted amyloid precursor protein-α enhances long-term potentiation in rats and a transgenic mouse model of Alzheimer's disease

scientific article published on 13 June 2019

A schizophrenia risk factor induces marked anatomical deficits at GABAergic ‐dopaminergic synapses in the rat ventral tegmental area: Essential evidence for new targeted therapies

scientific article published in September 2021

AAV-mediated delivery of BDNF augments neurogenesis in the normal and quinolinic acid-lesioned adult rat brain.

scientific article

Adult-born dentate granule cell excitability depends on the interaction of neuron age, ontogenetic age and experience

scientific article published on 23 May 2018

An altered secretome is an early marker of the pathogenesis of CLN6 Batten disease

scientific article published on 25 December 2020

CNS Transduction Benefits of AAV-PHP.eB over AAV9 Are Dependent on Administration Route and Mouse Strain

scientific article published on 20 October 2020

Cellular composition of human glial cultures from adult biopsy brain tissue

article

Characterisation of early changes in ovine CLN5 and CLN6 Batten disease neural cultures for the rapid screening of therapeutics

scientific article

Chimeric rabies SADB19-VSVg-pseudotyped lentiviral vectors mediate long-range retrograde transduction from the mouse spinal cord.

scientific article published on 29 January 2015

Combined Immunochemistry and Live Imaging of Fluorescent Protein Expressing Neurons in Mouse Brain

article by Ruth M. Empson et al published 2015 in Neuromethods

Creating a neurogenic environment: the role of BDNF and FGF2.

scientific article published on 4 July 2007

Diversity of layer 5 projection neurons in the mouse motor cortex.

scientific article published on 16 October 2013

Experimental therapies in the neuronal ceroid lipofuscinoses

scientific article

Expression of the developmental transcription factor Fezf2 identifies a distinct subpopulation of layer 5 intratelencephalic-projection neurons in mature mouse motor cortex.

scientific article

Fezf2 expression in layer 5 projection neurons of mature mouse motor cortex.

scientific article published on 3 August 2015

Functional correction of established central nervous system deficits in an animal model of lysosomal storage disease with feline immunodeficiency virus-based vectors

scientific article

Gene Therapy Corrects Brain and Behavioral Pathologies in CLN6-Batten Disease

scientific article published on 10 July 2019

Genetic targeting and chemogenetic inhibition of new born neurons

scientific article published on 07 December 2018

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

article by Daniel J Klionsky et al published January 2021 in Autophagy

Inhibition of storage pathology in prenatal CLN5-deficient sheep neural cultures by lentiviral gene therapy.

scientific article published on 19 November 2013

Lentiviral vectors as tools to understand central nervous system biology in mammalian model organisms.

scientific article published on 18 May 2015

Lentiviral-mediated gene transfer to the sheep brain: implications for gene therapy in Batten disease.

scientific article

Lentivirus-Mediated Expression of Human Secreted Amyloid Precursor Protein-Alpha Promotes Long-Term Induction of Neuroprotective Genes and Pathways in a Mouse Model of Alzheimer's Disease

scientific article published on 26 December 2020

Lentivirus-mediated expression of human secreted amyloid precursor protein-alpha prevents development of memory and plasticity deficits in a mouse model of Alzheimer's disease

scientific article published on 9 February 2018

Longitudinal In Vivo Monitoring of the CNS Demonstrates the Efficacy of Gene Therapy in a Sheep Model of CLN5 Batten Disease

article

Neural development in human embryonic stem cells-applications of lentiviral vectors.

scientific article published on August 2011

Neural progenitor cells derived from the adult rat subventricular zone: characterization and transplantation

scientific article published on 01 January 2007

Neuroproteomic Analysis after SARS-CoV-2 Infection Reveals Overrepresented Neurodegeneration Pathways and Disrupted Metabolic Pathways

scientific article published on 30 October 2023

Neutrophil-vascular interactions drive myeloperoxidase accumulation in the brain in Alzheimer's disease

scientific article published on 24 March 2022

Patterned, but not tonic, optogenetic stimulation in motor thalamus improves reaching in acute drug-induced Parkinsonian rats.

scientific article

Peroxiredoxin 1 functions as a signal peroxidase to receive, transduce, and transmit peroxide signals in mammalian cells

scientific article published on 8 August 2012

RNA-Sequencing Analysis Reveals a Regulatory Role for Transcription Factor Fezf2 in the Mature Motor Cortex

scientific article published on 7 September 2017

Recent studies of ovine neuronal ceroid lipofuscinoses from BARN, the Batten Animal Research Network

scientific article

Secreted Amyloid Precursor Protein Alpha (sAPPα) Regulates the Cellular Proteome and Secretome of Mouse Primary Astrocytes

scientific article published on 12 April 2023

Secreted Amyloid Precursor Protein Alpha, a Neuroprotective Protein in the Brain Has Widespread Effects on the Transcriptome and Proteome of Human Inducible Pluripotent Stem Cell-Derived Glutamatergic Neurons Related to Memory Mechanisms

scientific article published on 26 May 2022

The Tripeptide RER Mimics Secreted Amyloid Precursor Protein-Alpha in Upregulating LTP

scientific article published on 18 October 2019

The contribution of multicellular model organisms to neuronal ceroid lipofuscinosis research

scientific article published on 26 November 2019

Transcriptome Profiling of Layer 5 Intratelencephalic Projection Neurons From the Mature Mouse Motor Cortex

scholarly article by Alison J Clare published in January 2018

Transduction of murine cerebellar neurons with recombinant FIV and AAV5 vectors

scientific article published on 01 August 2000

Transduction of neurons lining the cerebral external capsules in mice with feline immunodeficiency virus based vectors ⬇️

scientific article published on November 13, 2003

Transplanted adult neural progenitor cells survive, differentiate and reduce motor function impairment in a rodent model of Huntington's disease.

scientific article published on 19 April 2006

Verification of functional AAV-mediated neurotrophic and anti-apoptotic factor expression.

scientific article published on 18 December 2006

Viral vector-based tools advance knowledge of basal ganglia anatomy and physiology

scientific article published on 17 February 2016

Viral-mediated gene transfer to mouse primary neural progenitor cells.

scientific article

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