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List of works by Robert Nistico

5-HT(2C) serotonin receptor blockade prevents tau protein hyperphosphorylation and corrects the defect in hippocampal synaptic plasticity caused by a combination of environmental stressors in mice

scientific article published on 2 July 2015

A Path Toward Precision Medicine for Neuroinflammatory Mechanisms in Alzheimer's Disease

scientific article published on 31 March 2020

A healthy gut for a healthy brain: preclinical, clinical and regulatory as-pects

scientific article published on 29 July 2020

A role for Ca2+ stores in kainate receptor-dependent synaptic facilitation and LTP at mossy fiber synapses in the hippocampus.

scientific article published in July 2003

ACET is a highly potent and specific kainate receptor antagonist: Characterisation and effects on hippocampal mossy fibre function

scientific article

Abnormal expression of neuronal nitric oxide synthase triggers limbic seizures and hippocampal damage in rat.

scientific article published in February 2002

Adenosine A1 receptor stimulation reduces D1 receptor-mediated GABAergic transmission from striato-nigral terminals and attenuates l-DOPA-induced dyskinesia in dopamine-denervated mice

scientific article

Advances in the therapy of Alzheimer's disease: targeting amyloid beta and tau and perspectives for the future

scientific article published on 24 December 2014

Age-related changes of hippocampal synaptic plasticity in AβPP-null mice are restored by NGF through p75NTR.

scientific article

Age-related changes of protein SUMOylation balance in the AβPP Tg2576 mouse model of Alzheimer's disease

scientific article published on 07 April 2014

Apoptosis in the dorsal lateral geniculate nucleus after monocular deprivation involves glutamate signaling, NO production, and PARP activation

scientific article published on 01 November 2000

Apoptosis in the mechanisms of neuronal plasticity in the developing visual system

scientific article

Apoptosis induced by gp120 in the neocortex of rat involves enhanced expression of cyclooxygenase type 2 and is prevented by NMDA receptor antagonists and by the 21-aminosteroid U-74389G.

scientific article published in August 2000

Biological Mechanism-based Neurology and Psychiatry: a BACE1/2 and Downstream Pathway Model

scientific article published in December 2021

Calcineurin Inhibition Rescues Early Synaptic Plasticity Deficits in a Mouse Model of Alzheimer’s Disease ⬇️

scientific article published on July 3, 2013

Central cardiovascular responses induced by interleukin 1 beta and tumor necrosis factor alpha infused into nucleus tractus solitarii, nucleus parabrachialis medialis and third cerebral ventricle of normotensive rats.

scientific article published in November 2001

Cerebrospinal Fluid Neurogranin as a Biomarker of Neurodegenerative Diseases: A Cross-Sectional Study

scientific article published on 18 July 2017

Cerebrospinal fluid and serum d-serine concentrations are unaltered across the whole clinical spectrum of Alzheimer's disease

scientific article published on 04 September 2020

Changes in mGlu5 receptor-dependent synaptic plasticity and coupling to homer proteins in the hippocampus of Ube3A hemizygous mice modeling angelman syndrome

scientific article

Characterisation of UBP296: a novel, potent and selective kainate receptor antagonist

scientific article

Cognitive impairment and dentate gyrus synaptic dysfunction in experimental parkinsonism

scientific article published on 28 March 2013

Connexin 26 (GJB2) mutations, causing KID Syndrome, are associated with cell death due to calcium gating deregulation.

scientific article published on 15 March 2010

D-aspartate: an atypical amino acid with neuromodulatory activity in mammals

scientific article published on January 2009

Dexamethasone inhibits the inducible bioconversion of glyceryl trinitrate to nitric oxide.

scientific article published on April 2002

Differential effect of carbamazepine and oxcarbazepine on excitatory synaptic transmission in rat hippocampus

scientific article published in October 2008

Early Alteration of Distribution and Activity of Hippocampal Type-1 Cannabinoid Receptor in Alzheimer's Disease-like Mice Overexpressing the Human Mutant Amyloid Precursor Protein.

scientific article published on 14 February 2018

Editorial: targeting synaptic dysfunction and neural connectivity in neurological and psychiatric disorders.

scientific article published in January 2013

Effects of intranasally-delivered pro-nerve growth factors on the septo-hippocampal system in healthy and diabetic rats

scientific article published on 15 July 2020

Electrophysiological and amperometric evidence that modafinil blocks the dopamine uptake transporter to induce behavioral activation ⬇️

scientific article published on August 8, 2013

Electrophysiological and metabolic effects of CHF5074 in the hippocampus: Protection against in vitro ischemia

scientific article published on 12 March 2014

Enhanced mGlu5-receptor dependent long-term depression at the Schaffer collateral-CA1 synapse of congenitally learned helpless rats

scientific article

Ethanol enhances GABAB-mediated inhibitory postsynaptic transmission on rat midbrain dopaminergic neurons by facilitating GIRK currents

scientific article published on 20 March 2009

Evidence that increases of mitochondrial immunoreactive IL-1β by HIV-1 gp120 implicatein situcleavage of pro-IL-1β in the neocortex of rat

article

Evidence that the HIV-1 coat protein gp120 causes neuronal apoptosis in the neocortex of rat via a mechanism involving CXCR4 chemokine receptor

scientific article published in October 2001

Excitotoxic mechanisms of apoptosis in the mammalian visual system following monocular visual deprivation.

scientific article

Exploitation of the HIV-1 coat glycoprotein, gp120, in neurodegenerative studies in vivo.

scientific article

Free D-aspartate regulates neuronal dendritic morphology, synaptic plasticity, gray matter volume and brain activity in mammals

scientific article

GLUK1 receptor antagonists and hippocampal mossy fiber function

scientific article published on January 2009

Gender difference in prescription opioid abuse: A focus on oxycodone and hydrocodone

scientific article published on 20 April 2016

Gender differences in pharmacokinetics and pharmacodynamics of methadone substitution therapy

scientific article published on 9 June 2015

Genders and the concurrent use of cocaine and alcohol: Pharmacological aspects.

scientific article published on 24 June 2014

Ginkgolic Acid Protects against Aβ-Induced Synaptic Dysfunction in the Hippocampus.

scientific article published on 26 October 2016

Growth factors and synaptic plasticity in relapsing-remitting multiple sclerosis.

scientific article

HIV-1 Coat Glycoprotein gp120 Induces Apoptosis in Rat Brain Neocortex by Deranging the Arachidonate Cascade in Favor of Prostanoids

scientific article published on 25 December 2001

HIV-1 gp120-induced apoptosis in the rat neocortex involves enhanced expression of cyclo-oxygenase type 2 (COX-2).

scientific article published in March 1998

Huperzine a restores cortico-hippocampal functional connectivity after bilateral AMPA lesion of the nucleus basalis of meynert.

scientific article

Increased D-aspartate brain content rescues hippocampal age-related synaptic plasticity deterioration of mice.

scientific article published on 25 January 2010

Increased levels of d-aspartate in the hippocampus enhance LTP but do not facilitate cognitive flexibility

scientific article published on 5 October 2007

Inflammation subverts hippocampal synaptic plasticity in experimental multiple sclerosis.

scientific article

Inhibition of hippocampal plasticity in rats performing contrafreeloading for water under repeated administrations of pramipexole

scientific article published on 17 November 2015

Insulin receptor β-subunit haploinsufficiency impairs hippocampal late-phase LTP and recognition memory.

scientific article published on 3 June 2012

Integrating Molecular Mechanisms with Synaptic Plasticity in Neurological Disease ⬇️

scientific article published on August 26, 2012

Interleukin-1β promotes long-term potentiation in patients with multiple sclerosis.

scientific article published on 28 July 2013

Involvement of interleukin-1beta in the mechanism of human immunodeficiency virus type 1 (HIV-1) recombinant protein gp120-induced apoptosis in the neocortex of rat.

scientific article published in January 1999

Kainate receptors and mossy fiber LTP.

scientific article

L-DOPA: a scapegoat for accelerated neurodegeneration in Parkinson's disease?

scientific article published on 24 June 2011

Learning discloses abnormal structural and functional plasticity at hippocampal synapses in the APP23 mouse model of Alzheimer's disease

scientific article published on 19 April 2010

Levels of the Rab GDP dissociation inhibitor (GDI) are altered in the prenatal restrain stress mouse model of schizophrenia and are differentially regulated by the mGlu2/3 receptor agonists, LY379268 and LY354740.

scientific article published on 22 July 2014

Lithium as a Treatment for Alzheimer's Disease: The Systems Pharmacology Perspective

scientific article published on 01 January 2019

Multifaceted roles of nitric oxide in the lateral geniculate nucleus: from visual signal transduction to neuronal apoptosis

scientific article

N-ethyl lidocaine (QX-314) protects striatal neurons against ischemia: an in vitro electrophysiological study.

scientific article published in February 2010

Na+ -Ca2+ exchanger (NCX3) knock-out mice display an impairment in hippocampal long-term potentiation and spatial learning and memory

scientific journal article

Neuregulin 1/ErbB signalling modulates hippocampal mGluRI-dependent LTD and object recognition memory

scientific article published on 7 February 2018

New insights on the role of free D-aspartate in the mammalian brain

scientific article published on August 2012

Oxidative stress in stroke pathophysiology validation of hydrogen peroxide metabolism as a pharmacological target to afford neuroprotection.

scientific article published in January 2009

PDGF Modulates Synaptic Excitability and Short-Latency Afferent Inhibition in Multiple Sclerosis.

scientific article published in February 2018

Paradoxical abatement of striatal dopaminergic transmission by cocaine and methylphenidate

scientific article

Persistent increase of D-aspartate in D-aspartate oxidase mutant mice induces a precocious hippocampal age-dependent synaptic plasticity and spatial memory decay.

scientific article

Perspective on future role of biological markers in clinical therapy trials of Alzheimer's disease: a long-range point of view beyond 2020.

scientific article

Phosphodiesterase 10A controls D1-mediated facilitation of GABA release from striato-nigral projections under normal and dopamine-depleted conditions.

scientific article

Potential therapeutic usefulness of hydrogen peroxide in conditions of brain ischemia

scientific article published on 14 April 2008

Precision medicine and drug development in Alzheimer's disease: the importance of sexual dimorphism and patient stratification

scientific article published on 12 June 2018

Presynaptic c-Jun N-terminal Kinase 2 regulates NMDA receptor-dependent glutamate release.

scientific article

Profile of gantenerumab and its potential in the treatment of Alzheimer's disease

scientific article

RANTES correlates with inflammatory activity and synaptic excitability in multiple sclerosis.

scientific article published on 5 January 2016

Regional specificity of synaptic plasticity deficits in a knock-in mouse model of DYT1 dystonia.

scientific article published on 3 February 2014

Reversal of Metabolic and Neurological Symptoms of Phenylketonuric Mice Treated with a PAH Containing Helper-Dependent Adenoviral Vector

scientific article published on February 1, 2012

Revolution of Alzheimer Precision Neurology Passageway of Systems Biology and Neurophysiology

scientific article published on 16 March 2018

Rhes influences striatal cAMP/PKA-dependent signaling and synaptic plasticity in a gender-sensitive fashion.

scientific article

Role of ASIC1a in Normal and Pathological Synaptic Plasticity

scientific article published on 14 August 2020

Role of aberrant striatal dopamine D1 receptor/cAMP/protein kinase A/DARPP32 signaling in the paradoxical calming effect of amphetamine

scientific article published on August 2010

SUMO: a (oxidative) stressed protein.

scientific article

SUMOylation in neuroplasticity and neurological disorders

scientific article

Selective regulation of recombinantly expressed mGlu7 metabotropic glutamate receptors by G protein-coupled receptor kinases and arrestins.

scientific article published on 19 October 2013

Stress dynamically regulates behavior and glutamatergic gene expression in hippocampus by opening a window of epigenetic plasticity.

scientific article

Subtle alterations of excitatory transmission are linked to presynaptic changes in the hippocampus of PINK1-deficient mice.

scientific article published on 5 February 2016

Synaptic plasticity and PDGF signaling defects underlie clinical progression in multiple sclerosis.

scientific article published in December 2013

Synaptic plasticity as a therapeutic target in the treatment of autism-related single-gene disorders.

scientific article published on January 2013

Synaptic plasticity in multiple sclerosis and in experimental autoimmune encephalomyelitis.

scientific article published on 02 December 2013

Synaptic plasticity in the basal ganglia: a similar code for physiological and pathological conditions.

scientific article published on 23 December 2007

Synaptoimmunology - roles in health and disease.

scientific article

Synergistic interactions between kainate and mGlu receptors regulate bouton Ca signalling and mossy fibre LTP.

scientific article published on 27 September 2011

Synthesis and pharmacology of willardiine derivatives acting as antagonists of kainate receptors.

scientific article published on December 2005

Systemic administration of cocaine, given alone or in combination with sensory stimuli, differentially affects L-arginine-nitric oxide metabolism in discrete regions of the brain of rat.

scientific article published in May 1999

Targeting SUMO-1ylation Contrasts Synaptic Dysfunction in a Mouse Model of Alzheimer's Disease

scientific article

Targeting Synaptic Plasticity in Experimental Models of Alzheimer's Disease

scientific article published on 16 July 2019

Targeting mGlu5 Metabotropic Glutamate Receptors in the Treatment of Cognitive Dysfunction in a Mouse Model of Phenylketonuria.

scientific article published on 16 March 2018

Targeting synaptic dysfunction in Alzheimer's disease therapy.

scientific article published on 23 August 2012

The Involvement of Post-Translational Modifications in Alzheimer's Disease

scientific article published on 4 May 2017

The blockade of K(+)-ATP channels has neuroprotective effects in an in vitro model of brain ischemia.

scientific article published in January 2007

The positive allosteric modulator at mGlu2 receptors, LY487379, reverses the effects of chronic stress-induced behavioral maladaptation and synaptic dysfunction in the adulthood

scientific article published on 23 May 2019

The protective effect of M40401, a superoxide dismutase mimetic, on post-ischemic brain damage in Mongolian gerbils

scientific article

The role of adiponectin receptors in the regulation of synaptic transmission in the hippocampus.

scientific article published on 10 February 2017

The role of oxidative stress in paraquat-induced neurotoxicity in rats: protection by non peptidyl superoxide dismutase mimetic

scientific article published in January 2003

The selective disruption of presynaptic JNK2/STX1a interaction reduces NMDA receptor-dependent glutamate release

scientific article published on 09 May 2019

The β-Secretase BACE1 in Alzheimer's Disease

scientific article published on 13 February 2020

The γ-secretase modulator CHF5074 restores memory and hippocampal synaptic plasticity in plaque-free Tg2576 mice.

scientific article published in January 2011

Therapeutic potential of targeting hydrogen peroxide metabolism in the treatment of brain ischaemia. ⬇️

scientific article published on June 2012

Unbalance between Excitation and Inhibition in Phenylketonuria, a Genetic Metabolic Disease Associated with Autism

scientific article

Unlocking the secrets of dopamine in Alzheimer's Disease

scientific article

Xanthurenic Acid Activates mGlu2/3 Metabotropic Glutamate Receptors and is a Potential Trait Marker for Schizophrenia

scientific article

d-Aspartate oxidase influences glutamatergic system homeostasis in mammalian brain.

scientific article published on 12 February 2015

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