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List of works by Laura Leyva

A New Risk Variant for Multiple Sclerosis at 11q23.3 Locus Is Associated with Expansion of CXCR5+ Circulating Regulatory T Cells

scientific article published on 26 February 2020

A functional variant that affects exon-skipping and protein expression of SP140 as genetic mechanism predisposing to multiple sclerosis.

scientific article

A new risk variant for multiple sclerosis at the immunoglobulin heavy chain locus associates with intrathecal IgG, IgM index and oligoclonal bands

scientific article published on 12 November 2014

ANKRD55 and DHCR7 are novel multiple sclerosis risk loci

article

Activation of the JAK-STAT Signaling Pathway after In Vitro Stimulation with IFNß in Multiple Sclerosis Patients According to the Therapeutic Response to IFNß.

scientific article

Adipose-derived mesenchymal stem cells (AdMSC) for the treatment of secondary-progressive multiple sclerosis: A triple blinded, placebo controlled, randomized phase I/II safety and feasibility study.

scientific article

Analysis of Plasminogen Genetic Variants in Multiple Sclerosis Patients

scientific article published on 18 May 2016

Antiviral, Immunomodulatory and Antiproliferative Activities of Recombinant Soluble IFNAR2 without IFN-ß Mediation

scientific article published on 31 March 2020

Candidate Gene Study of TRAIL and TRAIL Receptors: Association with Response to Interferon Beta Therapy in Multiple Sclerosis Patients ⬇️

scientific article published on April 29, 2013

Cell-based product classification procedure: What can be done differently to improve decisions on borderline products?

scientific article published on 18 May 2016

Cross-reactivity of antibodies against interferon beta in multiple sclerosis patients and interference of the JAK-STAT signaling pathway

scientific article published on 29 November 2017

DRB1*03:01 haplotypes: differential contribution to multiple sclerosis risk and specific association with the presence of intrathecal IgM bands

scientific article

Decreased soluble IFN-β receptor (sIFNAR2) in multiple sclerosis patients: A potential serum diagnostic biomarker.

scientific article published on 9 September 2016

Development and validation of an ELISA for quantification of soluble IFN-β receptor: assessment in multiple sclerosis

scientific article published on 16 November 2015

Differences in the immunological responses in drug- and virus-induced cutaneous reactions in children.

scientific article published in January 2003

Early development of anti-natalizumab antibodies in MS patients ⬇️

scientific article published on June 14, 2013

Effects of the multiple sclerosis associated -330 promoter polymorphism in IL2 allelic expression

scientific article published on March 2004

Exome sequencing in multiple sclerosis families identifies 12 candidate genes and nominates biological pathways for the genesis of disease

scientific article published on 06 June 2019

Expression of the skin-homing receptor in peripheral blood lymphocytes from subjects with nonimmediate cutaneousallergic drug reactions

scientific article published in November 2000

Gene expression in IFNß signalling pathway differs between monocytes, CD4 and CD8 T cells from MS patients ⬇️

scientific article published on November 24, 2010

Gene therapy with mesenchymal stem cells expressing IFN-ß ameliorates neuroinflammation in experimental models of multiple sclerosis

scientific article published on 24 November 2016

Genome-wide association study of multiple sclerosis confirms a novel locus at 5p13.1

scientific article (publication date: 2012)

Genome-wide significant association with seven novel multiple sclerosis risk loci

scientific article

Global methylation correlates with clinical status in multiple sclerosis patients in the first year of IFNbeta treatment

scientific article

HLA alleles as biomarkers of high-titre neutralising antibodies to interferon-β therapy in multiple sclerosis

scientific article published on 19 April 2014

HLA class II alleles in patients with multiple sclerosis in the Biscay province (Basque Country, Spain)

scientific article published on 01 December 2009

HLA class II and response to interferon-beta in multiple sclerosis.

scientific article

Hexose-6-phosphate dehydrogenase: a new risk gene for multiple sclerosis

scientific article

Human endogenous retrovirus HERV-Fc1 association with multiple sclerosis susceptibility: a meta-analysis

scientific article

IFNAR1 and IFNAR2 polymorphisms confer susceptibility to multiple sclerosis but not to interferon-beta treatment response

scientific article published on 22 April 2005

IL28B polymorphisms are not associated with the response to interferon-β in multiple sclerosis

scientific article published on 01 September 2011

IL2RA/CD25 gene polymorphisms: uneven association with multiple sclerosis (MS) and type 1 diabetes (T1D).

scientific article

Identification of a functional variant in the KIF5A-CYP27B1-METTL1-FAM119B locus associated with multiple sclerosis

scientific article published on 17 November 2012

In vitro T-cell responses to beta-lactam drugs in immediate and nonimmediate allergic reactions.

scientific article published in July 2001

Interferon receptor expression in multiple sclerosis patients.

scientific article

Interferon regulatory factor 5 (IRF5) gene variants are associated with multiple sclerosis in three distinct populations

scientific article published on 19 February 2008

Killer-cell immunoglobulin-like receptor expression on lymphocyte subsets in multiple sclerosis patients treated with interferon-β: evaluation as biomarkers for clinical response

scientific article published on 01 June 2014

Kinetics and incidence of anti-natalizumab antibodies in multiple sclerosis patients on treatment for 18 months

scientific article published on 21 December 2010

Lipid-specific immunoglobulin M bands in cerebrospinal fluid are associated with a reduced risk of developing progressive multifocal leukoencephalopathy during treatment with natalizumab

scientific article

Multiple sclerosis association study with theTENR-IL2-IL21region in a Spanish population

article

Multiple sclerosis in Gypsies from southern Spain: prevalence, mitochondrial DNA haplogroups and HLA class II association.

scientific article

Pharmacogenomic study in patients with multiple sclerosis: Responders and nonresponders to IFN-β.

scientific article

Predictors of Fatigue Severity in Early Systemic Sclerosis: A Prospective Longitudinal Study of the GENISOS Cohort ⬇️

scientific article published on October 14, 2011

Preferential Expression of the Skin–Homing Receptor CLA in Peripheral T Lymphocytes from Patients with Drug–Allergic Reactions

scientific article published in 1999

Protein tyrosine phosphatase gene (PTPN22) polymorphism in multiple sclerosis.

scientific article published on 17 March 2005

Recombinant soluble IFN receptor (sIFNAR2) exhibits intrinsic therapeutic efficacy in a murine model of Multiple Sclerosis

scientific article published on 21 July 2016

Replication of top markers of a genome-wide association study in multiple sclerosis in Spain.

scientific article published on 14 October 2010

Study of binding and neutralising antibodies to interferon-beta in two groups of relapsing-remitting multiple sclerosis patients

scientific article published on 01 May 2001

Subjects with allergic reactions to drugs show in vivo polarized patterns of cytokine expression depending on the chronology of the clinical reaction

scientific article published in October 2000

TRAIL and TRAIL receptors splice variants during long-term interferon β treatment of patients with multiple sclerosis: evaluation as biomarkers for therapeutic response

scientific article published on 3 March 2015

Tag-SNP analysis of the GFI1-EVI5-RPL5-FAM69 risk locus for multiple sclerosis

scientific article

The CD4+ T-cell subset lacking expression of the CD28 costimulatory molecule is expanded and shows a higher activation state in multiple sclerosis ⬇️

scientific article published on January 20, 2012

The HLA DRB1*03:01 allele is associated with NMO regardless of the NMO-IgG status in Brazilian patients from Rio de Janeiro.

scientific article published on 31 May 2017

The efficacy of natalizumab in patients with multiple sclerosis according to level of disability: results of an observational study.

scientific article published on 18 November 2010

The high producer variant of the Fc-receptor like-3 (FCRL3) gene is involved in protection against multiple sclerosis

scientific article published on 3 March 2008

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