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List of works by Joseph R Arron

A CEACAM6-High Airway Neutrophil Phenotype and CEACAM6-High Epithelial Cells Are Features of Severe Asthma.

scientific article published on 8 March 2017

A microRNA upregulated in asthma airway T cells promotes TH2 cytokine production

scientific article

A positive regulatory role for Cbl family proteins in tumor necrosis factor-related activation-induced cytokine (trance) and CD40L-mediated Akt activation.

scientific article published on 13 June 2001

A qPCR-based metric of Th2 airway inflammation in asthma.

scientific article published on 17 July 2013

A randomised pragmatic trial of corticosteroid optimization in severe asthma using a composite biomarker algorithm to adjust corticosteroid dose versus standard care: study protocol for a randomised trial

scientific article

A regulatory role for TRAF1 in antigen-induced apoptosis of T cells.

scientific article published on May 1997

Accurately measuring and modeling Th2 and Th17 endotypes in severe asthma

scientific article published on February 2017

Airway epithelial miRNA expression is altered in asthma.

scientific article

Airway pathological heterogeneity in asthma: Visualization of disease microclusters using topological data analysis

scientific article published on 7 March 2018

Analysis of protein-altering variants in telomerase genes and their association with MUC5B common variant status in patients with idiopathic pulmonary fibrosis: a candidate gene sequencing study

scientific article published on 18 June 2018

Asthma biomarkers: what constitutes a 'gold standard'?

scientific article

Beyond type 2 cytokines in asthma - new insights from old clinical trials

scientific article published on 30 March 2020

Biomarkers in the clinical development of asthma therapies.

scientific article

Bone versus immune system

scientific article (publication date: 30 November 2000)

Breaking into bone biology: target practice.

scientific article published on February 2009

CXCL14 is a candidate biomarker for Hedgehog signalling in idiopathic pulmonary fibrosis.

scientific article published in March 2017

Chemical rescue of cleft palate and midline defects in conditional GSK-3beta mice.

scientific article published on 11 February 2007

Comparative transcriptomic analyses of atopic dermatitis and psoriasis reveal shared neutrophilic inflammation.

scientific article

Dendritic cell development and survival require distinct NF-kappaB subunits

scientific article published on 01 February 2002

Disconnect between sputum neutrophils and other measures of airway inflammation in asthma

scientific article published on 31 October 2013

Endogenously expressed IL-13Rα2 attenuates IL-13-mediated responses but does not activate signaling in human lung fibroblasts

scientific article

Exacerbation Profile and Risk Factors in a Type-2–Low Enriched Severe Asthma Cohort: A Clinical Trial to Assess Asthma Exacerbation Phenotypes

scientific article published in 2022

Fit-for-purpose biomarker immunoassay qualification and validation: three case studies

scientific article

Glucocorticoid receptor β and histone deacetylase 1 and 2 expression in the airways of severe asthma.

scientific article published on 8 December 2011

High-dose paclitaxel, cyclophosphamide, and cisplatin with autologous hematopoietic progenitor-cell support: a phase I trial

scientific article published on 01 May 1996

IL-13 is a therapeutic target in radiation lung injury.

scientific article published on 22 December 2016

IL-13 mediates IL-33-dependent mast cell and type 2 innate lymphoid cell effects on bronchial epithelial cells.

scientific article published on 14 March 2015

Increased Autophagy-Related 5 Gene Expression Is Associated with Collagen Expression in the Airways of Refractory Asthmatics.

scientific article published on 29 March 2017

Increased expression of bronchial epithelial transient receptor potential vanilloid 1 channels in patients with severe asthma.

scientific article published on 8 November 2013

Increased expression of immunoreactive thymic stromal lymphopoietin in patients with severe asthma

scientific article published on 5 October 2011

Inhibition of the kinase ITK in a mouse model of asthma reduces cell death and fails to inhibit the inflammatory response.

scientific article published in December 2015

Interferon-stimulated Gene Expression, Type-2 Inflammation and Endoplasmic Reticulum Stress in Asthma.

scientific article

Interleukin-13 in Asthma and Other Eosinophilic Disorders.

scientific article published on 19 September 2017

Interleukin-18 has antipermeablity and antiangiogenic activities in the eye: reciprocal suppression with VEGF.

scientific article

Lebrikizumab Treatment in Adults with Asthma ⬇️

scientific article published on August 3, 2011

Lung gene expression in a rhesus allergic asthma model correlates with physiologic parameters of disease and exhibits common and distinct pathways with human asthma and a mouse asthma model

scientific article

Molecular mapping of interstitial lung disease reveals a phenotypically distinct senescent basal epithelial cell population

scientific article published in 2021

Molecular programs of fibrotic change in aging human lung

scientific article published on 02 November 2021

NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21.

scientific article

Noninvasive biomarkers that predict treatment benefit from biologic therapies in asthma.

scientific article published on December 2013

Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients

scientific article published on August 2012

Peripheral blood gene expression predicts clinical benefit from anti-IL-13 in asthma

scientific article published on 29 June 2016

Prognostic and predictive biomarkers for patients with idiopathic pulmonary fibrosis treated with pirfenidone: post-hoc assessment of the CAPACITY and ASCEND trials

scientific article published on 29 June 2018

Promising bone-related therapeutic targets for rheumatoid arthritis

scientific article

Ranibizumab for macular edema due to retinal vein occlusions: implication of VEGF as a critical stimulator.

scientific article published on 5 February 2008

Redefining approaches to asthma: developing targeted biologic therapies.

scientific article published on January 2013

Reduced epithelial suppressor of cytokine signalling 1 in severe eosinophilic asthma.

scientific article published on 23 June 2016

Reducing the risk of failure: biomarker-guided trial design.

scientific article published on 15 July 2016

Regulation of the subcellular localization of tumor necrosis factor receptor-associated factor (TRAF)2 by TRAF1 reveals mechanisms of TRAF2 signaling

scientific article published in October 2002

Relationships among aeroallergen sensitization, peripheral blood eosinophils, and periostin in pediatric asthma development

scientific article published on 5 July 2016

Reply

Research in progress: Medical Research Council United Kingdom Refractory Asthma Stratification Programme (RASP-UK)

scientific article (publication date: February 2016)

Revisiting the NIH Taskforce on the Research needs of Eosinophil-Associated Diseases (RE-TREAD)

scientific article published in July 2018

Roles of Periostin in Respiratory Disorders.

scientific article published on 12 January 2016

Seasonal variability of severe asthma exacerbations and clinical benefit from lebrikizumab

scientific article published on 24 February 2017

Stratified medicine in inflammatory disorders: From theory to practice

scientific article published on 28 April 2015

T Cell Receptor Signals Enhance Susceptibility to Fas-mediated Apoptosis ⬇️

scientific article published on December 1, 1997

T-helper type 2-driven inflammation defines major subphenotypes of asthma.

scientific article published on 29 May 2009

TH2 and TH17 inflammatory pathways are reciprocally regulated in asthma.

scientific article published on August 2015

TRAF-mediated TNFR-family signaling.

scientific article

TRAF6, a molecular bridge spanning adaptive immunity, innate immunity and osteoimmunology.

scientific article

TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells

scientific article

The airway microbiome in patients with severe asthma: Associations with disease features and severity.

scientific article published on 25 July 2015

The effects of lebrikizumab in patients with mild asthma following whole lung allergen challenge.

scientific article

The role of periostin in tissue remodeling across health and disease.

scientific article

Type 2 immunity is protective in metabolic disease but exacerbates NAFLD collaboratively with TGF-β.

scientific article published on June 2017

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