List of works - Timothy E Adams

A high-affinity ErbB4Fc fusion protein is a potent antagonist of heregulin-mediated receptor activation

scientific article

A new crystal form of human vascular adhesion protein 1

scientific article

A truncated soluble epidermal growth factor receptor-Fc fusion ligand trap displays anti-tumour activity in vivo

scientific article published on June 2009

APOMAB® antibody drug conjugates targeting dead tumor cells are effective in vivo

scientific article published on 09 November 2018

Activation of ERBB4 in Glioblastoma Can Contribute to Increased Tumorigenicity and Influence Therapeutic Response

scientific article published on 25 July 2018

Antibodies specifically targeting a locally misfolded region of tumor associated EGFR

scientific article

Biochemical characterization of individual human glycosylated pro-insulin-like growth factor (IGF)-II and big-IGF-II isoforms associated with cancer.

scientific article published on 19 November 2012

Blood-based protein biomarker panel for the detection of colorectal cancer

scientific article

C6orf106 is a novel inhibitor of the interferon-regulatory factor 3-dependent innate antiviral response

scientific article published in Journal of Biological Chemistry

CD52 glycan binds the proinflammatory B box of HMGB1 to engage the Siglec-10 receptor and suppress human T cell function

scientific article published on 11 July 2018

CD52 inhibits Toll-like receptor activation of NF-κB and triggers apoptosis to suppress inflammation

scientific article

CR1/CR2 interactions modulate the functions of the cell surface epidermal growth factor receptor.

scientific article published on 11 March 2004

Cloning and DNA sequence analysis of the cDNA for the common alpha-subunit of the ovine pituitary glycoprotein hormones

scientific article published on December 1989

Colorectal cancer biomarkers: to be or not to be? Cautionary tales from a road well travelled

scientific article published on January 2014

Comparison of alternative nucleophiles for Sortase A-mediated bioconjugation and application in neuronal cell labelling

scientific article published on 01 May 2014

Comparison of intrahepatic lymphocytes from normal and growth hormone transgenic mice with chronic hepatitis and liver cancer.

scientific article published in March 1997

Crystallization and preliminary X-ray analysis of the complexes between a Fab and two forms of human insulin-like growth factor II.

scientific article published on 26 August 2009

Development of an anti-ferret CD4 monoclonal antibody for the characterisation of ferret T lymphocytes.

scientific article

Differential Sensitivity of Human Hepatocellular Carcinoma Xenografts to an IGF-II Neutralizing Antibody May Involve Activated STAT3

scientific article published on 22 June 2018

Direct involvement of the TEN domain at the active site of human telomerase

scientific article

Dual Site-Specific Labeling of an Antibody Fragment through Sortase A and π-Clamp Conjugation

scientific article published on 03 October 2019

EGFRvIII-mediated transactivation of receptor tyrosine kinases in glioma: mechanism and therapeutic implications.

scientific article

Electrostatic interactions between Hendra virus matrix proteins are required for efficient virus-like particle assembly.

scientific article

Engineering of an anti-epidermal growth factor receptor antibody to single chain format and labeling by Sortase A-mediated protein ligation

scientific article

Functional expression of an ovine growth hormone receptor in transfected Chinese hamster ovary cells

scientific article published on July 1, 1992

Glioma Specific Extracellular Missense Mutations in the First Cysteine Rich Region of Epidermal Growth Factor Receptor (EGFR) Initiate Ligand Independent Activation

scientific article published on 18 April 2011

Glioma-specific Domain IV EGFR cysteine mutations promote ligand-induced covalent receptor dimerization and display enhanced sensitivity to dacomitinib in vivo

scientific article published on 21 April 2014

Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b)

scientific article (publication date: June 2002)

High, persistent hepatocellular proliferation and apoptosis precede hepatocarcinogenesis in growth hormone transgenic mice

scientific article published on 01 June 1999

Identification of a determinant of epidermal growth factor receptor ligand-binding specificity using a truncated, high-affinity form of the ectodomain.

scientific article

Identification of a liver-specific promoter for the ovine growth hormone receptor.

scientific article published on May 1994

Identification of the epitope for the epidermal growth factor receptor-specific monoclonal antibody 806 reveals that it preferentially recognizes an untethered form of the receptor

scientific article published on 9 April 2004

Incomplete target neutralization by the anti-cancer antibody rilotumumab

scientific article published on 11 January 2016

Investigation onto the correlation between systemic antibodies to surface glycoproteins of infectious laryngotracheitis virus (ILTV) and protective immunity

scientific article published on 11 December 2018

Koala and Wombat Gammaherpesviruses Encode the First Known Viral NTPDase Homologs and Are Phylogenetically Divergent from All Known Gammaherpesviruses

scientific article published on 05 March 2019

LRIG1 extracellular domain: structure and function analysis

scientific article

Megakaryocytes co-localise with hemopoietic stem cells and release cytokines that up-regulate stem cell proliferation.

scientific article published on 28 May 2013

Methylation and expression of a metallothionein promoter ovine growth hormone fusion gene (MToGH1) in transgenic mice

scientific article published on 01 March 1995

New Monoclonal Antibodies to Defined Cell Surface Proteins on Human Pluripotent Stem Cells

scientific article

Non-tolerance and autoantibodies to a transgenic self antigen expressed in pancreatic β cells

scientific article published in Nature

Notch ligand delta-like1: X-ray crystal structure and binding affinity

scientific article

Overexpressed growth hormone (GH) synergistically promotes carcinogen-initiated liver tumour growth by promoting cellular proliferation in emerging hepatocellular neoplasms in female and male GH-transgenic mice.

scientific article published in April 2001

Positive and negative regulatory elements in the late lactation protein-A gene promoter from the tammar wallaby (Macropus eugenii).

scientific article

Preparation of human vascular endothelial growth factor-D for structural and preclinical therapeutic studies.

scientific article published on 10 January 2012

Prevention of diabetes-induced albuminuria in transgenic rats overexpressing human aldose reductase

scientific article published on 01 June 2002

Production of methionyl-minus ovine growth hormone in Escherichia coli and one-step purification

scientific article published on 01 December 1992

Properties of an insulin receptor with an IGF-1 receptor loop exchange in the cysteine-rich region

scientific article published on 01 March 2000

Removal of 3'untranslated sequences dramatically enhances transient expression of ovine follicle-stimulating hormone Beta gene messenger ribonucleic Acid

scientific article published on 01 December 1992

STAT5b mediates the GH-induced expression of SOCS-2 and SOCS-3 mRNA in the liver

scientific article published on 01 December 1999

Signalling by the type 1 insulin-like growth factor receptor: interplay with the epidermal growth factor receptor

scientific article

Solution structure of ectodomains of the insulin receptor family: the ectodomain of the type 1 insulin-like growth factor receptor displays asymmetry of ligand binding accompanied by limited conformational change

scientific article published on 14 October 2009

Structural and biochemical analyses of a Clostridium perfringens sortase D transpeptidase

scientific article

Structural and functional characterisation of ferret interleukin-2

scientific article

Structural characterization of a novel monotreme-specific protein with antimicrobial activity from the milk of the platypus.

scientific article

Structural insights into ligand-induced activation of the insulin receptor.

scientific article published on January 2008

Structural model for the interaction of a designed Ankyrin Repeat Protein with the human epidermal growth factor receptor 2.

scientific article

Structure and function of the type 1 insulin-like growth factor receptor.

scientific article

Taking down the FLAG! How insect cell expression challenges an established tag-system

scientific article (publication date: 2012)

The crystal structure of a truncated ErbB2 ectodomain reveals an active conformation, poised to interact with other ErbB receptors

scientific article (publication date: February 2003)

The insulin and EGF receptor structures: new insights into ligand-induced receptor activation.

scientific article published on 5 February 2007

The sheep growth hormone receptor: molecular cloning and ontogeny of mRNA expression in the liver.

scientific article

The structure of vanin 1: a key enzyme linking metabolic disease and inflammation

scientific article

Total synthesis of the potent anticancer Aglaia metabolites (-)-silvestrol and (-)-episilvestrol and the active analogue (-)-4'-desmethoxyepisilvestrol.

scientific article

UV induced responses of the human epidermal IGF system: impaired anti-apoptotic effects of IGF-I in HaCaT keratinocytes.

scientific article published on June 2005

List of works by Timothy E Adams

A high-affinity ErbB4Fc fusion protein is a potent antagonist of heregulin-mediated receptor activation

A new crystal form of human vascular adhesion protein 1

A truncated soluble epidermal growth factor receptor-Fc fusion ligand trap displays anti-tumour activity in vivo

APOMAB® antibody drug conjugates targeting dead tumor cells are effective in vivo

Activation of ERBB4 in Glioblastoma Can Contribute to Increased Tumorigenicity and Influence Therapeutic Response

Antibodies specifically targeting a locally misfolded region of tumor associated EGFR

Biochemical characterization of individual human glycosylated pro-insulin-like growth factor (IGF)-II and big-IGF-II isoforms associated with cancer.

Blood-based protein biomarker panel for the detection of colorectal cancer

C6orf106 is a novel inhibitor of the interferon-regulatory factor 3-dependent innate antiviral response

CD52 glycan binds the proinflammatory B box of HMGB1 to engage the Siglec-10 receptor and suppress human T cell function

CD52 inhibits Toll-like receptor activation of NF-κB and triggers apoptosis to suppress inflammation

CR1/CR2 interactions modulate the functions of the cell surface epidermal growth factor receptor.

Cloning and DNA sequence analysis of the cDNA for the common alpha-subunit of the ovine pituitary glycoprotein hormones

Colorectal cancer biomarkers: to be or not to be? Cautionary tales from a road well travelled

Comparison of alternative nucleophiles for Sortase A-mediated bioconjugation and application in neuronal cell labelling

Comparison of intrahepatic lymphocytes from normal and growth hormone transgenic mice with chronic hepatitis and liver cancer.

Crystallization and preliminary X-ray analysis of the complexes between a Fab and two forms of human insulin-like growth factor II.

Development of an anti-ferret CD4 monoclonal antibody for the characterisation of ferret T lymphocytes.

Differential Sensitivity of Human Hepatocellular Carcinoma Xenografts to an IGF-II Neutralizing Antibody May Involve Activated STAT3

Direct involvement of the TEN domain at the active site of human telomerase

Dual Site-Specific Labeling of an Antibody Fragment through Sortase A and π-Clamp Conjugation

EGFRvIII-mediated transactivation of receptor tyrosine kinases in glioma: mechanism and therapeutic implications.

Electrostatic interactions between Hendra virus matrix proteins are required for efficient virus-like particle assembly.

Engineering of an anti-epidermal growth factor receptor antibody to single chain format and labeling by Sortase A-mediated protein ligation

Functional expression of an ovine growth hormone receptor in transfected Chinese hamster ovary cells

Glioma Specific Extracellular Missense Mutations in the First Cysteine Rich Region of Epidermal Growth Factor Receptor (EGFR) Initiate Ligand Independent Activation

Glioma-specific Domain IV EGFR cysteine mutations promote ligand-induced covalent receptor dimerization and display enhanced sensitivity to dacomitinib in vivo

Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b)

High, persistent hepatocellular proliferation and apoptosis precede hepatocarcinogenesis in growth hormone transgenic mice

Identification of a determinant of epidermal growth factor receptor ligand-binding specificity using a truncated, high-affinity form of the ectodomain.

Identification of a liver-specific promoter for the ovine growth hormone receptor.

Identification of the epitope for the epidermal growth factor receptor-specific monoclonal antibody 806 reveals that it preferentially recognizes an untethered form of the receptor

Incomplete target neutralization by the anti-cancer antibody rilotumumab

Investigation onto the correlation between systemic antibodies to surface glycoproteins of infectious laryngotracheitis virus (ILTV) and protective immunity

Koala and Wombat Gammaherpesviruses Encode the First Known Viral NTPDase Homologs and Are Phylogenetically Divergent from All Known Gammaherpesviruses

LRIG1 extracellular domain: structure and function analysis

Megakaryocytes co-localise with hemopoietic stem cells and release cytokines that up-regulate stem cell proliferation.

Methylation and expression of a metallothionein promoter ovine growth hormone fusion gene (MToGH1) in transgenic mice

New Monoclonal Antibodies to Defined Cell Surface Proteins on Human Pluripotent Stem Cells

Non-tolerance and autoantibodies to a transgenic self antigen expressed in pancreatic β cells

Notch ligand delta-like1: X-ray crystal structure and binding affinity

Overexpressed growth hormone (GH) synergistically promotes carcinogen-initiated liver tumour growth by promoting cellular proliferation in emerging hepatocellular neoplasms in female and male GH-transgenic mice.

Positive and negative regulatory elements in the late lactation protein-A gene promoter from the tammar wallaby (Macropus eugenii).

Preparation of human vascular endothelial growth factor-D for structural and preclinical therapeutic studies.

Prevention of diabetes-induced albuminuria in transgenic rats overexpressing human aldose reductase

Production of methionyl-minus ovine growth hormone in Escherichia coli and one-step purification

Properties of an insulin receptor with an IGF-1 receptor loop exchange in the cysteine-rich region

Removal of 3'untranslated sequences dramatically enhances transient expression of ovine follicle-stimulating hormone Beta gene messenger ribonucleic Acid

STAT5b mediates the GH-induced expression of SOCS-2 and SOCS-3 mRNA in the liver

Signalling by the type 1 insulin-like growth factor receptor: interplay with the epidermal growth factor receptor

Solution structure of ectodomains of the insulin receptor family: the ectodomain of the type 1 insulin-like growth factor receptor displays asymmetry of ligand binding accompanied by limited conformational change

Structural and biochemical analyses of a Clostridium perfringens sortase D transpeptidase

Structural and functional characterisation of ferret interleukin-2

Structural characterization of a novel monotreme-specific protein with antimicrobial activity from the milk of the platypus.

Structural insights into ligand-induced activation of the insulin receptor.

Structural model for the interaction of a designed Ankyrin Repeat Protein with the human epidermal growth factor receptor 2.

Structure and function of the type 1 insulin-like growth factor receptor.

Taking down the FLAG! How insect cell expression challenges an established tag-system

The crystal structure of a truncated ErbB2 ectodomain reveals an active conformation, poised to interact with other ErbB receptors

The insulin and EGF receptor structures: new insights into ligand-induced receptor activation.

The sheep growth hormone receptor: molecular cloning and ontogeny of mRNA expression in the liver.

The structure of vanin 1: a key enzyme linking metabolic disease and inflammation

Total synthesis of the potent anticancer Aglaia metabolites (-)-silvestrol and (-)-episilvestrol and the active analogue (-)-4'-desmethoxyepisilvestrol.

UV induced responses of the human epidermal IGF system: impaired anti-apoptotic effects of IGF-I in HaCaT keratinocytes.