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List of works by Francesco Antonio Aprile

A Rational Design Strategy for the Selective Activity Enhancement of a Molecular Chaperone toward a Target Substrate

scientific article published on 20 July 2015

A Rationally Designed Hsp70 Variant Rescues the Aggregation-Associated Toxicity of Human IAPP in Cultured Pancreatic Islet β-Cells.

scientific article published on 12 May 2018

A Water-Bridged Cysteine-Cysteine Redox Regulation Mechanism in Bacterial Protein Tyrosine Phosphatases

scientific article published on 12 October 2017

A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity

scientific article

Automated Behavioral Analysis of Large C. elegans Populations Using a Wide Field-of-view Tracking Platform

scientific article published on 28 November 2018

Biophysical approaches for the study of interactions between molecular chaperones and protein aggregates

scientific article published on 02 September 2015

C. elegans expressing D76N β2-microglobulin: a model for in vivo screening of drug candidates targeting amyloidosis

scientific article published on 27 December 2019

Cell surface localised Hsp70 is a cancer specific regulator of clathrin-independent endocytosis

scientific article published on 6 August 2015

Cooperative Assembly of Hsp70 Subdomain Clusters

scientific article published on 29 May 2018

Delivery of Native Proteins into C. elegans Using a Transduction Protocol Based on Lipid Vesicles

scientific article published on 8 November 2017

Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms

article

Direct observation of the interconversion of normal and toxic forms of α-synuclein

scientific article

Enhancement of the Anti-Aggregation Activity of a Molecular Chaperone Using a Rationally Designed Post-Translational Modification

scientific article published on 19 July 2019

Hsp70 oligomerization is mediated by an interaction between the interdomain linker and the substrate-binding domain

scientific article

Identification of an RNA Polymerase III Regulator Linked to Disease-Associated Protein Aggregation

scientific article published on March 2017

Inhibition of α-Synuclein Fibril Elongation by Hsp70 Is Governed by a Kinetic Binding Competition between α-Synuclein Species

scientific article published on 23 February 2017

Methods of probing the interactions between small molecules and disordered proteins

scientific article published on 19 June 2017

Microfluidic Diffusion Analysis of the Sizes and Interactions of Proteins under Native Solution Conditions

scientific article published on 17 December 2015

Microfluidic Diffusion Viscometer for Rapid Analysis of Complex Solutions

scientific article published on 16 March 2016

Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine

article

NMR characterization of the conformational fluctuations of the human lymphocyte function-associated antigen-1 I-domain

scientific article published on 5 September 2014

Nanobodies Raised against Monomeric α-Synuclein Distinguish between Fibrils at Different Maturation Stages

scientific article published on 01 April 2013

Publisher Correction: The polyglutamine protein ataxin-3 enables normal growth under heat shock conditions in the methylotrophic yeast Pichia pastoris.

scientific article

Rational design of a conformation-specific antibody for the quantification of Aβ oligomers

scientific article published on 03 June 2020

Rational design of antibodies targeting specific epitopes within intrinsically disordered proteins

scientific article

Rationally Designed Antibodies as Research Tools to Study the Structure-Toxicity Relationship of Amyloid-β Oligomers

scientific article published on 25 June 2020

Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method

scientific article

Sequence Specificity in the Entropy-Driven Binding of a Small Molecule and a Disordered Peptide

scientific article

Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer's disease

scientific article published on 04 November 2020

Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer's disease progression

scientific article published on 26 July 2019

Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation.

scientific article published on 8 April 2015

Structure and dynamics of the integrin LFA-1 I-domain in the inactive state underlie its inside-out/outside-in signaling and allosteric mechanisms

scientific article published on 12 March 2015

Structure of a low-population binding intermediate in protein-RNA recognition

scientific article published on 10 June 2016

Structure of a low-population intermediate state in the release of an enzyme product

scientific article published on 9 January 2015

Targeting Amyloid Aggregation: An Overview of Strategies and Mechanisms

scholarly article by Sofia Giorgetti published in September 2018

The CamSol method of rational design of protein mutants with enhanced solubility

scientific article published on 14 October 2014

The cellular modifier MOAG-4/SERF drives amyloid formation through charge complementation

scientific article published on 07 October 2021

The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress α-synuclein aggregation

scientific article

The polyglutamine protein ataxin-3 enables normal growth under heat shock conditions in the methylotrophic yeast Pichia pastoris

scientific article published on 17 October 2017

The relationship between aggregation and toxicity of polyglutamine-containing ataxin-3 in the intracellular environment of Escherichia coli

scientific article

Third generation antibody discovery methods: in silico rational design

scientific article published on 01 December 2018

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