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List of works by Hiroki Kakuta

3H-Imidazo[4,5-b]pyridine-6-carboxylic acid derivatives as rexinoids with reduced teratogenicity

scientific article published on 28 May 2019

An arylidene-thiazolidinedione derivative, GPU-4, without PPARγ activation, reduces retinal neovascularization

scientific article published on 01 February 2011

Analgesic agents without gastric damage: design and synthesis of structurally simple benzenesulfonanilide-type cyclooxygenase-1-selective inhibitors

scientific article (publication date: 15 January 2007)

Antimalarial effect of bis-pyridinium salts, N,N'-hexamethylenebis(4-carbamoyl-1-alkylpyridinium bromide).

scientific article published on 9 March 2006

Competitive Binding Assay with an Umbelliferone-Based Fluorescent Rexinoid for Retinoid X Receptor Ligand Screening

scientific article published on 18 September 2019

Convenient Retinoid X Receptor Binding Assay Based on Fluorescence Change of the Antagonist NEt-C343

scientific article published on 30 December 2020

Correction to Synthesis of 11C-Labeled RXR Partial Agonist 1-[(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)amino]benzotriazole-5-carboxylic Acid (CBt-PMN) by Direct [11C]Carbon Dioxide Fixation via Organolithiation of Trialkyltin Precurs

scientific article published on 19 April 2019

Cyclooxygenase inhibitors derived from thalidomide

scientific article (publication date: September 2003)

Cyclooxygenase-1-selective inhibitors are attractive candidates for analgesics that do not cause gastric damage. design and in vitro/in vivo evaluation of a benzamide-type cyclooxygenase-1 selective inhibitor.

scientific article

Design and synthesis of benzenesulfonanilides active against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus.

scientific article

Design and synthesis of novel cyclooxygenase-1 inhibitors as analgesics: 5-amino-2-ethoxy-N-(substituted-phenyl)benzamides

scientific article published on 07 January 2011

Discovery of a "Gatekeeper" Antagonist that Blocks Entry Pathway to Retinoid X Receptors (RXRs) without Allosteric Ligand Inhibition in Permissive RXR Heterodimers

scientific article published on 24 December 2020

Discovery of a Potent Retinoid X Receptor Antagonist Structurally Closely Related to RXR Agonist NEt-3IB.

scientific article published on 27 September 2011

Dual conformation of the ligand induces the partial agonistic activity of retinoid X receptor α (RXRα)

scientific article published on 21 December 2018

Effect of 5-aminosalicylate on allergic rhinitis model in mice.

scientific article published on 19 March 2010

Effect of the oral absorption of benzenesulfonanilide-type cyclooxygenase-1 inhibitors on analgesic action and gastric ulcer formation.

scientific article published in December 2008

Feasibility of structural modification of retinoid X receptor agonists to separate blood glucose-lowering action from adverse effects: studies in KKA(y) type 2 diabetes model mice

scientific article published on 01 January 2012

Fluorescent retinoid X receptor ligands for fluorescence polarization assay.

scientific article published on 8 July 2010

Fluorine-18 (18F)-labeled retinoid x receptor (RXR) partial agonist whose tissue transferability is affected by other RXR ligands

scientific article published on 30 May 2019

Identification of a Vitamin-D Receptor Antagonist, MeTC7, which Inhibits the Growth of Xenograft and Transgenic Tumors <i>In Vivo</i>

scientific article published on 11 April 2022

Identification of urine metabolites of TFAP, a cyclooxygenase-1 inhibitor.

scientific article published on 6 February 2010

In vitro anti-proliferative and anti-angiogenic activities of thalidomide dithiocarbamate analogs.

scientific article

Interspecies comparison of hepatic metabolism of six newly synthesized retinoid X receptor agonistic compounds possessing a 6-[N-ethyl-N-(alkoxyisopropylphenyl)amino]nicotinic acid skeleton in rat and human liver microsomes.

scientific article published on 19 June 2013

Involvement of glucocorticoid receptor activation on anti-inflammatory effect induced by peroxisome proliferator-activated receptor γ agonist in mice.

scientific article published on 27 June 2014

Involvement of the Retinoid X Receptor Ligand in the Anti-Inflammatory Effect Induced by Peroxisome Proliferator-Activated Receptor Agonist In Vivo ⬇️

scientific article published on December 11, 2011

Maternal gut microbiota in pregnancy influences offspring metabolic phenotype in mice

scientific article published on 01 February 2020

Mechanism of retinoid X receptor partial agonistic action of 1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-1H-benzotriazole-5-carboxylic acid and structural development to increase potency.

scientific article published on 20 February 2013

Modification at the Lipophilic Domain of RXR Agonists Differentially Influences Activation of RXR Heterodimers.

scientific article published on 27 August 2010

Necessity is the mother of invention: an ingenious method for leukocyte-targeted delivery of siRNA in stabilized nanoparticles demonstrates a role of cyclin D1 in inflammation

scientific article published on 01 July 2008

Paclitaxel and Sorafenib: The Effective Combination of Suppressing the Self-Renewal of Cancer Stem Cells

scientific article published on 26 May 2020

Pharmacokinetic properties of newly synthesized retinoid X receptor agonists possessing a 6-[N-ethyl-N-(3-alkoxy-4-isopropylphenyl)amino]nicotinic acid skeleton in rats

scientific article published on 21 March 2011

Pyridinium cationic-dimer antimalarials, unlike chloroquine, act selectively between the schizont stage and the ring stage of Plasmodium falciparum.

scientific article

RXR Partial Agonist CBt-PMN Exerts Therapeutic Effects on Type 2 Diabetes without the Side Effects of RXR Full Agonists.

scientific article

RXR partial agonist produced by side chain repositioning of alkoxy RXR full agonist retains antitype 2 diabetes activity without the adverse effects

scientific article published on 17 December 2014

Reduction of lipophilicity at the lipophilic domain of RXR agonists enables production of subtype preference: RXRalpha-preferential agonist possessing a sulfonamide moiety.

scientific article published in March 2008

Relevance of nuclear receptor expression in a Tchreg cell line, HOZOT: RXRα and PPARγ negatively regulate IFN-γ production.

scientific article

Replacement of the hydrophobic part of 9-cis-retinoic acid with cyclic terpenoid moiety results in RXR-selective agonistic activity

scientific article published on 21 March 2011

Replacing alkyl sulfonamide with aromatic sulfonamide in sulfonamide-type RXR agonists favors switch towards antagonist activity.

scientific article

Retinoid X Receptor Antagonists

scientific article published in 2018

Retinoid X Receptor Ligands with Anti-Type 2 Diabetic Activity

scientific article published on 16 June 2016

Retinoid X receptor ligands: a patent review (2007 - 2013).

scientific article published on 24 January 2014

Reversal of established liver fibrosis by IC-2-engineered mesenchymal stem cell sheets

scientific article published on 02 May 2019

Significance and creation of novel cyclooxygenase-1 (COX-1) selective inhibitors

scientific article published in March 2011

Specific nonpeptide inhibitors of puromycin-sensitive aminopeptidase with a 2,4(1H,3H)-quinazolinedione skeleton.

scientific article published on November 2003

Strategy for Tumor-Selective Disruption of Androgen Receptor Function in the Spectrum of Prostate Cancer

scientific article published on 05 September 2018

Synthesis of 11C-Labeled RXR Partial Agonist 1-[(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)amino]benzotriazole-5-carboxylic Acid (CBt-PMN) by Direct [11C]Carbon Dioxide Fixation via Organolithiation of Trialkyltin Precursor and PET Ima

scientific article published on 28 July 2017

The first potent subtype-selective retinoid X receptor (RXR) agonist possessing a 3-isopropoxy-4-isopropylphenylamino moiety, NEt-3IP (RXRalpha/beta-dual agonist).

scientific article

[Challenge of creating single-agents for the treatment of type 1 and 2 diabetes by targeting retinoid X receptor]

scientific article published on 01 January 2011

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