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List of works by Julian Ma

A functional antibody lacking N-linked glycans is efficiently folded, assembled and secreted by tobacco mesophyll protoplasts.

scientific article published in September 2005

A polymeric immunoglobulin - antigen fusion protein strategy for enhancing vaccine immunogenicity.

scientific article published on 23 April 2018

A recombinant multimeric immunoglobulin expressed in rice shows assembly-dependent subcellular localization in endosperm cells

article published in 2004

A synthetic peptide adhesion epitope as a novel antimicrobial agent.

scientific article

Alga-Made Anti-Hepatitis B Antibody Binds to Human Fcγ Receptors.

scientific article published on 30 November 2017

Antibody degradation in tobacco plants: a predominantly apoplastic process

scientific article

Antibody processing and engineering in plants, and new strategies for vaccine production.

scientific article

Assembly of monoclonal antibodies with IgG1 and IgA heavy chain domains in transgenic tobacco plants

scientific article published on 01 January 1994

Breakage of transgenic tobacco roots for monoclonal antibody release in an ultra‐scale down shearing device ⬇️

scientific article published on September 20, 2013

Characterization of VRC01, a potent and broadly neutralizing anti-HIV mAb, produced in transiently and stably transformed tobacco

scientific article

Characterization of a plant-produced recombinant human secretory IgA with broad neutralizing activity against HIV

scientific article

Characterization of mechanical properties of transgenic tobacco roots expressing a recombinant monoclonal antibody against tooth decay.

scientific article published in July 2008

Clinical Safety and Immunogenicity of Tumor-Targeted, Plant-Made Id-KLH Conjugate Vaccines for Follicular Lymphoma.

scientific article

Combinatorial de novo design and application of a biomimetic affinity ligand for the purification of human anti-HIV mAb 4E10 from transgenic tobacco.

scientific article

Commercialization of new biotechnology: a systematic review of 16 commercial case studies in a novel manufacturing sector

scientific article published on 03 July 2015

Considerations for extraction of monoclonal antibodies targeted to different subcellular compartments in transgenic tobacco plants.

scientific article

Cost-effective production of a vaginal protein microbicide to prevent HIV transmission.

scholarly article

Cytokine interactions that determine the outcome of Mycobacterial infection of macrophages.

scientific article

Design, expression, and characterization of a multivalent, combination HIV microbicide.

scientific article published on 26 May 2009

Development of rhizosecretion as a production system for recombinant proteins from hydroponic cultivated tobacco.

scientific article published on 26 May 2009

Dynamics of global disclosure through patent and journal publications for biopharmaceutical products

scientific article published on 01 July 2009

Engineering the interactions between a plant-produced HIV antibody and human Fc receptors

scientific article published on 10 August 2019

Engineering, expression in transgenic plants and characterisation of E559, a rabies virus-neutralising monoclonal antibody.

scientific article

Enhanced transport of plant-produced rabies single-chain antibody-RVG peptide fusion protein across an in cellulo blood-brain barrier device.

scientific article published on 8 March 2017

Evolution of a regulatory framework for pharmaceuticals derived from genetically modified plants.

scientific article published on September 2008

Exploring the vaccine potential of Dec-205 targeting in Mycobacterium tuberculosis infection in mice ⬇️

scientific article published on January 25, 2011

Expression and plasma membrane localization of the mammalian B-cell receptor complex in transgenic Nicotiana tabacum.

scientific article

Expression of an immunogenic Ebola immune complex in Nicotiana benthamiana.

scientific article

Functional characterization of the recombinant HIV-neutralizing monoclonal antibody 2F5 produced in maize seeds

article

Gene expression analysis, subcellular localization, and in planta antimicrobial activity of rice (Oryza sativa L.) defensin 7 and 8.

scientific article published on 30 January 2018

Generation of transgenic plants expressing antibodies to the environmental pollutant microcystin-LR

scientific article published on 19 October 2009

Generation of transgenic plants expressing plasma membrane-bound antibodies to the environmental pollutant microcystin-LR.

scientific article published on 30 July 2010

Genetically modified plants and human health

scientific article

HIV-1 p24-immunoglobulin fusion molecule: a new strategy for plant-based protein production.

scientific article published in March 2006

High-level expression of the HIV entry inhibitor griffithsin from the plastid genome and retention of biological activity in dried tobacco leaves

article

High-yield production of a human monoclonal IgG by rhizosecretion in hydroponic tobacco cultures.

scientific article published on 3 June 2015

Highly immunogenic and protective recombinant vaccine candidate expressed in transgenic plants.

scientific article

Identification of peptidases in Nicotiana tabacum leaf intercellular fluid

scientific article published in June 2008

Immune-Complex Mimics as a Molecular Platform for Adjuvant-Free Vaccine Delivery ⬇️

scientific article published on April 23, 2013

Immunogenicity of chloroplast‐derived HIV‐1 p24 and a p24‐Nef fusion protein following subcutaneous and oral administration in mice ⬇️

scientific article published on March 28, 2011

In situ delivery of passive immunity by lactobacilli producing single-chain antibodies

scientific article published on 01 July 2002

In vitro and in vivo evaluation of a single chain antibody fragment generated in planta with potent rabies neutralisation activity.

scientific article published on 6 March 2018

Molecular engineering and plant expression of an immunoglobulin heavy chain scaffold for delivery of a dengue vaccine candidate

scientific article (publication date: 19 April 2017)

Monoclonal antibodies for prophylactic and therapeutic use against viral infections.

scientific article published on 29 January 2013

Mucosal delivery of antigen-coated nanoparticles to lungs confers protective immunity against tuberculosis infection in mice

scientific article published on February 2014

New downstream processing strategy for the purification of monoclonal antibodies from transgenic tobacco plants

scientific article published on 04 October 2008

Passive immunity in the prevention of rabies.

scientific article published on May 2012

Phase system selection with fractional factorial design for purification of recombinant cyanovirin-N from a hydroponic culture medium using centrifugal partition chromatography

scientific article published on 18 February 2013

Plant molecular pharming for the treatment of chronic and infectious diseases

scientific article published on 24 February 2014

Plant-derived pharmaceuticals--the road forward

scientific article

Plant-derived recombinant immune complexes as self-adjuvanting TB immunogens for mucosal boosting of BCG.

scientific article

Plant-expressed Fc-fusion protein tetravalent dengue vaccine with inherent adjuvant properties.

scientific article published on 9 December 2017

Plant-made immunogens and effective delivery strategies ⬇️

scientific article published on August 1, 2010

Plant-made pharmaceuticals: leading products and production platforms.

scientific article published on January 2011

Production of different glycosylation variants of the tumour-targeting mAb H10 in Nicotiana benthamiana: influence on expression yield and antibody degradation

scientific article published on 12 January 2012

Production, characterization, and antigen specificity of recombinant 62-71-3, a candidate monoclonal antibody for rabies prophylaxis in humans.

scientific article published on 31 January 2013

Realising the value of plant molecular pharming to benefit the poor in developing countries and emerging economies.

scientific article published on 14 October 2013

Recombinant biologic products versus nutraceuticals from plants - a regulatory choice?

scientific article published on 13 June 2016

Recombinant human osteopontin expressed in Nicotiana benthamiana stimulates osteogenesis related genes in human periodontal ligament cells

scientific article published on 11 December 2017

Recombinant monoclonal antibody yield in transgenic tobacco plants is affected by the wounding response via an ethylene dependent mechanism.

scientific article published on 18 February 2012

Regulatory approval and a first-in-human phase I clinical trial of a monoclonal antibody produced in transgenic tobacco plants.

scientific article

Rhizosecretion improves the production of Cyanovirin-N in Nicotiana tabacum through simplified downstream processing

scientific article published on 22 February 2016

Rice endosperm produces an underglycosylated and potent form of the HIV-neutralizing monoclonal antibody 2G12.

scientific article published on 7 April 2015

Site-specific proteolytic degradation of IgG monoclonal antibodies expressed in tobacco plants.

scientific article

Site-targeted mutagenesis for stabilization of recombinant monoclonal antibody expressed in tobacco (Nicotiana tabacum) plants

scientific article published on 28 December 2015

Sowing the seeds of success: pharmaceutical proteins from plants.

scientific article

Synthetic gene design-The rationale for codon optimization and implications for molecular pharming in plants.

scientific article published on 12 September 2016

The C-terminal extension of a hybrid immunoglobulin A/G heavy chain is responsible for its Golgi-mediated sorting to the vacuole

scientific article

The production of recombinant pharmaceutical proteins in plants.

scientific article

Transformation of Althaea officinalis L. by Agrobacterium rhizogenes for the production of transgenic roots expressing the anti-HIV microbicide cyanovirin-N ⬇️

scientific article published on July 13, 2013

Transgenic plant production of Cyanovirin-N, an HIV microbicide.

scientific article published on 14 December 2005

Transgenic plants expressing antibodies: a model for phytoremediation.

scientific article published in December 2002

Trying to treat the untreatable: experimental approaches to clear rabies virus infection from the CNS

scientific article published on 25 June 2019

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