List of works by John S Mitcheson

A Novel Mechanism for Calmodulin-Dependent Inactivation of Transient Receptor Potential Vanilloid 6. ⬇️

scientific article published on 5 March 2018

A heme-binding domain controls regulation of ATP-dependent potassium channels.

scientific article

A mechanism for CO regulation of ion channels.

scientific article published on 2 March 2018

A novel cellular stress response characterised by a rapid reorganisation of membranes of the endoplasmic reticulum.

scientific article published on 7 September 2012

Action potentials, ion channel currents and transverse tubule density in adult rabbit ventricular myocytes maintained for 6 days in cell culture

scientific article published on 01 April 1996

Activation gating of hERG potassium channels: S6 glycines are not required as gating hinges.

scientific article published on 6 September 2007

An investigation of the role played by the E-4031-sensitive (rapid delayed rectifier) potassium current in isolated rabbit atrioventricular nodal and ventricular myocytes

scientific article published on 01 November 1999

Author Correction: A mechanism for CO regulation of ion channels

scientific article published in Nature Communications

Biophysical properties and molecular basis of cardiac rapid and slow delayed rectifier potassium channels.

scientific article

Calmodulin Regulates Human Ether à Go-Go 1 (hEAG1) Potassium Channels through Interactions of the Eag Domain with the Cyclic Nucleotide Binding Homology Domain

scientific journal article

Combined hERG channel inhibition and disruption of trafficking in drug-induced long QT syndrome by fluoxetine: a case-study in cardiac safety pharmacology.

scientific article

Comparative pharmacology of guinea pig cardiac myocyte and cloned hERG (I(Kr)) channel.

scientific article published in November 2004

Comparison of Na(+)/Ca(2+) exchanger current and of its response to isoproterenol between acutely isolated and short-term cultured adult ventricular myocytes.

scientific article published in September 2002

Computational design and discovery of "minimally structured" hERG blockers.

scientific article

Cultured adult cardiac myocytes: future applications, culture methods, morphological and electrophysiological properties.

scientific article

Cultured adult rabbit myocytes: effect of adding supplements to the medium, and response to isoprenaline

scientific article published on 01 September 1997

Drug binding to HERG channels: evidence for a 'non-aromatic' binding site for fluvoxamine

scientific article

Drug block of the hERG potassium channel: insight from modeling.

scientific article published on August 2007

Functional roles of charged residues in the putative voltage sensor of the HCN2 pacemaker channel.

scientific article published on November 2000

Insight into the mechanism of inactivation and pH sensitivity in potassium channels from molecular dynamics simulations.

scientific article published on 18 June 2008

Long-term channel block is required to inhibit cellular transformation by human ether-à-go-go-related gene (hERG1) potassium channels.

scientific article

Modulation by mexiletine of action potentials, L-type Ca current and delayed rectifier K current recorded from isolated rabbit atrioventricular nodal myocytes

scientific article published on 01 November 1997

Modulation of hERG potassium channels by a novel small molecule activator.

scientific article

Modulation of hERG potassium currents in HEK-293 cells by protein kinase C. Evidence for direct phosphorylation of pore forming subunits.

scientific article published on 15 March 2007

Molecular biology of K(+) channels and their role in cardiac arrhythmias

scientific article

Molecular determinants of HERG channel block.

scientific article published on 10 February 2006

Molecular mechanisms for drug interactions with hERG that cause long QT syndrome.

scientific article published on February 2006

New pyrimido-indole compound CD-160130 preferentially inhibits the KV11.1B isoform and produces antileukemic effects without cardiotoxicity

scientific article

Open channel block of HERG K(+) channels by vesnarinone.

scientific article

Predicting drug-hERG channel interactions that cause acquired long QT syndrome.

scientific article

Role of Intracellular Sodium Overload in the Genesis of Cardiac Arrhythmias ⬇️

scientific article published on June 1, 1997

Structural determinants of HERG channel block by clofilium and ibutilide.

scientific article

The S4-S5 linker couples voltage sensing and activation of pacemaker channels.

scientific article

The effect of internal sodium and caesium on phasic contraction of patch-clamped rabbit ventricular myocytes

scientific article published on 01 April 1996

The low-potency, voltage-dependent HERG blocker propafenone--molecular determinants and drug trapping.

scientific article published on 12 August 2004

Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate.

scientific article

Troubleshooting problems with in vitro screening of drugs for QT interval prolongation using HERG K+ channels expressed in mammalian cell lines and Xenopus oocytes

scientific article published on September 2002

Voltage dependence of the Fura-2 transient in rabbit left atrial myocytes at 37 degrees C

scientific article published on 01 April 1997

hERG potassium channel blockade by the HCN channel inhibitor bradycardic agent ivabradine

scientific article

hERG potassium channel inhibition by ivabradine may contribute to QT prolongation and risk of torsades de pointes.

scientific article

hERG potassium channel inhibition by ivabradine requires channel gating

scientific article published on 11 August 2015

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