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List of works by Maria E Figueroa

A molecular roadmap of reprogramming somatic cells into iPS cells

scientific article published on December 2012

A phase II, multicentre trial of decitabine in higher-risk chronic myelomonocytic leukemia

scientific article

Aberrant epigenetic and genetic marks are seen in myelodysplastic leukocytes and reveal Dock4 as a candidate pathogenic gene on chromosome 7q

scientific article

Autophagy maintains the metabolism and function of young and old stem cells.

scientific article published on March 2017

Azacitidine with or without Entinostat for the treatment of therapy-related myeloid neoplasm: further results of the E1905 North American Leukemia Intergroup study.

scientific article published on 18 November 2015

BCL6 repression of EP300 in human diffuse large B cell lymphoma cells provides a basis for rational combinatorial therapy

scientific article

Base-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in acute myeloid leukemia

scientific article

C/EBPα is an essential collaborator in Hoxa9/Meis1-mediated leukemogenesis

scientific article

C/EBPγ deregulation results in differentiation arrest in acute myeloid leukemia.

scientific article

CD2-positive B-cell precursor acute lymphoblastic leukemia with an early switch to the monocytic lineage.

scientific article published on 25 November 2013

Cell of origin determines clinically relevant subtypes of MLL-rearranged AML

scientific article

Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells

scientific article (publication date: August 2010)

Cytosine modifications in myeloid malignancies.

scientific article published on 05 May 2015

DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia

scientific article

DNA methylation signatures identify biologically distinct subtypes in acute myeloid leukemia.

scientific article

DNA methyltransferase 1 and DNA methylation patterning contribute to germinal center B-cell differentiation

scientific article

DNMT1-interacting RNAs block gene-specific DNA methylation

scientific article published on 09 October 2013

DNMT3A Haploinsufficiency Transforms FLT3ITD Myeloproliferative Disease into a Rapid, Spontaneous, and Fully Penetrant Acute Myeloid Leukemia

scientific article

DNMT3B7, a truncated DNMT3B isoform expressed in human tumors, disrupts embryonic development and accelerates lymphomagenesis.

scientific article

Dissecting the role of aberrant DNA methylation in human leukaemia

scientific article published on 22 May 2015

Dnmt3a regulates T-cell development and suppresses T-ALL transformation

scientific article

Enhanced reduced representation bisulfite sequencing for assessment of DNA methylation at base pair resolution.

scientific article published on 24 February 2015

Epigenetic Identity in AML Depends on Disruption of Nonpromoter Regulatory Elements and Is Affected by Antagonistic Effects of Mutations in Epigenetic Modifiers.

scientific article published on 13 April 2017

Epigenetic deregulation in myeloid malignancies.

scientific article published on 24 April 2014

Epigenetic roles of MLL oncoproteins are dependent on NF-κB

scientific article published on 19 September 2013

Genome-wide epigenetic analysis delineates a biologically distinct immature acute leukemia with myeloid/T-lymphoid features.

scientific article

H2.0-like Homeobox Regulates Early Hematopoiesis and Promotes Acute Myeloid Leukemia ⬇️

scientific article published on August 14, 2012

HDAC4 promotes growth of colon cancer cells via repression of p21.

scientific article published on 16 July 2008

HELP (HpaII tiny fragment enrichment by ligation-mediated PCR) assay for DNA methylation profiling of primary normal and malignant B lymphocytes.

scientific article published on January 2010

High-resolution genome-wide cytosine methylation profiling with simultaneous copy number analysis and optimization for limited cell numbers.

scientific article published on 22 April 2009

IDH mutation impairs histone demethylation and results in a block to cell differentiation

scientific article (publication date: 15 February 2012)

Inhibition of DNA methyltransferase activates tumor necrosis factor alpha-induced monocytic differentiation in acute myeloid leukemia cells.

scientific article

Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

scientific article (publication date: 14 December 2010)

Macrophage migration inhibitory factor is overproduced through EGR1 in TET2<sup>low</sup> resting monocytes

scientific article published on 03 February 2022

MethylSig: a whole genome DNA methylation analysis pipeline.

scientific article

Microsphere-based multiplex analysis of DNA methylation in acute myeloid leukemia

scientific article published on 25 December 2013

Mutant DNMT3A: a marker of poor prognosis in acute myeloid leukemia ⬇️

scientific article published on April 5, 2012

Mutation allele burden remains unchanged in chronic myelomonocytic leukaemia responding to hypomethylating agents

scientific article published on 24 February 2016

PRMT4 blocks myeloid differentiation by assembling a methyl-RUNX1-dependent repressor complex

scientific article

Plasticity of DNA methylation in a nerve injury model of pain.

scientific article

Polycomb complexes associate with enhancers and promote oncogenic transcriptional programs in cancer through multiple mechanisms

scientific article published in Nature Communications

Prolonged administration of azacitidine with or without entinostat for myelodysplastic syndrome and acute myeloid leukemia with myelodysplasia-related changes: results of the US Leukemia Intergroup trial E1905.

scientific article published on 24 March 2014

Promoter hypermethylation in MLL-r infant acute lymphoblastic leukemia: biology and therapeutic targeting.

scientific article

Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis

scientific article

Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression.

scientific article published on 16 August 2017

Satb1 regulates the self-renewal of hematopoietic stem cells by promoting quiescence and repressing differentiation commitment.

scientific article published on 7 April 2013

Specific molecular signatures predict decitabine response in chronic myelomonocytic leukemia.

scientific article

TET2 deficiency causes germinal center hyperplasia, impairs plasma cell differentiation and promotes B-cell lymphomagenesis

scientific article published on 01 October 2018

Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation

scientific journal article

Transcription and methylation analyses of preleukemic promyelocytes indicate a dual role for PML/RARA in leukemia initiation.

scientific article published on 18 June 2015

Validation of DNA methylation to predict outcome in acute myeloid leukemia by use of xMELP

scientific article

Wilms tumor 1 mutations in the pathogenesis of acute myeloid leukemia

scientific article

methylKit: a comprehensive R package for the analysis of genome-wide DNA methylation profiles

scientific article

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