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List of works by Siobhán McClean

A chronic strain of the cystic fibrosis pathogen Pandoraea pulmonicola expresses a heterogenous hypo-acylated lipid A

scientific article published on 13 October 2020

Activation of MMP-9 by human lung epithelial cells in response to the cystic fibrosis-associated pathogen Burkholderia cenocepacia reduced wound healing in vitro.

scientific article published on 8 July 2011

An improved method for the determination of distribution coefficients

scientific article published on 01 February 1990

An overview of membrane, cytosolic and nuclear proteins associated with the expression of resistance to multiple drugs in vitro

scientific article

Aspergillus fumigatus Inhibits Pseudomonas aeruginosa in Co-culture: Implications of a Mutually Antagonistic Relationship on Virulence and Inflammation in the CF Airway.

scientific article published on 5 June 2018

Aspergillus fumigatus Supernatants Disrupt Bronchial Epithelial Monolayers: Potential Role for Enhanced Invasion in Cystic Fibrosis

scientific article published in 2023

Bacterial Adaptation during Chronic Respiratory Infections.

scientific article

Bacterial host interactions in cystic fibrosis ⬇️

scientific article published on December 1, 2011

Binding and uptake of biodegradable poly-DL-lactide micro- and nanoparticles in intestinal epithelia.

scientific article published on April 1998

Biological activity and coordination modes of copper(II) complexes of Schiff base-derived coumarin ligands.

scientific article published on 15 October 2010

Bis-phenanthroline copper(ii) phthalate complexes are potent in vitro antitumour agents with ‘self-activating’ metallo-nuclease and DNA binding properties

scientific article published on 16 December 2010

Burkholderia cepacia complex: epithelial cell-pathogen confrontations and potential for therapeutic intervention.

scientific article published on January 2009

Characterization of the P-glycoprotein over-expressing drug resistance phenotype exhibited by Chinese hamster ovary cells following their in-vitro exposure to fractionated X-irradiation.

scientific article

Co-colonisation with Aspergillus fumigatus and Pseudomonas aeruginosa is associated with poorer health in cystic fibrosis patients: an Irish registry analysis.

scientific article

Copper(II) complexes of salicylic acid combining superoxide dismutase mimetic properties with DNA binding and cleaving capabilities display promising chemotherapeutic potential with fast acting in vitro cytotoxicity against cisplatin sensitive and r

scientific article published on 28 February 2012

Developing an international Pseudomonas aeruginosa reference panel

scientific article

Differences in invasion and translocation of Burkholderia cepacia complex species in polarised lung epithelial cells in vitro.

scientific article published on 30 August 2006

Differential cytotoxic effects of docetaxel in a range of mammalian tumor cell lines and certain drug resistant sublines in vitro

scientific article published on 01 January 1994

Eight Stranded β -Barrel and Related Outer Membrane Proteins: Role in Bacterial Pathogenesis ⬇️

scientific article published on October 1, 2012

Encapsulation in biodegradable microparticles enhances serum antibody response to parenterally-delivered beta-amyloid in mice

scientific article published on 01 July 2001

Evidence of post-translational regulation of P-glycoprotein associated with the expression of a distinctive multiple drug-resistant phenotype in Chinese hamster ovary cells

scientific article published on 01 January 1993

Exploiting molecular virulence determinants in Burkholderia to develop vaccine antigens

scientific article published on January 2015

Expression of P-glycoprotein-mediated drug resistance in CHO cells surviving a single X-ray dose of 30 Gy.

scientific article

Expression of drug resistance in Chinese hamster ovary (CHO) cells following X-ray pre-treatment in vitro

scientific article published on 01 August 1991

Genomic characterisation of an international Pseudomonas aeruginosa reference panel indicates that the two major groups draw upon distinct mobile gene pools

article

Hypoxia Reduces the Pathogenicity of Pseudomonas aeruginosa by Decreasing the Expression of Multiple Virulence Factors.

scientific article published on 25 March 2017

Hypoxia modulates infection of epithelial cells by Pseudomonas aeruginosa.

scientific article

IL-8 released from human lung epithelial cells induced by cystic fibrosis pathogens Burkholderia cepacia complex affects the growth and intracellular survival of bacteria.

scientific article published on 9 September 2010

Identification of a distinctive P-glycoprotein-mediated resistance phenotype in human ovarian carcinoma cells after their in vitro exposure to fractionated X-irradiation

scientific article published on June 1994

Identification of an OmpW homologue in Burkholderia pseudomallei, a protective vaccine antigen against melioidosis

scientific article

Immunoproteomic analysis of proteins expressed by two related pathogens, Burkholderia multivorans and Burkholderia cenocepacia, during human infection

scientific article

Immunoproteomics: the key to discovery of new vaccine antigens against bacterial respiratory infections.

scientific article published on December 2012

In vitro and in vivo antibacterial activity of environmental bacteriophages against Pseudomonas aeruginosa strains from cystic fibrosis patients

scientific article published on 12 March 2015

Increased Virulence of Bloodstream Over Peripheral Isolates of Identified Through Post-transcriptional Regulation of Virulence Factors

scientific article published on 26 October 2018

Inhibition of Burkholderia multivorans adhesion to lung epithelial cells by bivalent lactosides.

scientific article published on 24 August 2012

Inhibition of co-colonizing cystic fibrosis-associated pathogens by Pseudomonas aeruginosa and Burkholderia multivorans.

scientific article

Interaction of environmental Burkholderia cenocepacia strains with cystic fibrosis and non-cystic fibrosis bronchial epithelial cells in vitro

scientific article published on 9 February 2012

Invasion and biofilm formation of Burkholderia dolosa is comparable with Burkholderia cenocepacia and Burkholderia multivorans.

scientific article published on 15 June 2006

Invasion of Burkholderia cepacia complex isolates into lung epithelial cells involves glycolipid receptors.

scientific article published on 6 September 2010

Investigation of the multifaceted iron acquisition strategies of Burkholderia cenocepacia

scientific article

Linocin and OmpW Are Involved in Attachment of the Cystic Fibrosis-Associated Pathogen Burkholderia cepacia Complex to Lung Epithelial Cells and Protect Mice against Infection

scientific article published on 22 February 2016

Macrophage responses to CF pathogens: JNK MAP kinase signaling by Burkholderia cepacia complex lipopolysaccharide.

scientific article published on October 2010

Mast cell tryptase reduces junctional adhesion molecule-A (JAM-A) expression in intestinal epithelial cells: implications for the mechanisms of barrier dysfunction in irritable bowel syndrome.

scientific article published on 16 April 2013

Melittin as a permeability enhancer II: in vitro investigations in human mucus secreting intestinal monolayers and rat colonic mucosae.

scientific article published on 23 March 2007

Melittin as an epithelial permeability enhancer I: investigation of its mechanism of action in Caco-2 monolayers

scientific article published on 21 March 2007

Melittin exhibits necrotic cytotoxicity in gastrointestinal cells which is attenuated by cholesterol.

scientific article published on 4 November 2007

Novel silver(I) complexes of coumarin oxyacetate ligands and their phenanthroline adducts: Biological activity, structural and spectroscopic characterisation

scientific article

Phenotypic characterization of an international Pseudomonas aeruginosa reference panel: strains of cystic fibrosis (CF) origin show less in vivo virulence than non-CF strains.

scientific article

Polymeric prodrug combination to exploit the therapeutic potential of antimicrobial peptides against cancer cells.

scientific article published in October 2016

Prophages-Prevalence, Chromosome Location and Major Genes Involved

article

Prospects for subunit vaccines: Technology advances resulting in efficacious antigens requires matching advances in early clinical trial investment

scientific article published on 5 August 2016

Protection against Bordetella pertussis infection following parenteral or oral immunization with antigens entrapped in biodegradable particles: effect of formulation and route of immunization on induction of Th1 and Th2 cells

scientific article published on 01 February 2001

Protein with negative surface charge distribution, Bnr1, shows characteristics of a DNA-mimic protein and may be involved in the adaptation of Burkholderia cenocepacia

scientific article published on 01 February 2022

Proteomic profiling of Burkholderia cenocepacia clonal isolates with different virulence potential retrieved from a cystic fibrosis patient during chronic lung infection

scientific article

Quantum Dot Nanotoxicity Investigations Using Human Lung Cells and TOXOR Electrochemical Enzyme Assay Methodology.

scientific article

Radical-induced DNA damage by cytotoxic square-planar copper(II) complexes incorporating o-phthalate and 1,10-phenanthroline or 2,2'-dipyridyl.

scientific article

Real-time PCR method for the quantification of Burkholderia cepacia complex attached to lung epithelial cells and inhibition of that attachment.

scientific article published on 26 February 2010

Role of lipase in Burkholderia cepacia complex (Bcc) invasion of lung epithelial cells.

scientific article

Sequential Burkholderia cenocepacia Isolates from Siblings with Cystic Fibrosis Show Increased Lung Cell Attachment

scientific article published in March 2017

Spectroscopic studies, DFT calculations, and cytotoxic activity of novel silver(I) complexes of hydroxy ortho-substituted-nitro-2H-chromen-2-one ligands and a phenanthroline adduct.

scientific article published on 9 October 2015

Synthesis, DNA-cleaving properties and cytotoxicity of intercalating chelidamic acid derivatives

scientific article published on 01 December 1998

The Burkholderia cenocepacia peptidoglycan-associated lipoprotein is involved in epithelial cell attachment and elicitation of inflammation

scientific article

The effect of recombinant human lactoferrin on growth and the antibiotic susceptibility of the cystic fibrosis pathogen Burkholderia cepacia complex when cultured planktonically or as biofilms

scientific article published on 26 June 2007

The involvement of the low-oxygen-activated locus of Burkholderia cenocepacia in adaptation during cystic fibrosis infection

scientific article published in Scientific Reports

The role of Universal Stress Proteins in Bacterial Infections

scientific article published on 24 January 2017

The tyrosine kinase BceF and the phosphotyrosine phosphatase BceD of Burkholderia contaminans are required for efficient invasion and epithelial disruption of a cystic fibrosis lung epithelial cell line

scientific article

Understanding <i>Pseudomonas aeruginosa</i>-Host Interactions: The Ongoing Quest for an Efficacious Vaccine

scientific article published on 05 December 2020

Virulence factors of Moraxella catarrhalis outer membrane vesicles are major targets for cross-reactive antibodies and have adapted during evolution.

scientific article

Water-soluble and photo-stable silver(I) dicarboxylate complexes containing 1,10-phenanthroline ligands: Antimicrobial and anticancer chemotherapeutic potential, DNA interactions and antioxidant activity

scientific article published on 2 March 2016

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