List of works - Stuart J Forbes

11Beta-hydroxysteroid dehydrogenase-1 deficiency or inhibition enhances hepatic myofibroblast activation in murine liver fibrosis.

scientific article

3D human liver tissue from pluripotent stem cells displays stable phenotype in vitro and supports compromised liver function in vivo

scientific article published on 28 August 2018

A blueprint for translational regenerative medicine

scientific article published on 01 December 2020

A fat chance for hepatocyte transplantation?

scientific article published on 01 April 2009

A significant proportion of myofibroblasts are of bone marrow origin in human liver fibrosis

scientific article

Activation of stem cells in hepatic diseases.

scientific article

Adult stem cell plasticity

scientific article

Adult stem cell plasticity: new pathways of tissue regeneration become visible

scientific article

Advances in cholangiocarcinoma research: report from the third Cholangiocarcinoma Foundation Annual Conference

scientific article published on December 2016

Alternatively activated (M2) macrophages promote tumour growth and invasiveness in hepatocellular carcinoma.

scientific article

An orally active galectin-3 antagonist inhibits lung adenocarcinoma growth and augments response to PD-L1 blockade

scientific article published on 23 January 2019

Authors' reply

Bone marrow cells in the liver: Diverse cells, diverse effects

scientific article published on 01 August 2007

Bone marrow contributes to renal parenchymal turnover and regeneration

scientific article published on 01 September 2001

Bone marrow derivation of pericryptal myofibroblasts in the mouse and human small intestine and colon

scientific article published on June 2002

Bone marrow injection stimulates hepatic ductular reactions in the absence of injury via macrophage-mediated TWEAK signaling

scientific article

Bone marrow stem cells and liver disease.

scientific article published on 4 December 2006

Bone marrow stem cells contribute to healing of the kidney

scientific article

Bone marrow–derived liver stem cells: Their therapeutic potential

scientific article published on 01 August 2002

CD133+ cancer stem-like cells in small cell lung cancer are highly tumorigenic and chemoresistant but sensitive to a novel neuropeptide antagonist

scientific article published on 16 January 2014

CSF1 Restores Innate Immunity After Liver Injury in Mice and Serum Levels Indicate Outcomes of Patients With Acute Liver Failure

scientific article

Cell lineage tracing reveals a biliary origin of intrahepatic cholangiocarcinoma

scientific article published on 5 December 2013

Cell therapy for liver disease: From liver transplantation to cell factory

scientific article published on April 2015

Cellular plasticity in liver regeneration - spotlight on cholangiocytes

scientific article published on 19 February 2019

Characterisation of a stereotypical cellular and extracellular adult liver progenitor cell niche in rodents and diseased human liver

scientific article

Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration.

scientific article published on 12 July 2017

Corrigendum to “Alternatively activated (M2) macrophages promote tumour growth and invasiveness in hepatocellular carcinoma” [J Hepatol 2015;62:607–616]

scientific article published on 16 March 2016

Corrigendum: Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration

scientific article published in Nature

Corrigendum: The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size

scientific article published in October 2016

Development, functional characterization and validation of methodology for GMP-compliant manufacture of phagocytic macrophages: A novel cellular therapeutic for liver cirrhosis

scientific article published on 30 June 2017

Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis

scientific article

Differentiation of progenitors in the liver: a matter of local choice

scientific article published on May 2013

Elastin accumulation is regulated at the level of degradation by macrophage metalloelastase (MMP-12) during experimental liver fibrosis

scientific article published on 18 April 2012

Embryonic mesothelial-derived hepatic lineage of quiescent and heterogenous scar-orchestrating cells defined but suppressed by WT1

scientific article published on 15 October 2019

Enhanced in vitro and in vivo gene delivery using cationic agent complexed retrovirus vectors.

scientific article

Epigenetic remodelling licences adult cholangiocytes for organoid formation and liver regeneration

scientific article published on 04 November 2019

Experimental hepatology applied to stem cells.

scientific article published on 7 November 2007

Expert consensus document: Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA).

scientific article published on 20 April 2016

Functionalized superparamagnetic iron oxide nanoparticles provide highly efficient iron-labeling in macrophages for magnetic resonance-based detection in vivo

scientific article published on 15 February 2017

GADD45β loss ablates innate immunosuppression in cancer ⬇️

scientific article published on 26 December 2017

Galectin-3 regulates hepatic progenitor cell expansion during liver injury.

scientific article published on 16 May 2014

Generation of functional human hepatic endoderm from human induced pluripotent stem cells

scientific article

Granulocyte colony-stimulating factor and autologous CD133-positive stem-cell therapy in liver cirrhosis (REALISTIC): an open-label, randomised, controlled phase 2 trial

scientific article published on 7 November 2017

HGF and SDF-1-mediated mobilization of CD133+ BMSC for hepatic regeneration following extensive liver resection

scientific article published on 23 May 2013

Haematopoietic stem cells in cirrhosis – Authors' reply

scientific article published on 06 April 2018

Hepatic and renal differentiation from blood-borne stem cells.

scientific article

Hepatic fibrogenesis: from within and outwith

scientific article published on 07 September 2008

Hepatic progenitor cells of biliary origin with liver repopulation capacity

scientific article

Hepatic progenitors in liver regeneration

scientific article published on 01 November 2018

Hepatocyte-specific β-catenin deletion during severe liver injury provokes cholangiocytes to differentiate into hepatocytes

scientific article published on 04 January 2019

Highly efficient differentiation of hESCs to functional hepatic endoderm requires ActivinA and Wnt3a signaling

scholarly article

Human biliary epithelial cells from discarded donor livers rescue bile duct structure and function in a mouse model of biliary disease

scientific article published on 3 March 2022

Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation

scientific article published on 27 May 2022

Increased liver pathology in hepatitis C virus transgenic mice expressing the hepatitis B virus X protein

scientific article published on 20 January 2006

Interleukin-13 Activates Distinct Cellular Pathways Leading to Ductular Reaction, Steatosis, and Fibrosis

scientific article

Krüppel-Like Factor 4 Overexpression Initiates a Mesenchymal-to-Epithelial Transition and Redifferentiation of Human Pancreatic Cells following Expansion in Long Term Adherent Culture

scientific article published on 12 October 2015

Links between hepatic fibrosis, ductular reaction, and progenitor cell expansion

scientific article published on 04 December 2013

Liver development, regeneration, and carcinogenesis

scientific article published on 07 February 2010

Liver fibrogenic cells

scientific article published on April 2011

Liver regeneration - mechanisms and models to clinical application

scientific article published on 29 June 2016

Liver repopulation with bone marrow derived cells improves the metabolic disorder in the Gunn rat

scientific article

Liver sinusoidal endothelial cells in disease--and for therapy?

scientific article

Ly6ChiMonocytes Direct Alternatively Activated Profibrotic Macrophage Regulation of Lung Fibrosis

scientific article published in September 2011

Macrophage therapy for murine liver fibrosis recruits host effector cells improving fibrosis, regeneration, and function

scientific article published in June 2011

Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease.

scientific article

Markedly Increased High-Mobility Group Box 1 Protein in a Patient with Small-for-Size Syndrome

scientific article published on 29 January 2014

Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells

scientific article published on April 2011

Mesenchymal Stem Cells and Induced Bone Marrow-Derived Macrophages Synergistically Improve Liver Fibrosis in Mice

scientific article published on 05 November 2018

Milk Fat Globule-EGF Factor 8 for Liver Fibrosis Therapy: Creaming Off the Beneficial Effects of Mesenchymal Stromal Cells

scientific article published on 01 March 2017

Multiple organ engraftment by bone-marrow-derived myofibroblasts and fibroblasts in bone-marrow-transplanted mice.

scientific article published in January 2003

Myelomonocytic cells are sufficient for therapeutic cell fusion in the liver

scientific article published on 01 February 2005

New horizons for stem cell therapy in liver disease

scientific article published on 26 July 2011

Notch3 drives development and progression of cholangiocarcinoma.

scientific article published on 10 October 2016

Organoid cultures boost human liver cell expansion

article

PDGFRβ+ cells play a dual role as hematopoietic precursors and niche cells during mouse ontogeny

scientific article published on 19 July 2022

Paracrine cellular senescence exacerbates biliary injury and impairs regeneration.

scientific article published on 9 March 2018

Patients with the worst outcomes after paracetamol (acetaminophen)-induced liver failure have an early monocytopenia.

scientific article published on 28 November 2016

Persistence of functional hepatocyte-like cells in immune-compromised mice

scientific article published on 10 December 2010

Phenotypic and functional characterization of macrophages with therapeutic potential generated from human cirrhotic monocytes in a cohort study

scientific article

Polysialic acid/neural cell adhesion molecule modulates the formation of ductular reactions in liver injury.

scientific article published on 29 September 2014

Polyurethane: Stable Cell Phenotype Requires Plasticity: Polymer Supported Directed Differentiation Reveals a Unique Gene Signature Predicting Stable Hepatocyte Performance (Adv. Healthcare Mater. 12/2015).

scientific article published in August 2015

Portal venous endothelium in developing human liver contains haematopoietic and epithelial progenitor cells

scientific article

Practical barriers to delivering autologous bone marrow stem cell therapy as an adjunct to liver resection

scientific article published on February 2010

Preparing the ground for tissue regeneration: from mechanism to therapy

scientific article published on August 2014

Primary cilia as a targetable node between biliary injury, senescence and regeneration in liver transplantation

scientific article published on 13 June 2024

Progenitor cell characterization and location in the developing human liver

scientific article published on October 2007

Prospects for stem cell transplantation in the treatment of hepatic disease

scientific article published on July 2010

Proteinase activated receptor 1 mediated fibrosis in a mouse model of liver injury: a role for bone marrow derived macrophages

scientific article published on 27 January 2014

REpeated AutoLogous Infusions of STem cells In Cirrhosis (REALISTIC): a multicentre, phase II, open-label, randomised controlled trial of repeated autologous infusions of granulocyte colony-stimulating factor (GCSF) mobilised CD133+ bone marrow stem

scientific article

Raman spectroscopy and regenerative medicine: a review.

scientific article published on 15 May 2017

Recent advances in stem cells and regenerative medicine.

scientific article published on 6 February 2014

Recombinant Laminins Drive the Differentiation and Self-Organization of hESC-Derived Hepatocytes

scientific article

Recruited macrophages that colonize the post-inflammatory peritoneal niche convert into functionally divergent resident cells

scientific article published on 19 March 2021

Reducing Hepatocyte Injury and Necrosis in Response to Paracetamol Using Noncoding RNAs

scientific article published on 07 April 2016

Regenerative medicine. Knocking on the door to successful hepatocyte transplantation.

scientific article published on 25 March 2014

Regulation of alternative macrophage activation by galectin-3.

scientific article published on February 2008

Regulation of transforming growth factor-β1-driven lung fibrosis by galectin-3

scientific article

Relaxin modulates human and rat hepatic myofibroblast function and ameliorates portal hypertension in vivo

scientific article published on 3 March 2014

Remodelling of extracellular matrix is a requirement for the hepatic progenitor cell response

scientific article published on 23 November 2010

Review article: gene therapy in gastroenterology and hepatology.

scientific article published on October 1997

Runx1+ vascular smooth muscle cells are essential for hematopoietic stem and progenitor cell development in vivo ⬇️

scientific article published on 23 February 2024

Safety profile of autologous macrophage therapy for liver cirrhosis

scientific article published on 07 October 2019

Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair

scientific article

Senolytic treatment preserves biliary regenerative capacity lost through cellular senescence during cold storage

scientific article published on 7 December 2022

Side population (SP) cells: Taking center stage in regeneration and liver cancer?

scientific article published on 01 July 2006

Side population cells in developing human liver are primarily haematopoietic progenitor cells

scientific article published on 20 February 2009

Stem cell mobilization and collection in patients with liver cirrhosis

scientific article published on 29 February 2008

Stem cell therapy for chronic liver disease choosing the right tools for the job

scientific article published on 01 February 2008

Stem cells and liver repair

scientific article published on October 2009

Studies of macrophage therapy for cirrhosis - From mice to men.

scientific article published on 6 January 2018

Suppression of epithelial-to-mesenchymal transitioning enhances ex vivo reprogramming of human exocrine pancreatic tissue toward functional insulin-producing β-like cells

scientific article published on 22 April 2013

Systematic review: the effects of autologous stem cell therapy for patients with liver disease

scientific article

TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence

scientific article published on 01 August 2018

TWEAK/Fn14 signalling promotes cholangiocarcinoma niche formation and progression

scientific article published on 19 November 2020

Telomerase Activity Links to Regenerative Capacity of Hepatocytes

scientific article published on 01 October 2018

The Bone Marrow and Liver Fibrosis: Friend or Foe?

scientific article published on 29 August 2009

The Inhibitory Role of Stromal Cell Mesenchyme on Human Embryonic Stem Cell Hepatocyte Differentiation is Overcome by Wnt3a Treatment

scientific article published on 01 September 2008

The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size.

scientific article published on 18 April 2016

The STAT3-IL-10-IL-6 Pathway Is a Novel Regulator of Macrophage Efferocytosis and Phenotypic Conversion in Sterile Liver Injury

scientific article published on 20 December 2017

The bone marrow functionally contributes to liver fibrosis.

scientific article published in May 2006

The isolation and in vitro expansion of hepatic Sca-1 progenitor cells.

scientific article published on 20 February 2009

The new stem cell biology: something for everyone

scientific article

The sources of parenchymal regeneration after chronic hepatocellular liver injury in mice

scientific article published in February 2006

Two Fresh Streams to Fill the Liver’s Hepatocyte Pool

scientific article published on 01 October 2015

Unbiased screening of polymer libraries to define novel substrates for functional hepatocytes with inducible drug metabolism

scientific article

Understanding liver regeneration to bring new insights to the mechanisms driving cholangiocarcinoma.

scientific article published on 22 May 2017

Update on hepatic stem cells

scientific article

Vasopressin Regulates Extracellular Vesicle Uptake by Kidney Collecting Duct Cells

scientific article published on 28 March 2016

WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited

scientific article

Wnt signalling modulates transcribed-ultraconserved regions in hepatobiliary cancers

scientific article published on 12 September 2016

List of works by Stuart J Forbes

11Beta-hydroxysteroid dehydrogenase-1 deficiency or inhibition enhances hepatic myofibroblast activation in murine liver fibrosis.

3D human liver tissue from pluripotent stem cells displays stable phenotype in vitro and supports compromised liver function in vivo

A blueprint for translational regenerative medicine

A fat chance for hepatocyte transplantation?

A significant proportion of myofibroblasts are of bone marrow origin in human liver fibrosis

Activation of stem cells in hepatic diseases.

Adult stem cell plasticity

Adult stem cell plasticity: new pathways of tissue regeneration become visible

Advances in cholangiocarcinoma research: report from the third Cholangiocarcinoma Foundation Annual Conference

Alternatively activated (M2) macrophages promote tumour growth and invasiveness in hepatocellular carcinoma.

An orally active galectin-3 antagonist inhibits lung adenocarcinoma growth and augments response to PD-L1 blockade

Authors' reply

Bone marrow cells in the liver: Diverse cells, diverse effects

Bone marrow contributes to renal parenchymal turnover and regeneration

Bone marrow derivation of pericryptal myofibroblasts in the mouse and human small intestine and colon

Bone marrow injection stimulates hepatic ductular reactions in the absence of injury via macrophage-mediated TWEAK signaling

Bone marrow stem cells and liver disease.

Bone marrow stem cells contribute to healing of the kidney

Bone marrow–derived liver stem cells: Their therapeutic potential

CD133+ cancer stem-like cells in small cell lung cancer are highly tumorigenic and chemoresistant but sensitive to a novel neuropeptide antagonist

CSF1 Restores Innate Immunity After Liver Injury in Mice and Serum Levels Indicate Outcomes of Patients With Acute Liver Failure

Cell lineage tracing reveals a biliary origin of intrahepatic cholangiocarcinoma

Cell therapy for liver disease: From liver transplantation to cell factory

Cellular plasticity in liver regeneration - spotlight on cholangiocytes

Characterisation of a stereotypical cellular and extracellular adult liver progenitor cell niche in rodents and diseased human liver

Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration.

Corrigendum to “Alternatively activated (M2) macrophages promote tumour growth and invasiveness in hepatocellular carcinoma” [J Hepatol 2015;62:607–616]

Corrigendum: Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration

Corrigendum: The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size

Development, functional characterization and validation of methodology for GMP-compliant manufacture of phagocytic macrophages: A novel cellular therapeutic for liver cirrhosis

Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis

Differentiation of progenitors in the liver: a matter of local choice

Elastin accumulation is regulated at the level of degradation by macrophage metalloelastase (MMP-12) during experimental liver fibrosis

Embryonic mesothelial-derived hepatic lineage of quiescent and heterogenous scar-orchestrating cells defined but suppressed by WT1

Enhanced in vitro and in vivo gene delivery using cationic agent complexed retrovirus vectors.

Epigenetic remodelling licences adult cholangiocytes for organoid formation and liver regeneration

Experimental hepatology applied to stem cells.

Expert consensus document: Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA).

Functionalized superparamagnetic iron oxide nanoparticles provide highly efficient iron-labeling in macrophages for magnetic resonance-based detection in vivo

GADD45β loss ablates innate immunosuppression in cancer ⬇️

Galectin-3 regulates hepatic progenitor cell expansion during liver injury.

Generation of functional human hepatic endoderm from human induced pluripotent stem cells

Granulocyte colony-stimulating factor and autologous CD133-positive stem-cell therapy in liver cirrhosis (REALISTIC): an open-label, randomised, controlled phase 2 trial

HGF and SDF-1-mediated mobilization of CD133+ BMSC for hepatic regeneration following extensive liver resection

Haematopoietic stem cells in cirrhosis – Authors' reply

Hepatic and renal differentiation from blood-borne stem cells.

Hepatic fibrogenesis: from within and outwith

Hepatic progenitor cells of biliary origin with liver repopulation capacity

Hepatic progenitors in liver regeneration

Hepatocyte-specific β-catenin deletion during severe liver injury provokes cholangiocytes to differentiate into hepatocytes

Highly efficient differentiation of hESCs to functional hepatic endoderm requires ActivinA and Wnt3a signaling

Human biliary epithelial cells from discarded donor livers rescue bile duct structure and function in a mouse model of biliary disease

Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation

Increased liver pathology in hepatitis C virus transgenic mice expressing the hepatitis B virus X protein

Interleukin-13 Activates Distinct Cellular Pathways Leading to Ductular Reaction, Steatosis, and Fibrosis

Krüppel-Like Factor 4 Overexpression Initiates a Mesenchymal-to-Epithelial Transition and Redifferentiation of Human Pancreatic Cells following Expansion in Long Term Adherent Culture

Links between hepatic fibrosis, ductular reaction, and progenitor cell expansion

Liver development, regeneration, and carcinogenesis

Liver fibrogenic cells

Liver regeneration - mechanisms and models to clinical application

Liver repopulation with bone marrow derived cells improves the metabolic disorder in the Gunn rat

Liver sinusoidal endothelial cells in disease--and for therapy?

Ly6ChiMonocytes Direct Alternatively Activated Profibrotic Macrophage Regulation of Lung Fibrosis

Macrophage therapy for murine liver fibrosis recruits host effector cells improving fibrosis, regeneration, and function

Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease.

Markedly Increased High-Mobility Group Box 1 Protein in a Patient with Small-for-Size Syndrome

Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells

Mesenchymal Stem Cells and Induced Bone Marrow-Derived Macrophages Synergistically Improve Liver Fibrosis in Mice

Milk Fat Globule-EGF Factor 8 for Liver Fibrosis Therapy: Creaming Off the Beneficial Effects of Mesenchymal Stromal Cells

Multiple organ engraftment by bone-marrow-derived myofibroblasts and fibroblasts in bone-marrow-transplanted mice.

Myelomonocytic cells are sufficient for therapeutic cell fusion in the liver

New horizons for stem cell therapy in liver disease

Notch3 drives development and progression of cholangiocarcinoma.

Organoid cultures boost human liver cell expansion

PDGFRβ+ cells play a dual role as hematopoietic precursors and niche cells during mouse ontogeny

Paracrine cellular senescence exacerbates biliary injury and impairs regeneration.

Patients with the worst outcomes after paracetamol (acetaminophen)-induced liver failure have an early monocytopenia.

Persistence of functional hepatocyte-like cells in immune-compromised mice

Phenotypic and functional characterization of macrophages with therapeutic potential generated from human cirrhotic monocytes in a cohort study