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List of works by William B Klimstra

2'-O methylation of the viral mRNA cap evades host restriction by IFIT family members

scientific journal article

A Mouse Model for Studying Viscerotropic Disease Caused by Yellow Fever Virus Infection

scientific article

A Role for Human Skin Mast Cells in Dengue Virus Infection and Systemic Spread

scientific article published on 31 October 2016

A Vibrating Mesh Nebulizer as an Alternative to the Collison Three-Jet Nebulizer for Infectious Disease Aerobiology

scientific article published on 14 August 2019

A viral RNA structural element alters host recognition of nonself RNA

scientific article

Adaptation of Sindbis virus to BHK cells selects for use of heparan sulfate as an attachment receptor.

scientific article published on September 1998

Adaptation of alphaviruses to heparan sulfate: interaction of Sindbis and Semliki forest viruses with liposomes containing lipid-conjugated heparin

scientific article

Aedes aegypti D7 Saliva Protein Inhibits Dengue Virus Infection

scientific article (publication date: September 2016)

Alpha/Beta Interferon Inhibits Cap-Dependent Translation of Viral but Not Cellular mRNA by a PKR-Independent Mechanism

scientific article

Alpha/beta interferon protects adult mice from fatal Sindbis virus infection and is an important determinant of cell and tissue tropism

scientific article

Alphaviruses suppress host immunity by preventing myeloid cell replication and antagonizing innate immune responses

scientific article published on 10 March 2017

Animal models for COVID-19

scientific article published on 23 September 2020

Antibody Preparations from Human Transchromosomic Cows Exhibit Prophylactic and Therapeutic Efficacy against Venezuelan Equine Encephalitis Virus

scientific article published on 3 May 2017

Applications of minimally invasive multimodal telemetry for continuous monitoring of brain function and intracranial pressure in macaques with acute viral encephalitis

scientific article published on 25 June 2020

Approach to Strain Selection and the Propagation of Viral Stocks for Venezuelan Equine Encephalitis Virus Vaccine Efficacy Testing under the Animal Rule

scientific article published on 31 August 2019

Attenuation of Sindbis virus variants incorporating uncleaved PE2 glycoprotein is correlated with attachment to cell-surface heparan sulfate

scientific article published in April 2004

Can understanding the virulence mechanisms of RNA viruses lead us to a vaccine against eastern equine encephalitis virus and other alphaviruses?

scientific article published on 30 July 2014

Cell-specific targeting of lentiviral vectors mediated by fusion proteins derived from Sindbis virus, vesicular stomatitis virus, or avian sarcoma/leukosis virus

scientific article

Characteristics of alpha/beta interferon induction after infection of murine fibroblasts with wild-type and mutant alphaviruses.

scientific article published on 25 September 2009

Closing the gap between viral and noninfectious arthritis

scientific article published on 14 April 2014

Comparative dynamic aerosol efficiencies of three emergent coronaviruses and the unusual persistence of SARS-CoV-2 in aerosol suspensions

scientific article published on 18 April 2020

Conformational changes in Sindbis virions resulting from exposure to low pH and interactions with cells suggest that cell penetration may occur at the cell surface in the absence of membrane fusion

scientific article published on July 2004

Cooperativity between the 3' untranslated region microRNA binding sites is critical for the virulence of eastern equine encephalitis virus

scientific article published on 28 October 2019

Cryo-EM Structures of Eastern Equine Encephalitis Virus Reveal Mechanisms of Virus Disassembly and Antibody Neutralization

scientific article published on 01 December 2018

Cryo-EM structure of eastern equine encephalitis virus in complex with heparan sulfate analogues

scientific article published on 03 April 2020

DC-SIGN and L-SIGN Can Act as Attachment Receptors for Alphaviruses and Distinguish between Mosquito Cell- and Mammalian Cell-Derived Viruses

scientific article (publication date: November 2003)

DC-SIGN and L-SIGN Can Act as Attachment Receptors for Alphaviruses and Distinguish between Mosquito Cell- and Mammalian Cell-Derived Viruses.

scientific article published in July 2004

DNA-Launched Alphavirus Replicons Encoding a Fusion of Mycobacterial Antigens Acr and Ag85B Are Immunogenic and Protective in a Murine Model of TB Infection

scientific article published on 28 August 2015

Deliberate attenuation of chikungunya virus by adaptation to heparan sulfate-dependent infectivity: a model for rational arboviral vaccine design

scientific article

Early restriction of alphavirus replication and dissemination contributes to age-dependent attenuation of systemic hyperinflammatory disease

scientific article

Eastern and Venezuelan equine encephalitis viruses differ in their ability to infect dendritic cells and macrophages: impact of altered cell tropism on pathogenesis.

scientific article published on 03 September 2008

Effects of PKR/RNase L-dependent and alternative antiviral pathways on alphavirus replication and pathogenesis

scientific article published on January 2002

Electrocardiography Abnormalities in Macaques after Infection with Encephalitic Alphaviruses

scientific article published on 16 November 2019

Electroporation of Alphavirus RNA Translational Reporters into Fibroblastic and Myeloid Cells as a Tool to Study the Innate Immune System

scientific article published on January 2016

Encephalitic Alphaviruses Exploit Caveola-Mediated Transcytosis at the Blood-Brain Barrier for Central Nervous System Entry

scientific article published on 11 February 2020

Gamma-interferon exerts a critical early restriction on replication and dissemination of yellow fever virus vaccine strain 17D-204.

scientific article published on 23 January 2018

Heparan sulfate binding by natural eastern equine encephalitis viruses promotes neurovirulence ⬇️

scientific article published on September 6, 2011

Heparan sulfate binding can contribute to the neurovirulence of neuroadapted and nonneuroadapted Sindbis viruses

scientific article published on 10 January 2007

Host responses to alphavirus infection

scientific article published on October 2008

Host translation shutoff mediated by non-structural protein 2 is a critical factor in the antiviral state resistance of Venezuelan equine encephalitis virus

scientific article published on 15 June 2016

Human Antibodies Protect against Aerosolized Eastern Equine Encephalitis Virus Infection

scientific article published on 04 December 2020

Human immunoglobulin from transchromosomic bovines hyperimmunized with SARS-CoV-2 spike antigen efficiently neutralizes viral variants

scientific article published on 06 July 2021

Human trophoblasts confer resistance to viruses implicated in perinatal infection

scientific article

Identification and characterization of interferon-induced proteins that inhibit alphavirus replication

scientific journal article

In vivo imaging in an ABSL-3 regional biocontainment laboratory

scientific article published on 18 June 2014

Infection of neonatal mice with sindbis virus results in a systemic inflammatory response syndrome

scientific article

Interferon-alpha/beta deficiency greatly exacerbates arthritogenic disease in mice infected with wild-type chikungunya virus but not with the cell culture-adapted live-attenuated 181/25 vaccine candidate.

scientific article

LDLRAD3 is a receptor for Venezuelan equine encephalitis virus

scientific article published on 18 November 2020

Lower temperatures reduce type I interferon activity and promote alphaviral arthritis

scientific article published on 27 December 2017

Macromolecular Synthesis Shutoff Resistance by Myeloid Cells Is Critical to IRF7-Dependent Systemic Interferon Alpha/Beta Induction after Alphavirus Infection

scientific article published on 26 November 2019

MicroRNA Regulation of RNA Virus Replication and Pathogenesis

scientific article published on 15 December 2016

Microneedle array delivered recombinant coronavirus vaccines: Immunogenicity and rapid translational development

scientific article published on 01 April 2020

Mosquito saliva serine protease enhances dissemination of dengue virus into the mammalian host

scientific article published on 16 October 2013

Mutations in the E2 glycoprotein of Venezuelan equine encephalitis virus confer heparan sulfate interaction, low morbidity, and rapid clearance from blood of mice

scientific article published in October 2000

Mxra8 is a receptor for multiple arthritogenic alphaviruses

scientific article published in Nature

Natural variation in the heparan sulfate binding domain of the eastern equine encephalitis virus E2 glycoprotein alters interactions with cell surfaces and virulence in mice

scientific article published on 29 May 2013

Non-pathogenic Sindbis virus causes hemorrhagic fever in the absence of alpha/beta and gamma interferons

scientific article published on 2 August 2007

PE2 cleavage mutants of Sindbis virus: correlation between viral infectivity and pH-dependent membrane fusion activation of the spike heterodimer

scientific article

Persistence of Severe Acute Respiratory Syndrome Coronavirus 2 in Aerosol Suspensions

scientific article published on 22 June 2020

Protective antibodies against Eastern equine encephalitis virus bind to epitopes in domains A and B of the E2 glycoprotein

scientific article published on 19 November 2018

RNA viruses can hijack vertebrate microRNAs to suppress innate immunity

scientific article

Rational design of a live-attenuated eastern equine encephalitis virus vaccine through informed mutation of virulence determinants

scientific article published on 11 February 2019

Ribbon scanning confocal for high-speed high-resolution volume imaging of brain

scientific article

SARS-CoV-2 growth, furin-cleavage-site adaptation and neutralization using serum from acutely infected hospitalized COVID-19 patients

scientific article published on 21 August 2020

SARS-CoV-2 growth, furin-cleavage-site adaptation and neutralization using serum from acutely infected, hospitalized COVID-19 patients

scientific article published on 22 June 2020

SARS-CoV-2 infection of African green monkeys results in mild respiratory disease discernible by PET/CT imaging and shedding of infectious virus from both respiratory and gastrointestinal tracts

scientific article published on 18 September 2020

Similarities and differences in antagonism of neuron alpha/beta interferon responses by Venezuelan equine encephalitis and Sindbis alphaviruses.

scientific article published on 29 July 2009

Sindbis Virus Vectors Designed To Express a Foreign Protein as a Cleavable Component of the Viral Structural Polyprotein ⬇️

scientific article (publication date: May 2003)

Sindbis virus translation is inhibited by a PKR/RNase L-independent effector induced by alpha/beta interferon priming of dendritic cells

scientific article

Stable, high-level expression of reporter proteins from improved alphavirus expression vectors to track replication and dissemination during encephalitic and arthritogenic disease

scientific article published on 4 December 2013

T Cell-Mediated Immunity towards Yellow Fever Virus and Useful Animal Models

scientific article (publication date: 11 April 2017)

Targeting Sindbis virus-based vectors to Fc receptor-positive cell types

scientific article

The 17D-204 Vaccine Strain-Induced Protection against Virulent Yellow Fever Virus Is Mediated by Humoral Immunity and CD4+ but not CD8+ T Cells

scientific article

The 5' and 3' ends of alphavirus RNAs--Non-coding is not non-functional

scientific article

The Efficacy of the Interferon Alpha/Beta Response versus Arboviruses Is Temperature Dependent

scientific article published on 24 April 2018

The Interferon-Induced Exonuclease ISG20 Exerts Antiviral Activity through Upregulation of Type I Interferon Response Proteins

scientific article published on 19 September 2018

The expression level of C19MC miRNAs in early pregnancy and in response to viral infection

scientific article published on 16 March 2017

The furin protease cleavage recognition sequence of Sindbis virus PE2 can mediate virion attachment to cell surface heparan sulfate

scientific article

Type I interferon induction is correlated with attenuation of a South American eastern equine encephalitis virus strain in mice

scientific article

Vascular permeability in the brain is a late pathogenic event during Rift Valley fever virus encephalitis in rats

scientific article published on 02 November 2018

Venezuelan Equine Encephalitis Virus nsP3 Phosphorylation Can Be Mediated by IKKβ Kinase Activity and Abrogation of Phosphorylation Inhibits Negative-Strand Synthesis

scientific article published on 13 September 2020

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