Search filters

List of works by Anna Janecka

4-Methylideneisoxazolidin-5-ones--a new class of alpha-methylidene-gamma-lactones with high cytostatic activity.

scientific article published on 28 November 2005

A New Hybrid δ-Lactone Induces Apoptosis and Potentiates Anticancer Activity of Taxol in HL-60 Human Leukemia Cells

scientific article published on 25 March 2020

ABC Transporters in the Development of Multidrug Resistance in Cancer Therapy

scientific article published on March 2016

An association between low-dose hyper-radiosensitivity and the early G2-phase checkpoint in normal fibroblasts of cancer patients

scientific article published on 17 December 2015

Anticancer Activity of New Synthetic α-Methylene-δ-Lactones on Two Breast Cancer Cell Lines

scientific article published on 18 September 2013

Anticancer activity and radiosensitization effect of methyleneisoxazolidin-5-ones in hepatocellular carcinoma HepG2 cells.

scientific article published on 8 February 2016

Anticancer activity of new molecular hybrids combining 1,4-naphthalenedione motif with phosphonic acid moiety in hepatocellular carcinoma HepG2 cells.

scientific article published on 4 November 2016

Anticancer properties of a new hybrid analog AD-013 combining a coumarin scaffold with an α-methylene-δ-lactone motif.

scientific article published on 21 September 2017

Anticancer properties of new synthetic hybrid molecules combining naphtho[2,3-b]furan-4,9-dione or benzo[f]indole-4,9-dione motif with phosphonate subunit

scientific article published on 3 May 2016

Anticancer properties of novel 4-methylene-1,2-diphenylpyrazolidin-3-ones.

scientific article published in April 2015

Antidepressant-like effect of endomorphin-1 and endomorphin-2 in mice

scientific article published on 05 July 2006

Antinociceptive and antidepressant-like action of endomorphin-2 analogs with proline surrogates in position 2.

scientific article published on 9 July 2014

Antinociceptive potency of a fluorinated cyclopeptide Dmt-c[D-Lys-Phe-p-CF3-Phe-Asp]NH2.

scientific article published in December 2018

Apoptosis-mediated cytotoxic effects of parthenolide and the new synthetic analog MZ-6 on two breast cancer cell lines

scientific article published on 14 October 2012

Biased Agonism as an Emerging Strategy in the Search for Better Opioid Analgesics

scientific article published on 01 January 2020

Binding of the new morphiceptin analogs to human MCF-7 breast cancer cells and their effect on growth.

scientific article published on August 2004

Bioavailability of endomorphins and the blood-brain barrier--a review

scientific article published on January 2014

Biological activity of endomorphin and [Dmt1]endomorphin analogs with six-membered proline surrogates in position 2.

scientific article published on 3 May 2009

Bioselectivity Induced by Chirality of New Terpenyl Organoselenium Compounds

scientific article published on 31 October 2019

Characterization and distribution of NKD, a receptor for Drosophila tachykinin-related peptide 6.

scientific article

Characterization of antinociceptive activity of novel endomorphin-2 and morphiceptin analogs modified in the third position.

scientific article published in January 2005

Characterization of tachykinin-related peptides from different insect species on Drosophila tachykinin receptor-expressing cell line

scientific article published on November 2006

Characterization of the [125I]endomorphin-2 binding sites in the MCF7 breast cancer cell line.

scientific article

Clinical and Molecular Features of Laron Syndrome, A Genetic Disorder Protecting from Cancer

scientific article

Combined effect of parthenolide and various anti-cancer drugs or anticancer candidate substances on malignant cells in vitro and in vivo

scientific article published on January 2014

Combined effects of anticancer drugs and new synthetic α-methylene-δ-lactones on MCF-7 cells.

scientific article

Comparison of antagonist activity of spantide family at human neurokinin receptors measured by aequorin luminescence-based functional calcium assay.

scientific article published in November 2005

Comparison of anti-invasive activity of parthenolide and 3-isopropyl-2-methyl-4-methyleneisoxazolidin-5-one (MZ-6)--a new compound with α-methylene-γ-lactone motif--on two breast cancer cell lines.

scientific article published on 4 November 2011

Comparison of eight commercially available kits for DNA extraction from formalin-fixed paraffin-embedded tissues.

scientific article published on 30 January 2015

Conformationally restricted peptides as tools in opioid receptor studies

scientific article

Correction for "Synthesis of Mixed Opioid Affinity Cyclic Endomorphin-2 Analogues with Fluorinated Phenylalanines".

scientific article published on 9 May 2016

Crystal Growth, Single Crystal Structure, and Biological Activity of Thiazolo-Pyridine Dicarboxylic Acid Derivatives

scientific article published on 22 October 2020

Cyclic endomorphin analogs in targeting opioid receptors to achieve pain relief

scientific article published on January 2014

Cyclic mu-opioid receptor ligands containing multiple N-methylated amino acid residues

scientific article

Cyclic pentapeptide analogs based on endomorphin-2 structure: cyclization studies using liquid chromatography combined with on-line mass spectrometry and tandem mass spectrometry

scientific article published on 10 February 2014

Cyclic side-chain-linked opioid analogs utilizing cis- and trans-4-aminocyclohexyl-D-alanine

scientific article published in December 2014

Cyclization in opioid peptides

scientific article published on June 2013

Cyclopeptide Dmt-[D-Lys-p-CF3-Phe-Phe-Asp]NH2, a novel G protein-biased agonist of the mu opioid receptor

scientific article published on 28 November 2017

Design and characterization of opioid ligands based on cycle-in-macrocycle scaffold

scientific article

Design, Synthesis and Functional Analysis of Cyclic Opioid Peptides with Dmt-Tic Pharmacophore

scientific article published on 17 September 2020

Design, synthesis and cytotoxic evaluation of 4-methylidenepyrazolidin-3-ones

scientific article

Design, synthesis and pharmacological characterization of endomorphin analogues with non-cyclic amino acid residues in position 2.

scientific article published on 28 October 2009

Effect of 2′,6′-dimethyl-l-tyrosine (Dmt) on pharmacological activity of cyclic endomorphin-2 and morphiceptin analogs

scientific article published on 20 October 2011

Effect of potent endomorphin degradation blockers on analgesic and antidepressant-like responses in mice

scientific article published on 22 July 2011

Effect of tooth pulp and periaqueductal central gray electrical stimulation on β-endorphin release into the fluid perfusing the cerebral ventricles in rats

scientific article published on 8 July 2011

Effect of tooth pulp and periaqueductal central gray stimulation on the expression of genes encoding the selected neuropeptides and opioid receptors in the mesencephalon, hypothalamus and thalamus in rats

scientific article published on 15 January 2011

Effects of centrally administered endocannabinoids and opioids on orofacial pain perception in rats

scientific article

Effects of centrally administered vasopressin on orofacial pain perception in rats

scientific article published in July 2005

Enantioselective synthesis and cytotoxic evaluation of 4,5-dihydro-5-[aryl(hydroxy)methyl]-3-methylidenefuran-2(3H)-ones.

scientific article published on September 2005

Endless peptides--circular forms in nature

scientific article

Endomorphin analogs

scientific article published on January 2007

Endomorphin-2 analogs containing modified tyrosines: Biological and theoretical investigation of the influence on conformation and pharmacological profile

scientific article published on 28 June 2019

Endomorphins--endogenous ligands of the mu-opioid receptor

scientific article published in January 2009

Enzymatic degradation of endomorphins

scientific article published on 31 July 2008

Enzymatic degradation studies of endomorphin-2 and its analogs containing N-methylated amino acids.

scientific article published on 8 August 2005

First one-pot organocatalytic synthesis of α-methylene-γ-lactones.

scientific article published on 7 January 2013

Functional characterization of opioid receptor ligands by aequorin luminescence-based calcium assay

scientific article published on 23 February 2006

Functional comparison of two evolutionary conserved insect neurokinin-like receptors

scientific article published on 4 December 2006

HPV16 detection by qPCR method in relation to quantity and quality of DNA extracted from archival formalin fixed and paraffin embedded head and neck cancer tissues by three commercially available kits.

scientific article published on 22 July 2016

Helenalin - a sesquiterpene lactone with multidirectional activity

scientific article published on 01 January 2019

Identification of endomorphin-1 and endomorphin-2 binding sites in human mu-opioid receptor by antisense oligonucleotide strategy

scientific article

Immunomodulatory effects of endogenous and synthetic peptides activating opioid receptors

scientific article published on January 2014

In vitro and in vivo activity of opioid cyclopeptide with mu/delta agonist profile biased toward β-arrestin.

scientific article published on 20 April 2018

In vitro characterization of novel peptide inhibitors of endomorphin-degrading enzymes in the rat brain

scientific article published in September 2006

Inhibition of trigemino-hypoglossal reflex in rats by oxytocin is mediated by mu and kappa opioid receptors

scientific article published in February 2005

Involvement of a coumarin analog AD-013 in the DNA damage response pathways in MCF-7 cells

scholarly article by Angelika Długosz published in October 2018

Involvement of α-methylene-γ- and δ-lactones in the suppression of multidrug resistance in MCF-7 cells

scientific article published on 10 January 2018

Kinetic studies of novel inhibitors of endomorphin degrading enzymes

scientific article

Low-dose hyper-radiosensitivity is not a common effect in normal asynchronous and G2-phase fibroblasts of cancer patients

scientific article published on 01 February 2014

Molecular mechanisms of apoptosis induced by a novel synthetic quinolinone derivative in HL-60 human leukemia cells

scientific article published on 25 February 2020

Mu-opioid receptor ligands lack receptor subtype selectivity in the aequorin luminescence-based calcium assay

scientific article

Natural and synthetic α-methylenelactones and α-methylenelactams with anticancer potential

scientific article published on 28 January 2012

New Chiral Ebselen Analogues with Antioxidant and Cytotoxic Potential.

scientific article

New glutathione peroxidase mimetics-Insights into antioxidant and cytotoxic activity.

scientific article published on 18 October 2016

New neostigmine-based behavioral mouse model of abdominal pain

scientific article published on 01 January 2012

New stereocontrolled synthesis and biological evaluation of 5-(1'-hydroxyalkyl)-3-methylidenetetrahydro-2-furanones as potential cytotoxic agents.

scientific article published in February 2002

New uracil analog U-332 is an inhibitor of NF-κB in 5-fluorouracil-resistant human leukemia HL-60 cell line

scientific article published on 02 March 2020

New uracil analog with exocyclic methylidene group as potential anticancer agent

scientific article published on 10 December 2019

New uracil analogs as downregulators of ABC transporters in 5-fluorouracil-resistant human leukemia HL-60 cell line

scientific article published on 18 November 2019

Novel endomorphin analogues with antagonist activity at the mu-opioid receptor in the gastrointestinal tract

scientific article

Novel glycosylated endomorphin-2 analog produces potent centrally-mediated antinociception in mice after peripheral administration

scientific article published on 30 October 2013

Novel highly potent mu-opioid receptor antagonist based on endomorphin-2 structure

scientific article

Novel synthesis, cytotoxic evaluation, and structure-activity relationship studies of a series of alpha-alkylidene-gamma-lactones and lactams.

scientific article

Novobiocin Analogs as Potential Anticancer Agents

scientific article published on 23 December 2016

Opioid and Cannabinoid System in Food Intake

scientific article

Opioid antagonist-induced regulation of the mu-opioid receptor expression in MCF-7 breast cancer cell line

scientific article published on January 2009

Opioid peptides in cancer

scientific article published on August 2004

Opioid receptor binding and in vivo antinociceptive activity of position 3-substituted morphiceptin analogs

scientific article

Opioid receptors and their ligands

scientific article

Opioid-induced regulation of mu-opioid receptor gene expression in the MCF-7 breast cancer cell line

scientific article

Overview of metabolism and bioavailability enhancement of polyphenols.

scientific article published on 10 December 2013

Pharmacological Characterization of µ-Opioid Receptor Agonists with Biased G Protein or β-Arrestin Signaling, and Computational Study of Conformational Changes during Receptor Activation

scientific article published on 22 December 2020

Pharmacological characterization of endomorphin-2-based cyclic pentapeptides with methylated phenylalanine residues.

scientific article published on 13 March 2014

Pharmacological profile and molecular modeling of cyclic opioid analogs incorporating various phenylalanine derivatives

scientific article published on 15 May 2020

Pharmacological properties of novel cyclic pentapeptides with µ-opioid receptor agonist activity

scientific article

Pharmacology of stomoxytachykinin receptor depends on second messenger system.

scientific article published in January 2005

Phenylselanyl Group Incorporation for "Glutathione Peroxidase-Like" Activity Modulation

scientific article published on 24 July 2020

Potential of Nociceptin/Orphanin FQ Peptide Analogs for Drug Development

scientific article published on 22 December 2020

Prognostic value of PIK3CA mutation status, PTEN and androgen receptor expression for metastasis-free survival in HER2-positive breast cancer patients treated with trastuzumab in adjuvant setting

scientific article published on June 2015

Proteins Involved in HER2 Signalling Pathway, Their Relations and Influence on Metastasis-Free Survival in HER2-Positive Breast Cancer Patients Treated with Trastuzumab in Adjuvant Setting

scientific article published on January 2017

Proteomic analysis of proteins engaged in α-methylene-δ-lactone cytotoxic effects in hormone-independent breast cancer MDA-MB-231 cells

scientific article

Redoubling the ring size of an endomorphin-2 analog transforms a centrally acting mu-opioid receptor agonist into a pure peripheral analgesic

scientific article

Ring size in cyclic endomorphin-2 analogs modulates receptor binding affinity and selectivity.

scientific article published in June 2015

Rubiscolins - highly potent peptides derived from plant proteins

scientific article

Salvinorin A has antiinflammatory and antinociceptive effects in experimental models of colitis in mice mediated by KOR and CB1 receptors

scientific article

Selective natural kappa opioid and cannabinoid receptor agonists with a potential role in the treatment of gastrointestinal dysfunction

scientific article published on September 2009

Seleninic Acid Potassium Salts as Water-Soluble Biocatalysts with Enhanced Bioavailability

scientific article published on 02 February 2020

Strategies to Improve Bioavailability and In Vivo Efficacy of the Endogenous Opioid Peptides Endomorphin-1 and Endomorphin-2.

scientific article published on 16 August 2015

Structure-activity relationship, conformation and pharmacology studies of morphiceptin analogues--selective mu-opioid receptor ligands

scientific article

Substance P content in the cerebrospinal fluid and fluid perfusing cerebral ventricles during elicitation and inhibition of trigemino-hypoglossal reflex in rats

scientific article published in June 2002

Synthesis and Cytotoxic Evaluation of 3-Methylidenechroman-4-ones

scientific article published on 15 May 2019

Synthesis and Pharmacological Evaluation of Hybrids Targeting Opioid and Neurokinin Receptors

scientific article published on 05 December 2019

Synthesis and activity of opioid peptidomimetics with β2- and β3-amino acids

scientific article published on 3 August 2017

Synthesis and antinociceptive activity of cyclic endomorphin-2 and morphiceptin analogs

scientific article published on 10 November 2005

Synthesis and biological activity of N-methylated analogs of endomorphin-2

scientific article published on 06 September 2005

Synthesis and biological activity of endomorphin-2 analogs incorporating piperidine-2-, 3- or 4-carboxylic acids instead of proline in position 2.

scientific article published on 13 June 2008

Synthesis and biological evaluation of cyclic endomorphin-2 analogs

scientific article published on 6 December 2009

Synthesis and biological evaluation of novel peripherally active morphiceptin analogs

scientific article published on 29 April 2010

Synthesis and biological evaluation of α-methylidene-δ-lactones with 3,4-dihydrocoumarin skeleton

scientific article published on 19 June 2012

Synthesis and characterization of potent and selective mu-opioid receptor antagonists, [Dmt(1), D-2-Nal(4)]endomorphin-1 (Antanal-1) and [Dmt(1), D-2-Nal(4)]endomorphin-2 (Antanal-2).

scientific article

Synthesis and cytotoxic activity of gamma-aryl substituted alpha-alkylidene-gamma-lactones and alpha-alkylidene-gamma-lactams.

scientific article

Synthesis and cytotoxic evaluation of beta-alkyl or beta-aryl-delta-methyl-alpha-methylene-delta-lactones. Comparison with the corresponding gamma-lactones.

scientific article

Synthesis and opioid activity of novel 6-ketolevorphanol derivatives

scientific article published on February 2013

Synthesis and opioid activity of novel 6-substituted-6-demethoxy-ethenomorphinans

scientific article published on 29 March 2010

Synthesis of 2,2,6-Trisubstituted 5-Methylidene-tetrahydropyran-4-ones with Anticancer Activity

scientific article published on 30 January 2020

Synthesis of 3-Methylidene-1-tosyl-2,3-dihydroquinolin-4(1H)-ones as Potent Cytotoxic Agents

scientific article published on 08 August 2018

Synthesis of 4,4-Disubstituted 3-Methylidenechroman-2-ones as Potent Anticancer Agents.

scientific article

Synthesis of linear and cyclic opioid-based peptide analogs containing multiple N-methylated amino acid residues

scientific article published on 24 September 2015

Synthesis of mixed MOR/KOR efficacy cyclic opioid peptide analogs with antinociceptive activity after systemic administration

scientific article published on 12 December 2015

Synthesis of mixed opioid affinity cyclic endomorphin-2 analogues with fluorinated phenylalanines

scientific article published on 3 April 2015

Synthesis of target-specific radiolabeled peptides for diagnostic imaging

scientific article

Synthesis, Selected Transformations, and Biological Activity of Alkoxy Analogues of Lepidilines A and C

scientific article published on 21 September 2020

Synthesis, biological evaluation and structural analysis of novel peripherally active morphiceptin analogs.

scientific article published on 26 February 2016

Synthesis, receptor binding studies, optical spectroscopic and in silico structural characterization of morphiceptin analogs with cis-4-amino-L-proline residues.

scientific article published on 7 November 2017

Thapsigargin-From Traditional Medicine to Anticancer Drug

scientific article published on 22 December 2020

The endomorphin system and its evolving neurophysiological role

scientific article published on March 2007

The influence of opioids on matrix metalloproteinase-2 and -9 secretion and mRNA levels in MCF-7 breast cancer cell line

scientific article published on 20 June 2010

The influence of opioids on urokinase plasminogen activator on protein and mRNA level in MCF-7 breast cancer cell line

scientific article

The mu-opioid receptor-selective peptide antagonists, antanal-1 and antanal-2, produce anticonvulsant effects in mice

scientific article published on 11 August 2012

The novel endomorphin degradation blockers Tyr-Pro-DClPhe-Phe-NH (EMDB-1) and Tyr-Pro-Ala-NH (EMDB-2) prolong endomorphin-2 action in rat ileum in vitro

scientific article published on 23 April 2010

The role of morphine in regulation of cancer cell growth

scientific article published on 29 July 2011

The role of oxidative stress in anticancer activity of sesquiterpene lactones

scientific article published on 06 February 2015

The search for opioid analgesics with limited tolerance liability

scientific article published on 01 June 2020

Trigemino-hypoglossal somatic reflex in the pharmacological studies of nociception in orofacial area

scientific article published on January 2015

[(35)S]GTPgammaS binding stimulated by endomorphin-2 and morphiceptin analogs

scientific article published on 27 April 2006

[D-1-Nal4]endomorphin-2 is a potent micro-opioid receptor antagonist in the aequorin luminescence-based calcium assay

scientific article published on 21 March 2006

[Dmt1, d-1-Nal3]morphiceptin, a novel opioid peptide analog with high analgesic activity

scientific article

[Opioid receptors and their selective ligands]

scientific article published on 01 January 2006

[Salvinorin A and related diterpenes--biological activity and potential therapeutic uses].

scientific article

α-Methylene-γ-lactones as a novel class of anti-leukemic agents

scientific article published on June 2014

Paulina is supported by:

About Paulina

Help