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List of works by Amy S Lee

A Binding Site for the Cyclic Adenosine 3′,5′-Monophosphate-Response Element-Binding Protein as a Regulatory Element in the grp78 Promoter

scientific article published on December 1, 1991

A critical role for GRP78/BiP in the tumor microenvironment for neovascularization during tumor growth and metastasis

scientific article

A human HMG2 cDNA with a novel 3'-untranslated region

scientific article

ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1

scientific article

ATF6 modulates SREBP2-mediated lipogenesis.

scientific article published on 05 February 2004

Activator protein-2 overexpression accounts for increased insulin receptor expression in human breast cancer.

scientific article published on May 2006

Acute inducible ablation of GRP78 reveals its role in hematopoietic stem cell survival, lymphogenesis and regulation of stress signaling.

scientific article

Analysis of the expression of a glucose-regulated protein (GRP78) promoter/CAT fusion gene during early Xenopus laevis development.

scientific article published in January 1992

Beyond the endoplasmic reticulum: atypical GRP78 in cell viability, signalling and therapeutic targeting

scientific article

CDP and AP-2 mediated repression mechanism of the replication-dependent hamster histone H3.2 promoter

scientific article published on 01 January 2002

Calcium-sensitive transcriptional activation of the proximal CCAAT regulatory element of the grp78/BiP promoter by the human nuclear factor CBF/NF-Y.

scientific article

Cancer cells resistant to therapy promote cell surface relocalization of GRP78 which complexes with PI3K and enhances PI(3,4,5)P3 production

scientific article (publication date: 2013)

Characterization and mechanism of stress-induced translocation of 78-kilodalton glucose-regulated protein (GRP78) to the cell surface

scientific article

Comparison of the genomic organizations of the rat grp78 and hsc73 gene and their evolutionary implications

scientific article published on January 1, 1992

Conformation-defective herpes simplex virus 1 glycoprotein B activates the promoter of the grp94 gene that codes for the 94-kD stress protein in the endoplasmic reticulum.

scientific article published on May 1995

Conservation and divergence of the yeast and mammalian unfolded protein response. Activation of specific mammalian endoplasmic reticulum stress element of the grp78/BiP promoter by yeast Hac1.

scientific article published on October 1999

Constitutive nucleosome depletion and ordered factor assembly at the GRP78 promoter revealed by single molecule footprinting

scientific article

Cooperative interactions between the GRP78 enhancer and promoter elements in hamster fibroblasts.

scientific article

Critical role of the stress chaperone GRP78/BiP in tumor proliferation, survival, and tumor angiogenesis in transgene-induced mammary tumor development.

scientific article

De-regulation of GRP stress protein expression in human breast cancer cell lines.

scientific article published on March 1999

Deficiency of GRP94 in the hematopoietic system alters proliferation regulators in hematopoietic stem cells.

scientific article published on 20 August 2013

ER Chaperone BiP/GRP78 Is Required for Myelinating Cell Survival and Provides Protection during Experimental Autoimmune Encephalomyelitis.

scientific article

ER chaperones in mammalian development and human diseases

scientific article

ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response

scientific article published on 28 March 2013

ER stress induces epithelial differentiation in the mouse oesophagus.

scientific article published on 30 April 2014

Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer and Chemotoxic Resistance in Aged Mice

scientific article published on February 2017

Endoplasmic Reticulum Stress Response Promotes Cytotoxic Phenotype of CD8 + Intraepithelial Lymphocytes in a Mouse Model for Crohn's Disease-like Ileitis

article

Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: role of ATP binding site in suppression of caspase-7 activation

scientific article

Endoplasmic reticulum stress activates SRC, relocating chaperones to the cell surface where GRP78/CD109 blocks TGF-β signaling

scientific article published on 13 April 2018

Endoplasmic reticulum stress induction of the Grp78/BiP promoter: activating mechanisms mediated by YY1 and its interactive chromatin modifiers.

scientific article

Endoplasmic reticulum stress triggers an acute proteasome-dependent degradation of ATF6.

scientific article published on July 2004

Endoplasmic reticulum stress.

scientific article published on 4 May 2007

Enhanced synthesis of the glucose/calcium-regulated proteins in a hamster cell mutant deficient in transfer of oligosaccharide core to polypeptides

scientific article published on 01 December 1986

Enhanced transcription of the 78,000-dalton glucose-regulated protein (GRP78) gene and association of GRP78 with immunoglobulin light chains in a nonsecreting B-cell myeloma line (NS-1).

scientific article published on May 1989

Eradication of murine mammary adenocarcinoma through HSVtk expression directed by the glucose-starvation inducible grp78 promoter.

scientific article

Essential role of the unfolded protein response regulator GRP78/BiP in protection from neuronal apoptosis

scientific article

Establishment of a Chinese hamster ovary cell line that expresses grp78 antisense transcripts and suppresses A23187 induction of both GRP78 and GRP94

scientific article published on December 1, 1992

Expression of the glucose-regulated proteins (GRP94 and GRP78) in differentiated and undifferentiated mouse embryonic cells and the use of the GRP78 promoter as an expression system in embryonic cells.

scientific article published in February 1990

GRP78 haploinsufficiency suppresses acinar-to-ductal metaplasia, signaling, and mutant Kras-driven pancreatic tumorigenesis in mice

scientific article published in May 2017

GRP78 induction in cancer: therapeutic and prognostic implications.

scientific article published on April 2007

GRP78 promoter polymorphism rs391957 as potential predictor for clinical outcome in gastric and colorectal cancer patients.

scientific article

GRP78 regulates CD44v membrane homeostasis and cell spreading in tamoxifen-resistant breast cancer

scientific article published on 15 August 2019

GRP78/BiP is a novel downstream target of IGF‐1 receptor mediated signaling

scientific article published on December 1, 2012

GRP94 Regulates Circulating Cholesterol Levels through Blockade of PCSK9-Induced LDLR Degradation.

scientific article published on 23 November 2015

Glucose-regulated protein (GRP94 and GRP78) genes share common regulatory domains and are coordinately regulated by common trans-acting factors

scientific article

Glucose-regulated protein 78 is essential for cardiac myocyte survival.

scientific article published on 17 April 2018

Glucose-regulated protein 94 deficiency induces squamous cell metaplasia and suppresses PTEN-null driven endometrial epithelial tumor development.

scientific article published on 17 February 2016

Glucose-regulated proteins in cancer: molecular mechanisms and therapeutic potential

scientific article published on April 2014

Grp78 heterozygosity promotes adaptive unfolded protein response and attenuates diet-induced obesity and insulin resistance

scientific article

Grp78 heterozygosity regulates chaperone balance in exocrine pancreas with differential response to cerulein-induced acute pancreatitis

scientific article

Hepatitis C Virus Core Protein Interacts with Heterogeneous Nuclear Ribonucleoprotein K

scientific article published on July 10, 1998

Heterozygosity of Chaperone Grp78 Reduces Intestinal Stem Cell Regeneration Potential and Protects against Adenoma Formation

scientific article published on 19 September 2018

Human gene encoding the 78,000-dalton glucose-regulated protein and its pseudogene: structure, conservation, and regulation

scientific article

Identification of AP-2 as an interactive target of Rb and a regulator of the G1/S control element of the hamster histone H3.2 promoter.

scientific article published on November 1998

Impaired eyeblink conditioning in 78kDa-glucose regulated protein (GRP78)/immunoglobulin binding protein (BiP) conditional knockout mice

scientific article published on June 1, 2011

In vivo regulation of Grp78/BiP transcription in the embryonic heart: role of the endoplasmic reticulum stress response element and GATA-4.

scientific article published on February 2006

Inducible knockout of GRP78/BiP in the hematopoietic system suppresses Pten-null leukemogenesis and AKT oncogenic signaling

scientific article published on September 21, 2011

Induction of Grp78/BiP by translational block: activation of the Grp78 promoter by ATF4 through and upstream ATF/CRE site independent of the endoplasmic reticulum stress elements

scientific article

Induction of endoplasmic reticulum stress by deletion of Grp78 depletes Apc mutant intestinal epithelial stem cells.

scientific article published on 7 November 2016

Induction of glucose-regulated protein (glucose-regulated protein 78/BiP and glucose-regulated protein 94) and heat shock protein 70 transcripts in the immature rat brain following status epilepticus.

scientific article

Inositol 1,4,5-trisphosphate receptor 1 mutation perturbs glucose homeostasis and enhances susceptibility to diet-induced diabetes

scientific article published on May 12, 2011

Liver-specific knockout of GRP94 in mice disrupts cell adhesion, activates liver progenitor cells, and accelerates liver tumorigenesis.

scientific article

Liver-specific loss of glucose-regulated protein 78 perturbs the unfolded protein response and exacerbates a spectrum of liver diseases in mice

scientific article published on July 1, 2011

Localization of the gene encoding human BiP/GRP78, the endoplasmic reticulum cognate of the HSP70 family, to chromosome 9q34

scientific article (publication date: 15 March 1994)

Measurement and modification of the expression level of the chaperone protein and signaling regulator GRP78/BiP in mammalian cells.

scientific article published in January 2011

Mechanism for the Suppression of the Mammalian Stress Response by Genistein, an Anticancer Phytoestrogen From Soy

scientific article published on March 4, 1998

Monoclonal antibody against cell surface GRP78 as a novel agent in suppressing PI3K/AKT signaling, tumor growth, and metastasis.

scientific article

New role of endoplasmic reticulum chaperones in regulating metaplasia during tumorigenesis.

scientific article published on 30 June 2017

Novel mechanism of anti-apoptotic function of 78-kDa glucose-regulated protein (GRP78): endocrine resistance factor in breast cancer, through release of B-cell lymphoma 2 (BCL-2) from BCL-2-interacting killer (BIK).

scientific article

Overexpressing GRP78 influences Ca2+ handling and function of mitochondria in astrocytes after ischemia-like stress.

scientific article published on November 2010

Rat gene encoding the 78-kDa glucose-regulated protein GRP78: its regulatory sequences and the effect of protein glycosylation on its expression.

scientific article

Reduction of the molecular chaperone binding immunoglobulin protein (BiP) accentuates the effect of aging on sleep-wake behavior

scientific article published on 30 April 2018

Regulation of PERK signaling and leukemic cell survival by a novel cytosolic isoform of the UPR regulator GRP78/BiP

scientific article

Regulation of a hybrid gene by glucose and temperature in hamster fibroblasts.

scientific article

Reply: To PMID 24027047.

scientific article published on 24 December 2014

Requirement of the p38 mitogen-activated protein kinase signalling pathway for the induction of the 78 kDa glucose-regulated protein/immunoglobulin heavy-chain binding protein by azetidine stress: activating transcription factor 6 as a target [...]

scientific article

Requirement of tyrosine- and serine/threonine kinases in the transcriptional activation of the mammalian grp78/BiP promoter by thapsigargin.

scientific article published on January 1995

Role of the unfolded protein response regulator GRP78/BiP in development, cancer, and neurological disorders.

scientific article published on September 2009

Role of the unfolded protein response, GRP78 and GRP94 in organ homeostasis.

scientific article

Sensitization of calcium-induced calcium release by cyclic ADP-ribose and calmodulin

scientific article published on 01 April 1995

Sequences contained within the promoter of the human thymidine kinase gene can direct cell-cycle regulation of heterologous fusion genes

scientific article published on August 1, 1988

Soy food supplementation, dietary fat reduction and peripheral blood gene expression in postmenopausal women--a randomized, controlled trial

scientific article published on 08 August 2011

Spontaneous and controllable activation of suicide gene expression driven by the stress-inducible grp78 promoter resulting in eradication of sizable human tumors.

scientific article

Stress induction of GRP78/BiP and its role in cancer.

scientific article

Suppression of stress induction of the 78-kilodalton glucose regulated protein (GRP78) in cancer by IT-139, an anti-tumor ruthenium small molecule inhibitor

scientific article published on 03 July 2018

Targeted deletion of ER chaperone GRP94 in the liver results in injury, repopulation of GRP94-positive hepatocytes, and spontaneous hepatocellular carcinoma development in aged mice

scientific article

Targeted mutation of the mouse Grp94 gene disrupts development and perturbs endoplasmic reticulum stress signaling

scientific article (publication date: 2010)

Targeting the glucose-regulated protein-78 abrogates Pten-null driven AKT activation and endometrioid tumorigenesis.

scientific article

Temporal events regulating the early phases of the mammalian cell cycle.

scientific article published on April 1991

The 78-kD Glucose-Regulated Protein Regulates Endoplasmic Reticulum Homeostasis and Distal Epithelial Cell Survival during Lung Development

scientific article published on 27 January 2016

The Endoplasmic Reticulum Chaperone GRP78/BiP Modulates Prion Propagation in vitro and in vivo

scientific article published on 23 March 2017

The Par-4-GRP78 TRAIL, more twists and turns.

scientific article

The critical role of GRP78 in physiologic and pathologic stress.

scientific article

The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies

scientific article published on 16 April 2012

The endoplasmic reticulum chaperone glycoprotein GRP94 with Ca(2+)-binding and antiapoptotic properties is a novel proteolytic target of calpain during etoposide-induced apoptosis

scientific article

The endoplasmic reticulum stress marker, glucose-regulated protein-78 (GRP78) in visceral adipocytes predicts endometrial cancer progression and patient survival

scientific article

The endothelial cell receptor GRP78 is required for mucormycosis pathogenesis in diabetic mice.

scientific article

The nucleotide sequence encoding the hamster 78-kDa glucose-regulated protein (GRP78) and its conservation between hamster and rat.

scientific article published in January 1987

The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas.

scientific article

Transactivation of the grp78 promoter by malfolded proteins, glycosylation block, and calcium ionophore is mediated through a proximal region containing a CCAAT motif which interacts with CTF/NF-I

scientific article published on November 1, 1991

Transcriptional induction of GRP78/BiP by histone deacetylase inhibitors and resistance to histone deacetylase inhibitor-induced apoptosis.

scientific article

Transduction of calcium stress through interaction of the human transcription factor CBF with the proximal CCAAT regulatory element of the grp78/BiP promoter

scientific article published on April 1995

Underglycosylation of ATF6 as a novel sensing mechanism for activation of the unfolded protein response.

scientific article published on 29 December 2003

Upregulation of BiP and CHOP by the unfolded-protein response is independent of presenilin expression.

scientific article

Use of a cell cycle mutant to delineate the critical period for the control of histone mRNA levels in the mammalian cell cycle.

scientific article published on November 1984

miR-30d, miR-181a and miR-199a-5p cooperatively suppress the endoplasmic reticulum chaperone and signaling regulator GRP78 in cancer.

scientific article